Paul Hoskisson 🧫 🦠🐸
@paulhoskisson.bsky.social
Professor of Molecular Microbiology, Fellow of the Royal Society of Edinburgh, Editor at Microbial Genomics & mBio, Scouse, interested in Streptomyces, Evolution, Antibiotics, AMR, microbiology, Phage, herpetology, Cricket, EvertonFC
Reposted by Paul Hoskisson 🧫 🦠🐸
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Really great episode of @convergingdialogues.skystack.xyz podcast with @matthewcobb.bsky.social on his new biography Crick - wonderfully engaging as always and a great conversation with @xavierbonilla.bsky.social - well worth a listen! podcasts.apple.com/gb/podcast/c...
#459 - Crick: A Dialogue with Matthew Cobb
Podcast Episode · Converging Dialogues · 22/12/2025 · 1h 15m
podcasts.apple.com
December 22, 2025 at 6:20 PM
Really great episode of @convergingdialogues.skystack.xyz podcast with @matthewcobb.bsky.social on his new biography Crick - wonderfully engaging as always and a great conversation with @xavierbonilla.bsky.social - well worth a listen! podcasts.apple.com/gb/podcast/c...
Reposted by Paul Hoskisson 🧫 🦠🐸
Yes: deleterious recessives aren’t completely recessive! An important study confirming intuitions from at least some of us.
Our latest preprint revisits the classic model of mutation-selection balance.
Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io
www.biorxiv.org/content/10.6...
Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io
www.biorxiv.org/content/10.6...
Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes
The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ...
www.biorxiv.org
December 13, 2025 at 5:14 PM
Yes: deleterious recessives aren’t completely recessive! An important study confirming intuitions from at least some of us.
Reposted by Paul Hoskisson 🧫 🦠🐸
Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
Danna Gifford
School of Biological Sciences | Faculty of Biology Medicine and Health | University of Manchester
dannagifford.com
November 28, 2025 at 11:45 AM
Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
@frimanscience.bsky.social great to see you man, hope to hang out soon!
November 27, 2025 at 9:54 PM
@frimanscience.bsky.social great to see you man, hope to hang out soon!
@seanmeaden.bsky.social good to see you Sean!
November 27, 2025 at 6:21 PM
@seanmeaden.bsky.social good to see you Sean!
Super meeting, and @microbiologysociety.org staff organisation was incredible as always! This meeting really fills a niche in evolutionary microbiology, let make sure it runs again! Great to see old friends and make new ones @gmknght.bsky.social
Absolutely brilliant #MicroEvo25 some great talks and talent that has me thinking about our research. And great to catch up with @brockhurstlab.bsky.social @craigmaclean.bsky.social @paulhoskisson.bsky.social
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more
November 27, 2025 at 6:19 PM
Super meeting, and @microbiologysociety.org staff organisation was incredible as always! This meeting really fills a niche in evolutionary microbiology, let make sure it runs again! Great to see old friends and make new ones @gmknght.bsky.social
Reposted by Paul Hoskisson 🧫 🦠🐸
Absolutely brilliant #MicroEvo25 some great talks and talent that has me thinking about our research. And great to catch up with @brockhurstlab.bsky.social @craigmaclean.bsky.social @paulhoskisson.bsky.social
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more
November 27, 2025 at 4:49 PM
Absolutely brilliant #MicroEvo25 some great talks and talent that has me thinking about our research. And great to catch up with @brockhurstlab.bsky.social @craigmaclean.bsky.social @paulhoskisson.bsky.social
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more
Just arrived - very excited to read @matthewcobb.bsky.social ‘s latest
November 17, 2025 at 12:48 PM
Just arrived - very excited to read @matthewcobb.bsky.social ‘s latest
Incredible paper - Genomic architecture of eggmimicry and its consequencesfor speciation in parasitic cuckoos www.science.org/doi/epdf/10.... and a great commentary here www.science.org/doi/epdf/10.... @btobirds.bsky.social
Genomic architecture of egg mimicry and its consequences for speciation in parasitic cuckoos
Host-parasite arms races facilitate rapid evolution and can fuel speciation. Cuculus cuckoos are deceptive egg mimics that exhibit a broad diversity of counterfeit egg phenotypes, representing host-ad...
