Tempera_Lab
@itphilly.bsky.social
We’re a virology and chromatin lab digging into how Epstein-Barr Virus (EBV) rewires the host cell to cause cancer. We mix epigenetics, 3D genome biology, and metabolism to figure out how it all works—and how to stop it.
🧬 New from our Lab!
Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling.
#Epigenetics #EBV #CancerResearch
www.biorxiv.org/content/10.1...
Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling.
#Epigenetics #EBV #CancerResearch
www.biorxiv.org/content/10.1...
Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV associated gastric cancer
Epstein-Barr virus associated gastric cancer (EBVaGC) accounts for ∼9–10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA....
www.biorxiv.org
October 21, 2025 at 6:05 PM
🧬 New from our Lab!
Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling.
#Epigenetics #EBV #CancerResearch
www.biorxiv.org/content/10.1...
Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling.
#Epigenetics #EBV #CancerResearch
www.biorxiv.org/content/10.1...
We are excited to share our recent work:
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation
Abstract. Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), fu
academic.oup.com
July 13, 2025 at 12:54 AM
We are excited to share our recent work:
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
Reposted by Tempera_Lab
RFK Jr.: “Thank you [to the NIH] for public service. We’re going to give infectious disease a break for about eight years.”
Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles.
www.nbcnews.com/politics/pol...
Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles.
www.nbcnews.com/politics/pol...
RFK Jr. comes ‘home’ to his anti-vaccine group, commits to ‘a break’ for U.S. infectious disease research
He has suggested without evidence that researchers and pharmaceutical companies are driven by profit to neglect chronic conditions.
www.nbcnews.com
November 17, 2024 at 2:45 PM
RFK Jr.: “Thank you [to the NIH] for public service. We’re going to give infectious disease a break for about eight years.”
Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles.
www.nbcnews.com/politics/pol...
Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles.
www.nbcnews.com/politics/pol...