Raff Lab
@jrafflab.bsky.social
Interested in how centriole and centrsomes build themselves
Reposted by Raff Lab
Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶♂️'s CDK5RAP2.
Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1
October 5, 2025 at 4:19 AM
Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶♂️'s CDK5RAP2.
Reposted by Raff Lab
Today we welcomed MP Adam Thompson(@adamthompsonmp.bsky.social) to the Dunn School, part of the @royalsociety.org Pairing Scheme.
Adam got to see our science in action and share his reflections on a career in science and politics with our students and postdocs. Thanks for your visit Adam!
Adam got to see our science in action and share his reflections on a career in science and politics with our students and postdocs. Thanks for your visit Adam!
August 14, 2025 at 3:32 PM
Today we welcomed MP Adam Thompson(@adamthompsonmp.bsky.social) to the Dunn School, part of the @royalsociety.org Pairing Scheme.
Adam got to see our science in action and share his reflections on a career in science and politics with our students and postdocs. Thanks for your visit Adam!
Adam got to see our science in action and share his reflections on a career in science and politics with our students and postdocs. Thanks for your visit Adam!
Reposted by Raff Lab
We are featuring Jordan Raff as our next extraordinary biologist. He is a former Company Director and Founding Editor-in-Chief of Biology Open. #100biologists
@jordanraff.bsky.social
@jordanraff.bsky.social
January 14, 2025 at 12:35 PM
We are featuring Jordan Raff as our next extraordinary biologist. He is a former Company Director and Founding Editor-in-Chief of Biology Open. #100biologists
@jordanraff.bsky.social
@jordanraff.bsky.social
Reposted by Raff Lab
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
April 17, 2025 at 9:13 PM
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
🔬 Exciting findings from our collaborative study with Lea, Raff, van Breugel&Feng Lab! We've uncovered how Spd-2/CEP192 proteins with an SP2D structure are crucial for centrosome assembly. Crystal structures&mutations reveal new insights into PCM scaffold formation.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly
A conserved structural domain within CEP192/Spd-2 protein promotes centrosome scaffold assembly during centrosome maturation.
www.science.org
March 30, 2025 at 4:28 AM
🔬 Exciting findings from our collaborative study with Lea, Raff, van Breugel&Feng Lab! We've uncovered how Spd-2/CEP192 proteins with an SP2D structure are crucial for centrosome assembly. Crystal structures&mutations reveal new insights into PCM scaffold formation.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Raff Lab
#biologists100
Please come to my poster on Wed at the Liverpool conference and see how the @jrafflab.bsky.social with @dunngogreen.bsky.social @dunnschool.bsky.social is conducting our world class science in an environment friendly way at @ox.ac.uk ! Saving money & planet! There is no planet B!
Please come to my poster on Wed at the Liverpool conference and see how the @jrafflab.bsky.social with @dunngogreen.bsky.social @dunnschool.bsky.social is conducting our world class science in an environment friendly way at @ox.ac.uk ! Saving money & planet! There is no planet B!
March 24, 2025 at 4:30 PM
#biologists100
Please come to my poster on Wed at the Liverpool conference and see how the @jrafflab.bsky.social with @dunngogreen.bsky.social @dunnschool.bsky.social is conducting our world class science in an environment friendly way at @ox.ac.uk ! Saving money & planet! There is no planet B!
Please come to my poster on Wed at the Liverpool conference and see how the @jrafflab.bsky.social with @dunngogreen.bsky.social @dunnschool.bsky.social is conducting our world class science in an environment friendly way at @ox.ac.uk ! Saving money & planet! There is no planet B!
🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
www.science.org
February 10, 2025 at 6:45 AM
🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...
Happy to be here. Hopefully this will be fun and useful. Like Twitter used to be.
November 19, 2024 at 8:33 AM
Happy to be here. Hopefully this will be fun and useful. Like Twitter used to be.