Graham Dellaire
@docdellaire.bsky.social
Cancer biologist, environment and cancer, guitarist, would-be evolutionary molecular biologist, bread baker, sometimes coder, amateur photographer, professional microscopist, & gardener. Lab site: https://blogs.dal.ca/dellairelab/
Pinned
Graham Dellaire
@docdellaire.bsky.social
· Jun 19
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
Mis-splicing of autophagy genes contributes to diverse pathologies including cancer.
Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase
PRP4K leads to impaired autophagy...
www.cell.com
🔥12 years in the making!🔥
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
TL;DR... read to your kids folks
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Screen time, brain network development and socio-emotional competence in childhood: moderation of associations by parent–child reading | Psychological Medicine | Cambridge Core
Screen time, brain network development and socio-emotional competence in childhood: moderation of associations by parent–child reading - Volume 54 Issue 9
www.cambridge.org
January 5, 2026 at 2:29 AM
TL;DR... read to your kids folks
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
😮Maybe a huge finding... norepinephrine pulses during deep sleep are a key factor for clearance of "waste" in the brain, and not sleep duration or amount of NREM sleep per se. 😴💤
TL;DR Ambien (zolpidem) blocks this process, so probably not great for you www.cell.com/cell/abstrac...
TL;DR Ambien (zolpidem) blocks this process, so probably not great for you www.cell.com/cell/abstrac...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral
blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic
and pharmacological manipulations...
www.cell.com
January 3, 2026 at 2:47 AM
😮Maybe a huge finding... norepinephrine pulses during deep sleep are a key factor for clearance of "waste" in the brain, and not sleep duration or amount of NREM sleep per se. 😴💤
TL;DR Ambien (zolpidem) blocks this process, so probably not great for you www.cell.com/cell/abstrac...
TL;DR Ambien (zolpidem) blocks this process, so probably not great for you www.cell.com/cell/abstrac...
Reposted by Graham Dellaire
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...
www.nature.com
December 31, 2025 at 5:53 PM
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
THIS... every damn time. 👇
Every time I submit a scientific manuscript, I am confronted with the counter-intuitive fact of PAYING to publish work that I created.
December 30, 2025 at 9:39 PM
THIS... every damn time. 👇
Challah bread french toast with orange and brandy!
December 29, 2025 at 5:22 PM
Challah bread french toast with orange and brandy!
In case anyone needs a reminder...
December 27, 2025 at 10:00 PM
In case anyone needs a reminder...
Reposted by Graham Dellaire
Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.
Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination - Nature Communications
Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...
www.nature.com
December 23, 2025 at 9:15 PM
Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.
Reposted by Graham Dellaire
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
December 24, 2025 at 10:44 PM
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
French dip and Mac N Cheese - yes please! #homemade #baguettes
December 23, 2025 at 8:52 PM
French dip and Mac N Cheese - yes please! #homemade #baguettes
Baguette time! The essential ingredient to an amazing French Beef Dip… #oMGTheSmellIsAmazing
December 23, 2025 at 6:52 PM
Baguette time! The essential ingredient to an amazing French Beef Dip… #oMGTheSmellIsAmazing
You probably heard about the Government of Canada’s $1.7 billion Canada Global Impact+ Research Talent Initiative... well apparently Dalhousie is recruiting 30 Tenure-track positions.
See (and search for Impact+) for more jobs: link.webtrackz.com/hEtS?recipie...
See (and search for Impact+) for more jobs: link.webtrackz.com/hEtS?recipie...
Canada Impact+ Research Chair
About the Canada Impact+ Research Chairs opportunityDalhousie University invites applications from exceptional, internationally based researchers for the Canada Impact+ Research Chairs program. This n...
link.webtrackz.com
December 19, 2025 at 8:14 PM
You probably heard about the Government of Canada’s $1.7 billion Canada Global Impact+ Research Talent Initiative... well apparently Dalhousie is recruiting 30 Tenure-track positions.
See (and search for Impact+) for more jobs: link.webtrackz.com/hEtS?recipie...
See (and search for Impact+) for more jobs: link.webtrackz.com/hEtS?recipie...
Sooo… PML nuclear bodies (NBs) are conspicuously missing in the big 4D nucleome project overview. Were the chromatin interactions at their periphery too dynamic to capture reliably or just ignored? PML NBs exist in most vertebrates (except boney fish) but are missing in fungi and invertebrates.
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
www.nature.com
December 18, 2025 at 12:17 PM
Sooo… PML nuclear bodies (NBs) are conspicuously missing in the big 4D nucleome project overview. Were the chromatin interactions at their periphery too dynamic to capture reliably or just ignored? PML NBs exist in most vertebrates (except boney fish) but are missing in fungi and invertebrates.
Reposted by Graham Dellaire
"By curating a diverse dataset of 200 papers and evaluating 15 domain-specific jailbreak strategies, we demonstrated that "Lazy Reviewers" relying on Language Models can be easily manipulated into accepting rejected papers"
arxiv.org/html/2512.10...
arxiv.org/html/2512.10...
When Reject Turns into Accept: Quantifying the Vulnerability of LLM-Based Scientific Reviewers to Indirect Prompt Injection
arxiv.org
December 14, 2025 at 12:34 PM
"By curating a diverse dataset of 200 papers and evaluating 15 domain-specific jailbreak strategies, we demonstrated that "Lazy Reviewers" relying on Language Models can be easily manipulated into accepting rejected papers"
arxiv.org/html/2512.10...
arxiv.org/html/2512.10...
