Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶♂️'s CDK5RAP2.
Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1
October 5, 2025 at 4:19 AM
Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶♂️'s CDK5RAP2.
Reposted by Isaac Wong
🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab
Deadline 31 August
www.nature.com/naturecareer...
Deadline 31 August
www.nature.com/naturecareer...
Postdoctoral Researcher in Quantitative Cell Biology/Biochemistry (10374) - Harwell, Didcot job with The Rosalind Franklin Institute | 12841894
The Rosalind Franklin Institute (the Franklin) is a technology institute for life science, creating innovative technologies that transform our unde...
www.nature.com
August 8, 2025 at 8:18 PM
🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab
Deadline 31 August
www.nature.com/naturecareer...
Deadline 31 August
www.nature.com/naturecareer...
Reposted by Isaac Wong
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
August 7, 2025 at 1:38 PM
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
Exciting news! Our latest paper reveals that Spd-2 (CEP192) recruits Polo & Aurora A to build two scaffolds—Polo-dependent Cnn (for strength) & Aurora A–dependent TACC (for protein concentration)—crucial for centrosome assembly in Drosophila. #CellBiology #Centrosome www.science.org/doi/10.1126/...
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
www.science.org
February 8, 2025 at 5:04 AM
Exciting news! Our latest paper reveals that Spd-2 (CEP192) recruits Polo & Aurora A to build two scaffolds—Polo-dependent Cnn (for strength) & Aurora A–dependent TACC (for protein concentration)—crucial for centrosome assembly in Drosophila. #CellBiology #Centrosome www.science.org/doi/10.1126/...