Prof Anthony Isles
@profantisles.bsky.social
#Neuroscience 🧠 | #ImprintedGenes 🧬 | #preclinical models 🐭🧫| MURIDAE lead @mrcmousenetwork.bsky.social | Cardiff University | posting in a personal capacity, mostly about science
https://profiles.cardiff.ac.uk/staff/islesar1
https://profiles.cardiff.ac.uk/staff/islesar1
Pinned
Great last day at the Valencian Genomic Imprinting meeting! It has been wonderful to catch up with colleagues old and new, and we have heard some fantastic research - here is to the next meeting!
Huge thanks to Sacri Ferron and the Ferron lab for organising and running such a brilliant conference 🤩
Great last day at the Valencian Genomic Imprinting meeting! It has been wonderful to catch up with colleagues old and new, and we have heard some fantastic research - here is to the next meeting!
November 19, 2025 at 6:20 PM
Huge thanks to Sacri Ferron and the Ferron lab for organising and running such a brilliant conference 🤩
Great last day at the Valencian Genomic Imprinting meeting! It has been wonderful to catch up with colleagues old and new, and we have heard some fantastic research - here is to the next meeting!
November 19, 2025 at 6:18 PM
Great last day at the Valencian Genomic Imprinting meeting! It has been wonderful to catch up with colleagues old and new, and we have heard some fantastic research - here is to the next meeting!
Day 2 - Great to hear about a variety of imprinting research, covering #epigenetic regulation, #metabolism, #placenta function and #brain and #behaviour. A full day finished off with a lovely dinner in the botanic gardens 🤩
Fantastic first day at the First Genomic Imprinting Valencian Meeting! Great to catch up with colleagues, but really nice to hear about research from newer imprinters such as Julie Demars, Ariella Weinberg-Shukron and Daniel Andergassen
November 19, 2025 at 8:15 AM
Day 2 - Great to hear about a variety of imprinting research, covering #epigenetic regulation, #metabolism, #placenta function and #brain and #behaviour. A full day finished off with a lovely dinner in the botanic gardens 🤩
Fantastic first day at the First Genomic Imprinting Valencian Meeting! Great to catch up with colleagues, but really nice to hear about research from newer imprinters such as Julie Demars, Ariella Weinberg-Shukron and Daniel Andergassen
November 17, 2025 at 9:45 PM
Fantastic first day at the First Genomic Imprinting Valencian Meeting! Great to catch up with colleagues, but really nice to hear about research from newer imprinters such as Julie Demars, Ariella Weinberg-Shukron and Daniel Andergassen
Reposted by Prof Anthony Isles
I am agnostic about whether there is a link between #microbiome and #brain, but this commentary raises some important issues about the reproducibility and reliability of the studies thus far…
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 14, 2025 at 12:19 PM
I am agnostic about whether there is a link between #microbiome and #brain, but this commentary raises some important issues about the reproducibility and reliability of the studies thus far…
Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting!
🧠🧠🧠🧠
🧠🧠🧠🧠
November 14, 2025 at 3:25 PM
Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting!
🧠🧠🧠🧠
🧠🧠🧠🧠
I am agnostic about whether there is a link between #microbiome and #brain, but this commentary raises some important issues about the reproducibility and reliability of the studies thus far…
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 14, 2025 at 12:19 PM
I am agnostic about whether there is a link between #microbiome and #brain, but this commentary raises some important issues about the reproducibility and reliability of the studies thus far…
Reposted by Prof Anthony Isles
1/Paper out today in Phil Trans B @royalsocietypublishing.org alsocietypublishing.org in a Special Issue «Evolutionary functions of consciousness», by @axc.bsky.social, Catherine Tallon-Baudry, @krysdolega.bsky.social and myself.
👉Open-access at this link: doi.org/10.1098/rstb...
⬇️ Summary below:
👉Open-access at this link: doi.org/10.1098/rstb...
⬇️ Summary below:
The value of consciousness: experiences worth having | Philosophical Transactions of the Royal Society B: Biological Sciences
DC. Dennett (2020,personal communication) asked: ‘How do we go from doing things for
reasons to having reasons for doing things?’. This question targets a fundamental
shift in nature: while all organi...
doi.org
November 13, 2025 at 2:25 PM
1/Paper out today in Phil Trans B @royalsocietypublishing.org alsocietypublishing.org in a Special Issue «Evolutionary functions of consciousness», by @axc.bsky.social, Catherine Tallon-Baudry, @krysdolega.bsky.social and myself.
👉Open-access at this link: doi.org/10.1098/rstb...
⬇️ Summary below:
👉Open-access at this link: doi.org/10.1098/rstb...
