Lena Steckelberg
@lenasteckelberg.bsky.social
RNA biologist and virologist @Columbia. Studying how viruses use RNA structure to manipulate cellular processes. She/her
www.steckelberglab.org
www.steckelberglab.org
Pinned
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
A conserved viral RNA fold enables nuclease resistance across kingdoms of life
Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence
academic.oup.com
So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology
So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
A conserved viral RNA fold enables nuclease resistance across kingdoms of life
Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence
academic.oup.com
September 4, 2025 at 8:54 PM
So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology
Reposted by Lena Steckelberg
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
A conserved viral RNA fold enables nuclease resistance across kingdoms of life
Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence
academic.oup.com
September 2, 2025 at 6:58 PM
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
Excited to be back in the Rhineland this week to celebrate #RNAday with all the other RNA lovers!
Reminder for the Rhineland RNA Club this Friday (1st AUG)
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
July 28, 2025 at 5:02 PM
Excited to be back in the Rhineland this week to celebrate #RNAday with all the other RNA lovers!
Reposted by Lena Steckelberg
The most important story in the world right now.
July 25, 2025 at 9:12 AM
The most important story in the world right now.
Reposted by Lena Steckelberg
Registration is now ✨open✨ for the 2025 Eukaryotic RNA turnover meeting, this year in Brighton, UK 🏖️☀️ www.biochemistry.org/events-and-t... Lots of great invited speakers and @biochemsoc.bsky.social bursaries for student/postdoc attendees who register early!
April 24, 2025 at 6:20 AM
Registration is now ✨open✨ for the 2025 Eukaryotic RNA turnover meeting, this year in Brighton, UK 🏖️☀️ www.biochemistry.org/events-and-t... Lots of great invited speakers and @biochemsoc.bsky.social bursaries for student/postdoc attendees who register early!
Sad that #RNA2025 is almost over? Join us in August in the UK for another fun meeting on RNA! #RNAsky #RNAdecay
Please join us for an exciting meeting on "Eukaryotic RNA turnover: from fundamentals to applications" in Brighton, UK this August! We have an exciting lineup of speakers, and will feature many selected talks. Abstract deadline is June 27! www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
May 31, 2025 at 4:01 PM
Reposted by Lena Steckelberg
Save the Date: 2025 NYC RNA Symposium — Tuesday, October 21, 2025
more @ www.nycrnasymposium.com
more @ www.nycrnasymposium.com
Home | Nycrnasymposium
Register for the inaugural NYCRNASymposium. Come share your RNA research in NYC!
www.nycrnasymposium.com
May 20, 2025 at 3:31 PM
Save the Date: 2025 NYC RNA Symposium — Tuesday, October 21, 2025
more @ www.nycrnasymposium.com
more @ www.nycrnasymposium.com
It was so much fun being part of this project. Much progress on the RNA structure modeling front, but so much more left to be done! Can’t wait to see when RNA structure predictions finally catch up to AF and co!
Nucleic acid structural biologists expose that many CASP16 predictions, even ones obtaining high scores by CASP metrics, are inaccurate in the most functionally relevant regions! Read more insights on functionally relevant features by the expert structure determiners (doi.org/10.1101/2025...).
Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers
Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, exper...
doi.org
May 20, 2025 at 10:39 PM
It was so much fun being part of this project. Much progress on the RNA structure modeling front, but so much more left to be done! Can’t wait to see when RNA structure predictions finally catch up to AF and co!
Reposted by Lena Steckelberg
TV watching recommendations
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
April 27, 2025 at 10:19 AM
TV watching recommendations
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
Reposted by Lena Steckelberg
Can confirm: 60 Minutes will be worth watching tonight about #NIH.
TV watching recommendations
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
April 27, 2025 at 11:25 AM
Can confirm: 60 Minutes will be worth watching tonight about #NIH.
Reposted by Lena Steckelberg
Out in today's @science.org: Rallying for US science! I wrote about speaking at Stand Up for Science in DC. "Science delivers breakthroughs even though its path is unpredictable. I emphasized the importance of investing in science & warned that trust in science is under threat.
April 25, 2025 at 4:00 PM
Out in today's @science.org: Rallying for US science! I wrote about speaking at Stand Up for Science in DC. "Science delivers breakthroughs even though its path is unpredictable. I emphasized the importance of investing in science & warned that trust in science is under threat.
Please join us for an exciting meeting on "Eukaryotic RNA turnover: from fundamentals to applications" in Brighton, UK this August! We have an exciting lineup of speakers, and will feature many selected talks. Abstract deadline is June 27! www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
April 25, 2025 at 3:02 PM
Please join us for an exciting meeting on "Eukaryotic RNA turnover: from fundamentals to applications" in Brighton, UK this August! We have an exciting lineup of speakers, and will feature many selected talks. Abstract deadline is June 27! www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
April 25, 2025 at 2:37 PM
Please join us for an exciting meeting on "Eukaryotic RNA turnover: from fundamentals to applications" in Brighton, UK this August! We have an exciting lineup of speakers, and will feature many selected talks. Abstract deadline is June 27! www.eventsforce.net/biochemsoc/f...
Reposted by Lena Steckelberg
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
March 28, 2025 at 2:15 AM
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Reposted by Lena Steckelberg
Sobering portraits of some of the people facing the dire consequences of disruptions to HIV treatment as a fall out in cuts to US foreign aid. It's easy to erase dehumanize human lives when framed as "DOGE cuts and reducing the size of government".
www.npr.org/sections/goa...
www.npr.org/sections/goa...
