Charles C Roseman
@evoroseman.bsky.social
Evolution and genetics of complex traits. Genes, evolution, and society.
Masculine pronouns and noun classes in whichever language.
Masculine pronouns and noun classes in whichever language.
Reposted by Charles C Roseman
Happy to share our new preprint from @sashagusevposts.bsky.social and @nmancuso.bsky.social labs! We introduce Mr. PEG, a framework integrating perturbational screens, eQTL, and GWAS data to identify mediating genes for complex traits. (1/n) www.medrxiv.org/content/10.6...
Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits
Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational sc...
www.medrxiv.org
January 5, 2026 at 10:27 PM
Happy to share our new preprint from @sashagusevposts.bsky.social and @nmancuso.bsky.social labs! We introduce Mr. PEG, a framework integrating perturbational screens, eQTL, and GWAS data to identify mediating genes for complex traits. (1/n) www.medrxiv.org/content/10.6...
Reposted by Charles C Roseman
Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A
January 5, 2026 at 5:32 PM
Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A
Reposted by Charles C Roseman
Jonathan Anomaly responds in a long comment to my post criticizing his writing on eugenics and that of his company Herasight. He argues against several specific points and I encourage reading it in full.
open.substack.com/pub/theinfin...
open.substack.com/pub/theinfin...
December 29, 2025 at 3:33 AM
Jonathan Anomaly responds in a long comment to my post criticizing his writing on eugenics and that of his company Herasight. He argues against several specific points and I encourage reading it in full.
open.substack.com/pub/theinfin...
open.substack.com/pub/theinfin...
I have a face for radio and a voice for silent cinema.
i have said this before but if you are actually interested in influencing people beyond a narrow circle of too-online journalists you will be making direct to camera videos on tiktok, instagram and youtube. if you primarily post on text-based social media then you're just dicking around.
December 15, 2025 at 8:22 PM
I have a face for radio and a voice for silent cinema.
Reposted by Charles C Roseman
Today, for the first time in a very long time, I had to engage seriously with a Windows computer.
I had not realized how Actively Hostile interacting with Windows has become.
I had not realized how Actively Hostile interacting with Windows has become.
December 15, 2025 at 7:18 PM
Today, for the first time in a very long time, I had to engage seriously with a Windows computer.
I had not realized how Actively Hostile interacting with Windows has become.
I had not realized how Actively Hostile interacting with Windows has become.
🧪🦴🦷🧬🐭🐒
Reviewer 2,
I don't know who you are, but thankyouthankyouthankyou for giving me the opportunity to put this reference into my paper.
Reviewer 2,
I don't know who you are, but thankyouthankyouthankyou for giving me the opportunity to put this reference into my paper.
December 15, 2025 at 7:56 PM
🧪🦴🦷🧬🐭🐒
Reviewer 2,
I don't know who you are, but thankyouthankyouthankyou for giving me the opportunity to put this reference into my paper.
Reviewer 2,
I don't know who you are, but thankyouthankyouthankyou for giving me the opportunity to put this reference into my paper.
Reposted by Charles C Roseman
I posted a long reply to Freddie deBoer's comment on my piece about intelligence with Dan Willingham @dtwuva.bsky.social. substack.com/profile/1707...
Eric Turkheimer (@ericturkheimer2)
Not sure if this is intended as a comment on my piece with @Daniel Willingham: https://www.aft.org/ae/winter2025-2026/turkheimer_willingham But I will go ahead and respond to it as if it is. Speaking ...
substack.com
December 11, 2025 at 3:42 PM
I posted a long reply to Freddie deBoer's comment on my piece about intelligence with Dan Willingham @dtwuva.bsky.social. substack.com/profile/1707...
Fishify a song
"Sole Man" by Sam and Dave
"Sole Man" by Sam and Dave
Fishify a song
“This Must Be the Plaice” by Talking Heads
“This Must Be the Plaice” by Talking Heads
Fishify a song
O magnum mysterium, et admirabile sacramentum, ut pisces viderent dominum natum...
O magnum mysterium, et admirabile sacramentum, ut pisces viderent dominum natum...
December 11, 2025 at 5:19 PM
Fishify a song
"Sole Man" by Sam and Dave
"Sole Man" by Sam and Dave
Reposted by Charles C Roseman
New on Pinkerite: Gutter racists Steven Pinker and Scott Siskind team up to promote neo-Nazi Emil Kirkegaard
www.pinkerite.com/2025/12/gutt...
www.pinkerite.com/2025/12/gutt...