⬇️ Summary below:
Reposted by Prof Anthony Isles
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
October 31, 2025 at 12:20 PM
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Reposted by Prof Anthony Isles
In a new article in Disease Models & Mechanisms, the COST Action TEATIME welfare group makes the argument for increased use of automated welfare and phenotypic analysis in animal research, while discussing the significant challenges that need to be overcome:
www.har.mrc.ac.uk/news/advocat...
www.har.mrc.ac.uk/news/advocat...
Advocating for automation in animal research | Mary Lyon Centre
In a new article in Disease Models & Mechanisms, the COST Action TEATIME welfare group, which includes the Mary Lyon Centre’s Hilary Gates, Sonia Bains, and Sara Wells, makes the argument for increased use of automated welfare and phenotypic analysis in animal research, while discussing the significant challenges that need to be overcome to realise […]
www.har.mrc.ac.uk
November 7, 2025 at 2:35 PM
In a new article in Disease Models & Mechanisms, the COST Action TEATIME welfare group makes the argument for increased use of automated welfare and phenotypic analysis in animal research, while discussing the significant challenges that need to be overcome:
www.har.mrc.ac.uk/news/advocat...
www.har.mrc.ac.uk/news/advocat...
Reposted by Prof Anthony Isles
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 12, 2025 at 11:31 AM
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Reposted by Prof Anthony Isles
My SWBio PhD DTP project with Lukasz Chrobok (@chroboklab.bsky.social) and Kate Elliott (@neuroendo.bsky.social) is now advertised:
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
bpb-eu-w2.wpmucdn.com
November 11, 2025 at 9:07 PM
My SWBio PhD DTP project with Lukasz Chrobok (@chroboklab.bsky.social) and Kate Elliott (@neuroendo.bsky.social) is now advertised:
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
Reposted by Prof Anthony Isles
Original Ladybird artwork - John Berry’s sensitive portrait of the ‘handler’ in a scene from ‘The Pottery Makers’ (Stoke on Trent, 1969)
November 12, 2025 at 7:44 AM
Original Ladybird artwork - John Berry’s sensitive portrait of the ‘handler’ in a scene from ‘The Pottery Makers’ (Stoke on Trent, 1969)
Reposted by Prof Anthony Isles
Please join us in congratulating Marissa Ehringer, the new Editor-In-Chief of the Society's Journal, Genes, Brain and Behavior. We look forward to a successful partnership. @wileybrainpsych.bsky.social @ehringermaeiii.bsky.social @ibg.colorado.edu
November 12, 2025 at 9:35 AM
Please join us in congratulating Marissa Ehringer, the new Editor-In-Chief of the Society's Journal, Genes, Brain and Behavior. We look forward to a successful partnership. @wileybrainpsych.bsky.social @ehringermaeiii.bsky.social @ibg.colorado.edu
Reposted by Prof Anthony Isles
Love being reminded to do this every year. It's a win/win all round
November 11, 2025 at 11:00 AM
Love being reminded to do this every year. It's a win/win all round
Reposted by Prof Anthony Isles
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
November 10, 2025 at 9:55 AM
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
November 10, 2025 at 9:55 AM
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
Reposted by Prof Anthony Isles
Other work by the Ladybird artists
Red Squirrel
Artist: CF Tunnicliffe
Red Squirrel
Artist: CF Tunnicliffe
November 7, 2025 at 8:16 AM
Other work by the Ladybird artists
Red Squirrel
Artist: CF Tunnicliffe
Red Squirrel
Artist: CF Tunnicliffe
Reposted by Prof Anthony Isles
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
November 6, 2025 at 12:45 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Reposted by Prof Anthony Isles
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 29, 2025 at 1:33 PM
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
Reposted by Prof Anthony Isles
This was a worthwhile use of my morning 🔉
October 25, 2025 at 12:07 PM
This was a worthwhile use of my morning 🔉
Just catching up on the Life Scientific on #BBCR4 with @jimalkhalili.bsky.social - this episode featuring AP De Silva is wonderful 😊
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
The Life Scientific - AP De Silva on building molecular fluorescence sensors for healthcare - BBC Sounds
Photochemist AP De Silva on engineering molecular sensors to help revolutionise healthcare
www.bbc.co.uk
October 31, 2025 at 5:32 PM
Just catching up on the Life Scientific on #BBCR4 with @jimalkhalili.bsky.social - this episode featuring AP De Silva is wonderful 😊
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 29, 2025 at 1:33 PM
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
Reposted by Prof Anthony Isles
Minority representation on TV causes outrage
From the new Private Eye, in shops now.
From the new Private Eye, in shops now.
October 29, 2025 at 12:01 PM
Minority representation on TV causes outrage
From the new Private Eye, in shops now.
From the new Private Eye, in shops now.
Reposted by Prof Anthony Isles
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 26, 2025 at 10:32 AM
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1