Lindsay K Pino
@lindsaykpino.com
#massspectrometry, #proteomics, and #bioinformatics | hiking and coffee | co-founder & CTO @talusbio | opinions my own
Pinned
Lindsay K Pino
@lindsaykpino.com
· Sep 27
Hello! 👋 Most of you are friends from Twitter/X already, but for those new connections, a brief intro:
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
Reposted by Lindsay K Pino
Lorne Proteins 2026 🏖️ features Princeton University protein cognoscenti Michael Hecht, designing an artificial proteome with new folds and functions; and Jerelle Joseph, on tractable MD simulations of multiprotein condensates & synthetic condensate engineering.
🔗 Register now www.lorneproteins.org
🔗 Register now www.lorneproteins.org
January 6, 2026 at 11:51 PM
Lorne Proteins 2026 🏖️ features Princeton University protein cognoscenti Michael Hecht, designing an artificial proteome with new folds and functions; and Jerelle Joseph, on tractable MD simulations of multiprotein condensates & synthetic condensate engineering.
🔗 Register now www.lorneproteins.org
🔗 Register now www.lorneproteins.org
VERY well deserved. @rhuttenhain.bsky.social !! Congratulations 🎉
I'm honored to have received the 2025 HUPO Distinguished Service Award (hupo.org/HUPO-Awards-...) with @mlaval6.bsky.social for building a dynamic early career researcher (ECR) community within @hupo-org.bsky.social. Empowering and amplifying ECRs has been deeply meaningful to me—thank you, HUPO.
January 4, 2026 at 11:36 PM
VERY well deserved. @rhuttenhain.bsky.social !! Congratulations 🎉
Reposted by Lindsay K Pino
We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org
Cancer Research Laboratory | Trumanlab | UNC Charlotte | United States
The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...
www.trumanlab.org
January 3, 2026 at 10:23 PM
We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org
Reposted by Lindsay K Pino
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles
Montaño et al. generate an integrated proteomic and cysteine reactivity resource for
the NCI-60 cancer cell line panel, offering quantitative data on over 12,000 proteins
and 36,000 cysteines to enabl...
www.cell.com
January 2, 2026 at 5:10 PM
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
Reposted by Lindsay K Pino
Looking for a fresh start to 2026? Check out the US HUPO Job Board for new open positions in proteomics!
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
January 2, 2026 at 8:10 PM
Looking for a fresh start to 2026? Check out the US HUPO Job Board for new open positions in proteomics!
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
Reposted by Lindsay K Pino
Is anyone else getting through a terrible project that needs to be done, just so it won't go into next year? 😂
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
December 22, 2025 at 8:58 PM
Is anyone else getting through a terrible project that needs to be done, just so it won't go into next year? 😂
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
Reposted by Lindsay K Pino
Advice I now give to grad students and postdocs in the sciences: Don’t just try to meet and impress senior scientists. They’ll retire soon. Get to know your fellow students - make friends where possible, be colleagues at least. These are the people you’ll be sharing the field with for decades.
December 26, 2025 at 7:01 PM
Advice I now give to grad students and postdocs in the sciences: Don’t just try to meet and impress senior scientists. They’ll retire soon. Get to know your fellow students - make friends where possible, be colleagues at least. These are the people you’ll be sharing the field with for decades.
Reposted by Lindsay K Pino
Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants - EMBO Reports
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperacti...
link.springer.com
December 22, 2025 at 7:25 PM
Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Isopropanol.
Y'all. I forgot the isopropanol soak.
😭
Y'all. I forgot the isopropanol soak.
😭
Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.
Watch out, it's that time of year again. The PI is getting back into the lab.
December 24, 2025 at 5:08 PM
Isopropanol.
Y'all. I forgot the isopropanol soak.
😭
Y'all. I forgot the isopropanol soak.
😭
Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.
Watch out, it's that time of year again. The PI is getting back into the lab.
December 23, 2025 at 6:59 PM
Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.
Reposted by Lindsay K Pino
#AminoAcidAdvent Day 20: Asparagine (Asn; N)
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
December 23, 2025 at 1:53 PM
#AminoAcidAdvent Day 20: Asparagine (Asn; N)
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
Reposted by Lindsay K Pino
HUPO 2026 is currently being promoted. Sep 27 to Oct 1, 2026, in Singapore.
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
HUPO2026 Promo
YouTube video by ICS Events
m.youtube.com
December 18, 2025 at 10:45 AM
HUPO 2026 is currently being promoted. Sep 27 to Oct 1, 2026, in Singapore.