Gutter racists Steven Pinker and Scott Siskind team up to promote neo-Nazi Emil Kirkegaard
So the last post I wrote was focused on Eric Turkheimer's bet over hereditarian beliefs with Charles Murray and hereditarian Murray lost. ...
www.pinkerite.com
December 4, 2025 at 11:51 PM
New on Pinkerite: Gutter racists Steven Pinker and Scott Siskind team up to promote neo-Nazi Emil Kirkegaard
www.pinkerite.com/2025/12/gutt...
www.pinkerite.com/2025/12/gutt...
Reposted by Charles C Roseman
New Current Biology study from @minyaaa.bsky.social and colleagues shows how early CYC expression patterns establish dorsal identity in Mimulus parishii meristems. A clear step forward in understanding floral symmetry and developmental evolution. 🧪 🧪
🔗 buff.ly/3JOjkV1
🔗 buff.ly/3JOjkV1
December 3, 2025 at 4:02 PM
New Current Biology study from @minyaaa.bsky.social and colleagues shows how early CYC expression patterns establish dorsal identity in Mimulus parishii meristems. A clear step forward in understanding floral symmetry and developmental evolution. 🧪 🧪
🔗 buff.ly/3JOjkV1
🔗 buff.ly/3JOjkV1
Reposted by Charles C Roseman
Interesting essay on Julian Huxley: “A committed leftist, he argued fiercely that science had failed to prove any innate racial differences (although he personally suspected such differences existed). He was also an ardent and unrepentant eugenicist”
I have an unpublished paper that I really need to get out there on Huxley's eugenic worldview, but here's a popular essay I wrote on the topic for io9 way, way back in the day, in case that's of interest (the headline was not my choice)
The First Religion Devoted to Evolution
Julian Huxley (1887-1975) is remembered as one of the most eminent biologists and science writers of the 20th century. He's less well known for what he
gizmodo.com
December 3, 2025 at 6:45 PM
Interesting essay on Julian Huxley: “A committed leftist, he argued fiercely that science had failed to prove any innate racial differences (although he personally suspected such differences existed). He was also an ardent and unrepentant eugenicist”
Reposted by Charles C Roseman
This week's Philosophy for the People essay is up:
Fuentes is a Symptom
When the whole landscape is soaking in ethnic essentialism, it's hard to draw the cordon sanitaire around one particular version.
benburgis.substack.com
November 30, 2025 at 4:47 PM
This week's Philosophy for the People essay is up:
Reposted by Charles C Roseman
Brain eating vending machine
We can't really say this enough...
> Anastasia Berg [at UCL Irvine] said that new research — and what she's hearing directly from colleagues across various industries — shows that employees who heavily rely on AI are losing core skills at a startling rate.
www.businessinsider.com/ai-tools-are...
> Anastasia Berg [at UCL Irvine] said that new research — and what she's hearing directly from colleagues across various industries — shows that employees who heavily rely on AI are losing core skills at a startling rate.
www.businessinsider.com/ai-tools-are...
AI tools are 'deskilling' workers, philosophy professor says
A philosophy professor warns that AI reliance is weakening workers' judgment, creativity, and problem-solving.
www.businessinsider.com
November 30, 2025 at 6:59 PM
Brain eating vending machine
Reposted by Charles C Roseman
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
GitHub - alanrogers/popgen: A course on population genetics
A course on population genetics. Contribute to alanrogers/popgen development by creating an account on GitHub.
github.com
November 27, 2025 at 7:10 PM
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
Reposted by Charles C Roseman
I would support a system in which reviewers get credits to offset/waive APCs so as to align an interest in valuing the labor and valuing access
I think we need to pay reviewers.
25 no response out of 30 requests to review!
Drives me mad this selfish behaviour, which I also see as a journal editor. And it's almost always established folk with secure jobs, not least those endlessly brandishing their right-on-ness on social media
Drives me mad this selfish behaviour, which I also see as a journal editor. And it's almost always established folk with secure jobs, not least those endlessly brandishing their right-on-ness on social media
November 24, 2025 at 2:35 PM
I would support a system in which reviewers get credits to offset/waive APCs so as to align an interest in valuing the labor and valuing access
Reposted by Charles C Roseman
Another great post from Sasha demonstrating what will ring true to many of us-- our environments include our siblings, making it unlikely that siblings have identical environments.
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:55 PM
Another great post from Sasha demonstrating what will ring true to many of us-- our environments include our siblings, making it unlikely that siblings have identical environments.
