Jose A Escudero
@jaescudero.bsky.social
Scientist interested in #integrons, antimicrobial resistance and the molecular basis of adaptation. Working at at Univ. Complutense (http://ucm.es/mbalab).
Reposted by Jose A Escudero
New preprint out! 📣🚨
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection https://www.biorxiv.org/content/10.1101/2025.10.24.684370v1
October 25, 2025 at 12:29 PM
New preprint out! 📣🚨
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
Reposted by Jose A Escudero
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
www.science.org
September 6, 2025 at 9:35 AM
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Reposted by Jose A Escudero
Excited to share my latest review, now published in the Royal Society theme issue on ‘The ecology and evolution of bacterial immune systems' (available OA):
Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae royalsocietypublishing.org/doi/10.1098/...
Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae royalsocietypublishing.org/doi/10.1098/...
Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae | Philosophical Transactions of the Royal Society B: Biological Sciences
Vibrio cholerae, the causative agent of cholera, has triggered seven pandemics, with the seventh pandemic emerging in 1961. The success of seventh pandemic El Tor (7PET) V. cholerae as a human pathogen is linked to its acquisition of mobile genetic ...
royalsocietypublishing.org
September 6, 2025 at 1:02 PM
Excited to share my latest review, now published in the Royal Society theme issue on ‘The ecology and evolution of bacterial immune systems' (available OA):
Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae royalsocietypublishing.org/doi/10.1098/...
Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae royalsocietypublishing.org/doi/10.1098/...
Reposted by Jose A Escudero
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.
https://f.mtr.cool/rnstpoiucs
https://f.mtr.cool/rnstpoiucs
August 26, 2025 at 7:01 AM
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.
https://f.mtr.cool/rnstpoiucs
https://f.mtr.cool/rnstpoiucs
Reposted by Jose A Escudero
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.
https://f.mtr.cool/czgfpzevqu
https://f.mtr.cool/czgfpzevqu
August 18, 2025 at 7:01 AM
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.
https://f.mtr.cool/czgfpzevqu
https://f.mtr.cool/czgfpzevqu
Reposted by Jose A Escudero
Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects? 🦠 =>processes evolutionarily tuned to be sensitive to translation speed eg: motility, iron homeostasis, leader peptide attenuation (ex: trp). #rnasky #microsky www.sciencedirect.com/science/arti...
Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects?
By integrating a literature review with transcriptomic, proteomic, and phenotypic data from two model bacteria, Escherichia coli and Vibrio cholerae, …
www.sciencedirect.com
August 5, 2025 at 8:35 PM
Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects? 🦠 =>processes evolutionarily tuned to be sensitive to translation speed eg: motility, iron homeostasis, leader peptide attenuation (ex: trp). #rnasky #microsky www.sciencedirect.com/science/arti...
Reposted by Jose A Escudero
Oxygen levels can affect how resistance genes work, impacting antibiotic efficacy. This can be relevant for the most used ones: for example, resistance to fosfomycin varies with oxygen.
Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social
#AntibioticResistance
Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social
#AntibioticResistance
August 4, 2025 at 8:52 AM
Oxygen levels can affect how resistance genes work, impacting antibiotic efficacy. This can be relevant for the most used ones: for example, resistance to fosfomycin varies with oxygen.
Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social
#AntibioticResistance
Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social
#AntibioticResistance
Reposted by Jose A Escudero
A 2 yr postdoc position at the Bacterial
Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
July 24, 2025 at 4:58 PM
A 2 yr postdoc position at the Bacterial
Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
Reposted by Jose A Escudero
🚨🚨 New paper in @narjournal.bsky.social! 🍾
Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons).
We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín.
👇
Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons).
We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín.
👇
ExcludonFinder: mapping transcriptional overlaps between neighboring genes
Abstract. Bacteria regulate neighboring genes via overlapping transcription in untranslated regions (UTRs), forming excludons. This overlap leads to transc
academic.oup.com
July 25, 2025 at 9:26 PM
🚨🚨 New paper in @narjournal.bsky.social! 🍾
Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons).
We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín.
👇
Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons).
We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín.
👇
Reposted by Jose A Escudero
When the MSc student of Enea @phagemuffin.bsky.social is working in a brewery... 🍺🧬
July 22, 2025 at 8:55 AM
When the MSc student of Enea @phagemuffin.bsky.social is working in a brewery... 🍺🧬
Reposted by Jose A Escudero
A gym that you go to but instead of working out you write papers
July 22, 2025 at 8:20 AM
A gym that you go to but instead of working out you write papers
Reposted by Jose A Escudero
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
July 22, 2025 at 3:05 PM
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
Reposted by Jose A Escudero
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
Garud Lab
garud.eeb.ucla.edu
July 22, 2025 at 5:51 PM
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
Reposted by Jose A Escudero
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
See thread for more information and reach out!
