Neha Ghosh
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nehaghosh.bsky.social
Neha Ghosh
@nehaghosh.bsky.social
850 followers 620 following 160 posts
K99|R00 NEI, NIH Postdoctoral Fellow
Treisman Lab
NYU School of Medicine
Tissue patterning| Organ morphogenesis
#WomeninSTEM
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nehaghosh.bsky.social
Neha Ghosh @nehaghosh.bsky.social · Aug 28
🚨pre-print alert🚨

Excited to share the latest work on how cell specific secretion of chitin controls the shape of the fly corneal lens, an #aECM structure.
Reposted by Neha Ghosh
epimechfc.bsky.social
Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.

Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
February 8, 2026 at 7:59 AM
Reposted by Neha Ghosh
embojournal.org
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 10:37 AM
Reposted by Neha Ghosh
katrinvogt.bsky.social
The first paper from the lab is now out in Science Advances: Multimodal social context modulates larval behavior in Drosophila
www.science.org/doi/10.1126/...
We find that fly larvae keep their distance to conspecifics in the absence of food, enjoy reading! @cbehav.bsky.social @uni-konstanz.de
February 2, 2026 at 8:31 PM
Reposted by Neha Ghosh
michelcayouette.bsky.social
Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...
Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species
A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.
www.science.org
February 4, 2026 at 7:16 PM
Reposted by Neha Ghosh
ritamateus.bsky.social
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
Injury-induced electrochemical coupling triggers organ growth
Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.
www.science.org
February 5, 2026 at 9:33 AM
Reposted by Neha Ghosh
meera-sundaram.bsky.social
Lipocalins and Scavenger Receptors affect the luminal matrix that prevents narrow tubes from collapsing - now in press in Development! #aECM #Celegans

journals.biologists.com/dev/article/...
Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity
Summary: Lipocalins and SCARBs are lipid transporters that influence susceptibility to infection and disease. This study shows that lipocalin and SCARB mutations affect the organization of a protectiv...
journals.biologists.com
January 20, 2026 at 10:37 PM
Reposted by Neha Ghosh
epimechfc.bsky.social
How can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse
January 10, 2026 at 8:01 PM
Reposted by Neha Ghosh
jcb.org
How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...
January 6, 2026 at 7:02 PM
Reposted by Neha Ghosh
plosbiology.org
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5
The image depicts P-cadherin levels at cell–cell junctions in a planar view of whole-mount preparation of embryonic mouse skin. The image was derived from confocal microscopy data and artistically enhanced for visual clarity. Image credit: Krithika Kalyanakrishnan and Alexandra Jetté
January 7, 2026 at 1:55 PM
Reposted by Neha Ghosh
interactivefly.bsky.social
Harsh, S., Liu, H. Y., Bhaskar, P. K., Rushlow, C., Bach, E. A. (2025). Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. PLoS Biol, 23(12):e3003535 journals.plos.org/plosbiology/...
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
Somatic gonadal sex fate must be actively upheld throughout adulthood to support proper gametogenesis, but how do adult tissues maintain their sexual identity? This study identifies a post-transcripti...
journals.plos.org
January 5, 2026 at 10:19 PM
Reposted by Neha Ghosh
jcellsci.bsky.social
In their Review, John James, Darius Köster and colleagues consider E-cadherin-mediated cell-cell adhesion, focusing on recent advances in our understanding how actin cortex dynamics affect adherens junction stability.
journals.biologists.com/jcs/article/...
AJs maintain tissue integrity by maturing in response to actomyosin generated tension at cell–cell contacts. (A) AJs are formed in the apical region of polarised epithelial tissues. Subsequent figures show a top-down view of an x-y plane at the apical region. (B) Schematic defining the key components involved in cell–cell adhesion, as discussed in this Review. Cadherin–catenin complexes (CCCs) hold together the actin cytoskeletons of adjacent cells at regions of cell–cell contact. Clustering of CCCs forms AJs. (C) Pulling forces exerted on CCCs changes their bio-mechanical properties. The E-cadherin trans interaction changes from an X- (left) to a strand-swap (right) conformation and α-catenin recruits vinculin, which strengthens the binding of α-catenin to F-actin. Florette indicate catch bonds, which increase in lifetime with applied force (E-cadherin X dimer, α-catenin tail domain–actin and vinculin tail domain–actin). Created in BioRender by Winn, L., 2025. https://BioRender.com/l1sc933. This figure was sublicensed under CC-BY 4.0 terms.
December 9, 2025 at 10:05 AM
Reposted by Neha Ghosh
pritiagarwal.bsky.social
Our Lab @ NCBS, Bangalore is hiring PhD students!

