Graham Dellaire
LightNews LightNews
banner
docdellaire.bsky.social
Graham Dellaire
@docdellaire.bsky.social
1.6K followers 230 following 2K posts
Cancer biologist, environment and cancer, guitarist, would-be evolutionary molecular biologist, bread baker, sometimes coder, amateur photographer, professional microscopist, & gardener. Lab site: https://blogs.dal.ca/dellairelab/
Posts Replies Media Videos
Pinned
docdellaire.bsky.social
Graham Dellaire @docdellaire.bsky.social · Jun 19
🔥12 years in the making!🔥
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
Mis-splicing of autophagy genes contributes to diverse pathologies including cancer. Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase PRP4K leads to impaired autophagy...
www.cell.com
Reposted by Graham Dellaire
lucksmith.bsky.social
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4

rdcu.be/eOc0q
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...
rdcu.be
November 10, 2025 at 4:43 PM
docdellaire.bsky.social
If 1/250 people have a loss of function mutation in ANGPTL3 (leading to low LDL) - it is for a reason in the deep evolutionary past. Mutating this in healthy people may lead to some consequences we have no idea about… so caveat medicus
November 9, 2025 at 1:58 PM
docdellaire.bsky.social
I need to try this! 👀
kwolbachia.bsky.social Kevin Terretaz @kwolbachia.bsky.social · 6d
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 8, 2025 at 9:14 PM
Reposted by Graham Dellaire
timnfeinstein.bsky.social
Not looking to disrupt anyone’s day, but a whole new endomembrane system just dropped. What does that stuff do? No one knows yet!
buzzbaum.bsky.social Buzz Baum @buzzbaum.bsky.social · 4d
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 8, 2025 at 7:43 PM
Reposted by Graham Dellaire
trentpetersclarke.bsky.social
Hijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery | JACS
@jacs.acspublications.org @ucsfcancer.bsky.social @jimwellsucsf.bsky.social
pubs.acs.org/doi/10.1021/...
Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells. Among these, antibody–drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depe...
pubs.acs.org
October 16, 2025 at 6:41 PM
Reposted by Graham Dellaire
cashwood.proteaglyco.com
New TMT Tribrid from Thermo for #ASMS2026 (public info)
- IRMPD is the new UPVD
- IRMPD with TMT boosts reporter intensity by up to 240% without affecting quant
- New resolutions -> Down to 1k res, with an associated loss of signal, but at least it looks faster!
- Improved proton transfer reaction
November 6, 2025 at 7:18 AM
Reposted by Graham Dellaire
francoisebaylis.bsky.social
I am so very excited about this new chapter of my life. Looking forward to working alongside talented colleagues to find creatives ways to leverage knowledge for the benefit of Canadians www.dal.ca/news/2025/11...
Dalhousie’s Dr. Françoise Baylis begins new chapter as president of the Royal Society of Canada
Global bioethics leader steps into a pivotal national role, aiming to deepen public trust in research, amplify Canadian voices on the world stage, and champion science for societal good.
www.dal.ca
November 6, 2025 at 9:17 PM
Reposted by Graham Dellaire
carexcanada.bsky.social
November is Lung Cancer Awareness Month #LCAM. Radon is the second leading cause of #lungcancer in Canada. It is a naturally occurring radioactive gas found in public buildings, schools, hospitals, and new and older homes. Learn more www.carexcanada.ca/special-topi... @cancersociety.bsky.social
November 6, 2025 at 10:20 PM
docdellaire.bsky.social
This is something I have often wondered about - how DNA damage alters genome architecture and if it is heritable across the cell cycle even after repair?
Well here is a nice study addressing this fundamental question 👇👇👇😍
sbantele.bsky.social Susi Bantele @sbantele.bsky.social · 4d
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 12:33 PM
Reposted by Graham Dellaire
michaelrera.bsky.social
Happy to announce the latest preprint of PhD candidate Mariana Abakarova (not yet on bluesky) tinyurl.com/4ewd2v85 in co-supervision with Prof. @laineelodie.bsky.social @sorbonne-universite.fr / @upariscite
tinyurl.com/2ntnfvw3
Funded by @agencerecherche.bsky.social ADAGIO and @erc.europa.eu PROMISE
Proteome-wide prediction of the Functional Impact of Missense Variants with ProteoCast
Background: Dissecting the functional impact of genetic mutations is essential to advancing our understanding of genotype-phenotype relationships and identifying new therapeutic targets. Despite the p...
www.biorxiv.org
February 11, 2025 at 9:15 AM
docdellaire.bsky.social
Time for a timeline cleanser?
Here is a cool street mural in #Calgary Alberta, Canada #StreetArt #StreetMurals

Follow for more murals and pics posted each week.
November 4, 2025 at 5:13 PM
docdellaire.bsky.social
Time for a timeline cleanser?
Here is a cool street mural in #Calgary Alberta, Canada #StreetArt #StreetMurals

Follow for more murals and pics posted each week.
November 3, 2025 at 4:53 PM
Reposted by Graham Dellaire
longchrom.bsky.social
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
jcb.org Journal of Cell Biology @jcb.org · 10d
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...

