Fernán Agüero
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ferag.bsky.social
Fernán Agüero
@ferag.bsky.social
390 followers 800 following 76 posts
Biologist | UNSAM-CONICET | Bioinformatics | Cheminformatics | Genomics | Drug discovery | Diagnostics | Neglected Tropical Diseases | Argentina 🇦🇷
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Reposted by Fernán Agüero
training.ebi.embl.org
Applications for our training course, 'Bioinformatics for immunologists' are open until 15 March 2026: www.ebi.ac.uk/training/eve...

Travel grants and fee waivers are available for this essential bioinformatics training course.

🧬🖥️📊🎗️
February 4, 2026 at 9:59 AM
Reposted by Fernán Agüero
miangoar.bsky.social
I’ve recorded ~8h explaining the architectures of AlphaFold, AF2 & AF3, as well as the context needed to understand their development, applications and limitations :)
youtu.be/_jDRr5BcTaY

Slides
drive.google.com/file/d/1i4QE...

English is available only via auto-translated subtitles
February 2, 2026 at 9:23 PM
Reposted by Fernán Agüero
embojournal.org
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 10:37 AM
Reposted by Fernán Agüero
thamlab.bsky.social
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎

Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕

Please share widely- love to hear your feedback!
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...
journals.plos.org
February 2, 2026 at 8:36 AM
Reposted by Fernán Agüero
bsc-cns.bsky.social
📢 #BSCSeminar: “Guiding directed evolution of enzymes”.

🗣️ Rocio Espada, University of Buenos Aires
📆 04 February

➡️ bsc.es/4JB

#EquityinBSC #WomeninBSC

@sommalliance.bsky.social
February 2, 2026 at 10:22 AM
Reposted by Fernán Agüero
interprodb.bsky.social
🚀 InterPro 108.0 is live!
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
January 30, 2026 at 7:10 AM
Reposted by Fernán Agüero
swisstph.ch
On World NTD Day, we are highlighting innovative approaches to fighting NTDs.

A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans.

👉Read more: bit.ly/47WdrXA
January 30, 2024 at 10:12 AM
Reposted by Fernán Agüero
martinsteinegger.bsky.social
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
www.science.org
January 30, 2026 at 6:11 AM
Reposted by Fernán Agüero
coalicionchagas.org
⚕️Tomorrow is #WorldNTDDay🌐2026, and Chagas Coalition will be supporting it through a webinar with our colleagues from PAHO & @dndi.org. It's about data management related to these 21 neglected diseases

✍️ paho-org.zoom.us/webinar/regi...

On January 30, let's #BeatNTDs & call for #UniteActEliminate
January 29, 2026 at 8:54 PM
Reposted by Fernán Agüero
cantinilab.bsky.social
PhD position in my team at @pasteur.fr ! The selected canddiate will work on the development of new methods combining biophysicial and machine learning modelling for single-cell multi-omics spatiotemporal data.

emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - PhD (M/F) in development of machine learning methods for single-cell omics data integration
Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler
emploi.cnrs.fr
January 30, 2026 at 9:28 AM
Reposted by Fernán Agüero
pabnik.bsky.social
Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social
journals.asm.org/doi/10.1128/...
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio
Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term use and broad ad...
journals.asm.org
January 27, 2026 at 7:43 PM
Reposted by Fernán Agüero
natmicrobiol.nature.com
Parasex generates highly recombinant progeny in Candida albicans with increased virulence
Nature Microbiology, Published online: 21 January 2026; doi:10.1038/s41564-025-02247-6An alternative mating system, termed parasex, produces progeny with high levels of genotypic diversity and is able to fulfil the roles of meiosis when it is absent in the fungal pathobiont Candida albicans.
go.nature.com
January 26, 2026 at 9:53 PM
Reposted by Fernán Agüero
elisabethbik.bsky.social
Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money
1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI
@manuelansede.bsky.social
english.elpais.com/science-tech...
Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money
An analysis of 100,000 special issues of academic journals reveals that one in eight is filled with articles written by the editor, particularly at the publisher MDPI
english.elpais.com
January 25, 2026 at 7:41 PM
Reposted by Fernán Agüero
leventallab.bsky.social
Excited to share a new story that transformed how we think about membrane domains in the ER!

rdcu.be/eR7Cn

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export

Wondering what’s so new and exciting? Skytorial below!

