Fernán Agüero
@ferag.bsky.social
Biologist | UNSAM-CONICET | Bioinformatics | Cheminformatics | Genomics | Drug discovery | Diagnostics | Neglected Tropical Diseases | Argentina 🇦🇷
Reposted by Fernán Agüero
I wrote something about publication bias at statmodeling.stat.columbia.edu/2025/11/14/t...
November 14, 2025 at 9:17 PM
I wrote something about publication bias at statmodeling.stat.columbia.edu/2025/11/14/t...
Reposted by Fernán Agüero
Gosh, it feels so good to finally have released Zensical on November 5! Together with the search, we've basically worked in the dark for 2 years – generally a very bad idea, as you can't know whether you nail the problem you're aiming to solve or not.
A thread ⬇ 1/4
A thread ⬇ 1/4
November 15, 2025 at 12:37 PM
Gosh, it feels so good to finally have released Zensical on November 5! Together with the search, we've basically worked in the dark for 2 years – generally a very bad idea, as you can't know whether you nail the problem you're aiming to solve or not.
A thread ⬇ 1/4
A thread ⬇ 1/4
Reposted by Fernán Agüero
A synthetic transcription cascade enables direct in planta shoot regeneration for transgenesis and gene editing in multiple plants #resource #MolecularPlant cell.com/molecular-pl...
November 15, 2025 at 12:50 PM
A synthetic transcription cascade enables direct in planta shoot regeneration for transgenesis and gene editing in multiple plants #resource #MolecularPlant cell.com/molecular-pl...
Reposted by Fernán Agüero
Direct shoot regeneration using Arabidopsis WIND1 (35S:AtWIND1) + pAtESR:IPT. The idea is WIND1 both reprograms and activates ESR promter, and subsequently activates cytokinin synthesis via pESR:IPT for shoot regeneration. #PlantScience
From: www.cell.com/molecular-pl...
From: www.cell.com/molecular-pl...
A synthetic transcription cascade enables direct in planta shoot regeneration for transgenesis and gene editing in multiple plants
This work presents an in planta system for inducing transgenic and gene-edited de
novo meristems via the wounding pathway. By combining the transcriptional regulator
WIND1 with developmental regulator...
www.cell.com
November 15, 2025 at 2:15 PM
Direct shoot regeneration using Arabidopsis WIND1 (35S:AtWIND1) + pAtESR:IPT. The idea is WIND1 both reprograms and activates ESR promter, and subsequently activates cytokinin synthesis via pESR:IPT for shoot regeneration. #PlantScience
From: www.cell.com/molecular-pl...
From: www.cell.com/molecular-pl...
Reposted by Fernán Agüero
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Fernán Agüero
Reposted by Fernán Agüero
Adding citations of people who might review the paper
November 14, 2025 at 10:06 AM
Adding citations of people who might review the paper
Reposted by Fernán Agüero
Imagine you could explicate the relationship between language and the world with the same precision we define any mathematical function! I mean, you can’t, but imagine you could!
I recently learned about the double bracket interpretation function in Linguistics and my fucking head almost exploded. I twisted myself in knots trying to write a paper that essentially explicates this (some differences, but generally this idea) and yeah…it’s so simple 💁♂️
November 13, 2025 at 11:47 PM
Imagine you could explicate the relationship between language and the world with the same precision we define any mathematical function! I mean, you can’t, but imagine you could!
Reposted by Fernán Agüero
Confusing stats language:
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
November 14, 2025 at 9:08 AM
Confusing stats language:
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
Reposted by Fernán Agüero
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...
rdcu.be
November 12, 2025 at 11:15 AM
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Reposted by Fernán Agüero
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
November 12, 2025 at 10:38 AM
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
Reposted by Fernán Agüero
Tapping the XKCD sign again to explain that no, I won't be seeing an aurora tonight. Or at least I really hope not. That would be bad. :)
November 12, 2025 at 2:08 AM
Tapping the XKCD sign again to explain that no, I won't be seeing an aurora tonight. Or at least I really hope not. That would be bad. :)
Reposted by Fernán Agüero
The Next Open Revolution: Equity, Impact, and the Architecture of Knowledge scholarlykitchen.sspnet.org/2025/11/12/t...
The Next Open Revolution: Equity, Impact, and the Architecture of Knowledge - The Scholarly Kitchen
Today, Alison Mudditt reflects on a Charleston Conference session that asked: what would it take to make the scholarly communication system truly equitable, impactful, and future-ready?
scholarlykitchen.sspnet.org
November 12, 2025 at 11:05 AM
The Next Open Revolution: Equity, Impact, and the Architecture of Knowledge scholarlykitchen.sspnet.org/2025/11/12/t...
Reposted by Fernán Agüero
AlphaFold Database users can now temporarily integrate and visualise their own protein annotations, making the resource a more interactive and personalised platform for structural bioinformatics analysis.
www.ebi.ac.uk/about/news/u...
#AlphaFold
www.ebi.ac.uk/about/news/u...
#AlphaFold
AlphaFold Database launches custom annotations feature
The AlphaFold Database (AlphaFold DB) has introduced a new functionality that enables users to integrate and visualise custom sequence annotations. These annotations are processed in the browser for t...
www.ebi.ac.uk
November 11, 2025 at 2:23 PM
AlphaFold Database users can now temporarily integrate and visualise their own protein annotations, making the resource a more interactive and personalised platform for structural bioinformatics analysis.
www.ebi.ac.uk/about/news/u...
