MRC National Mouse Genetics Network
@mrcmousenetwork.bsky.social
Distributed challenge-led research clusters working with the Mary Lyon Centre at MRC Harwell to accelerate understanding of human disease using #MouseModels
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
November 12, 2025 at 1:31 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 12, 2025 at 11:33 AM
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
November 6, 2025 at 12:45 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
November 4, 2025 at 8:20 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
October 31, 2025 at 12:20 PM
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Nice place for a bit of work and hopefully some fun!
We recently welcomed Prof. Fiona Powrie and her team to the MRC CMM for the yearly Microbiome Cluster @mrcmousenetwork.bsky.social meeting. The Microbiome Cluster studies the impact of the microbiome on genetic diseases involving barrier surface malfunction.
🔗 Find out more buff.ly/zuLgJ1J
🔗 Find out more buff.ly/zuLgJ1J
October 9, 2025 at 5:15 PM
Nice place for a bit of work and hopefully some fun!
Last session in full swing! #OrganoidsAreUs2025
September 25, 2025 at 2:11 PM
Last session in full swing! #OrganoidsAreUs2025
Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research.
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
September 25, 2025 at 9:42 AM
Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research.
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
Second session on #StemCells #regeneration and #cancer. We start with
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
September 24, 2025 at 12:28 PM
Second session on #StemCells #regeneration and #cancer. We start with
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025
September 24, 2025 at 8:46 AM
A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
September 23, 2025 at 5:01 PM
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025
September 23, 2025 at 11:18 AM
We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
September 16, 2025 at 12:15 PM
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
Reposted by MRC National Mouse Genetics Network
If you lead a facility or research group whose primary focus is on genetic engineering, our upcoming workshop held on behalf of the @mrcmousenetwork.bsky.social may be for you.
Find out more and apply ⬇️
www.crick.ac.uk/whats-on/uk-...
Find out more and apply ⬇️
www.crick.ac.uk/whats-on/uk-...
UK facilities workshop on genome engineering technologies
www.crick.ac.uk
August 22, 2025 at 12:53 PM
If you lead a facility or research group whose primary focus is on genetic engineering, our upcoming workshop held on behalf of the @mrcmousenetwork.bsky.social may be for you.
Find out more and apply ⬇️
www.crick.ac.uk/whats-on/uk-...
Find out more and apply ⬇️
www.crick.ac.uk/whats-on/uk-...
Reposted by MRC National Mouse Genetics Network
Nice write up on the @mrcmousenetwork.bsky.social
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
Understanding the Protein Tagging Problem: A New Study from the NMGN Degron Tagging Cluster | National Mouse Genetics Network
Celebrating Research Specialists: Driving Innovation in Mouse Genetics Research specialists are often the unsung heroes in biomedical research groups, providing continuity in long-term research progra...
nmgn.mrc.ukri.org
August 26, 2025 at 12:21 PM
Nice write up on the @mrcmousenetwork.bsky.social
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
Claus Nerlov, from the @imm.ox.ac.uk and Haem Cluster member, was awarded a @wellcometrust.bsky.social Discovery Award to map the regulatory networks in blood cell production. This will provide invaluable insight for the development of better therapies for patients
nmgn.mrc.ukri.org/news/wellcom...
nmgn.mrc.ukri.org/news/wellcom...
Wellcome Discovery Award for Claus Nerlov of the Heam Cluster | National Mouse Genetics Network
Claus Nerlov, Professor of Stem Cell Biology and member of our Haem Cluster, has been awarded funding from Wellcome to map the gene regulatory networks in blood cell production and […]
nmgn.mrc.ukri.org
August 13, 2025 at 10:59 AM
Claus Nerlov, from the @imm.ox.ac.uk and Haem Cluster member, was awarded a @wellcometrust.bsky.social Discovery Award to map the regulatory networks in blood cell production. This will provide invaluable insight for the development of better therapies for patients
nmgn.mrc.ukri.org/news/wellcom...
nmgn.mrc.ukri.org/news/wellcom...
A workshop about data science and DeepLabCut organised with our colleagues of the University of York and Generation Research. Check out our story about it! nmgn.mrc.ukri.org/news/a-works...
