Keenan Lab
@keenanlab.bsky.social
The Keenan Lab at UChicago
keenanlab.bsd.uchicago.edu
keenanlab.bsd.uchicago.edu
Reposted by Keenan Lab
Never seen our campus like this before. Like every single tree decided to turn red at the same moment
October 30, 2025 at 11:37 PM
Never seen our campus like this before. Like every single tree decided to turn red at the same moment
Reposted by Keenan Lab
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Keenan Lab
🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
October 27, 2025 at 9:28 AM
🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Reposted by Keenan Lab
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:43 PM
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
Reposted by Keenan Lab
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 12, 2025 at 12:49 AM
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Global analysis of translocon remodeling during protein synthesis at the ER - Nature Structural & Molecular Biology
The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis ...
www.nature.com
October 20, 2025 at 8:08 PM
This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Keenan Lab
New online: Global analysis of translocon remodeling during protein synthesis at the ER
Global analysis of translocon remodeling during protein synthesis at the ER
Nature Structural & Molecular Biology, Published online: 20 October 2025; doi:10.1038/s41594-025-01691-6The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis of secretory and membrane proteins at the endoplasmic reticulum.
go.nature.com
October 20, 2025 at 6:53 PM
New online: Global analysis of translocon remodeling during protein synthesis at the ER
Reposted by Keenan Lab
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
October 18, 2025 at 12:05 AM
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell www.cell.com/cell/fulltex...
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation
Development of LOV-domain-controlled ligase for translation localization (LOCL-TL),
an optogenetic approach for monitoring translation with codon resolution at any defined
subcellular location under p...
www.cell.com
October 17, 2025 at 10:45 PM
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in
human cells are imported during translation on cytosolic ribosomes. Cotranslational
import requires an N-terminal pres...
www.cell.com
October 17, 2025 at 10:41 PM
Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www-science-org.proxy.uchicago.edu/doi/10.1126/...
October 17, 2025 at 10:27 PM
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www-science-org.proxy.uchicago.edu/doi/10.1126/...
Reposted by Keenan Lab
Thanks to the reviewers and the editor @katciazynska.bsky.social
September 19, 2025 at 1:52 PM
Thanks to the reviewers and the editor @katciazynska.bsky.social
Reposted by Keenan Lab
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
“Revolutionary Science Comes from Unexpected Angles”
magazine.hms.harvard.edu
July 29, 2025 at 4:00 PM
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...