Alexander Price
@pricelesssci.bsky.social
Assistant professor at the Wistar Institute studying Gene Regulation |
Virologist interested in all things RNA and DNA.
Virologist interested in all things RNA and DNA.
Reposted by Alexander Price
🧬 Exciting news from our lab 🧬 The Swiss National Science Foundation (SNSF) has approved our project studying KSHV and RNA decay: our first grant since re-launching the lab in Switzerland 🎉 We’re now looking for a Postdoc and a PhD student to join the team (start date January 2026) - please repost!
October 6, 2025 at 9:19 AM
🧬 Exciting news from our lab 🧬 The Swiss National Science Foundation (SNSF) has approved our project studying KSHV and RNA decay: our first grant since re-launching the lab in Switzerland 🎉 We’re now looking for a Postdoc and a PhD student to join the team (start date January 2026) - please repost!
Reposted by Alexander Price
I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com
Genoyer Lab
genoyerlab.com
October 3, 2025 at 6:10 PM
I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com
Very excited to share the first publication from the Price Lab, "Replication-competent adenovirus reporters utilizing endogenous viral expression architecture", is now online at Journal of Virology!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Replication-competent adenovirus reporters utilizing endogenous viral expression architecture | Journal of Virology
This research provides powerful new tools to rapidly study adenovirus gene expression
and replication. By integrating fluorescent and secreted luciferase reporters into
native viral regulatory element...
journals.asm.org
September 16, 2025 at 6:12 PM
Very excited to share the first publication from the Price Lab, "Replication-competent adenovirus reporters utilizing endogenous viral expression architecture", is now online at Journal of Virology!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Alexander Price
So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
A conserved viral RNA fold enables nuclease resistance across kingdoms of life
Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence
academic.oup.com
September 4, 2025 at 8:54 PM
So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology
First ever Price Lab paper accepted this morning!!! Hopefully follow-up post soon to showcase our new systems.
August 20, 2025 at 2:15 PM
First ever Price Lab paper accepted this morning!!! Hopefully follow-up post soon to showcase our new systems.
Reposted by Alexander Price
Stats: www.smbc-comics.com/comic/number...
(also you can buy the mug and other smbc stuff here: smbc-store.myshopify.com/products/goo...)
#smbc
(also you can buy the mug and other smbc stuff here: smbc-store.myshopify.com/products/goo...)
#smbc
July 27, 2025 at 4:55 PM
Stats: www.smbc-comics.com/comic/number...
(also you can buy the mug and other smbc stuff here: smbc-store.myshopify.com/products/goo...)
#smbc
(also you can buy the mug and other smbc stuff here: smbc-store.myshopify.com/products/goo...)
#smbc
The 20 years of sneezes to the face is what sent me, but every panel has a line that makes me laugh!
July 28, 2025 at 5:12 PM
The 20 years of sneezes to the face is what sent me, but every panel has a line that makes me laugh!
Reposted by Alexander Price
Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!
In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription.
Learn more here:
➡️ tinyurl.com/gd352654
Learn more here:
➡️ tinyurl.com/gd352654
July 14, 2025 at 2:57 PM
Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!
Reposted by Alexander Price
We are excited to share our recent work:
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation
Abstract. Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), fu
academic.oup.com
July 13, 2025 at 12:54 AM
We are excited to share our recent work:
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
The Price Lab turned two years old this week! Of course we celebrated with cake, but the cherry on top was submitting our labs very first manuscript today! Excited to see what the rest of the year holds.
July 3, 2025 at 8:05 PM
The Price Lab turned two years old this week! Of course we celebrated with cake, but the cherry on top was submitting our labs very first manuscript today! Excited to see what the rest of the year holds.
Reposted by Alexander Price
Postdoc positions available! Please re-post!
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Avgousti Lab
Investigating viral manipulation of host chromatin dynamics
avgoustilab.org
June 26, 2025 at 8:24 PM
Postdoc positions available! Please re-post!
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Reposted by Alexander Price
Excited to share with you my postdoctoral work published today in Nature Microbiology!
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
www.nature.com
June 25, 2025 at 11:55 AM
Excited to share with you my postdoctoral work published today in Nature Microbiology!
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
Reposted by Alexander Price
#NewResearch
🚨Out now!
Environmental stress drives clearance of a persistent enteric virus in mice 🐀
@christinviral.bsky.social @cadwelllab.bsky.social
#MicroSky #VirusSky
www.nature.com/articles/s41...
🚨Out now!
Environmental stress drives clearance of a persistent enteric virus in mice 🐀
@christinviral.bsky.social @cadwelllab.bsky.social
#MicroSky #VirusSky
www.nature.com/articles/s41...
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
www.nature.com
June 25, 2025 at 2:37 PM
#NewResearch
🚨Out now!
Environmental stress drives clearance of a persistent enteric virus in mice 🐀
@christinviral.bsky.social @cadwelllab.bsky.social
#MicroSky #VirusSky
www.nature.com/articles/s41...
🚨Out now!
