Sascha Martens
@martenslab.bsky.social
Biochemist and cell biologist working on autophagy at the Max Perutz Labs, University of Vienna
Reposted by Sascha Martens
Reposted by Sascha Martens
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
January 20, 2026 at 10:01 AM
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Reposted by Sascha Martens
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
January 13, 2026 at 2:39 PM
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
Reposted by Sascha Martens
If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
January 10, 2026 at 11:54 AM
If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!
Reposted by Sascha Martens
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
January 10, 2026 at 12:47 AM
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Reposted by Sascha Martens
CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪
🔗 Read the #publication: bit.ly/4qeZiOY
🔗 Read the #publication: bit.ly/4qeZiOY
January 9, 2026 at 3:51 PM
CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪
🔗 Read the #publication: bit.ly/4qeZiOY
🔗 Read the #publication: bit.ly/4qeZiOY
Reposted by Sascha Martens
The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair
Dale Corkery, Yao-Wen Wu et al
link.springer.com/article/10.1...
Dale Corkery, Yao-Wen Wu et al
link.springer.com/article/10.1...
The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair - The EMBO Journal
After damage from pathogenic, chemical or physical stress, endolysosomal membranes are repaired and resealed by the endosomal sorting complex required for transport (ESCRT) machinery, but how this mem...
link.springer.com
January 5, 2026 at 2:31 PM
The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair
Dale Corkery, Yao-Wen Wu et al
link.springer.com/article/10.1...
Dale Corkery, Yao-Wen Wu et al
link.springer.com/article/10.1...
Reposted by Sascha Martens
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 18, 2025 at 8:36 PM
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Reposted by Sascha Martens
Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!
December 1, 2025 at 5:44 PM
Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!
Reposted by Sascha Martens
There are a couple of empty chairs at our table — want to sit with us?
Reach out to me or any lab member www.oeaw.ac.at/gmi/research... We’ll be hiring two postdocs in 2026.
We’re excited about ambitious and creative ideas and are committed to supporting future group leaders 1/2
Reach out to me or any lab member www.oeaw.ac.at/gmi/research... We’ll be hiring two postdocs in 2026.
We’re excited about ambitious and creative ideas and are committed to supporting future group leaders 1/2
November 29, 2025 at 8:46 PM
There are a couple of empty chairs at our table — want to sit with us?
Reach out to me or any lab member www.oeaw.ac.at/gmi/research... We’ll be hiring two postdocs in 2026.
We’re excited about ambitious and creative ideas and are committed to supporting future group leaders 1/2
Reach out to me or any lab member www.oeaw.ac.at/gmi/research... We’ll be hiring two postdocs in 2026.
We’re excited about ambitious and creative ideas and are committed to supporting future group leaders 1/2
Reposted by Sascha Martens
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
November 12, 2025 at 10:32 AM
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
Reposted by Sascha Martens
Join us later today 👇
Join us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.”
We look forward to seeing you there!
We look forward to seeing you there!
November 12, 2025 at 6:04 AM
Join us later today 👇
Reposted by Sascha Martens
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Sascha Martens
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...
doi.org
November 10, 2025 at 7:06 AM
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Reposted by Sascha Martens
Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease.
🔗 kurzlinks.de/50j8
🔗 kurzlinks.de/50j8
ERC Synergy Grant for Prof. Dr. Claudine Kraft
CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.
kurzlinks.de
November 6, 2025 at 12:17 PM
Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease.
🔗 kurzlinks.de/50j8
🔗 kurzlinks.de/50j8
Reposted by Sascha Martens
Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!
November 6, 2025 at 2:18 PM
Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!
Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social
Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
November 6, 2025 at 11:12 AM
Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social
Reposted by Sascha Martens
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
Tenure-Track Professorship in Genome Biology - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12848567
Launch your lab at the Max Perutz Labs and join us in our mission to analyze and reconstitute complex biological systems across scales.
www.nature.com
November 4, 2025 at 2:43 PM
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
Reposted by Sascha Martens
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Sascha Martens
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 31, 2025 at 6:24 AM
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by Sascha Martens
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
September 20, 2025 at 12:53 PM
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
Reposted by Sascha Martens
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...
www.nature.com
September 17, 2025 at 9:35 PM
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Reposted by Sascha Martens
Just one more week left to get an application in! Starting my lab at the Perutz and the @viennabiocenter.bsky.social has been a fantastic opportunity that shaped me as a scientist!
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c
September 10, 2025 at 5:32 PM
Just one more week left to get an application in! Starting my lab at the Perutz and the @viennabiocenter.bsky.social has been a fantastic opportunity that shaped me as a scientist!
Reposted by Sascha Martens
📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin.
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
September 2, 2025 at 5:03 PM
📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin.
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
Reposted by Sascha Martens
We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15.
Find out more and apply here: ist.ac.at/en/job/maste...
Find out more and apply here: ist.ac.at/en/job/maste...
Master Thesis Position – Loose Research Group
Our Group
The Loose lab at the Institute of Science and Technology Austria (ISTA) is looking for a highly motivated Master student to join our research on the in vitro reconstitution of signaling n...
ist.ac.at
September 1, 2025 at 9:15 AM
We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15.
Find out more and apply here: ist.ac.at/en/job/maste...
Find out more and apply here: ist.ac.at/en/job/maste...