Eva Estébanez-Perpiñá, Ph.D.
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estebanezlab.bsky.social
Eva Estébanez-Perpiñá, Ph.D.
@estebanezlab.bsky.social
250 followers 350 following 72 posts
Prof. Eva Estébanez-Perpiñá @UniBarcelona / Leading the Nuclear Receptor Lab @IBUB_UB @PCB_UB/ Psychologist + Structural Biologist + Proud Mom 🚀🪐
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estebanezlab.bsky.social
Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 20d
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...

@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
Reposted by Eva Estébanez-Perpiñá, Ph.D.
ibub-ub.bsky.social
#ArticleOfTheMonth I November 2025
✒️The multimerization pathway of the glucocorticoid receptor

🔗Access the full article here 👉 www.biorxiv.org/content/10.1...

@ub.edu @biologiaub.bsky.social @farmaciaub.bsky.social @www.pcb.ub.edu @estebanezlab.bsky.social
November 10, 2025 at 11:06 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
meadekrosby.bsky.social
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 7, 2025 at 7:58 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
www.pcb.ub.edu
#PCBCommunity |🔬 L'@ibub-ub.bsky.social
@bqbiomedmolub.bsky.social @biologiaub.bsky.social desxifra el mecanisme de multimerització del receptor de #glucocorticoides (GR), obrint una via crucial per desenvolupar #fàrmacs més selectius capaços de minimitzar efectes adversos greus.

👉 tuit.cat/eDIgJ
October 31, 2025 at 11:09 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
bqbiomedmolub.bsky.social
🔊Nova recerca al dpt @bqbiomedmolub.bsky.social pel grup @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social‼️
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides - Actualitat - Universitat de Barcelona web.ub.edu/ca/web/actua...
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides
web.ub.edu
October 27, 2025 at 5:25 PM
estebanezlab.bsky.social
🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...
Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor
web.ub.edu
October 27, 2025 at 11:33 AM
estebanezlab.bsky.social
The multimerization pathway of the glucocorticoid receptor url: academic.oup.com/nar/article/...
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 26, 2025 at 9:02 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
presmanlab.bsky.social
Happy to share the latest publication led by Pablo Fuentes-Prior, G. Hager, and @estebanezlab.bsky.social, with talented co-first authors Andrea, Alba, and Agustina.

This one feels special to me, as I explain in this thread below....
estebanezlab.bsky.social Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 20d
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
October 23, 2025 at 3:39 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
estebanezlab.bsky.social
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
October 22, 2025 at 10:02 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
estebanezlab.bsky.social
🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️
academic.oup.com/nar/article/...
May 16, 2025 at 3:06 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
bqbiomedmolub.bsky.social
🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá ‪@estebanezlab.bsky.social ‬@ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋
October 22, 2025 at 11:07 AM
estebanezlab.bsky.social
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...

@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 22, 2025 at 10:09 AM
estebanezlab.bsky.social
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
October 22, 2025 at 10:02 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
estebanezlab.bsky.social
📢 Another bioRxiv on GR from our lab in collaboration with Pablo Fuentes, Gordon Hager NIH, Diego Presman @palomaperezlab.bsky.social FRecio & the amazing Andrea Alegre, Alba Jiménez @aguslafuent.bsky.social Inés Montoya Montse Abella 🚀
doi: doi.org/10.1101/2024.1…
June 8, 2025 at 3:50 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
estebanezlab.bsky.social
📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site
June 7, 2025 at 2:26 PM
estebanezlab.bsky.social
📢 Today we had the IBUB-Day with top Science, scientific discussions and absolutely gorgeous venue at Reial Cercle Artístic @ibub-ub.bsky.social @biologiaub.bsky.social
October 3, 2025 at 4:30 PM
estebanezlab.bsky.social
🎯 We do research at the University of Barcelona where we study Nuclear Receptors from a structural & functional perspective using X-ray crystallography and several complementary biochemical/physical tecniques 💎⚡️ @ibub-ub.bsky.social @biologiaub.bsky.social
September 30, 2025 at 3:50 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
djost-physbiol.bsky.social
New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...
Loop extrusion provides mechanical robustness to chromatin
Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...
www.biorxiv.org
September 29, 2025 at 1:24 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
mspielmann.bsky.social
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics
Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...
www.nature.com
July 7, 2025 at 11:12 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
alexis-verger.cpesr.fr
If you like transcription regulation and its mechanisms, this WIP list is for you.

I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.

go.bsky.app/8vTgeXB
August 28, 2025 at 12:48 PM
estebanezlab.bsky.social
📢 Thrilled to present & attend the EMBO Workshop in marvellous Palermo on When Predictions Meet Experiments. Fantastic speaker lineup, venue & organizers Caterina Alfano, Sandra Macedo & Pedro Pereira ✨️🚀🔥
September 10, 2025 at 8:36 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
genesdev.bsky.social
REVIEW: Timing is everything: transcription bursting in development
By Jee Min Kim and Daniel Larson
➡️ https://tinyurl.com/gd352465

#transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism
September 8, 2025 at 3:06 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
matthewcobb.bsky.social
News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n
History of Molecular Biology Collection
This unparalleled collection includes Rosalind Franklin's historic 'Photo 51,' which revealed the double-helix structure of DNA.
www.sciencehistory.org
September 8, 2025 at 12:28 PM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
biomolstructure.bsky.social
meetings.embo.org/event/25-str...
#EMBOStructuralBio
When predictions meet experiments: the next challenges in structural biology
Building on the success of the 2022 EMBO Workshop “When Predictions Meet Experiments: The Future of Structure Determination”, this second edition continues the journey at the interface of computation…
meetings.embo.org
March 24, 2025 at 7:14 AM
Reposted by Eva Estébanez-Perpiñá, Ph.D.
estebanezlab.bsky.social
📢 New publication on the Glucocorticoid Receptor IDP domain in collaboration with @alirezamashaghi.bsky.social lab. Always a pleasure to learn from new approaches & techniques. So much still to understand from #nuclearreceptors
alirezamashaghi.bsky.social Alireza Mashaghi @alirezamashaghi.bsky.social · Jul 19
On disordered topologically compact states in intrinsically disordered proteins! We explored this concept in the context of the human Glucocorticoid Receptor.
pubs.acs.org/doi/10.1021/...

#ChemSky #IDP #Protein #Biophysics #Topology #CompChem
July 19, 2025 at 1:19 PM
estebanezlab.bsky.social
📢 Looking so much forward to present our work at EMBO Workshop Palermo (Sicilia, Italy) to meet structural biologists tackling structure-function from complementary approaches to undestand, predict & design macromolecules 🚀⚡️
September 7, 2025 at 7:40 AM