File under you can't make this 💩up... #BCPolitics #ThisIsWild pentictonwesternnews.com/2025/12/14/o...
One B.C. board says Dallas Brodie removed as party leader - Penticton Western News
Tara Armstrong says she’s lost confidence in Brodie,
pentictonwesternnews.com
December 15, 2025 at 3:49 AM
File under you can't make this 💩up... #BCPolitics #ThisIsWild pentictonwesternnews.com/2025/12/14/o...
Evolutionary biology for the win (again)!
E. Coli derived LplA rescues mammalian Lipt1 (lipoyltransferase) deficiency in Lipt1 KO mice 😱 www.science.org/doi/full/10....
E. Coli derived LplA rescues mammalian Lipt1 (lipoyltransferase) deficiency in Lipt1 KO mice 😱 www.science.org/doi/full/10....
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase
One bacterial enzyme LplA or LplJ rescues multiple lethal genetic defects in mitochondrial diseases.
www.science.org
December 15, 2025 at 1:35 AM
Evolutionary biology for the win (again)!
E. Coli derived LplA rescues mammalian Lipt1 (lipoyltransferase) deficiency in Lipt1 KO mice 😱 www.science.org/doi/full/10....
E. Coli derived LplA rescues mammalian Lipt1 (lipoyltransferase) deficiency in Lipt1 KO mice 😱 www.science.org/doi/full/10....
Good to know!
A reminder to use the right P2A sequence to produce separate proteins - the images are from a GPCR-P2A-mCherry construct using a P2A variant without (upper row) and with (lower row) a preceding GSG linker.
December 13, 2025 at 3:00 AM
Good to know!
How do people feel about Nanodrop for RNA and DNA quantification? Less flaky now? Alternatives? Thoughts/comments?
December 12, 2025 at 2:14 PM
How do people feel about Nanodrop for RNA and DNA quantification? Less flaky now? Alternatives? Thoughts/comments?
Reposted by Graham Dellaire
Billy Strings on NPR's Tiny Desk Concerts! This makes me so happy... check it out, crank it up and enjoy 👇https://youtu.be/WgqaxMOKfnI?si=mqSHb1bMh1_p2vai
Billy Strings: Tiny Desk Concert
YouTube video by NPR Music
youtu.be
December 12, 2025 at 2:36 AM
Billy Strings on NPR's Tiny Desk Concerts! This makes me so happy... check it out, crank it up and enjoy 👇https://youtu.be/WgqaxMOKfnI?si=mqSHb1bMh1_p2vai
Reposted by Graham Dellaire
I really want to know who the Libs are consulting to come up with these ideas.
Because no person who knows anything about the current research and funding ecosystem in 🇨🇦 (or who has historical insight on similar past schemes) would come up w this as a priority policy, let alone a good use of funds.
Because no person who knows anything about the current research and funding ecosystem in 🇨🇦 (or who has historical insight on similar past schemes) would come up w this as a priority policy, let alone a good use of funds.
Canada’s new government is investing big to attract world-class talent in science and technology — and become an innovation powerhouse.
December 12, 2025 at 12:01 AM
I really want to know who the Libs are consulting to come up with these ideas.
Because no person who knows anything about the current research and funding ecosystem in 🇨🇦 (or who has historical insight on similar past schemes) would come up w this as a priority policy, let alone a good use of funds.
Because no person who knows anything about the current research and funding ecosystem in 🇨🇦 (or who has historical insight on similar past schemes) would come up w this as a priority policy, let alone a good use of funds.
My first attempt “no-bake” cheese cake!
December 11, 2025 at 11:32 PM
My first attempt “no-bake” cheese cake!
👀waat!
Ummm guys, we've just found ribose (sugar in RNA) and glucose on an asteroid www.nature.com/articles/s41...
Bio-essential sugars in samples from asteroid Bennu - Nature Geoscience
Samples returned from asteroid Bennu contain bio-essential sugars such as ribose and glucose that may have formed in the parent asteroid from brines containing formaldehyde, according to a geochemical...
www.nature.com
December 11, 2025 at 4:51 PM
👀waat!
📣Another great collaboration with Neale Ridgway (Dalhousie University) on the promyelocytic leukemia (PML) protein and lipids.
Here we show how induction of inner nuclear membrane (INM) curvature stress leads to PML II patches at the INM. Check it out 👇 www.molbiolcell.org/doi/10.1091/...
Here we show how induction of inner nuclear membrane (INM) curvature stress leads to PML II patches at the INM. Check it out 👇 www.molbiolcell.org/doi/10.1091/...
Membrane curvature elastic stress triggers recruitment of PML-II onto the inner nuclear membrane | Molecular Biology of the Cell
Promyelocytic leukemia (PML) protein isoform II is a component of PML nuclear bodies (PML NBs) that also forms patches on nuclear lipid droplets (nLDs) and the inner nuclear membrane (INM). Here we te...
www.molbiolcell.org
December 11, 2025 at 3:01 PM
📣Another great collaboration with Neale Ridgway (Dalhousie University) on the promyelocytic leukemia (PML) protein and lipids.
Here we show how induction of inner nuclear membrane (INM) curvature stress leads to PML II patches at the INM. Check it out 👇 www.molbiolcell.org/doi/10.1091/...
Here we show how induction of inner nuclear membrane (INM) curvature stress leads to PML II patches at the INM. Check it out 👇 www.molbiolcell.org/doi/10.1091/...
Reposted by Graham Dellaire
Reposted by Graham Dellaire
December 10, 2025 at 2:33 PM