Lindsay K Pino
@lindsaykpino.com
#massspectrometry, #proteomics, and #bioinformatics | hiking and dogs | co-founder & CTO @talusbio | opinions my own
Pinned
Lindsay K Pino
@lindsaykpino.com
· Sep 27
Hello! 👋 Most of you are friends from Twitter/X already, but for those new connections, a brief intro:
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
Reposted by Lindsay K Pino
🚨🚨 HIRING ALERT: DATA SCIENCE INTERN (ML / METABOLOMICS) – INDIA (REMOTE) 🚨🚨
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
November 21, 2025 at 7:39 AM
🚨🚨 HIRING ALERT: DATA SCIENCE INTERN (ML / METABOLOMICS) – INDIA (REMOTE) 🚨🚨
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
Reposted by Lindsay K Pino
Watching Lauren Celano talk about the state of jobs in industry. The state of industry is in flux which is due to issues with funding. Funders prefer to support 1 company with a large amount of capital versus 10 companies with less each. ##ABRCMS2025
November 21, 2025 at 3:38 PM
Watching Lauren Celano talk about the state of jobs in industry. The state of industry is in flux which is due to issues with funding. Funders prefer to support 1 company with a large amount of capital versus 10 companies with less each. ##ABRCMS2025
Reposted by Lindsay K Pino
Note that the one repost on X came from me, as well as one of those likes
Taking it at face value, this example suggests that Bluesky is >100x enriched over X for users interested in this topic, which covers the intersection of life science/drug development/bioinformatics/AI
#Bsky #Twitter #Xitter
Taking it at face value, this example suggests that Bluesky is >100x enriched over X for users interested in this topic, which covers the intersection of life science/drug development/bioinformatics/AI
#Bsky #Twitter #Xitter
November 22, 2025 at 6:44 AM
Nice! @nmriley.bsky.social
Know an inspiring early-career chemist? Nominate an early-career chemist for the 2026 Talented 12 at cen.acs.org/sections/tal...
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
November 21, 2025 at 4:31 AM
Nice! @nmriley.bsky.social
Reposted by Lindsay K Pino
Quick heads up - there will soon be a job posting for a Staff Scientist / Senior Staff Scientist in our lab in Copenhagen to support all our mass spec proteomics adventures!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
November 20, 2025 at 5:09 PM
Quick heads up - there will soon be a job posting for a Staff Scientist / Senior Staff Scientist in our lab in Copenhagen to support all our mass spec proteomics adventures!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
Reposted by Lindsay K Pino
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
Reposted by Lindsay K Pino
We show that the total #RNA isolated from cell cultures can contain substantial non-RNA glycoconjugates, which was found out to be #glycoproteins (characterized in Kegel et al paper), and those glycoconjugates persist even after protease treatment and rounds of purification.
November 15, 2025 at 3:38 PM
We show that the total #RNA isolated from cell cultures can contain substantial non-RNA glycoconjugates, which was found out to be #glycoproteins (characterized in Kegel et al paper), and those glycoconjugates persist even after protease treatment and rounds of purification.
Reposted by Lindsay K Pino
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Reposted by Lindsay K Pino
Okay, #TeamMassSpec, I have a challenge for you: I want to vary the senstivity of my Orbitrap full scan analysis. Part of my chromatogram has very little signal and part has too much. If I set AGC to 1e6 and max IT to 120 ms I get too much signal and have to reduce my injection volume.
November 13, 2025 at 3:41 AM
Okay, #TeamMassSpec, I have a challenge for you: I want to vary the senstivity of my Orbitrap full scan analysis. Part of my chromatogram has very little signal and part has too much. If I set AGC to 1e6 and max IT to 120 ms I get too much signal and have to reduce my injection volume.
Reposted by Lindsay K Pino
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
November 11, 2025 at 6:55 PM
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Reposted by Lindsay K Pino
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
"I have lost count of the number of times over the years that I’ve said “Huh, I didn’t think mass spec could do that”."
Mass spec ID after screening hundreds of thousands of mixed library compounds - without any sort of tagging or labeling? Yikes:
Screening Without Tagging
www.science.org
November 10, 2025 at 10:52 PM
"I have lost count of the number of times over the years that I’ve said “Huh, I didn’t think mass spec could do that”."
Reposted by Lindsay K Pino
May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu
November 10, 2025 at 4:39 PM
May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu
Reposted by Lindsay K Pino
I've just come across a resource for finding MS prices beyond the US (GSA Advantage).
It's called EU Tenders (ted.europa.eu) and has many recent MS prices on there.
E.g. Astral Zoom with FAIMS Pro Duo is listed as $1.75 million Euro ($2 million USD)
Limited info but probably includes an unlisted LC
It's called EU Tenders (ted.europa.eu) and has many recent MS prices on there.
E.g. Astral Zoom with FAIMS Pro Duo is listed as $1.75 million Euro ($2 million USD)
Limited info but probably includes an unlisted LC
TED - EU Tenders, the Supplement to the Official Journal - TED - Liferay DXP
Homepage of the official portal of TED, Tenders Electronic Daily. TED contains all active notices published in the Supplement to the EU Official Journal.
ted.europa.eu
November 10, 2025 at 1:05 AM
I've just come across a resource for finding MS prices beyond the US (GSA Advantage).
It's called EU Tenders (ted.europa.eu) and has many recent MS prices on there.