1/9
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
January 24, 2026 at 8:20 PM
Reposted by Fernán Agüero
labwaggoner.bsky.social
The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA @cincyresearch.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
January 25, 2026 at 1:58 AM
Reposted by Fernán Agüero
sciencecharles.bsky.social
A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.

More: rdcu.be/eXksT
Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap
Nature Communications - The vaccinia virus produces mRNA lacking the 5′ m7G cap structure. These uncapped mRNAs have long poly(A) leaders and dominate late in infection, suggesting a novel...
rdcu.be
January 5, 2026 at 8:41 AM
Reposted by Fernán Agüero
enirenberg.bsky.social
This is really cool. Who said IgG can't protect the mucosae? #immunosky

www.thelancet.com/journals/lan...
Mucosal immune responses to Bordetella pertussis in Gambian infants after maternal and primary vaccination: an immunological substudy of a single-centre, randomised, controlled, double-blind, phase 4 ...
Tdap–IPV vaccination during pregnancy induces antibodies that are transferred across the placenta to reach the upper airway mucosa of the infant and could contribute to local protection. Although mate...
www.thelancet.com
January 16, 2026 at 11:50 PM
Reposted by Fernán Agüero
natcomms.nature.com
#Virology

Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications
Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.
dlvr.it
January 16, 2026 at 4:47 PM
Reposted by Fernán Agüero
cashwood.proteaglyco.com
Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)?

This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec
January 17, 2026 at 2:39 AM
Reposted by Fernán Agüero
alanjstedman.bsky.social
This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,

The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance

Iconic imo
Photograph from 1911 taken by Herbert Ponting whilst with Scott's Antarctic Expedition The monochrome photo is taken from within a cave. The walls of the cave are made of ice. The cave entrance is in the mid distance with two figures standing looking out towards a distant ship. Between them and the ship there is first a 'beach' of ice before the sea itself. The ship could be up to 800 metres away What makes the photo so special is that where the figures are at the cave entrance there is a band of very white snow and ice (contrasting with the comparatively dark inside of the cave) that creates a stark framework in which the men and the ship are captured. It is made even more dramatic by the fact that the cave entrance is at least 30 metres high and is in the shape of a distorted elipse with the tail sloping off to the right at the top of the elipse The photo being in monochrome in a largely white environment makes the photographers skill all the more laudable
January 17, 2026 at 7:12 AM
ferag.bsky.social
New Year, New Paper from the lab!

An enhanced fluorogenic phenotyping assay for screening of new drugs against Trypanosoma cruzi, the causative agent of #Chagas disease.

And two new antifungals with activity against T. cruzi!

@unsamoficial @CONICETDialoga @ebynunsam

🧵 1
January 16, 2026 at 3:50 PM
Reposted by Fernán Agüero
stephenbheard.bsky.social
I despise the coining of new acronyms.

Except this one: when is a paper in a special issue PISS (Published In Support of Self)? The answer, of course, is way too often.
hansonmark.bsky.social Mark A. Hanson @hansonmark.bsky.social · 27d
We've got ISSUES. Literally.

We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?

arxiv.org/abs/2601.07563

A 🧵 1/n
January 13, 2026 at 5:12 PM
ferag.bsky.social
The Issue with Special Issues: when Guest Editors Publish in Support of Self. arxiv.org/abs/2601.07563

Thanks @hansonmark.bsky.social for putting the effort in documenting this plague.

We need to stop it. #PISS is damaging academia.
The Issue with Special Issues: when Guest Editors Publish in Support of Self
The recent exceptional growth in the number of special issues has led to the largest delegation of editorial power in the history of scientific publishing. Has this power been used responsibly? In thi...
arxiv.org
January 14, 2026 at 3:11 PM
Reposted by Fernán Agüero
apdu-unige.bsky.social
Ever wonder why some projects just work and others slowly eat your soul? In this paper by @urialonlab.bsky.social discuss the importance of choosing both interesting and actually doable ideas. Impact matters as well as feasibility!
January 14, 2026 at 7:43 AM
Reposted by Fernán Agüero
odedrechavi.bsky.social
When you think you met the right phd advisor but then he stops answering emails
January 14, 2026 at 10:35 AM