Lingchen He 何灵尘
@lingchenhe.bsky.social
Someone‖‖Postdoc‖MGEs‖HGT‖Phage person but sometimes anti-phage
Reposted by Lingchen He 何灵尘
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New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While
increased mobility can easily evolve by incorporating phage DNA into plasmids, this
is disadvantageous because it...
www.cell.com
October 22, 2025 at 9:22 PM
🤟🤟🤟🤟🤟
Reposted by Lingchen He 何灵尘
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
www.gla.ac.uk
September 30, 2025 at 11:02 AM
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
🔥🔥🔥
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
September 26, 2025 at 9:38 AM
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Congrats!!
It’s been a long but beautiful journey. Grateful for the support from all co-authors and colleagues, especially @filizkuybu.bsky.social 🙌, with whom I shared many long days and restless nights. Many more questions lie ahead!
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
September 24, 2025 at 10:08 PM
Congrats!!
Reposted by Lingchen He 何灵尘
Phage "satellites" that produce capsids but have no genes to produce tails have puzzled scientists for a long time. These are abundant as prophages in bacteria, but it was unclear how they can infect without tails
Now, Penadés & co show that they hijack tails from other phages. Incredible!
Now, Penadés & co show that they hijack tails from other phages. Incredible!
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails
from unrelated species to transfer their DNA across bacterial hosts. This tail piracy
enables broad dissemination and ...
www.cell.com
September 11, 2025 at 11:23 AM
Phage "satellites" that produce capsids but have no genes to produce tails have puzzled scientists for a long time. These are abundant as prophages in bacteria, but it was unclear how they can infect without tails
Now, Penadés & co show that they hijack tails from other phages. Incredible!
Now, Penadés & co show that they hijack tails from other phages. Incredible!
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
September 9, 2025 at 9:10 PM
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
Reposted by Lingchen He 何灵尘
Did you get the email I sent 😭
August 10, 2025 at 1:57 PM
Did you get the email I sent 😭
Reposted by Lingchen He 何灵尘
Picking blueberries 💙🐦
August 1, 2025 at 12:50 PM
Picking blueberries 💙🐦
Reposted by Lingchen He 何灵尘
Congratulations Franklin, Yi and all the authors!! Very beautiful work!
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses
phage attachment at the membrane and assembles a transmembrane complex that halts
infection by blocking phage DNA re...
www.cell.com
July 28, 2025 at 8:31 PM
Congratulations Franklin, Yi and all the authors!! Very beautiful work!
Reposted by Lingchen He 何灵尘
Thank you to everyone who attended the 3rd UK MGE workshop. What an incredible few days of science and community building! Next stop: York 2026, hosted by @pcmfogg.bsky.social. See you all next year! #UKMGE
June 19, 2025 at 11:04 AM
Thank you to everyone who attended the 3rd UK MGE workshop. What an incredible few days of science and community building! Next stop: York 2026, hosted by @pcmfogg.bsky.social. See you all next year! #UKMGE
Reposted by Lingchen He 何灵尘
1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below.
shorturl.at/o6S1w
shorturl.at/o6S1w
A bacterial CARD-NLR immune system controls the release of gene transfer agents
Bacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ...
shorturl.at
May 9, 2025 at 8:08 AM
1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below.
shorturl.at/o6S1w
shorturl.at/o6S1w
Reposted by Lingchen He 何灵尘
Good papers, like good wine, need maturing. I'm proud and thrilled to share our work on genomic epidemiology of K.pneumoniae in Valencia and differential transmission patterns of resistances, part of Neris Garcia's PhD thesis and the NLSAR consortium. go.uv.es/td8iL4c #publichealth #EpiSky 🧬🖥️
Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018–2020 - ...
Background The emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics wi...
go.uv.es
May 7, 2025 at 6:17 PM
Good papers, like good wine, need maturing. I'm proud and thrilled to share our work on genomic epidemiology of K.pneumoniae in Valencia and differential transmission patterns of resistances, part of Neris Garcia's PhD thesis and the NLSAR consortium. go.uv.es/td8iL4c #publichealth #EpiSky 🧬🖥️
Reposted by Lingchen He 何灵尘
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Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 8, 2025 at 8:27 PM
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Three to one, tales! (✓)
Virtual Virology is back - our first ever phage session. Do join us...
