Lingchen He 何灵尘
@lingchenhe.bsky.social
Someone‖‖Postdoc‖MGEs‖HGT‖Phage person but sometimes anti-phage
Thank you Joao!
September 10, 2025 at 1:19 PM
Thank you Joao!
😉Thank you Aisling!
September 10, 2025 at 7:57 AM
😉Thank you Aisling!
😊Thank you Nuria!
September 10, 2025 at 7:54 AM
😊Thank you Nuria!
A big thank you for everyone involved Jinlong,
@alfredfisa.bsky.social, Laura and Christopher. For more details, plz read www.cell.com/cell/fulltex...
@alfredfisa.bsky.social, Laura and Christopher. For more details, plz read www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails
from unrelated species to transfer their DNA across bacterial hosts. This tail piracy
enables broad dissemination and ...
www.cell.com
September 9, 2025 at 9:10 PM
A big thank you for everyone involved Jinlong,
@alfredfisa.bsky.social, Laura and Christopher. For more details, plz read www.cell.com/cell/fulltex...
@alfredfisa.bsky.social, Laura and Christopher. For more details, plz read www.cell.com/cell/fulltex...
Finally, we demonstrated evolutionary homology between cf-PICI and phage HK97 capsids, while showing that cf-PICIs avoid interference during capsid assembly through finely tuned interactions, thereby ensuring efficient and specific packaging of their own DNA. @jonaszpatkowski.bsky.social
September 9, 2025 at 9:10 PM
Finally, we demonstrated evolutionary homology between cf-PICI and phage HK97 capsids, while showing that cf-PICIs avoid interference during capsid assembly through finely tuned interactions, thereby ensuring efficient and specific packaging of their own DNA. @jonaszpatkowski.bsky.social
In addition, we identified adaptor and connector genes as central to capsid–tail chimeric assembly, with high variability during the evolution of tail-less capsids.
September 9, 2025 at 9:10 PM
In addition, we identified adaptor and connector genes as central to capsid–tail chimeric assembly, with high variability during the evolution of tail-less capsids.
This uncovers unexpected complexity in phage–satellite interactions, challenging the long-held view that satellites rely on a single helper phage to complete their lifecycle.
September 9, 2025 at 9:10 PM
This uncovers unexpected complexity in phage–satellite interactions, challenging the long-held view that satellites rely on a single helper phage to complete their lifecycle.
We revealed a key feature of tail piracy: cf-PICIs can exploit multiple helper phages—one inducing their cycle, another supplying tails. Remarkably, cf-PICIs can even accumulate tail-less particles without helper phage induction, and factors causing cell lysis can release them.
September 9, 2025 at 9:10 PM
We revealed a key feature of tail piracy: cf-PICIs can exploit multiple helper phages—one inducing their cycle, another supplying tails. Remarkably, cf-PICIs can even accumulate tail-less particles without helper phage induction, and factors causing cell lysis can release them.