Ian Kelsall
@iankelsall.bsky.social
Senior Research Scientist at MRC-PPU, working in the lab of Yogesh Kulathu. Interested in ubiquitin, RBR ligases, innate immune signalling and heavy metal 🤘
Reposted by Ian Kelsall
JESUS CHRIST IN RICHMOND PARK: ORIGINAL UPLOAD
YouTube video by JAGGL113
youtu.be
November 13, 2025 at 8:43 AM
Reposted by Ian Kelsall
"I DON'T NEED YOU TO FUCKING REWRITE WHAT I'VE JUST WRITTEN!"
October 28, 2025 at 10:46 AM
"I DON'T NEED YOU TO FUCKING REWRITE WHAT I'VE JUST WRITTEN!"
Reposted by Ian Kelsall
This morning my ChatGPT quota was inexplicably exhausted.
It took a while but I pieced it together. Voice mode somehow got activated when I went to bed.
The bot then engaged in a 10 hour conversation with my snoring dog, answering questions the pup wasn’t asking and praising him for his insight.
It took a while but I pieced it together. Voice mode somehow got activated when I went to bed.
The bot then engaged in a 10 hour conversation with my snoring dog, answering questions the pup wasn’t asking and praising him for his insight.
October 18, 2025 at 9:04 AM
This morning my ChatGPT quota was inexplicably exhausted.
It took a while but I pieced it together. Voice mode somehow got activated when I went to bed.
The bot then engaged in a 10 hour conversation with my snoring dog, answering questions the pup wasn’t asking and praising him for his insight.
It took a while but I pieced it together. Voice mode somehow got activated when I went to bed.
The bot then engaged in a 10 hour conversation with my snoring dog, answering questions the pup wasn’t asking and praising him for his insight.
Reposted by Ian Kelsall
A good day to remember John Gurdon’s school report from his biology master at Eton
October 7, 2025 at 8:45 PM
A good day to remember John Gurdon’s school report from his biology master at Eton
Reposted by Ian Kelsall
Get in loser, we’re going to the rapture.
September 23, 2025 at 6:49 AM
Get in loser, we’re going to the rapture.
Reposted by Ian Kelsall
Reposted by Ian Kelsall
Look at the size of that pointer! That thing looks like a lightsabre.
1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer
September 10, 2025 at 8:08 AM
Look at the size of that pointer! That thing looks like a lightsabre.
Reposted by Ian Kelsall
A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic:
rdcu.be/eETIT
rdcu.be/eETIT
The rise of ADP-ribose–ubiquitin
Nature Structural & Molecular Biology - Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational...
rdcu.be
September 8, 2025 at 3:24 PM
A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic:
rdcu.be/eETIT
rdcu.be/eETIT
Reposted by Ian Kelsall
Art class
From the latest Private Eye, out now.
From the latest Private Eye, out now.
September 9, 2025 at 8:36 AM
Art class
From the latest Private Eye, out now.
From the latest Private Eye, out now.
Reposted by Ian Kelsall
FACT OF THE DAY. 2 September 1752. Britain replaced the Julian calendar with the Gregorian one which was used in most of Europe. The following day was 14 September 1752, meaning 11 days were cut from the 1752 British calendar. These days simply never existed.
September 2, 2025 at 8:31 AM
FACT OF THE DAY. 2 September 1752. Britain replaced the Julian calendar with the Gregorian one which was used in most of Europe. The following day was 14 September 1752, meaning 11 days were cut from the 1752 British calendar. These days simply never existed.
Reposted by Ian Kelsall
Your mam shouts at hotels and your dad paints roundabouts
August 29, 2025 at 6:15 AM
Your mam shouts at hotels and your dad paints roundabouts
Reposted by Ian Kelsall
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 27, 2025 at 4:14 PM
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ian Kelsall
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase,
which is activated through nucleic-acid-induced oligomerization and is critical for
cell survival during immune ...
www.cell.com
August 27, 2025 at 7:04 PM
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Ian Kelsall
Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...
ZNFX1 compacts and tags RNA to keep immunity in check
Tim Clausen’s lab at the IMP and collaborators have uncovered how the ancient immune protein ZNFX1 enables cells to walk the fine line between fighting infection and avoiding autoimmune damage. The te...
www.imp.ac.at
August 28, 2025 at 7:33 AM
Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...