#Cytokinesis
November 1, 2025 at 8:06 AM
Reposted by Graham Dellaire
andrewcraigscri.bsky.social
Masterclass in session with Dr Nada Jabado who has led efforts to understand oncohistone mechanisms and potential treatments for pediatric cancers #CCRC2025 @ccralliance.bsky.social
November 3, 2025 at 3:23 PM
Reposted by Graham Dellaire
peiferlabunc.bsky.social
Yesterday I was discussing the intractibility of glioblastoma with a neuroscience colleague--this could be transformative 🧪
November 1, 2025 at 12:45 PM
docdellaire.bsky.social
😍
germusthermophilus.bsky.social Germán Bonilla-Rosso @germusthermophilus.bsky.social · 9d
We are our best when we collaborate. 🧪🦠🔬🧬🌍🍄
This mural about the invisible #soil #biodiversity in Moers(🇩🇪) resulted from the collaboration between my friend Dr. Arne Schwelm, the people from sci:moers and the Stiftung für Umwelt und Entwicklung under the artistic direction of #cokyone.
A mural designed by members of sci:moers under the artistic direction of urban artist cokyone (https://cokyone.myportfolio.com), after the biodiversity analysis in soil done by Dr. Arne Schwelm. The organisms are a Gastrotrichia, Tardigrade, a nematode, a ciliate, a testate amoeba and the fruiting body of a fungus.
November 2, 2025 at 2:35 PM
docdellaire.bsky.social
Me before a flight… “did I lock the door?” #CalgaryBound #CCRC2025
November 1, 2025 at 9:56 AM
docdellaire.bsky.social
The Moderna that has lost 90% of its market cap is the same Corp that the Canadian Liberal government made a big bet on for vaccine production in Canada… so what is the expiry date on Moderna making vaccines in Canada? 1 year, 2 years?
October 31, 2025 at 11:48 PM
docdellaire.bsky.social
Chromatic aberration correction for microscopy - Github link via @ekatruhkha.bsky.social 👇
ekatrukha.bsky.social Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 11d
Mmm, it could be, I guess, if you segment fluorogram and intensity not changing much in the process. But I expect it would not work well, since it is pixel wise and color aberration usually affects small % of total pixels. I would stick with Gaussian fitting github.com/UU-cellbiolo...
Chromatic correction
Detection of Molecules plugin for ImageJ, Utrecht University - UU-cellbiology/DoM_Utrecht
github.com
October 31, 2025 at 12:36 PM
docdellaire.bsky.social
A week ago I never heard of “fee simple title” = freehold property. eg there are ~200 million fee simple titles owned by private citizens in British Columbia alone, worth $140 trillion 😳

If you are Canadian and own property, you may want to pay attention to this 👇 globalnews.ca/news/1150102...
Richmond homeowners have a right to be ‘mad,’ experts say over Cowichan ruling - BC | Globalnews.ca
'There's a lot of frustration, but I think people have every right to be mad,' Caroline Elliott with the Public Land Use Society told Global News.
globalnews.ca
October 31, 2025 at 1:58 AM
docdellaire.bsky.social
Boom! 💥
cejkalab.bsky.social Petr Cejka @cejkalab.bsky.social · 11d
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social

www.science.org/doi/10.1126/...
October 30, 2025 at 8:59 PM
docdellaire.bsky.social
The calm before Hurricane Melissa side swipes Halifax #sleepypuppies #whathurricane
October 30, 2025 at 4:19 PM
Reposted by Graham Dellaire
landongetz.bsky.social
Excited to share: DNA glycosylases are diverse antiviral effectors. They recognize phage base modifications and initiate genome destruction. A structure‑guided approach made the scope of this discovery possible! 🧪 #phagesky doi.org/10.1101/2025... #phage #microbiology
Antiviral Defence is a Conserved Function of Diverse DNA Glycosylases
Bacteria are frequently attacked by viruses, known as phages, and rely on diverse defence systems like restriction endonucleases and CRISPR-Cas to survive. While phages can evade these defences by cov...
doi.org
October 30, 2025 at 12:16 PM