Ethan (Chee Kiang) Ewe
@ethanewe.bsky.social
Postdoc, firstgen, scientist, worm breeder, cats dad 🏳️🌈
Pinned
🔥my latest paper from @odedrechavi.bsky.social lab🔥
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
Reposted by Ethan (Chee Kiang) Ewe
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
Environmental fluctuations influence heritable phenotypes through complex molecular mechanisms. In zebrafish (Danio rerio), the interplay between temperature variation, transposable element (TE) activ...
www.biorxiv.org
November 16, 2025 at 10:18 AM
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Reposted by Ethan (Chee Kiang) Ewe
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 13, 2025 at 4:10 PM
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Reposted by Ethan (Chee Kiang) Ewe
New preprint!
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Extrachromosomal arrays are unique chromosome-like structures created from DNA injected into the C. elegans germline. Arrays are easy to create and allow for high expression of multiple transgenes. Th...
www.biorxiv.org
November 13, 2025 at 2:59 AM
New preprint!
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
Reposted by Ethan (Chee Kiang) Ewe
C. elegans enthusiasts- save the date for two consecutive C. elegans meetings, taking place in Bordeaux, 29 June–3 July 2026.
Abstract submission will open around January, with many opportunities for oral presentations.
Check out our website for more details: ceneuroeuro2026.sciencesconf.org.
Abstract submission will open around January, with many opportunities for oral presentations.
Check out our website for more details: ceneuroeuro2026.sciencesconf.org.
European C. elegans and CeNEURO Meeting 2026 - Sciencesconf.org
2026 European C. elegans and CeNEURO meeting
ceneuroeuro2026.sciencesconf.org
November 13, 2025 at 1:08 PM
C. elegans enthusiasts- save the date for two consecutive C. elegans meetings, taking place in Bordeaux, 29 June–3 July 2026.
Abstract submission will open around January, with many opportunities for oral presentations.
Check out our website for more details: ceneuroeuro2026.sciencesconf.org.
Abstract submission will open around January, with many opportunities for oral presentations.
Check out our website for more details: ceneuroeuro2026.sciencesconf.org.
Reposted by Ethan (Chee Kiang) Ewe
The C. elegans community is amazing. I email a Nobel laureate for a favor. He immediately responds yes and offers additional help!
a woman with a big hairdo is singing and the words simply the best are above her
ALT: a woman with a big hairdo is singing and the words simply the best are above her
media.tenor.com
November 11, 2025 at 10:48 PM
The C. elegans community is amazing. I email a Nobel laureate for a favor. He immediately responds yes and offers additional help!
Reposted by Ethan (Chee Kiang) Ewe
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans - Nature Communications
This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...
www.nature.com
November 10, 2025 at 3:16 PM
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ethan (Chee Kiang) Ewe
Just channeling Stephen J Gould: "I am, somehow, less interested in the weight and convolutions of Einstein's brain than in the near certainty that people of equal talent have lived and died in cotton fields and sweatshops"
November 8, 2025 at 12:12 AM
Just channeling Stephen J Gould: "I am, somehow, less interested in the weight and convolutions of Einstein's brain than in the near certainty that people of equal talent have lived and died in cotton fields and sweatshops"
Reposted by Ethan (Chee Kiang) Ewe
Harmit is the anti-toxin to Watson
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:51 PM
Harmit is the anti-toxin to Watson
Reposted by Ethan (Chee Kiang) Ewe
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
November 8, 2025 at 1:58 PM
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
Reposted by Ethan (Chee Kiang) Ewe
Watson's original title for The Double Helix was Honest Jim.
I think it was honest, but only in the sense that it revealed Watson and not reality.
He was an ambitious, arrogant, misogynistic, and opportunistic man who managed to get himself into the right place at the right time.
41/41
I think it was honest, but only in the sense that it revealed Watson and not reality.
He was an ambitious, arrogant, misogynistic, and opportunistic man who managed to get himself into the right place at the right time.
41/41
November 8, 2025 at 1:58 PM
Watson's original title for The Double Helix was Honest Jim.
I think it was honest, but only in the sense that it revealed Watson and not reality.
He was an ambitious, arrogant, misogynistic, and opportunistic man who managed to get himself into the right place at the right time.
41/41
I think it was honest, but only in the sense that it revealed Watson and not reality.
He was an ambitious, arrogant, misogynistic, and opportunistic man who managed to get himself into the right place at the right time.
41/41
Reposted by Ethan (Chee Kiang) Ewe
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Ethan (Chee Kiang) Ewe
Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 6, 2025 at 1:17 PM
Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Ethan (Chee Kiang) Ewe
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
Tardigrade Dsup extends C. elegans life span by reducing mitochondrial activity and enhancing stress resistance.
www.science.org
November 4, 2025 at 7:26 PM
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Ethan (Chee Kiang) Ewe
1/ Evolutionary trade-offs between intergenerational and transgenerational fitness effects
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
November 5, 2025 at 12:18 PM
1/ Evolutionary trade-offs between intergenerational and transgenerational fitness effects
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
Reposted by Ethan (Chee Kiang) Ewe
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1
November 3, 2025 at 6:30 PM
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1
Reposted by Ethan (Chee Kiang) Ewe
1/ @reviewcommons.org, @embo.org's preprint peer review platform, is taking an important step forward. Multiple publishers, including eLife, are now jointly running the peer-review process on behalf of the platform.
🔗 buff.ly/Rm1XotK
🔗 buff.ly/Rm1XotK
October 30, 2025 at 2:45 PM
1/ @reviewcommons.org, @embo.org's preprint peer review platform, is taking an important step forward. Multiple publishers, including eLife, are now jointly running the peer-review process on behalf of the platform.
🔗 buff.ly/Rm1XotK
🔗 buff.ly/Rm1XotK
Reposted by Ethan (Chee Kiang) Ewe
And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!
Pseudouridine selects RNAs for extracellular transport
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...
www.biorxiv.org
November 2, 2025 at 7:44 PM
And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!
Reposted by Ethan (Chee Kiang) Ewe
Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche
Read this #LifelongDevSI #OA Research Article by Nilay Gupta, Mia Sinks and E. Jane Albert Hubbard doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Research Article by Nilay Gupta, Mia Sinks and E. Jane Albert Hubbard doi.org/10.1242/dev....
October 31, 2025 at 6:02 PM
Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche
Read this #LifelongDevSI #OA Research Article by Nilay Gupta, Mia Sinks and E. Jane Albert Hubbard doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Research Article by Nilay Gupta, Mia Sinks and E. Jane Albert Hubbard doi.org/10.1242/dev....
Reposted by Ethan (Chee Kiang) Ewe
Our new tool for automating the quantification of synapses (or any other fluorescent puncta) in C. elegans is published- please try it out!! journals.plos.org/ploscompbiol...
WormSNAP: A software for fast, accurate, and unbiased detection of fluorescent puncta in C. elegans
Author summary Here we describe software designed to increase the ease, speed and reliability of analyzing images of fluorescently tagged proteins in C. elegans, a microscopic worm proven to be a powe...
journals.plos.org
October 31, 2025 at 10:16 PM
Our new tool for automating the quantification of synapses (or any other fluorescent puncta) in C. elegans is published- please try it out!! journals.plos.org/ploscompbiol...
Reposted by Ethan (Chee Kiang) Ewe
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
doi.org
October 29, 2025 at 11:57 AM
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
Reposted by Ethan (Chee Kiang) Ewe
New preprint! We unexpectedly discovered that some Caenorhabditis species delete parts of their somatic genome early in development, which fragments their chromosomes and eliminates key germline genes. Multiple lines of evidence suggest this bizarre process was present in the ancestors of C. elegans
October 28, 2025 at 12:11 PM
New preprint! We unexpectedly discovered that some Caenorhabditis species delete parts of their somatic genome early in development, which fragments their chromosomes and eliminates key germline genes. Multiple lines of evidence suggest this bizarre process was present in the ancestors of C. elegans
Reposted by Ethan (Chee Kiang) Ewe
Conserved Gene Expression Plasticity in Development Is More Pervasive Than Expression Divergence Between Species of Caenorhabditis Nematodes https://onlinelibrary.wiley.com/doi/10.1111/ede.70018 #EvoDevo
October 26, 2025 at 1:00 PM
Conserved Gene Expression Plasticity in Development Is More Pervasive Than Expression Divergence Between Species of Caenorhabditis Nematodes https://onlinelibrary.wiley.com/doi/10.1111/ede.70018 #EvoDevo
Reposted by Ethan (Chee Kiang) Ewe
!!
Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis
www.pnas.org/doi/10.1073/...
Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis
www.pnas.org/doi/10.1073/...
Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis | PNAS
Zygotic reproductive isolation frequently initiates with hybrid incompatibility in
the heterogametic sex, such as males in XX/XY systems. The genet...
www.pnas.org
October 26, 2025 at 2:16 AM
!!
Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis
www.pnas.org/doi/10.1073/...
Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis
www.pnas.org/doi/10.1073/...
👇👇👇👇👇👇👇
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
October 25, 2025 at 7:02 PM
👇👇👇👇👇👇👇
Reposted by Ethan (Chee Kiang) Ewe
Excited to share our new work on transgenerational adaptation www.science.org/doi/epdf/10.... out today spearheaded by outstanding former undergraduate @kathleenkim.bsky.social. C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content, + longevity 1/9
Transgenerational adaptation to hypoxia
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www.science.org
October 24, 2025 at 7:32 PM
Excited to share our new work on transgenerational adaptation www.science.org/doi/epdf/10.... out today spearheaded by outstanding former undergraduate @kathleenkim.bsky.social. C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content, + longevity 1/9