Graham Dellaire
@docdellaire.bsky.social
Cancer biologist, environment and cancer, guitarist, would-be evolutionary molecular biologist, bread baker, sometimes coder, amateur photographer, professional microscopist, & gardener. Lab site: https://blogs.dal.ca/dellairelab/
Pinned
Graham Dellaire
@docdellaire.bsky.social
· Jun 19
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
Mis-splicing of autophagy genes contributes to diverse pathologies including cancer.
Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase
PRP4K leads to impaired autophagy...
www.cell.com
🔥12 years in the making!🔥
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
Reposted by Graham Dellaire
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer
Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...
forum.image.sc
November 21, 2025 at 9:29 AM
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
Not going to lie… this is pretty awesome! 👏 👇
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
www.science.org
November 21, 2025 at 12:18 PM
Not going to lie… this is pretty awesome! 👏 👇
Reposted by Graham Dellaire
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
The two industries that need to have the greatest open trade between provinces, and greater competition (which will increase affordability) is FOOD & the WINE/BEER industry. So WTF Liberal Government - trade barriers drop for all goods EXCEPT Food and Alcohol... AYFKM?!🤦 www.cbc.ca/news/canada/...
Provinces sign agreement to drop interprovincial trade barriers on goods except food, alcohol | CBC News
An agreement, signed today, between all Canadian provinces, territories, and the federal government, will drop interprovincial trade barriers on many goods except food and alcohol. It's part of an eff...
www.cbc.ca
November 20, 2025 at 1:34 PM
The two industries that need to have the greatest open trade between provinces, and greater competition (which will increase affordability) is FOOD & the WINE/BEER industry. So WTF Liberal Government - trade barriers drop for all goods EXCEPT Food and Alcohol... AYFKM?!🤦 www.cbc.ca/news/canada/...
Looking forward to the supplemental data... it has to be huge.
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 20, 2025 at 1:02 PM
Looking forward to the supplemental data... it has to be huge.
Reposted by Graham Dellaire
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 11:58 AM
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
😍
quick test with SAM3 - impressed with how well it seems to track long protrusions? prompted for "cell", does not find anything when looking for "fibroblast" or "nucleus"
November 19, 2025 at 8:51 PM
😍
Reposted by Graham Dellaire
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
ubc.wd10.myworkdayjobs.com
November 18, 2025 at 11:52 PM
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Totally not on my evolution bingo card… 🤯
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 2:12 PM
Totally not on my evolution bingo card… 🤯
November 18, 2025 at 12:37 PM
I don’t think I have ever used the word “sesh” to describe a lab meeting… #StuffSeenOnThisApp
November 18, 2025 at 12:35 PM
I don’t think I have ever used the word “sesh” to describe a lab meeting… #StuffSeenOnThisApp
😂😂😂😂
Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.
November 18, 2025 at 12:07 PM
😂😂😂😂
Reposted by Graham Dellaire
Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
November 17, 2025 at 5:24 AM
Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
A really nice break down (or maybe “take down”) of liquid-liquid phase separation (LLPS) and the concept of biomolecular condensates. A really popular theory and experimental framework applied to non-membrane bound cell organelles/bodies and even chromatin. As with most theories it has limitations.
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 12:10 PM
A really nice break down (or maybe “take down”) of liquid-liquid phase separation (LLPS) and the concept of biomolecular condensates. A really popular theory and experimental framework applied to non-membrane bound cell organelles/bodies and even chromatin. As with most theories it has limitations.
Neotribalism - an overview from Marilynne Robinson. TL;DR it is not great for society www.youtube.com/watch?v=nOMz...
Marilynne Robinson: The Threat of Neotribalism | Big Think
YouTube video by Big Think
www.youtube.com
November 16, 2025 at 6:12 PM
Neotribalism - an overview from Marilynne Robinson. TL;DR it is not great for society www.youtube.com/watch?v=nOMz...
Reposted by Graham Dellaire
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
Environmental fluctuations influence heritable phenotypes through complex molecular mechanisms. In zebrafish (Danio rerio), the interplay between temperature variation, transposable element (TE) activ...
www.biorxiv.org
November 16, 2025 at 10:18 AM
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Doesn’t it take at least two neurons to make a synapse ?🤔 @christlet.bsky.social
It’s too late. I’ve already depicted you as few synapses, tiny think, and myself as many synapses, big think. it’s over
November 15, 2025 at 12:48 PM
Doesn’t it take at least two neurons to make a synapse ?🤔 @christlet.bsky.social
Here we go - “enshitification” or peer review activated 🫠
November 15, 2025 at 12:02 PM
Here we go - “enshitification” or peer review activated 🫠
Reposted by Graham Dellaire
Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social
Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals
go.nature.com/4i0i61w
go.nature.com/4i0i61w
Convergent genome evolution shaped the emergence of terrestrial animals - Nature
Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent genomic evolution across the animal kingdom and recurring periods of terrestrial colonization.
go.nature.com
November 13, 2025 at 3:18 PM
Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social
Reposted by Graham Dellaire
A moment of relief:
Sponges have been restored at the root of the evolutionary tree -- and not the comb jellies, those hot freaks.
Sponges have been restored at the root of the evolutionary tree -- and not the comb jellies, those hot freaks.
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 9:33 PM
A moment of relief:
Sponges have been restored at the root of the evolutionary tree -- and not the comb jellies, those hot freaks.
Sponges have been restored at the root of the evolutionary tree -- and not the comb jellies, those hot freaks.
👀 very cool!
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 14, 2025 at 4:13 AM
👀 very cool!
Reposted by Graham Dellaire
Check out our new biosensor technology to study DDR kinase signaling: ProKAS.
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
November 13, 2025 at 6:22 PM
Check out our new biosensor technology to study DDR kinase signaling: ProKAS.
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
Reposted by Graham Dellaire
Site-specific DNA insertion into the human genome with engineered recombinases www.nature.com/articles/s41...
Site-specific DNA insertion into the human genome with engineered recombinases - Nature Biotechnology
Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.
www.nature.com
November 12, 2025 at 11:10 PM
Site-specific DNA insertion into the human genome with engineered recombinases www.nature.com/articles/s41...
Homemade yogurt this morning - used L. reuteri and L. gasseri strains. #MoreStuffScientistsDo #CultureSkills #SourdoughWasAgatewayToThis
November 13, 2025 at 12:27 PM
Homemade yogurt this morning - used L. reuteri and L. gasseri strains. #MoreStuffScientistsDo #CultureSkills #SourdoughWasAgatewayToThis
Time for a timeline cleanser?
Here is a nice street mural in #Halifax Nova Scotia, Canada #StreetArt #StreetMurals
Follow for more murals and pics posted each week.
Here is a nice street mural in #Halifax Nova Scotia, Canada #StreetArt #StreetMurals
Follow for more murals and pics posted each week.
November 13, 2025 at 12:06 PM
Time for a timeline cleanser?
Here is a nice street mural in #Halifax Nova Scotia, Canada #StreetArt #StreetMurals
Follow for more murals and pics posted each week.
Here is a nice street mural in #Halifax Nova Scotia, Canada #StreetArt #StreetMurals
Follow for more murals and pics posted each week.