Lüders Lab
@luderslab.bsky.social
Professional #microtubule organizers and #centrosome deconstructors
@irbbarcelona.bsky.social
@irbbarcelona.bsky.social
Pinned
Lüders Lab
@luderslab.bsky.social
· Jan 24
Hmm… customs GIFs are not working yet it seems?
So here is what we do in a movie!
So here is what we do in a movie!
Reposted by Lüders Lab
Happy Halloween everyone! 🎃
October 31, 2025 at 10:10 PM
Happy Halloween everyone! 🎃
Congratulations to the @estebanezlab.bsky.social lab and collaborators!!! A great story on the surprising repertoire of nuclear receptor oligomeric configurations and their regulatory roles.
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 31, 2025 at 8:45 AM
Congratulations to the @estebanezlab.bsky.social lab and collaborators!!! A great story on the surprising repertoire of nuclear receptor oligomeric configurations and their regulatory roles.
Reposted by Lüders Lab
Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com
August 16, 2025 at 8:39 AM
Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...
Reposted by Lüders Lab
FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz
💚 Thanks to the team @biswashere.bsky.social, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay @matthewkraushar.bsky.social @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social 💚
💚 Thanks to the team @biswashere.bsky.social, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay @matthewkraushar.bsky.social @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social 💚
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes
Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...
rdcu.be
August 15, 2025 at 11:54 AM
FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz
💚 Thanks to the team @biswashere.bsky.social, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay @matthewkraushar.bsky.social @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social 💚
💚 Thanks to the team @biswashere.bsky.social, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay @matthewkraushar.bsky.social @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social 💚
Reposted by Lüders Lab
See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪
ERC to introduce seven-year €7 million ‘super grants’ in 2026
The European Research Council (ERC) is set to launch its first seven-year €7 million super grant call in May next year.The grants, called ERC+, will be open to researchers at all career stages and in ...
sciencebusiness.net
July 13, 2025 at 6:31 AM
See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪
Reposted by Lüders Lab
"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem
July 13, 2025 at 3:15 PM
"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem
Reposted by Lüders Lab
The #ESEB2025 meeting in Barcelona is getting closer, there are still places available but time for registration is running up. Are you going to miss the main evolutionary biology event in Europe this year?
👇
eseb2025.com/registration/
👇
eseb2025.com/registration/
July 9, 2025 at 6:03 AM
The #ESEB2025 meeting in Barcelona is getting closer, there are still places available but time for registration is running up. Are you going to miss the main evolutionary biology event in Europe this year?
👇
eseb2025.com/registration/
👇
eseb2025.com/registration/
Reposted by Lüders Lab
Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules.
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!
July 6, 2025 at 4:33 PM
Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules.
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!
Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Centriole biogenesis is seeded by CEP152-CEP63-PCNT aggregates propagating outside the centriole through the Alström syndrome protein ALMS1
While subcellular structures like centrioles assemble flawlessly from protein components, it is unknown whether instructions from outside the components are involved. Centrioles build on the cartwheel...
www.biorxiv.org
July 3, 2025 at 10:03 AM
Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It is alive!!!
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”
July 2, 2025 at 8:58 AM
It is alive!!!
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”
A new AI video generation tool popped up in my Google workspace today - this did not go so well 😂
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”
July 2, 2025 at 8:49 AM
A new AI video generation tool popped up in my Google workspace today - this did not go so well 😂
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”
Great news not only for the #CRG but also for the wider Barcelona cell biology research community! And of course also for all #centrosome and #cilia aficionados!
Excited about this new role! I have admired CRG for long, its amazing science, and how it constantly innovates in how research is done and how it connects with society. Happy to follow Luis Serrano´s work with this incredible community + the ecosystem it is part of & push the boundaries together!
Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...
www.crg.eu/en/news/moni...
July 1, 2025 at 9:49 PM
Great news not only for the #CRG but also for the wider Barcelona cell biology research community! And of course also for all #centrosome and #cilia aficionados!
Planning killer experiments during evening ride with view
June 16, 2025 at 7:18 PM
Planning killer experiments during evening ride with view
#UExM Tetris by @luderslab.bsky.social members Marcos Fariña and Júlia Mestres reveals highly abnormal #centriole configurations 👀
Let's start this Thursday having some fun with #June 's Image of the Month!
🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.
Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!
#ImageOfTheMonth #CancerResearch
🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.
Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!