E.g. Astral Zoom with FAIMS Pro Duo is listed as $1.75 million Euro ($2 million USD)
Limited info but probably includes an unlisted LC
It's called EU Tenders (ted.europa.eu) and has many recent MS prices on there.
E.g. Astral Zoom with FAIMS Pro Duo is listed as $1.75 million Euro ($2 million USD)
Limited info but probably includes an unlisted LC
Upcoming talks at Human Proteome Organization! Come check out what Talus Bio has been working on over the last year, from mapping the regulome to manipulating it and modeling it, all using mass spectrometry proteomics as a driving force.
November 10, 2025 at 6:25 AM
Upcoming talks at Human Proteome Organization! Come check out what Talus Bio has been working on over the last year, from mapping the regulome to manipulating it and modeling it, all using mass spectrometry proteomics as a driving force.
Reposted by Lindsay K Pino
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
November 9, 2025 at 10:34 PM
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My personal experience, and anecdotes from friends, agreed with these observations.
For the last 3 years, the story of the biotech financing environment has been much the same. Venture funding is slow, IPOs are few and far between. Mergers and acquisitions are beginning to pick up, but they tend to be smaller transactions: cen.acs.org/business/fin... #chemsky 🧪
Biotech markets aren't picking up just yet
Despite some recent eye-catching deals, the financing environment is still sluggish
cen.acs.org
November 7, 2025 at 10:05 PM
My personal experience, and anecdotes from friends, agreed with these observations.
Finally, the R package we needed, but don't deserve. I can already hear @benneely.com cackling from across the country.
Thanks to @willfondrie.com for alerting me to this amazing repo.
Thanks to @willfondrie.com for alerting me to this amazing repo.
Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....
genzplyr is dplyr, but bussin fr fr no cap.
genzplyr is dplyr, but bussin fr fr no cap.
GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap
dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.
github.com
November 7, 2025 at 6:38 PM
Finally, the R package we needed, but don't deserve. I can already hear @benneely.com cackling from across the country.
Thanks to @willfondrie.com for alerting me to this amazing repo.
Thanks to @willfondrie.com for alerting me to this amazing repo.
Preparing for my flight, 20 items on the to-do list but nine books loaded up on my Kindle. Hmm...
November 7, 2025 at 2:36 PM
Preparing for my flight, 20 items on the to-do list but nine books loaded up on my Kindle. Hmm...
Reposted by Lindsay K Pino
🎓 Upcoming Online Course: R/Bioconductor for Mass Spectrometry & Proteomics
📅 November 17–19, 2025
Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.
👉 Register & learn more: www.physalia-courses.org/courses-work...
📅 November 17–19, 2025
Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.
👉 Register & learn more: www.physalia-courses.org/courses-work...
R/Bioconductor for Mass Spectrometry and Proteomics
Dates 17-19 November 2025 To foster international participation, this course will be held online
www.physalia-courses.org
November 6, 2025 at 10:00 AM
🎓 Upcoming Online Course: R/Bioconductor for Mass Spectrometry & Proteomics
📅 November 17–19, 2025
Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.
👉 Register & learn more: www.physalia-courses.org/courses-work...
📅 November 17–19, 2025
Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.
👉 Register & learn more: www.physalia-courses.org/courses-work...
Reposted by Lindsay K Pino
Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Carafe enables high quality in silico spectral library generation for data-independent acquisition proteomics - Nature Communications
Accurate spectral libraries are essential for analyzing data-independent acquisition (DIA) proteomics data. Here, the authors present Carafe, which trains on DIA data to build experiment-specific spec...
www.nature.com
November 6, 2025 at 3:49 PM
Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
It is going to SNOW at HUPO?! I have zero professional clothes for snow.
November 7, 2025 at 2:40 AM
It is going to SNOW at HUPO?! I have zero professional clothes for snow.
Reposted by Lindsay K Pino
I try the newest version of DIA-NN, version 2.3 and its new Infini search approach on some Lumos and tismTOF HT datasets. If you're new to DIA-NN this might be a good video to watch. youtu.be/MIMnDw0loCk
We try the new DIA-NN 2.3 (November 2025)
YouTube video by Brett Phinney
youtu.be
November 3, 2025 at 8:01 PM
I try the newest version of DIA-NN, version 2.3 and its new Infini search approach on some Lumos and tismTOF HT datasets. If you're new to DIA-NN this might be a good video to watch. youtu.be/MIMnDw0loCk
Reposted by Lindsay K Pino
Get Connected at the HUPO World Congress through WhatsApp!
Join the HUPO 2025 WhatsApp group here: https://chat.whatsapp.com/CMu3ooxDsqhKCAX05WGLeI?mode=wwt
#HUPO2025 #Proteomics #ScienceNetworking #USHUPO #HUPO
Join the HUPO 2025 WhatsApp group here: https://chat.whatsapp.com/CMu3ooxDsqhKCAX05WGLeI?mode=wwt
#HUPO2025 #Proteomics #ScienceNetworking #USHUPO #HUPO
November 3, 2025 at 5:47 PM
Get Connected at the HUPO World Congress through WhatsApp!
Join the HUPO 2025 WhatsApp group here: https://chat.whatsapp.com/CMu3ooxDsqhKCAX05WGLeI?mode=wwt
#HUPO2025 #Proteomics #ScienceNetworking #USHUPO #HUPO
Join the HUPO 2025 WhatsApp group here: https://chat.whatsapp.com/CMu3ooxDsqhKCAX05WGLeI?mode=wwt
#HUPO2025 #Proteomics #ScienceNetworking #USHUPO #HUPO