Richard Maguire
@drmagsmaguire.bsky.social
Developmental biologist, biomedical sciences leaning lecturer @BiologyatYork , stats nerd. Personal account. Boring views.
Interested in too many things. Pretends to be an 'all rounder'. Not actually good at much.
Interested in too many things. Pretends to be an 'all rounder'. Not actually good at much.
Reposted by Richard Maguire
Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!
#DBFeature 🐣🫁
Increasing fluid pressure in chick embryonic airways disrupts normal branching and proliferation, while lower pressure encourages branching without affecting cell proliferation
By S Mohr-Allen, J Gleghorn, and V Varner
tinyurl.com/5fyevrd3
#SpecialIssue on Avian model systems
Increasing fluid pressure in chick embryonic airways disrupts normal branching and proliferation, while lower pressure encourages branching without affecting cell proliferation
By S Mohr-Allen, J Gleghorn, and V Varner
tinyurl.com/5fyevrd3
#SpecialIssue on Avian model systems
September 18, 2025 at 12:04 PM
Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!
Reposted by Richard Maguire
Are some GLP-1 medicines more cardioprotective than others? #easd25 A new real world study using US Medicare data www.novonordisk.com/content/nnco...
September 18, 2025 at 10:26 AM
Are some GLP-1 medicines more cardioprotective than others? #easd25 A new real world study using US Medicare data www.novonordisk.com/content/nnco...
Reposted by Richard Maguire
I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt
A robustly rooted tree of eukaryotes reveals their excavate ancestry - Nature
The root of the eukaryote Tree of Life is estimated from a new, larger dataset of mitochondrial proteins including all known eukaryotic supergroups, showing it lies between two multi-supergroup assemb...
doi.org
March 14, 2025 at 11:38 AM
I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt
Reposted by Richard Maguire
Fantastic city, excellent university.
Apply!
Apply!
Can I tempt some young minds to consider Old York for a PhD?
Some days left to apply.
Open to applicants WORLDWIDE 🌎.
Some days left to apply.
Open to applicants WORLDWIDE 🌎.
March 16, 2025 at 8:59 AM
Fantastic city, excellent university.
Apply!
Apply!
Reposted by Richard Maguire
An ascidian egg dividing - as seen with fluorescent LifeAct protein (labels actin). The cleavage ring becoming smaller. Thanks to the Ascidian BioCell Team at LBDV
December 3, 2024 at 3:14 PM
An ascidian egg dividing - as seen with fluorescent LifeAct protein (labels actin). The cleavage ring becoming smaller. Thanks to the Ascidian BioCell Team at LBDV
Reposted by Richard Maguire
Happy New Year! I hope 2025 is good for you all. We start this year with a somewhat controversial review. www.sciencedirect.com/science/arti.... Here, we discuss how a cell receives signalling receptors from neighbouring cells, allowing the receivers to transduce a previously unknown signal. 1/3
January 6, 2025 at 9:31 AM
Happy New Year! I hope 2025 is good for you all. We start this year with a somewhat controversial review. www.sciencedirect.com/science/arti.... Here, we discuss how a cell receives signalling receptors from neighbouring cells, allowing the receivers to transduce a previously unknown signal. 1/3
Reposted by Richard Maguire
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The lives of cells, recorded - Nature Reviews Genetics
Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...
www.nature.com
November 25, 2024 at 5:29 PM
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Richard Maguire
Context is everything: How context influences the way the brain processes concepts.
Context is everything
How the brain processes concepts is influenced by contextual information, such as what a person is seeing, suggests new study.
buff.ly
December 8, 2024 at 9:21 AM
Context is everything: How context influences the way the brain processes concepts.
Reposted by Richard Maguire
How to read a scientific paper @science.org
"Nothing makes you feel stupid quite like reading a scientific journal article."
Open Access
www.science.org/content/arti...
"Nothing makes you feel stupid quite like reading a scientific journal article."
Open Access
www.science.org/content/arti...
