Ben Goult
@bengoult.bsky.social
Talin as a memory molecule #MeshCODE.
Talin shock absorbing materials #TSAM.
Professor of Mechanistic Cell Biology at University of Liverpool
Dad, Husband. Hobbies: Mechanobiology, talin, looking at the sky
Talin shock absorbing materials #TSAM.
Professor of Mechanistic Cell Biology at University of Liverpool
Dad, Husband. Hobbies: Mechanobiology, talin, looking at the sky
Pinned
Ben Goult
@bengoult.bsky.social
· Aug 28
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
Reposted by Ben Goult
🧵
Many interpret my comments on this appointment as personal hostility. Wrong, I defend my doctoral alma mater EMBL from pseudoscience and I started this from within Max Planck. I will spend the next weeks explaining why I consider Hyman’s main papers on LLPS pseudoscience. If interested, stay tuned
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 29, 2025 at 1:44 PM
🧵
Reposted by Ben Goult
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Integrin-based adhesion complexes serve as primary sites for actomyosin force transmission to the extracellular matrix, providing traction that drives cell mechanical responses including adhesion, mig...
journals.biologists.com
November 24, 2025 at 4:49 PM
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
(BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool on FindAPhD.com
PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
November 11, 2025 at 10:29 AM
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
Reposted by Ben Goult
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Reposted by Ben Goult
Another great opportunity for a PhD linking hypoxia to cell matrix mechanobiology!
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
November 1, 2025 at 9:33 AM
Another great opportunity for a PhD linking hypoxia to cell matrix mechanobiology!
Thanks to inattentive travel booking I have given myself a cheeky 6hr stopover in Munich. 🤦
November 1, 2025 at 9:11 AM
Thanks to inattentive travel booking I have given myself a cheeky 6hr stopover in Munich. 🤦
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The project is now live on FindaPhD and open for applications. Deadline December 4th
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
October 31, 2025 at 10:07 AM
The project is now live on FindaPhD and open for applications. Deadline December 4th
Reposted by Ben Goult
New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...
Episode 27: CDKL5 Science Chat with Ben Goult
open.spotify.com
October 25, 2025 at 3:04 PM
New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...
This was good fun to do, and I really enjoyed getting to chat about our CDKL5 research for a non-scientist audience with Marissa and Amanda. Thanks for having me.
New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...
Episode 27: CDKL5 Science Chat with Ben Goult
open.spotify.com
October 26, 2025 at 10:09 AM
This was good fun to do, and I really enjoyed getting to chat about our CDKL5 research for a non-scientist audience with Marissa and Amanda. Thanks for having me.
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
October 24, 2025 at 3:03 PM
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
Off to Boston tomorrow to present our work on talin in epilepsy at the CDKL5 Forum.
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
October 24, 2025 at 2:56 PM
Off to Boston tomorrow to present our work on talin in epilepsy at the CDKL5 Forum.
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme.
www.biorxiv.org/content/10.1...
Great time in Paris at the Valorant Champions with Oliver.
October 4, 2025 at 5:56 PM
Great time in Paris at the Valorant Champions with Oliver.
First day back at @liverpooluni.bsky.social after my 4 week trip, and got off to a bad start as broke my best espresso cup. 😭
September 26, 2025 at 7:26 AM
First day back at @liverpooluni.bsky.social after my 4 week trip, and got off to a bad start as broke my best espresso cup. 😭
This was an excellent meeting.
Exciting science in Leipzig at the Physics of Cancer Meeting.
conference.uni-leipzig.de/poc/2025/
conference.uni-leipzig.de/poc/2025/
September 24, 2025 at 5:45 PM
This was an excellent meeting.
Reposted by Ben Goult
So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work
Molecular exaptation by the integrin αI domain
An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.
www.science.org
September 10, 2025 at 7:34 PM
So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work
Reposted by Ben Goult
Venkatesh B, et al. (@tanentzapflab.bsky.social lab) Inside-out integrin activation is essential for early mammalian development. Mol Biol Cell. 2025 Sep 3;:mbcE25030106. [Epub ahead of print]. PMID: 40901728
September 4, 2025 at 9:25 AM
Venkatesh B, et al. (@tanentzapflab.bsky.social lab) Inside-out integrin activation is essential for early mammalian development. Mol Biol Cell. 2025 Sep 3;:mbcE25030106. [Epub ahead of print]. PMID: 40901728
Reposted by Ben Goult
Excellent science, inspiring discussions … and scientists in the sea!
Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬
Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬
September 8, 2025 at 12:36 PM
Excellent science, inspiring discussions … and scientists in the sea!
Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬
Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬
Reposted by Ben Goult
🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!
Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling
Cardiomyocytes’ sensing of extracellular matrix stiffness is imprinted in the talin interactome and regulates their phenotype.
www.science.org
September 5, 2025 at 8:41 PM
🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!
Really happy to have contributed to this great story as part of our BHF special project grant.
🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!
Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling
Cardiomyocytes’ sensing of extracellular matrix stiffness is imprinted in the talin interactome and regulates their phenotype.
www.science.org
September 5, 2025 at 9:01 PM
Really happy to have contributed to this great story as part of our BHF special project grant.
Reposted by Ben Goult
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
August 28, 2025 at 10:25 AM
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
Sea was quite moody tonight
August 30, 2025 at 7:42 PM
Sea was quite moody tonight
Almost all previous studies on CDKL5 have used a C-terminal tagging strategy (presumably to position the tag away from the kinase domain), but here we show that such modification of the C-term is disasterous as it abolishes CDKL5 synaptic localisation and function. www.biorxiv.org/content/10.1...
August 30, 2025 at 1:28 PM
Almost all previous studies on CDKL5 have used a C-terminal tagging strategy (presumably to position the tag away from the kinase domain), but here we show that such modification of the C-term is disasterous as it abolishes CDKL5 synaptic localisation and function. www.biorxiv.org/content/10.1...
ADHERE 2 conference is next week!
Great line up of speakers and fun acitivities planned, this is going to be amazing!
Hope to see you all in Zadar, Croatia. ☀️
event.fourwaves.com/adhere2/pages
Great line up of speakers and fun acitivities planned, this is going to be amazing!
Hope to see you all in Zadar, Croatia. ☀️
event.fourwaves.com/adhere2/pages
August 28, 2025 at 11:19 AM
ADHERE 2 conference is next week!
Great line up of speakers and fun acitivities planned, this is going to be amazing!
Hope to see you all in Zadar, Croatia. ☀️
event.fourwaves.com/adhere2/pages
Great line up of speakers and fun acitivities planned, this is going to be amazing!
Hope to see you all in Zadar, Croatia. ☀️
event.fourwaves.com/adhere2/pages