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
Reposted by Lindsay K Pino
Experience in #archaeological #proteomics?
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
T: 01642 342201
E: HRrecruitment@tees.ac.uk
tuwpapps.tees.ac.uk
December 16, 2025 at 2:39 PM
Experience in #archaeological #proteomics?
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
Reposted by Lindsay K Pino
#AminoAcidAdvent Day 14: Glutamine (Gln; Q)
Maybe one of the funnier Dayhoff naming moments ("Q-tamine"), this amide of glutamic acid will spontaneously cyclize and deamidate when on the N-terminus (not a rare event! Ig beware)... making this new post-doc convinced his SIS peptide was contaminated.
Maybe one of the funnier Dayhoff naming moments ("Q-tamine"), this amide of glutamic acid will spontaneously cyclize and deamidate when on the N-terminus (not a rare event! Ig beware)... making this new post-doc convinced his SIS peptide was contaminated.
December 17, 2025 at 1:19 PM
#AminoAcidAdvent Day 14: Glutamine (Gln; Q)
Maybe one of the funnier Dayhoff naming moments ("Q-tamine"), this amide of glutamic acid will spontaneously cyclize and deamidate when on the N-terminus (not a rare event! Ig beware)... making this new post-doc convinced his SIS peptide was contaminated.
Maybe one of the funnier Dayhoff naming moments ("Q-tamine"), this amide of glutamic acid will spontaneously cyclize and deamidate when on the N-terminus (not a rare event! Ig beware)... making this new post-doc convinced his SIS peptide was contaminated.
Reposted by Lindsay K Pino
@asms.org only 4 more days to vote. Great candidates for this election so express yourselves. I’m at pacific chem in Honolulu checking out venues! I would like your vote.
December 16, 2025 at 3:12 AM
@asms.org only 4 more days to vote. Great candidates for this election so express yourselves. I’m at pacific chem in Honolulu checking out venues! I would like your vote.
Reposted by Lindsay K Pino
Proteomic Ruler question:
In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit.
Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1?
#proteomics #massspec
In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit.
Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1?
#proteomics #massspec
December 14, 2025 at 1:41 PM
Proteomic Ruler question:
In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit.
Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1?
#proteomics #massspec
In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit.
Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1?
#proteomics #massspec
Reposted by Lindsay K Pino
#THEProteomicsShow is back and now we’re talking about #USHUPO2026. Me and Ben @proteomicsnews.bsky.social got to talk to Mike MacCoss @maccoss.bsky.social and it’s everything you’d want: quant, mentoring and car discussions. Find it wherever you find fine podcast or here anchor.fm/theproteomic...
December 12, 2025 at 1:14 PM
#THEProteomicsShow is back and now we’re talking about #USHUPO2026. Me and Ben @proteomicsnews.bsky.social got to talk to Mike MacCoss @maccoss.bsky.social and it’s everything you’d want: quant, mentoring and car discussions. Find it wherever you find fine podcast or here anchor.fm/theproteomic...
Reposted by Lindsay K Pino
After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
Programmatic design and editing of cis-regulatory elements
The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...
www.biorxiv.org
December 10, 2025 at 3:18 PM
After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
Reposted by Lindsay K Pino
Senior Research Fellow, Proteomics Facility Manager - Adelaide, Australia www.timeshighereduca...
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#proteomics #prot-jobs
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#proteomics #prot-jobs
December 11, 2025 at 10:20 AM
Senior Research Fellow, Proteomics Facility Manager - Adelaide, Australia www.timeshighereduca...
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#proteomics #prot-jobs
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#proteomics #prot-jobs
Reposted by Lindsay K Pino
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Lindsay K Pino
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
Reposted by Lindsay K Pino
#AminoAcidAdvent Day 6: Cysteine (Cys; C)
Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.
Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.
December 9, 2025 at 1:41 PM
#AminoAcidAdvent Day 6: Cysteine (Cys; C)
Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.
Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.
Reposted by Lindsay K Pino
It is the most Whimsical of the otherwise dull, bureaucratic amino acids.
December 6, 2025 at 1:50 PM
It is the most Whimsical of the otherwise dull, bureaucratic amino acids.
Top 8% of #TheProteomicsShow podcast listeners, who is ahead of me?! @benneely.com @proteomicsnews.bsky.social
December 6, 2025 at 12:34 AM
Top 8% of #TheProteomicsShow podcast listeners, who is ahead of me?! @benneely.com @proteomicsnews.bsky.social
Reposted by Lindsay K Pino
Our latest article is out in Cell !
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
December 3, 2025 at 4:41 PM
Our latest article is out in Cell !
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...