Environmental stress drives clearance of a persistent enteric virus in mice 🐀
@christinviral.bsky.social @cadwelllab.bsky.social
#MicroSky #VirusSky
www.nature.com/articles/s41...
Reposted by Alexander Price
Love Park in Philly today for the No Kings protest 👏👏👏
June 14, 2025 at 5:59 PM
Love Park in Philly today for the No Kings protest 👏👏👏
Reposted by Alexander Price
Excited to share our editorial on peer review, out now in #mBio! This was a mighty group effort with my mBio Early Career Editorial Board peer mentoring group
@proctordm.bsky.social and Rachy Abraham.
From novice to expert: preparing your peer review | mBio journals.asm.org/doi/10.1128/...
@proctordm.bsky.social and Rachy Abraham.
From novice to expert: preparing your peer review | mBio journals.asm.org/doi/10.1128/...
From novice to expert: preparing your peer review | mBio
Peer review is the process that academic journals, conferences, and funding agencies
use to ensure the quality of scholarly work before it is published, presented, or
funded. Reviewers for academic jo...
journals.asm.org
June 6, 2025 at 3:13 PM
Excited to share our editorial on peer review, out now in #mBio! This was a mighty group effort with my mBio Early Career Editorial Board peer mentoring group
@proctordm.bsky.social and Rachy Abraham.
From novice to expert: preparing your peer review | mBio journals.asm.org/doi/10.1128/...
@proctordm.bsky.social and Rachy Abraham.
From novice to expert: preparing your peer review | mBio journals.asm.org/doi/10.1128/...
Reposted by Alexander Price
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs journals.asm.org/doi/10.1128/...
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs | mBio
Diverse conditions of infection and cellular stress incite the cleavage of transfer
RNAs (tRNAs), leading to the formation of tRNA fragments (tRFs) that can directly
regulate gene expression. In our s...
journals.asm.org
June 4, 2025 at 3:44 PM
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs journals.asm.org/doi/10.1128/...
With all that is happening it is very exciting to see the Price Lab's very first, in-house, Oxford Nanopore direct RNA seq running! Not bad for a ~3 year expired flow cell!
May 30, 2025 at 1:57 PM
With all that is happening it is very exciting to see the Price Lab's very first, in-house, Oxford Nanopore direct RNA seq running! Not bad for a ~3 year expired flow cell!
Reposted by Alexander Price
🚨 URGENT RESPONSE CALL 🚨
Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.
We’ve launched an open letter.
SIGN & SHARE NOW: actionnetwork.org/petitions/op...
Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.
We’ve launched an open letter.
SIGN & SHARE NOW: actionnetwork.org/petitions/op...
Sign The Open Letter to Stand Up For Science Now!
Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...
actionnetwork.org
May 26, 2025 at 4:19 PM
🚨 URGENT RESPONSE CALL 🚨
Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.
We’ve launched an open letter.
SIGN & SHARE NOW: actionnetwork.org/petitions/op...
Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.
We’ve launched an open letter.
SIGN & SHARE NOW: actionnetwork.org/petitions/op...
Reposted by Alexander Price
🚨 Out Now!
Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production
#MicroSky #Virus 🦠
www.nature.com/articles/s41...
Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production
#MicroSky #Virus 🦠
www.nature.com/articles/s41...
Kaposi’s sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production - Nature Microbiology
Kaposi’s sarcoma-associated herpesvirus changes mitochondrial architecture via vBcl-2 interaction with a host NDP kinase, which triggers mitochondrial fission and inhibition of MAVS allowing for virus...
www.nature.com
May 23, 2025 at 3:40 PM
🚨 Out Now!
Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production
#MicroSky #Virus 🦠
www.nature.com/articles/s41...
Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production
#MicroSky #Virus 🦠
www.nature.com/articles/s41...
Potentially one of the coolest models I have ever seen...
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
May 16, 2025 at 4:22 PM
Potentially one of the coolest models I have ever seen...
Amazing!! Need to read right away to finally understand what I've been working with!
Happy to share yet another story back from my days as a postdoc 👇 we uncovered how the J2 antibody specifically recognizes #dsRNA. J2 is a quintessential tool used to discover #RNA, QC #RNA therapeutics and much more
Where and how to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by @bounaderlab.bsky.social, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025...
May 14, 2025 at 11:48 PM
Amazing!! Need to read right away to finally understand what I've been working with!
Reposted by Alexander Price
Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!
Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses
Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and
high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions.
Hydrophobic targeting is then...
www.cell.com
April 23, 2025 at 6:23 PM
Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!
Reposted by Alexander Price
Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses
Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and
high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions.
Hydrophobic targeting is then...
www.cell.com
April 23, 2025 at 3:41 PM
Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Alexander Price
Mysteries of adenovirus packaging journals.asm.org/doi/10.1128/...
Mysteries of adenovirus packaging | Journal of Virology
DNA viruses include a diverse range of important human pathogens and powerful therapeutic
tools. These agents are obligate intracellular parasites that can only replicate inside
the living cells of a ...
journals.asm.org
April 17, 2025 at 2:53 PM
Mysteries of adenovirus packaging journals.asm.org/doi/10.1128/...