May 8, 2025 at 6:29 PM
Three to one, tales! (✓)
Reposted by Lingchen He 何灵尘
Interested in fighting AMR? Come and join us at St Andrews. applications are open until 15th May to students worldwide!
🚨 PhD opportunity in my lab with @mfwhite2.bsky.social!
Use bacterial viruses (phages) to take on antibiotic-resistant superbugs 🦠🧫
Join us at St Andrews to explore virus–bacteria battles.
🔬 Apply now: www.findaphd.com/phds/project...
#PhD #Microbiology #PhageTherapy #AntibioticResistance
Use bacterial viruses (phages) to take on antibiotic-resistant superbugs 🦠🧫
Join us at St Andrews to explore virus–bacteria battles.
🔬 Apply now: www.findaphd.com/phds/project...
#PhD #Microbiology #PhageTherapy #AntibioticResistance
Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections at University of St Andrews on FindAPhD.com
PhD Project - Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections at University of St Andrews, listed on FindAPhD.com
www.findaphd.com
May 1, 2025 at 4:25 PM
Interested in fighting AMR? Come and join us at St Andrews. applications are open until 15th May to students worldwide!
Reposted by Lingchen He 何灵尘
"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors”
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons
Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.
www.science.org
May 1, 2025 at 10:04 PM
"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors”
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Lingchen He 何灵尘
Unique investigation of some errors in long read assemblers.
In particular these remarkably chimeric contigs are 😱, if rare....
Improving long read assemblers is definitely the space to be in when it comes to the future of metagenomics, as short reads won't be part of it 😉
In particular these remarkably chimeric contigs are 😱, if rare....
Improving long read assemblers is definitely the space to be in when it comes to the future of metagenomics, as short reads won't be part of it 😉
April 25, 2025 at 2:46 PM
Unique investigation of some errors in long read assemblers.
In particular these remarkably chimeric contigs are 😱, if rare....
Improving long read assemblers is definitely the space to be in when it comes to the future of metagenomics, as short reads won't be part of it 😉
In particular these remarkably chimeric contigs are 😱, if rare....
Improving long read assemblers is definitely the space to be in when it comes to the future of metagenomics, as short reads won't be part of it 😉
Reposted by Lingchen He 何灵尘
New paper @isme-microbes.bsky.social : Among a sample of 1044 vibrio phages, we found 17 new Schizotequatrovirus with large genomes (>250kb), a broad host range, and yet a low frequency in our samples (?!). #MicroSky #PhageSky
April 14, 2025 at 8:36 AM
New paper @isme-microbes.bsky.social : Among a sample of 1044 vibrio phages, we found 17 new Schizotequatrovirus with large genomes (>250kb), a broad host range, and yet a low frequency in our samples (?!). #MicroSky #PhageSky
Reposted by Lingchen He 何灵尘
The BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX
April 8, 2025 at 4:55 PM
The BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX
Congratulations Alex and the team!! Nice one!
And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣
April 8, 2025 at 8:53 AM
Congratulations Alex and the team!! Nice one!
Reposted by Lingchen He 何灵尘
We welcome on BlueSky Alfred Fillol Salom @alfredfisa.bsky.social, the leader of the The Ecology of Mobile Genetic Elements group at our research institute #microsky 🧫🦠🧪 #phages #virology #viruses
March 22, 2025 at 6:49 PM
We welcome on BlueSky Alfred Fillol Salom @alfredfisa.bsky.social, the leader of the The Ecology of Mobile Genetic Elements group at our research institute #microsky 🧫🦠🧪 #phages #virology #viruses
Why the ground is always breaking?
March 13, 2025 at 10:26 PM
Why the ground is always breaking?
Reposted by Lingchen He 何灵尘
We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
March 11, 2025 at 11:50 PM
We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable