Ben Goult
@bengoult.bsky.social
Talin as a memory molecule #MeshCODE.
Talin shock absorbing materials #TSAM.
Professor of Mechanistic Cell Biology at University of Liverpool
Dad, Husband. Hobbies: Mechanobiology, talin, looking at the sky
Talin shock absorbing materials #TSAM.
Professor of Mechanistic Cell Biology at University of Liverpool
Dad, Husband. Hobbies: Mechanobiology, talin, looking at the sky
Pinned
Ben Goult
@bengoult.bsky.social
· Aug 28
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
Reposted by Ben Goult
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
January 14, 2026 at 6:38 PM
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
January 14, 2026 at 6:38 PM
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
Reposted by Ben Goult
Delighted to share the latest paper from the lab
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal
The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...
link.springer.com
January 6, 2026 at 11:42 AM
Delighted to share the latest paper from the lab
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
Reposted by Ben Goult
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
January 2, 2026 at 4:00 PM
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
Reposted by Ben Goult
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
The Center is a wonderful collaboration with scientists extraordinaire @taijamakinenlab.bsky.social Kari Vaahtomeri and Cecilia Sahlgren.
We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
I am delighted to introduce our new Centre of Excellence in Immune-Endothelial Interfaces (IMMENs) funded by the Research Council of Finland.
www.helsinki.fi/en/researchg...
I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
www.helsinki.fi/en/researchg...
I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
December 21, 2025 at 8:58 AM
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
Reposted by Ben Goult
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover th...
www.biorxiv.org
December 6, 2025 at 6:48 AM
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
🎉
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover th...
www.biorxiv.org
December 6, 2025 at 9:27 AM
🎉
This title has "very lethal" energy
December 3, 2025 at 7:20 PM
This title has "very lethal" energy
Reposted by Ben Goult
Reposted by Ben Goult
November 30, 2025 at 12:56 PM
Reposted by Ben Goult
Reposted by Ben Goult
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Integrin-based adhesion complexes serve as primary sites for actomyosin force transmission to the extracellular matrix, providing traction that drives cell mechanical responses including adhesion, mig...
journals.biologists.com
November 24, 2025 at 4:49 PM
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
(BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool on FindAPhD.com
PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
November 11, 2025 at 10:29 AM
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
Reposted by Ben Goult
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Reposted by Ben Goult
Another great opportunity for a PhD linking hypoxia to cell matrix mechanobiology!
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
November 1, 2025 at 9:33 AM
Another great opportunity for a PhD linking hypoxia to cell matrix mechanobiology!
Thanks to inattentive travel booking I have given myself a cheeky 6hr stopover in Munich. 🤦
November 1, 2025 at 9:11 AM
Thanks to inattentive travel booking I have given myself a cheeky 6hr stopover in Munich. 🤦
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The project is now live on FindaPhD and open for applications. Deadline December 4th
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
October 31, 2025 at 10:07 AM
The project is now live on FindaPhD and open for applications. Deadline December 4th
Reposted by Ben Goult
New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...
Episode 27: CDKL5 Science Chat with Ben Goult
open.spotify.com
October 25, 2025 at 3:04 PM
New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...
This was good fun to do, and I really enjoyed getting to chat about our CDKL5 research for a non-scientist audience with Marissa and Amanda. Thanks for having me.
New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...
Episode 27: CDKL5 Science Chat with Ben Goult
open.spotify.com
October 26, 2025 at 10:09 AM
This was good fun to do, and I really enjoyed getting to chat about our CDKL5 research for a non-scientist audience with Marissa and Amanda. Thanks for having me.
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
October 24, 2025 at 3:03 PM
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
Off to Boston tomorrow to present our work on talin in epilepsy at the CDKL5 Forum.
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
October 24, 2025 at 2:56 PM
Off to Boston tomorrow to present our work on talin in epilepsy at the CDKL5 Forum.
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
Great time in Paris at the Valorant Champions with Oliver.
October 4, 2025 at 5:56 PM
Great time in Paris at the Valorant Champions with Oliver.