If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬

CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉 lnkd.in/gr9EUHnp
LinkedIn
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lnkd.in
December 8, 2025 at 10:55 AM
Reposted by Neha Ghosh
meera-sundaram.bsky.social
#aECM at #CellBio2025 On Sunday, the Sundaram lab will have 2 posters on #Celegans aECM - boards 223 and 225
December 6, 2025 at 8:07 PM
Reposted by Neha Ghosh
focalplane.bsky.social
Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Epithelial Mechanics Fan Club - FocalPlane
Epithelial Mechanics Fan Club - News
focalplane.biologists.com
December 5, 2025 at 1:35 PM
Reposted by Neha Ghosh
peiferlabunc.bsky.social
Drosophila colleagues--Please submit nominations for the Larry Sandler Award. which recognizes excellent recent graduates who have completed a PhD in Drosophila research. Details are below and at this link:
genetics-gsa.org/drosophila-2...
The Larry Sandler Award recognizes excellent recent graduates who have completed a PhD in Drosophila research. The awardee will receive a fantastic opportunity to present the Larry Sandler Memorial Lecture at the 67th Annual Drosophila Research Conference in Chicago, IL! The deadline to nominate is December 15, 2025. Nominate Here Eligibility Any student completing a PhD in an area of Drosophila research between July 2024 and December 2025 is eligible. Students may be nominated by their thesis advisor, department chair, or supervisory committee member. Nominations Nominations may be submitted by the student’s thesis advisor, department chair, or supervisory committee member, and should include the following: Nominee's CV Nominee's thesis abstract of 1–2 pages A nomination letter directly answering the following questions: What are the main discoveries in the nominee's thesis? What are the intellectual and experimental contributions of the nominee to the project? How does the thesis work advance what was previously known in the field and to previous work from your lab?
December 4, 2025 at 4:41 PM
Reposted by Neha Ghosh
flyeyelab.bsky.social
Excited to announce that the newest paper from my lab on the Drosophila visual system is out today!

Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila url: journals.biologists.com/dev/article-...
Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila
Summary: Modulation of members of the retinal determination gene regulatory network and their co-factors in Drosophila eyes reveals that differential expression of transcription factors is sufficient ...
journals.biologists.com
December 2, 2025 at 5:56 AM
Reposted by Neha Ghosh
rohankhadilkar.bsky.social
My 1st PhD student, Ujjayita's 1st preprint! We show how the niche-progenitor micro-environment & hematopoiesis is remodelled during tumor induced cachexia conditions in Drosophila!
#cancer #cachexia #Drosophila #hematopoiesis #signaling
www.biorxiv.org/content/10.1...
Drosophila midgut tumor-induced insulin resistance systemically remodels lymph gland hematopoiesis during cancer cachexia
Cancer cachexia involves systemic metabolic deregulation along with classical features of muscle wasting, lipolysis, and chronic inflammation. While tumor non-autonomous effects on peripheral organs a...
www.biorxiv.org
November 30, 2025 at 4:11 AM
Reposted by Neha Ghosh
robinjournot.bsky.social
🚨 New preprint!
We built a single-cell atlas of 14 multilayered epithelia and revealed a conserved transcriptomic program guiding tissue architecture and fate composition. Our work brings decades of tissue-specific studies together into a unified evo-devo framework.
www.biorxiv.org/content/10.1...
November 17, 2025 at 12:33 PM
Reposted by Neha Ghosh
rister.bsky.social
It was an honor being interviewed about our new color vision project by the 'Eye on Vision' WYPL Memphis radio show! 🪰👀🧪
@umassboston.bsky.social
eyeonvision.blogspot.com/2025/11/hmx-...
Hmx Protein's Effect On Fruit Flies' Photoreceptors and Info On The NFB Performing Arts Division
Dr. Jens Rister (University of Massachusetts - Boston) Katelyn MacIntyre (National Federation of the Blind Performing Arts Division - Baltim...
eyeonvision.blogspot.com
November 27, 2025 at 4:41 PM
Reposted by Neha Ghosh
natalieadye.bsky.social
My lab @poldresden.bsky.social is now CLOSED! The fabulous @sanikajah.bsky.social has left (defense soon). The lab @mbisg.bsky.social in SG is now 1yr old and growing!
PhD students apply here (Jan 12): www.mbi.nus.edu.sg/education/gr...
Undergrads (Jan 31): www.mbi.nus.edu.sg/education/mu...
November 28, 2025 at 2:51 AM
Reposted by Neha Ghosh
juanmagararc.bsky.social
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
November 27, 2025 at 2:14 PM
Reposted by Neha Ghosh
maikbischoff.bsky.social
2/2 If you’re into #cellbio, cellular interfaces, #mechanobiology, #membranes, anything related, come to Münster, Germany, May 27–29!

www.uni-muenster.de/SFB1348/en/i...

Please spread the word. It’s a fantastic (and FREE!) meeting. And while you’re here, explore Münster… it’s worth it.

#Science
The historc city center of Münster, famous for the Peace of Westphalia!
November 28, 2025 at 8:34 AM
Reposted by Neha Ghosh
jcellsci.bsky.social
Ditipriya Mallick, Siddhartha Sankar Jana and colleagues discover that cellular elasticity drives mechano-adaptation against fluid shear stress.
journals.biologists.com/jcs/article/...
November 27, 2025 at 8:04 AM
Reposted by Neha Ghosh
plosbiology.org
Despite advances in #ProximityLabeling tools, we can't capture intermediary proteins that bridge two associated non-interacting proteins. STUPPIT is a novel method to label intermediary proteins between two non-interacting partners in signaling pathways @plosbiology.org 🧪 plos.io/4ab6YwQ
This artwork was inspired by the ancient Chinese legend of "The Cowherd and the Weaver Girl," where two star-crossed lovers are reunited once a year by a bridge of magpies. Here, the Cowherd and Weaver Girl represent two non-interacting proteins (e.g., actin and YAP1), separated by the Milky Way—symbolizing the complex cellular environment. The magpie bridge, formed by STUPPIT components with Pup(E) as the body and Split-TurboID fragments as glowing wings, enables their connection. Soaring lanterns released from the bridge represent biotin-labeled proximal proteins (e.g., AMOT), illuminating the functional interactome between the once-distant proteins. Xie et al. demonstrate how the STUPPIT system acts as a molecular "magpie bridge," enabling proximity labeling and revealing functional interactomes between proteins that do not directly bind—just as the magpie bridge reunites the star-crossed lovers. Artwork by graduate student Xin Li.
November 27, 2025 at 8:55 AM
Reposted by Neha Ghosh
manuelthery.bsky.social
So called microtubule organizing centers (MTOCs) are not "organizing centers". They don't control their position (network center), nor MT orientation, length and shape (network shape). The actual organizers are MTs, molecular motors and regulators of MT +ends. MTOCs nucleate MTs.
Let's rename MTOCs.
November 27, 2025 at 8:47 AM