www.science.org
October 31, 2025 at 9:31 AM
Incredible paper - Genomic architecture of eggmimicry and its consequencesfor speciation in parasitic cuckoos www.science.org/doi/epdf/10.... and a great commentary here www.science.org/doi/epdf/10.... @btobirds.bsky.social
Reposted by Paul Hoskisson 🧫 🦠🐸
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
www.gla.ac.uk
September 30, 2025 at 11:02 AM
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
@papersapp.com hi guys, is this a bug, I’ve noticed in the last couple of weeks on chrome - when clicking ‘save PDF to Papers by ReadCube’ - the dialogue box is blank? Is there a way to fix? It’s running v4.37.2395
October 9, 2025 at 2:01 PM
@papersapp.com hi guys, is this a bug, I’ve noticed in the last couple of weeks on chrome - when clicking ‘save PDF to Papers by ReadCube’ - the dialogue box is blank? Is there a way to fix? It’s running v4.37.2395
Reposted by Paul Hoskisson 🧫 🦠🐸
Two new positions are available at the MPI for Evolutionary Biology to support development of our genomics facility. Both stand to become permanent. Both offer a ton of opportunity to engage in a wide range of creative science.
Pls repost 🙏
www.evolbio.mpg.de/3838377/job_...
Pls repost 🙏
www.evolbio.mpg.de/3838377/job_...
Two full-time positions | Bioinformatician (m/f/d) + Applications Specialist (m/f/d) - Molecular Biology
The Genome Facility at the Max Planck Institute for Evolutionary Biology in Plön is seeking to fill two positions (full time) to support and expand our core facility services.
www.evolbio.mpg.de
October 6, 2025 at 11:17 AM
Two new positions are available at the MPI for Evolutionary Biology to support development of our genomics facility. Both stand to become permanent. Both offer a ton of opportunity to engage in a wide range of creative science.
Pls repost 🙏
www.evolbio.mpg.de/3838377/job_...
Pls repost 🙏
www.evolbio.mpg.de/3838377/job_...
‘Thrilled’ Indonesian scientists celebrate return of fossil trove from the Netherlands - well done @naturalis.bsky.social www.science.org/content/arti...
‘Thrilled’ Indonesian scientists celebrate return of fossil trove from the Netherlands
The items to be returned, which include Java Man, were collected during the colonial era
www.science.org
October 3, 2025 at 8:50 AM
‘Thrilled’ Indonesian scientists celebrate return of fossil trove from the Netherlands - well done @naturalis.bsky.social www.science.org/content/arti...
Reposted by Paul Hoskisson 🧫 🦠🐸
Our new preprint by @nanamikubota.bsky.social shows that P. aeruginosa, and likely many other bacteria carrying filamentous prophages (like V. parahaemolyticus), risk being exploited by these phages in a runaway process that reduces fitness of both host and virus. www.biorxiv.org/content/10.1... 🧵
Filamentous cheater phages drive bacterial and phage populations to lower fitness
Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...
www.biorxiv.org
April 3, 2025 at 5:06 PM
Our new preprint by @nanamikubota.bsky.social shows that P. aeruginosa, and likely many other bacteria carrying filamentous prophages (like V. parahaemolyticus), risk being exploited by these phages in a runaway process that reduces fitness of both host and virus. www.biorxiv.org/content/10.1... 🧵
Reposted by Paul Hoskisson 🧫 🦠🐸
Apply for a #PhD with @paulhoskisson.bsky.social and me on all things #Streptomyces, #evolution, #AMR, #antibiotics, #biotech!
Deadline 21st November. #MicroSky please share!