#ImageOfTheMonth #CancerResearch
June 5, 2025 at 8:05 PM
#UExM Tetris by @luderslab.bsky.social members Marcos Fariña and Júlia Mestres reveals highly abnormal #centriole configurations 👀
During #mitosis, before assembling the mitotic spindle, the early mouse embryo lacking #centrosomes uses #actin rather than #microtubules for chromosome congression 👀👇🏼
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
May 24, 2025 at 11:03 AM
During #mitosis, before assembling the mitotic spindle, the early mouse embryo lacking #centrosomes uses #actin rather than #microtubules for chromosome congression 👀👇🏼
Reposted by Lüders Lab
This is big - the effect of cancer mutations on HSCs is determined by pre-existing properties of the stem cell affected! Crazy results on NPM1 🤩
🔥 New Fraticelli lab publication🔥
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
February 26, 2025 at 10:58 AM
This is big - the effect of cancer mutations on HSCs is determined by pre-existing properties of the stem cell affected! Crazy results on NPM1 🤩
Insightful work from the Raff lab on how to build mitotic centrosomes (including artificial ones)!
🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
www.science.org
February 10, 2025 at 11:17 AM
Insightful work from the Raff lab on how to build mitotic centrosomes (including artificial ones)!
Reposted by Lüders Lab
🚨New paper out!🚨
Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan
@dutcherlab.bsky.social and Steve Brody.
We asked a simple question: why do some PCD patients develop more severe lung disease than others?
1/
www.science.org/doi/10.1126/...
Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan
@dutcherlab.bsky.social and Steve Brody.
We asked a simple question: why do some PCD patients develop more severe lung disease than others?
1/
www.science.org/doi/10.1126/...
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.
www.science.org
January 29, 2025 at 9:33 PM
🚨New paper out!🚨
Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan
@dutcherlab.bsky.social and Steve Brody.
We asked a simple question: why do some PCD patients develop more severe lung disease than others?
1/
www.science.org/doi/10.1126/...
Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan
@dutcherlab.bsky.social and Steve Brody.
We asked a simple question: why do some PCD patients develop more severe lung disease than others?
1/
www.science.org/doi/10.1126/...
Reposted by Lüders Lab
We are now accepting applications for two PhD positions within the Cilia-AI PhD training network (cilia-ai.eu). Please apply via the link below. Application deadline March 15th, start date September 1st, 2025.
employment.ku.dk/all-vacancies/…
employment.ku.dk/all-vacancies/…
https://employment.ku.dk/all-vacancies/…
January 27, 2025 at 3:28 PM
We are now accepting applications for two PhD positions within the Cilia-AI PhD training network (cilia-ai.eu). Please apply via the link below. Application deadline March 15th, start date September 1st, 2025.
employment.ku.dk/all-vacancies/…
employment.ku.dk/all-vacancies/…
Hmm… customs GIFs are not working yet it seems?
So here is what we do in a movie!
So here is what we do in a movie!
January 24, 2025 at 10:33 PM
Hmm… customs GIFs are not working yet it seems?
So here is what we do in a movie!
So here is what we do in a movie!
Reposted by Lüders Lab
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
www.biorxiv.org
January 11, 2025 at 7:51 PM
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Hot (and cold) microtubules👇🏼
How did microtubules adapt to support life across 🐸 species at divergent thermal niches?
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Mechanistic basis of temperature adaptation in microtubule dynamics across frog species
Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.
www.cell.com
January 10, 2025 at 9:30 PM
Hot (and cold) microtubules👇🏼
Reposted by Lüders Lab
From random gliding to ordered patterns.
The movie starts with microtubules gliding on a minus-end directed molecular motor.
Then, @bhagyanaths.bsky.social added a plus-end directed motor (magenta) to induce this polarity sorting and ordering process.
more details here:
www.pnas.org/doi/10.1073/...
The movie starts with microtubules gliding on a minus-end directed molecular motor.
Then, @bhagyanaths.bsky.social added a plus-end directed motor (magenta) to induce this polarity sorting and ordering process.
more details here:
www.pnas.org/doi/10.1073/...
January 8, 2025 at 10:21 AM
From random gliding to ordered patterns.
The movie starts with microtubules gliding on a minus-end directed molecular motor.
Then, @bhagyanaths.bsky.social added a plus-end directed motor (magenta) to induce this polarity sorting and ordering process.
more details here:
www.pnas.org/doi/10.1073/...
The movie starts with microtubules gliding on a minus-end directed molecular motor.
Then, @bhagyanaths.bsky.social added a plus-end directed motor (magenta) to induce this polarity sorting and ordering process.
more details here:
www.pnas.org/doi/10.1073/...
Prepping for Los Reyes (Three Kings Day) #2
January 6, 2025 at 4:51 PM
Prepping for Los Reyes (Three Kings Day) #2
Prepping for Los Reyes (Three Kings Day) #1
January 6, 2025 at 4:46 PM
Prepping for Los Reyes (Three Kings Day) #1