A workshop for behavioural scientists on the use of DeepLabCut | National Mouse Genetics Network
As part of the effort to disseminate knowledge and skills across the Network and the community, we asked some of our GenerationResearch colleagues at the University of York to organise […]
nmgn.mrc.ukri.org
August 11, 2025 at 11:32 AM
A workshop about data science and DeepLabCut organised with our colleagues of the University of York and Generation Research. Check out our story about it! nmgn.mrc.ukri.org/news/a-works...
Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
August 5, 2025 at 10:01 AM
Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
www.crukscotlandinstitute.ac.uk
July 17, 2025 at 10:11 AM
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
www.crukscotlandinstitute.ac.uk
July 8, 2025 at 8:51 AM
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
Interested in staying current with the latest applications and discoveries using
#organoids? Subscribe to Organoid News by STEMCELL Science News to stay on top
of the latest publications, reviews, industry news, and more.
www.stemcellsciencenews.com/organoid-new...
#organoids? Subscribe to Organoid News by STEMCELL Science News to stay on top
of the latest publications, reviews, industry news, and more.
www.stemcellsciencenews.com/organoid-new...
Organoid News | Science News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
www.stemcellsciencenews.com
July 1, 2025 at 1:30 PM
Interested in staying current with the latest applications and discoveries using
#organoids? Subscribe to Organoid News by STEMCELL Science News to stay on top
of the latest publications, reviews, industry news, and more.
www.stemcellsciencenews.com/organoid-new...
#organoids? Subscribe to Organoid News by STEMCELL Science News to stay on top
of the latest publications, reviews, industry news, and more.
www.stemcellsciencenews.com/organoid-new...
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
www.crukscotlandinstitute.ac.uk
June 27, 2025 at 11:25 AM
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
📆23 - 26 September 2025
📍Glasgow, Scotland
Early bird registration extended to 18th July. Register below! 👇
Reposted by MRC National Mouse Genetics Network
A great example of the Network’s fundamental contributions to our understanding of the biological consequences of molecular manipulation and the benefits of cross cluster #collaborations. Lastly, but not in order of importance, another Network #ECR shining here! Well done Gillian Taylor!
Pleased to share our latest work and the first manuscript from the Degron Tagging Cluster in the MRC National Mouse Genetics Network. If you work with protein tags, particularly in tissue biology models, this should be of interest:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 24, 2025 at 8:12 AM
A great example of the Network’s fundamental contributions to our understanding of the biological consequences of molecular manipulation and the benefits of cross cluster #collaborations. Lastly, but not in order of importance, another Network #ECR shining here! Well done Gillian Taylor!
A great example of the Network’s fundamental contributions to our understanding of the biological consequences of molecular manipulation and the benefits of cross cluster #collaborations. Lastly, but not in order of importance, another Network #ECR shining here! Well done Gillian Taylor!
Pleased to share our latest work and the first manuscript from the Degron Tagging Cluster in the MRC National Mouse Genetics Network. If you work with protein tags, particularly in tissue biology models, this should be of interest:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 24, 2025 at 8:12 AM
A great example of the Network’s fundamental contributions to our understanding of the biological consequences of molecular manipulation and the benefits of cross cluster #collaborations. Lastly, but not in order of importance, another Network #ECR shining here! Well done Gillian Taylor!
Reposted by MRC National Mouse Genetics Network
Join us for Organoids Are Us 2025, a symposium featuring #organoids, #stemcells, #cancer, inflammatory disorders and infectious disease.
📆23-26 Sep 2025
📍Glasgow, UK
Early bird registration ends 15 June. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
📆23-26 Sep 2025
📍Glasgow, UK
Early bird registration ends 15 June. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
www.crukscotlandinstitute.ac.uk
June 11, 2025 at 8:45 AM
Join us for Organoids Are Us 2025, a symposium featuring #organoids, #stemcells, #cancer, inflammatory disorders and infectious disease.
📆23-26 Sep 2025
📍Glasgow, UK
Early bird registration ends 15 June. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...
📆23-26 Sep 2025
📍Glasgow, UK
Early bird registration ends 15 June. Register below! 👇
www.crukscotlandinstitute.ac.uk/events/organ...