December 6, 2024 at 11:46 AM
How to read a scientific paper @science.org
"Nothing makes you feel stupid quite like reading a scientific journal article."
Open Access
www.science.org/content/arti...
"Nothing makes you feel stupid quite like reading a scientific journal article."
Open Access
www.science.org/content/arti...
Reposted by Richard Maguire
This is such a cool example (and one of the most convincing I've seen) of non-coding RNAs having powerful and direct control over phenotype (melanization)! 🦋
A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
www.science.org
December 6, 2024 at 10:58 AM
This is such a cool example (and one of the most convincing I've seen) of non-coding RNAs having powerful and direct control over phenotype (melanization)! 🦋
Reposted by Richard Maguire
All the time
December 6, 2024 at 10:56 AM
All the time
Reposted by Richard Maguire
This episode hits the nail on its head. It failed to mention the negative impact on research capacity & that unis are held back from educating talent to raise UK's competitiveness. The lady calling lecturers lazy should apologise. I would love to compare our workloads! www.bbc.co.uk/sounds/play/...
File on 4 - The International Student Scandal - BBC Sounds
Are UK universities ignoring poor English language skills to attract overseas students?
www.bbc.co.uk
December 4, 2024 at 9:57 AM
This episode hits the nail on its head. It failed to mention the negative impact on research capacity & that unis are held back from educating talent to raise UK's competitiveness. The lady calling lecturers lazy should apologise. I would love to compare our workloads! www.bbc.co.uk/sounds/play/...
Reposted by Richard Maguire
"Researchers studying ageing disagree on just about everything — including what ageing is, whether it is a disease and when it starts — according to a survey of about 100 scientists working in the field."
by @smritimallapaty.bsky.social in Nature.
www.nature.com/articles/d41...
by @smritimallapaty.bsky.social in Nature.
www.nature.com/articles/d41...
What is ageing? Even the field’s researchers can’t agree
Survey of scientists who study ageing finds no consensus on the fundamentals.
www.nature.com
December 3, 2024 at 9:36 PM
"Researchers studying ageing disagree on just about everything — including what ageing is, whether it is a disease and when it starts — according to a survey of about 100 scientists working in the field."
by @smritimallapaty.bsky.social in Nature.
www.nature.com/articles/d41...
by @smritimallapaty.bsky.social in Nature.
www.nature.com/articles/d41...
Reposted by Richard Maguire
I've been having a lot of fun with this (ongoing) project with my colleagues @zunlongke.bsky.social and @danleahy.bsky.social, who have both just joined bluesky. 1/4
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
November 29, 2024 at 5:47 PM
I've been having a lot of fun with this (ongoing) project with my colleagues @zunlongke.bsky.social and @danleahy.bsky.social, who have both just joined bluesky. 1/4
Reposted by Richard Maguire
Such cool structures of signaling receptors here!
I've been having a lot of fun with this (ongoing) project with my colleagues @zunlongke.bsky.social and @danleahy.bsky.social, who have both just joined bluesky. 1/4
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
November 29, 2024 at 5:53 PM
Such cool structures of signaling receptors here!
Cool starter packs 8 & 9! by @aineurolab.bsky.social , Dev Bio I & II:
bsky.app/starter-pack...
bsky.app/starter-pack...
I merged these into a single list: bsky.app/profile/drma... using this excellent tool: nws-bot.us/bskyStarterP...
There doesn't seem to be a limit & I can use them as feeds!
bsky.app/starter-pack...
bsky.app/starter-pack...
I merged these into a single list: bsky.app/profile/drma... using this excellent tool: nws-bot.us/bskyStarterP...
There doesn't seem to be a limit & I can use them as feeds!
November 30, 2024 at 10:13 AM
Cool starter packs 8 & 9! by @aineurolab.bsky.social , Dev Bio I & II:
bsky.app/starter-pack...
bsky.app/starter-pack...
I merged these into a single list: bsky.app/profile/drma... using this excellent tool: nws-bot.us/bskyStarterP...