July 22, 2025 at 7:34 PM
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
See thread for more information and reach out!
Reposted by Jose A Escudero
A #short about mirror bacteria in French with subtitles, except for me, by @leblob.bsky.social
youtube.com/shorts/i0N55...
youtube.com/shorts/i0N55...
Bactérie miroir : pourquoi elle inquiète autant ? #short #science
YouTube video by Le Blob
youtube.com
July 20, 2025 at 1:52 AM
A #short about mirror bacteria in French with subtitles, except for me, by @leblob.bsky.social
youtube.com/shorts/i0N55...
youtube.com/shorts/i0N55...
Reposted by Jose A Escudero
This Craig Maclean guy looks like he’s going places, one to keep an eye on! 👀
July 18, 2025 at 1:30 PM
This Craig Maclean guy looks like he’s going places, one to keep an eye on! 👀
Reposted by Jose A Escudero
New paper with @rwheatley8.bsky.social and Cedric Lood
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Chromosomal capture of beneficial genes drives plasmids toward ecological redundancy
Abstract. Plasmids are a ubiquitous feature of bacterial genomes, but the forces driving genes and phenotypes to become associated with plasmids are poorly
academic.oup.com
July 16, 2025 at 9:17 AM
New paper with @rwheatley8.bsky.social and Cedric Lood
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Reposted by Jose A Escudero
Super proud of the lab for their outstanding presentations at #FEMS2025 in Milano!
Science is better when you work with such a stellar team!🚀✨
@femsmicro.org
Science is better when you work with such a stellar team!🚀✨
@femsmicro.org
July 17, 2025 at 8:21 PM
Super proud of the lab for their outstanding presentations at #FEMS2025 in Milano!
Science is better when you work with such a stellar team!🚀✨
@femsmicro.org
Science is better when you work with such a stellar team!🚀✨
@femsmicro.org
Reposted by Jose A Escudero
Proud of the talk of Iván Linares at the #FEMS2025 on hospital-associated microbiomes and its role on pathogens persistance 🦠 @femsmicro.org
July 17, 2025 at 3:56 PM
Proud of the talk of Iván Linares at the #FEMS2025 on hospital-associated microbiomes and its role on pathogens persistance 🦠 @femsmicro.org
Reposted by Jose A Escudero
Great session! A pity it was only 2'5h and not the full day 😅. Computing with oscillations encoding information in frequency, distributed computing with high information capacity wires, neuromorphic computing at the verge of learning, stochastic and probabilistic computing, heterotic computing...
Four leading researchers on bacterial computing in the @femsmicro.org Workshop on the the topic during the Congress—quite amazing talks by @angelgm.bsky.social, Yolanda Schaerli, Manish Kushwaha & Samgram Bagh. Do bacteria compute? Can we make them to compute wth our logic or do they have their own?
July 15, 2025 at 5:35 PM
Great session! A pity it was only 2'5h and not the full day 😅. Computing with oscillations encoding information in frequency, distributed computing with high information capacity wires, neuromorphic computing at the verge of learning, stochastic and probabilistic computing, heterotic computing...
Reposted by Jose A Escudero
Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
July 8, 2025 at 10:06 AM
Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
Reposted by Jose A Escudero
Super proud of amazing lab alumnus @mbottery.bsky.social who has been awarded a prestigious @wellcometrust.bsky.social fellowship to grow his lab @officialuom.bsky.social studying the evolution of fungal pathogens!
Mike has multiple postdoc positions available on his exciting project (details 👇)
Mike has multiple postdoc positions available on his exciting project (details 👇)
Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
July 15, 2025 at 8:04 AM
Super proud of amazing lab alumnus @mbottery.bsky.social who has been awarded a prestigious @wellcometrust.bsky.social fellowship to grow his lab @officialuom.bsky.social studying the evolution of fungal pathogens!
Mike has multiple postdoc positions available on his exciting project (details 👇)
Mike has multiple postdoc positions available on his exciting project (details 👇)
My summer read. Well, actually not sure it will make it to August untouched…
July 14, 2025 at 8:39 PM
My summer read. Well, actually not sure it will make it to August untouched…
Reposted by Jose A Escudero
Webinar on Mirror Biology: Global risks, national security concerns, and practical actions
Jul 17, 2025 12:00 PM ET
Hosted by Brown Pandemic Center
Register here:
brown.zoom.us/webinar/regi...
Jul 17, 2025 12:00 PM ET
Hosted by Brown Pandemic Center
Register here:
brown.zoom.us/webinar/regi...
July 13, 2025 at 2:33 AM
Webinar on Mirror Biology: Global risks, national security concerns, and practical actions
Jul 17, 2025 12:00 PM ET
Hosted by Brown Pandemic Center
Register here:
brown.zoom.us/webinar/regi...
Jul 17, 2025 12:00 PM ET
Hosted by Brown Pandemic Center
Register here:
brown.zoom.us/webinar/regi...