Portraits: A 10-year-old, a house painter and a mom who are running out of HIV pills
HIV medications were supposed to be exempt from U.S. aid cuts. In Zambia, for example, those on the ground say otherwise.
www.npr.org
April 23, 2025 at 4:06 PM
Sobering portraits of some of the people facing the dire consequences of disruptions to HIV treatment as a fall out in cuts to US foreign aid. It's easy to erase dehumanize human lives when framed as "DOGE cuts and reducing the size of government".
www.npr.org/sections/goa...
www.npr.org/sections/goa...
Reposted by Lena Steckelberg
A tragic turn of events for understanding the health of 50.5% of our population. This has been a landmark study and such a waste to end it early and disassemble the massive infrastructure built to yield new insights into women's health.
I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
www.science.org
April 23, 2025 at 2:53 PM
A tragic turn of events for understanding the health of 50.5% of our population. This has been a landmark study and such a waste to end it early and disassemble the massive infrastructure built to yield new insights into women's health.
Reposted by Lena Steckelberg
What an incredibly good idea! At UNC alone PhD students come from hundreds of hometowns across the nation. If you're a scientist help your home community see the value of your work & the importance of supporting the next generation of scientists by bring it home to them. Happy to share an example RT
Federal research cuts impact local economies, and stall progress.
Publish an opinion piece in your hometown paper on June 16th to SPREAD THE WORD about how scientific research contributes to the everyday health and wealth of the general public.
#McClintockLetters
blogs.cornell.edu/asap/events-...
Publish an opinion piece in your hometown paper on June 16th to SPREAD THE WORD about how scientific research contributes to the everyday health and wealth of the general public.
#McClintockLetters
blogs.cornell.edu/asap/events-...
April 23, 2025 at 10:31 AM
What an incredibly good idea! At UNC alone PhD students come from hundreds of hometowns across the nation. If you're a scientist help your home community see the value of your work & the importance of supporting the next generation of scientists by bring it home to them. Happy to share an example RT
Reposted by Lena Steckelberg
Abstracts for poster sessions at the RNA Society meeting are due March 31st! This includes the first education session - see here for more! www2.rnasociety.org/conferences/... #RNASky #RNA2025 #RNA@PUI #RNASociety
Education Session – Training Future Scientists through RNA Research | RNA Society
www2.rnasociety.org
March 13, 2025 at 6:01 AM
Abstracts for poster sessions at the RNA Society meeting are due March 31st! This includes the first education session - see here for more! www2.rnasociety.org/conferences/... #RNASky #RNA2025 #RNA@PUI #RNASociety
Reposted by Lena Steckelberg
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Lena Steckelberg
We are in a biotech space race, cutting off basic science via slashing NIH and NSF funding robs the US of our competitive advantage: early innovation.
China is poised to dominate biotechnology in the 21st century - The Hill
March 12, 2025 at 1:34 AM
We are in a biotech space race, cutting off basic science via slashing NIH and NSF funding robs the US of our competitive advantage: early innovation.
Reposted by Lena Steckelberg
A massive loss to the virology community. Ann was an amazing scientist and mentor, whose service to UW and the virology community in general will be sorely missed.
www.cressfuneralservice.com/obituaries/a...
www.cressfuneralservice.com/obituaries/a...
Ann Carol Palmenberg, Ph.D Obituary February 20, 2025 - Cress Funeral and Cremation Services
View Ann Carol Palmenberg, Ph.D's obituary, find service dates, and sign the guestbook.
www.cressfuneralservice.com
March 2, 2025 at 8:01 PM
A massive loss to the virology community. Ann was an amazing scientist and mentor, whose service to UW and the virology community in general will be sorely missed.
www.cressfuneralservice.com/obituaries/a...
www.cressfuneralservice.com/obituaries/a...
Reposted by Lena Steckelberg
I wonder if spreading extremely encouraging experimental results on helping treat pancreatic cancer with *gasp* mRNA vaccines may help people who have villainized them come around. This is a good press release on the study and links to the Nature paper. www.mskcc.org/news/can-mrn...
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
www.mskcc.org
February 28, 2025 at 5:02 PM
I wonder if spreading extremely encouraging experimental results on helping treat pancreatic cancer with *gasp* mRNA vaccines may help people who have villainized them come around. This is a good press release on the study and links to the Nature paper. www.mskcc.org/news/can-mrn...
Reposted by Lena Steckelberg
Interested in RNA education&efforts to engage students in RNA research? RNA2025 will feature two education-related events this year - a PRE-MEETING WORKSHOP and a NEW IN-MEETING SESSION with oral and poster presentations. See below links to learn more! #RNAsky #RNA2025 #RNASociety #RNA@PUI #RNA
February 13, 2025 at 12:31 AM
Interested in RNA education&efforts to engage students in RNA research? RNA2025 will feature two education-related events this year - a PRE-MEETING WORKSHOP and a NEW IN-MEETING SESSION with oral and poster presentations. See below links to learn more! #RNAsky #RNA2025 #RNASociety #RNA@PUI #RNA
Only one more week until the abstract submission deadline of RNA2025!
I’m looking forward to chairing a session on „Viral RNA and innate immune responses“. If you have some exciting new science to share, don’t forget to submit your abstracts! #RNAsky #lovevirology
I’m looking forward to chairing a session on „Viral RNA and innate immune responses“. If you have some exciting new science to share, don’t forget to submit your abstracts! #RNAsky #lovevirology
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
February 20, 2025 at 2:17 PM
Only one more week until the abstract submission deadline of RNA2025!
I’m looking forward to chairing a session on „Viral RNA and innate immune responses“. If you have some exciting new science to share, don’t forget to submit your abstracts! #RNAsky #lovevirology
I’m looking forward to chairing a session on „Viral RNA and innate immune responses“. If you have some exciting new science to share, don’t forget to submit your abstracts! #RNAsky #lovevirology