Deadline 21st November. #MicroSky please share!
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
www.gla.ac.uk
October 2, 2025 at 3:23 PM
Apply for a #PhD with @paulhoskisson.bsky.social and me on all things #Streptomyces, #evolution, #AMR, #antibiotics, #biotech!
Deadline 21st November. #MicroSky please share!
Deadline 21st November. #MicroSky please share!
Today was the first day of life after my @raeng.org.uk Research Chair - the award was transformative to me and our team and I’ll be forever grateful to the Academy for supporting our science and vision of how it was time for synthetic biology and engineering biology to deliver for industry
October 1, 2025 at 9:07 PM
Today was the first day of life after my @raeng.org.uk Research Chair - the award was transformative to me and our team and I’ll be forever grateful to the Academy for supporting our science and vision of how it was time for synthetic biology and engineering biology to deliver for industry
Reposted by Paul Hoskisson 🧫 🦠🐸
I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky
Please share the ad below with anyone who may be interested.
Please share the ad below with anyone who may be interested.
September 16, 2025 at 8:08 AM
I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky
Please share the ad below with anyone who may be interested.
Please share the ad below with anyone who may be interested.
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
www.gla.ac.uk
September 30, 2025 at 11:02 AM
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces
www.gla.ac.uk/postgraduate...
please repost
This is super cool from @brianhie.bsky.social et al-
Generative design of novel bacteriophages with genome language models www.biorxiv.org/content/10.1...
Generative design of novel bacteriophages with genome language models www.biorxiv.org/content/10.1...
Generative design of novel bacteriophages with genome language models
Many important biological functions arise not from single genes, but from complex interactions encoded by entire genomes. Genome language models have emerged as a promising strategy for designing biol...
www.biorxiv.org
September 17, 2025 at 6:16 PM
This is super cool from @brianhie.bsky.social et al-
Generative design of novel bacteriophages with genome language models www.biorxiv.org/content/10.1...
Generative design of novel bacteriophages with genome language models www.biorxiv.org/content/10.1...
Reposted by Paul Hoskisson 🧫 🦠🐸
Some good stuff in here 😊
A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1
September 6, 2025 at 8:13 PM
Some good stuff in here 😊
Delighted to have been selected as a Sub-panel member (Assessment phase) for Sub-panel 5: Biological sciences for REF2029 #REF2029
The names of panel members for the criteria-setting phase of REF 2029 have now been announced on our panels pages. 2029.ref.ac.uk/news/expert-...
Expert panels appointed for REF 2029 – REF 2029
2029.ref.ac.uk
September 4, 2025 at 12:43 PM
Delighted to have been selected as a Sub-panel member (Assessment phase) for Sub-panel 5: Biological sciences for REF2029 #REF2029
Reposted by Paul Hoskisson 🧫 🦠🐸
The names of panel members for the criteria-setting phase of REF 2029 have now been announced on our panels pages. 2029.ref.ac.uk/news/expert-...
Expert panels appointed for REF 2029 – REF 2029
2029.ref.ac.uk
September 4, 2025 at 12:12 PM
The names of panel members for the criteria-setting phase of REF 2029 have now been announced on our panels pages. 2029.ref.ac.uk/news/expert-...
Reposted by Paul Hoskisson 🧫 🦠🐸
The four UK higher education funding bodies confirm the pause in the criteria setting and publication of final guidance for REF 2029 for a short period, as announced by the UK Science Minister Lord Vallance today at the Universities UK conference. 2029.ref.ac.uk/news/pause-t...
Pause to REF 2029 criteria setting and publication of final guidance – REF 2029
2029.ref.ac.uk
September 4, 2025 at 9:33 AM
The four UK higher education funding bodies confirm the pause in the criteria setting and publication of final guidance for REF 2029 for a short period, as announced by the UK Science Minister Lord Vallance today at the Universities UK conference. 2029.ref.ac.uk/news/pause-t...