We believe these tools will be useful to adenovirologists, as well as those that simply use this powerful little virus as a vector. In the manuscript we demonstrate using the E4 region for multicistronic gene expression, as well as a single vector system for doxycycline-induced gene expression.

Using the amazing AdenoBuilder system we have constructed a set of fluorescent and bioluminescent Ad5 viruses. By exploiting the existing transcriptional units of the virus, our single color and dual color (early/late) reporters reflect the staging of the virus with wildtype replication kinetics.

The Price Lab turned two years old this week! Of course we celebrated with cake, but the cherry on top was submitting our labs very first manuscript today! Excited to see what the rest of the year holds.

I also thought the experience was rather painless, but our grad student (who made this slide for our following lab meeting) had different opinions?

With all that is happening it is very exciting to see the Price Lab's very first, in-house, Oxford Nanopore direct RNA seq running! Not bad for a ~3 year expired flow cell!

Happy Holidays from the Price Lab! Very excited to host our inaugural lab get-together, complete with secret white elephant gift exchange and hot chocolate bar. I am grateful to this team we are creating together, and looking forward to some big announcements in 2025 and beyond!