There doesn't seem to be a limit & I can use them as feeds!
bsky.app/starter-pack...
bsky.app/starter-pack...
I merged these into a single list: bsky.app/profile/drma... using this excellent tool: nws-bot.us/bskyStarterP...
There doesn't seem to be a limit & I can use them as feeds!
Reposted by Richard Maguire
A concerning #trend in #basicsciences🧪: Following a drop in student numbers, the University of Hull is closing its Chemistry Department because courses are “not financially nor educationally sustainable” 😳🤔
#education #academic #stem #highereducation
www.bbc.com/news/article...
#education #academic #stem #highereducation
www.bbc.com/news/article...
University of Hull to close its chemistry department - BBC News
The university is also merging some of its schools following a drop in student numbers.
www.bbc.com
November 30, 2024 at 9:17 AM
A concerning #trend in #basicsciences🧪: Following a drop in student numbers, the University of Hull is closing its Chemistry Department because courses are “not financially nor educationally sustainable” 😳🤔
#education #academic #stem #highereducation
www.bbc.com/news/article...
#education #academic #stem #highereducation
www.bbc.com/news/article...
Reposted by Richard Maguire
For our very first #FluorescenceFriday on #BlueSky, let's go back to arguably the most fundamental process of development: mitosis. I just never get tired of watching the chromosomes dance. Sample: ectodermal cells, nuclei: H2B-mCherry, plasma membrane: RFP-CAAX.
November 30, 2024 at 12:06 AM
For our very first #FluorescenceFriday on #BlueSky, let's go back to arguably the most fundamental process of development: mitosis. I just never get tired of watching the chromosomes dance. Sample: ectodermal cells, nuclei: H2B-mCherry, plasma membrane: RFP-CAAX.
Reposted by Richard Maguire
Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration
Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues:
https://buff.ly/49hhwIf
Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues:
https://buff.ly/49hhwIf
November 30, 2024 at 9:51 AM
Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration
Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues:
https://buff.ly/49hhwIf
Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues:
https://buff.ly/49hhwIf
Reposted by Richard Maguire
Reposted by Richard Maguire
Right??? There was a great paper from Rachel Green's lab on this too. doi.org/10.1016/j.ce...
November 27, 2024 at 6:59 AM
Right??? There was a great paper from Rachel Green's lab on this too. doi.org/10.1016/j.ce...
Reposted by Richard Maguire
sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
Solar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cel…
www.sciencedirect.com
November 27, 2024 at 1:22 AM
sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...
Reposted by Richard Maguire
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Richard Maguire
Really excited to launch the megabouts.ai project from @adrienjouary.bsky.social. The era of large-scale behavioral data brings with it the challenge of how to integrate and compare data acquired using diverse set-ups and tracking approaches. (1/n)
November 29, 2024 at 1:30 PM
Really excited to launch the megabouts.ai project from @adrienjouary.bsky.social. The era of large-scale behavioral data brings with it the challenge of how to integrate and compare data acquired using diverse set-ups and tracking approaches. (1/n)
Reposted by Richard Maguire
So far I tend to agree with this. Bluesky's corporate aims and goals are different than the user expectation for it, and no one company will make 23 million users 100% happy 100% of the time. But they've been good at communication and in giving users tools to create their own space. Tricky stuff.
Go too far in the enshittification direction and you become Twitter. But go too far in the opposite direction, prioritizing purity over engagement and onboarding, and you become Mastodon.
BlueSky has managed this tradeoff so well. We should still be vigilant, but kudos to a fantastic platform.
BlueSky has managed this tradeoff so well. We should still be vigilant, but kudos to a fantastic platform.
November 29, 2024 at 1:48 PM
So far I tend to agree with this. Bluesky's corporate aims and goals are different than the user expectation for it, and no one company will make 23 million users 100% happy 100% of the time. But they've been good at communication and in giving users tools to create their own space. Tricky stuff.