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luderslab.bsky.social
Lüders Lab
@luderslab.bsky.social
240 followers 210 following 38 posts
Professional #microtubule organizers and #centrosome deconstructors
@irbbarcelona.bsky.social
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luderslab.bsky.social
Lüders Lab @luderslab.bsky.social · Jan 24
Hmm… customs GIFs are not working yet it seems?
So here is what we do in a movie!
Reposted by Lüders Lab
manuelthery.bsky.social
The mother of all meetings is here:
meetings.embo.org/event/26-cen...
Centrosomes: From fundamentals to diseases
Centrosomes are critical microtubule organizing centers comprising centrioles surrounded by PeriCentriolar Material (PCM). Centrioles also template the axoneme of cilia and flagella. As a result of t…
meetings.embo.org
January 21, 2026 at 1:37 PM
Reposted by Lüders Lab
jekely.biologists.social.ap.brid.gy
Flexible tool use by a cow. Best video I have seen in a while, including the closing statement by the farmer.
Veronika for #president!

https://www.cell.com/current-biology/fulltext/S0960-9822(25)01597-0
Pictures of a cow (Bos taurus), Veronika, who uses a deck brush to self-scratch.
January 20, 2026 at 8:00 AM
Reposted by Lüders Lab
embo.org
The EMBO Workshop "#Centrosomes: From fundamentals to diseases" in #Lausanne, Switzerland, 1–4 September 2026 will highlight the advances in the field of centrosome #research. Register now!

Deadline: 1 June

https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪
January 16, 2026 at 12:10 PM
Reposted by Lüders Lab
cilialab.bsky.social
We must have been #ExtraNice this year- our #cilia & #centrosome 🧪 community- 🎅 Santa just dropped the 1st session of 2026 line-up @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposia- www.eventbrite.co.uk/e/bscb-genso... See you on the other side! Happy Holidays!
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
www.eventbrite.co.uk
December 24, 2025 at 10:59 AM
Reposted by Lüders Lab
cellarchlab.com
Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪
plosbiology.org PLOS Biology @plosbiology.org · Dec 10
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
December 10, 2025 at 11:02 AM
Reposted by Lüders Lab
centriolelab.bsky.social
🥳 Our new paper on C2CD3 is out in @plosbiology.org
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
plosbiology.org PLOS Biology @plosbiology.org · Dec 10
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
December 10, 2025 at 12:36 PM
luderslab.bsky.social
Congratulations Dr. Fariña-Mosquera!!! A new doctor in the @luderslab.bsky.social!!! Big thanks to tribunal members Isabelle Vernos, Virginie Hamel @centriolelab.bsky.social , and Fernando Romero-Balestra!
Marcos Fariña thesis defense presentation Marcos Fariña thesis defense with Flowers and tribunal members
December 6, 2025 at 11:18 AM
Reposted by Lüders Lab
ruizhangmt.bsky.social
Happy Halloween everyone! 🎃
October 31, 2025 at 10:10 PM
luderslab.bsky.social
Congratulations to the @estebanezlab.bsky.social lab and collaborators!!! A great story on the surprising repertoire of nuclear receptor oligomeric configurations and their regulatory roles.
October 31, 2025 at 8:45 AM
Reposted by Lüders Lab
milanlab.bsky.social
Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com
August 16, 2025 at 8:39 AM
Reposted by Lüders Lab
simonereber.bsky.social
FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz

💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes
Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...
rdcu.be
August 15, 2025 at 11:54 AM
Reposted by Lüders Lab
mads100tist.bsky.social
See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪
ERC to introduce seven-year €7 million ‘super grants’ in 2026
The European Research Council (ERC) is set to launch its first seven-year €7 million super grant call in May next year.The grants, called ERC+, will be open to researchers at all career stages and in ...
sciencebusiness.net
July 13, 2025 at 6:31 AM
Reposted by Lüders Lab
docdellaire.bsky.social
"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem
July 13, 2025 at 3:15 PM
Reposted by Lüders Lab
tonigabaldon.bsky.social
The #ESEB2025 meeting in Barcelona is getting closer, there are still places available but time for registration is running up. Are you going to miss the main evolutionary biology event in Europe this year?
👇
eseb2025.com/registration/
July 9, 2025 at 6:03 AM
Reposted by Lüders Lab
septinlab.bsky.social
Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules.
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!
July 6, 2025 at 4:33 PM
luderslab.bsky.social
Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!!

www.biorxiv.org/content/10.1...
Centriole biogenesis is seeded by CEP152-CEP63-PCNT aggregates propagating outside the centriole through the Alström syndrome protein ALMS1
While subcellular structures like centrioles assemble flawlessly from protein components, it is unknown whether instructions from outside the components are involved. Centrioles build on the cartwheel...
www.biorxiv.org
July 3, 2025 at 10:03 AM
luderslab.bsky.social
It is alive!!!
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”
July 2, 2025 at 8:58 AM
luderslab.bsky.social
A new AI video generation tool popped up in my Google workspace today - this did not go so well 😂
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”
July 2, 2025 at 8:49 AM
luderslab.bsky.social
Great news not only for the #CRG but also for the wider Barcelona cell biology research community! And of course also for all #centrosome and #cilia aficionados!
monicabettencourt.bsky.social Monica Bettencourt-Dias @monicabettencourt.bsky.social · Jul 1
Excited about this new role! I have admired CRG for long, its amazing science, and how it constantly innovates in how research is done and how it connects with society. Happy to follow Luis Serrano´s work with this incredible community + the ecosystem it is part of & push the boundaries together!
crg.eu Centre de Regulació Genòmica (CRG) @crg.eu · Jul 1
Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...
July 1, 2025 at 9:49 PM
luderslab.bsky.social
Planning killer experiments during evening ride with view
Barcelona city view
June 16, 2025 at 7:18 PM
luderslab.bsky.social
#UExM Tetris by @luderslab.bsky.social members Marcos Fariña and Júlia Mestres reveals highly abnormal #centriole configurations 👀
irbbarcelona.org IRB Barcelona @irbbarcelona.org · Jun 5
Let's start this Thursday having some fun with #June 's Image of the Month!

🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.

Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!

#ImageOfTheMonth #CancerResearch
June 5, 2025 at 8:05 PM
luderslab.bsky.social
During #mitosis, before assembling the mitotic spindle, the early mouse embryo lacking #centrosomes uses #actin rather than #microtubules for chromosome congression 👀👇🏼
loxstoplox.bsky.social Blake Hernandez @loxstoplox.bsky.social · May 23
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
May 24, 2025 at 11:03 AM
Reposted by Lüders Lab
larsplus.bsky.social
This is big - the effect of cancer mutations on HSCs is determined by pre-existing properties of the stem cell affected! Crazy results on NPM1 🤩
alejofraticelli.bsky.social Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · Feb 25
🔥 New Fraticelli lab publication🔥

“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”

Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.

Performed with the support of Cris Cancer and @erc.europa.eu
February 26, 2025 at 10:58 AM
luderslab.bsky.social
Insightful work from the Raff lab on how to build mitotic centrosomes (including artificial ones)!
February 10, 2025 at 11:17 AM
Reposted by Lüders Lab
mahjoublab.bsky.social
🚨New paper out!🚨

Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan
@dutcherlab.bsky.social and Steve Brody.

We asked a simple question: why do some PCD patients develop more severe lung disease than others?
1/
www.science.org/doi/10.1126/...
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.
www.science.org
January 29, 2025 at 9:33 PM