Reposted by Charles C Roseman
Interactions with polygenic background impact quantitative traits in the UK Biobank https://www.medrxiv.org/content/10.1101/2025.11.14.25340263v1
November 18, 2025 at 5:40 AM
Interactions with polygenic background impact quantitative traits in the UK Biobank https://www.medrxiv.org/content/10.1101/2025.11.14.25340263v1
Reposted by Charles C Roseman
Some history of science grad student is going to have one hell of a dissertation about how Arthur Jensen wrecked two disciplines for half a century.
November 21, 2025 at 11:53 PM
Some history of science grad student is going to have one hell of a dissertation about how Arthur Jensen wrecked two disciplines for half a century.
@sashagusevposts.bsky.social is pretty damn good at this.
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 22, 2025 at 12:47 AM
@sashagusevposts.bsky.social is pretty damn good at this.
Reposted by Charles C Roseman
What a disastrous move on the side of the
@uniofleicester.bsky.social . In a world affected by the global change which needs a multitude of perspective, they are planning to narrow-down all Earth sciences to few unoriginal generics. Please sign the petition 👇
🧪 ⚒️ #Geology #EvoBio #Paleobio
@uniofleicester.bsky.social . In a world affected by the global change which needs a multitude of perspective, they are planning to narrow-down all Earth sciences to few unoriginal generics. Please sign the petition 👇
🧪 ⚒️ #Geology #EvoBio #Paleobio
Geology and palaeobiology at the University of Leicester are under threat, with at least 14 staff expected to be made redundant. Support them, their postdocs, and their students by signing this petition: c.org/SK8Xm8dhqK
Sign the Petition
Save Geology at the University of Leicester
c.org
November 20, 2025 at 3:01 PM
What a disastrous move on the side of the
@uniofleicester.bsky.social . In a world affected by the global change which needs a multitude of perspective, they are planning to narrow-down all Earth sciences to few unoriginal generics. Please sign the petition 👇
🧪 ⚒️ #Geology #EvoBio #Paleobio
@uniofleicester.bsky.social . In a world affected by the global change which needs a multitude of perspective, they are planning to narrow-down all Earth sciences to few unoriginal generics. Please sign the petition 👇
🧪 ⚒️ #Geology #EvoBio #Paleobio
Reposted by Charles C Roseman
AI is "approaching human reasoning" through the steady degradation of human reasoning (especially about AI... 🙄)
"We thought AI would only approach human reasoning around 2050. Now we expect this to happen already next year." — Ursula von der Leyen
November 18, 2025 at 11:21 AM
AI is "approaching human reasoning" through the steady degradation of human reasoning (especially about AI... 🙄)
Reposted by Charles C Roseman
I talked a bit with Jason about Grokipedia and it is, without exaggeration, like if you trained an LLM solely on white supremacist blogs and had it try to write Wikipedia entries. Some of the most insane stuff I’ve seen on the internet
Hard to find a clearer distillation of the gen ai project.
White nationalist talking points and racial pseudoscience: welcome to Elon Musk’s Grokipedia
World’s richest person wanted to ‘purge’ propaganda from Wikipedia, so he created a compendium of racist disinformation
www.theguardian.com
November 17, 2025 at 7:08 PM
I talked a bit with Jason about Grokipedia and it is, without exaggeration, like if you trained an LLM solely on white supremacist blogs and had it try to write Wikipedia entries. Some of the most insane stuff I’ve seen on the internet
Reposted by Charles C Roseman
The link between the gut microbiome and autism not backed by science, experts say www.dailymail.co.uk/health/artic...
Link between gut microbiome and autism not backed by science, study
The role of the gut in autism continues to attract widespread attention, but experts now say there is no scientific evidence that the gut microbiome causes autism.
www.dailymail.co.uk
November 14, 2025 at 9:35 AM
The link between the gut microbiome and autism not backed by science, experts say www.dailymail.co.uk/health/artic...
Reposted by Charles C Roseman
"What James Watson got wrong about DNA"
By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com).
www.bostonglobe.com/2025/11/14/o...
By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com).
www.bostonglobe.com/2025/11/14/o...
What James Watson got wrong about DNA - The Boston Globe
The science he helped pioneer consistently undermines his view that genes determine everything about us.
www.bostonglobe.com
November 14, 2025 at 4:50 PM
"What James Watson got wrong about DNA"
By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com).
www.bostonglobe.com/2025/11/14/o...
By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com).
www.bostonglobe.com/2025/11/14/o...
Reposted by Charles C Roseman
Today is the day! Our reply to the two concurrent critiques (from the same set of authors) is now published in the journal Intelligence 🧵 1/
November 12, 2025 at 3:31 PM
Today is the day! Our reply to the two concurrent critiques (from the same set of authors) is now published in the journal Intelligence 🧵 1/