#AlphaFold
www.ebi.ac.uk/about/news/u...
#AlphaFold
Reposted by Fernán Agüero
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
November 11, 2025 at 8:35 AM
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
Reposted by Fernán Agüero
Reposted by Fernán Agüero
I find this remarkable:
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
November 11, 2025 at 12:49 AM
I find this remarkable:
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
Reposted by Fernán Agüero
New review on mixed Machine Learning/Molecular mechanics methods just dropped !
Great collaboration between University of Buenos Aires and U Florida.
doi.org/10.1063/5.02...
Great collaboration between University of Buenos Aires and U Florida.
doi.org/10.1063/5.02...
From QM/MM to ML/MM: A new era in multiscale modeling
Hybrid machine-learning/molecular-mechanics (ML/MM) methods extend the classical QM/MM paradigm by replacing the quantum description with neural network interat
doi.org
November 10, 2025 at 9:03 PM
New review on mixed Machine Learning/Molecular mechanics methods just dropped !
Great collaboration between University of Buenos Aires and U Florida.
doi.org/10.1063/5.02...
Great collaboration between University of Buenos Aires and U Florida.
doi.org/10.1063/5.02...
Reposted by Fernán Agüero
I'm often asked how human genetic data can be used to validate drug targets.
In our new @natcardiovascres.nature.com paper, we provide an end-to-end framework for genetically validating IL-6 inhibition for atherosclerotic cardiovascular disease outcomes 🧵
In our new @natcardiovascres.nature.com paper, we provide an end-to-end framework for genetically validating IL-6 inhibition for atherosclerotic cardiovascular disease outcomes 🧵
August 27, 2025 at 2:02 PM
I'm often asked how human genetic data can be used to validate drug targets.
In our new @natcardiovascres.nature.com paper, we provide an end-to-end framework for genetically validating IL-6 inhibition for atherosclerotic cardiovascular disease outcomes 🧵
In our new @natcardiovascres.nature.com paper, we provide an end-to-end framework for genetically validating IL-6 inhibition for atherosclerotic cardiovascular disease outcomes 🧵
Reposted by Fernán Agüero
Reformation of science publishing: the Stockholm Declaration
A call to action for universities, academies, science organizations and funders to unite and join this effort.
Bernhard Sabel and Dan Larhammar
royalsocietypublishing.org/doi/10.1098/...
A call to action for universities, academies, science organizations and funders to unite and join this effort.
Bernhard Sabel and Dan Larhammar
royalsocietypublishing.org/doi/10.1098/...
Reformation of science publishing: the Stockholm Declaration | Royal Society Open Science
Science relies on integrity and trustworthiness. But scientists under career pressure
are lured to purchase fake publications from ‘paper mills’ that use AI-generated data,
text and image fabrication....
royalsocietypublishing.org
November 9, 2025 at 8:43 PM
Reformation of science publishing: the Stockholm Declaration
A call to action for universities, academies, science organizations and funders to unite and join this effort.
Bernhard Sabel and Dan Larhammar
royalsocietypublishing.org/doi/10.1098/...
A call to action for universities, academies, science organizations and funders to unite and join this effort.
Bernhard Sabel and Dan Larhammar
royalsocietypublishing.org/doi/10.1098/...
Reposted by Fernán Agüero
Reposted by Fernán Agüero
![Comic. PERSON 1 with white hat: How tall are you? PERSON 2: 5ft 24cm [caption] When switching to metric, make the process easier by doing it in steps.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreifptvo6h6kdpf75j3i443ospzumiii7a3pblah2urjrawmyymh3ga@jpeg)
November 6, 2025 at 11:33 PM
Reposted by Fernán Agüero
Our work with AstraZeneca on developing multi-task graph neural network models for cell permeability predictions is finally out in ACS Omega! #chemsky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
November 6, 2025 at 12:03 PM
Our work with AstraZeneca on developing multi-task graph neural network models for cell permeability predictions is finally out in ACS Omega! #chemsky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Fernán Agüero
Zensical – a modern static site generator.
We're excited to release @zensical.org, our new SSG that is compatible with Material for MkDocs:
– 5x faster rebuilds
– Modern design
– Blazing-fast search
Read the full announcement on our blog:
squidfunk.github.io/mkdocs-mater...
A thread ⬇ 1/7
We're excited to release @zensical.org, our new SSG that is compatible with Material for MkDocs:
– 5x faster rebuilds
– Modern design
– Blazing-fast search
Read the full announcement on our blog:
squidfunk.github.io/mkdocs-mater...
A thread ⬇ 1/7
Zensical - A modern static site generator - Material for MkDocs
We are thrilled to announce Zensical, our next-gen static site generator that addresses and overcomes the technical limitations of MkDocs
squidfunk.github.io
November 5, 2025 at 2:24 PM
Zensical – a modern static site generator.
We're excited to release @zensical.org, our new SSG that is compatible with Material for MkDocs:
– 5x faster rebuilds
– Modern design
– Blazing-fast search
Read the full announcement on our blog:
squidfunk.github.io/mkdocs-mater...
A thread ⬇ 1/7
We're excited to release @zensical.org, our new SSG that is compatible with Material for MkDocs:
– 5x faster rebuilds
– Modern design
– Blazing-fast search
Read the full announcement on our blog:
squidfunk.github.io/mkdocs-mater...
A thread ⬇ 1/7
Reposted by Fernán Agüero
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications
Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...
www.nature.com
November 5, 2025 at 3:24 PM
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
www.nature.com/articles/s41...