Reposted by Ian Kelsall
Showing the endangered leader of an invaded country my hats
August 19, 2025 at 2:08 AM
Showing the endangered leader of an invaded country my hats
Reposted by Ian Kelsall
An incomparable legend.
July 22, 2025 at 7:17 PM
An incomparable legend.
Who's that weird man with Olivia Rodrigo daddy?
Oh, that's Robert Smith. He wrote this.
But why is he dressed like a horror clown?
Erm...
#Glastonbury2025
Oh, that's Robert Smith. He wrote this.
But why is he dressed like a horror clown?
Erm...
#Glastonbury2025
June 30, 2025 at 7:07 AM
Who's that weird man with Olivia Rodrigo daddy?
Oh, that's Robert Smith. He wrote this.
But why is he dressed like a horror clown?
Erm...
#Glastonbury2025
Oh, that's Robert Smith. He wrote this.
But why is he dressed like a horror clown?
Erm...
#Glastonbury2025
Reposted by Ian Kelsall
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
Reposted by Ian Kelsall
I absolutely love this poem by @holliemcnish.bsky.social – 5 in 6 boys think Andrew Tate is a prick
May 21, 2025 at 1:22 PM
I absolutely love this poem by @holliemcnish.bsky.social – 5 in 6 boys think Andrew Tate is a prick
Reposted by Ian Kelsall
The fascinating story behind the Institute for Advanced Study, home to scientists who revolutionized math and physics 🧪
www.ias.edu/about/missio...
www.ias.edu/about/missio...
May 14, 2025 at 11:38 AM
The fascinating story behind the Institute for Advanced Study, home to scientists who revolutionized math and physics 🧪
www.ias.edu/about/missio...
www.ias.edu/about/missio...
Reposted by Ian Kelsall
How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia
The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways and cause ciliopathies. Although K63-linked ubiquitination appears to trigger protein export from cilia, the mechanisms coupling polyubiquitinated proteins to IFT remain unclear. Using a multidisciplinary approach, we demonstrate that a complex of CFAP36, a conserved ciliary protein of previously unknown function, and ARL3, a GTPase involved in ciliary import, binds polyubiquitinated proteins and links them to retrograde IFT trains. CFAP36 uses a coincidence detection mechanism to simultaneously bind two IFT subunits accessible only in retrograde trains. Depleting CFAP36 accumulates K63-linked ubiquitin in cilia and disrupts Hedgehog signaling, a pathway reliant on the retrieval of ubiquitinated receptors. These findings advance our understanding of ubiquitin-mediated protein transport and ciliary homeostasis, and demonstrate how structural changes in IFT trains achieve cargo selectivity. ### Competing Interest Statement The authors have declared no competing interest. Sara Elizabeth O'Brien Trust Postdoctoral Fellowship awarded through the Charles A. King Trust Postdoctoral Research Fellowship Program, , 8460873-01 Richard and Susan Smith Family Foundation, https://ror.org/05j95n956, National Institute of General Medical Sciences (NIGMS), , R01GM141109, R01GM143183
www.biorxiv.org
April 29, 2025 at 3:04 PM
How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n
Reposted by Ian Kelsall
632 job cuts have been proposed by the executive team at the University of Dundee.
Today we launch our first full-length video that highlights the devastating impact this news is having on staff, and how this will affect Dundee.
Please share to amplify our voice. #WeAreThe632
youtu.be/oXkCu-bruiI
Today we launch our first full-length video that highlights the devastating impact this news is having on staff, and how this will affect Dundee.
Please share to amplify our voice. #WeAreThe632
youtu.be/oXkCu-bruiI
We Are The 632: University of Dundee staff speak out
YouTube video by Dundee UCU
youtu.be
March 24, 2025 at 8:58 AM
632 job cuts have been proposed by the executive team at the University of Dundee.
Today we launch our first full-length video that highlights the devastating impact this news is having on staff, and how this will affect Dundee.
Please share to amplify our voice. #WeAreThe632
youtu.be/oXkCu-bruiI
Today we launch our first full-length video that highlights the devastating impact this news is having on staff, and how this will affect Dundee.
Please share to amplify our voice. #WeAreThe632
youtu.be/oXkCu-bruiI