Edward Marcotte
@edwardmarcotte.bsky.social
Systems & synthetic biologist, proteomics, bioinformatics; Professor of Molecular Biosciences @ UT Austin; Cofounder, Erisyon
Reposted by Edward Marcotte
Integrative Biology at UT is hiring an Evolutionary Biologist! Happy to answer any questions about the position/dept/UT. Come join us!
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
Decoding Nature’s Networks
The Department of Integrative Biology at The University of Texas at Austin
integrativebio.utexas.edu
November 17, 2025 at 3:52 PM
Integrative Biology at UT is hiring an Evolutionary Biologist! Happy to answer any questions about the position/dept/UT. Come join us!
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
Really enjoying watching science happen in real time, with @archaeal.bsky.social, @valdeanda.bsky.social, and colleagues live streaming their robot sub data collection from the R/V Falkor off of the coast of Uruguay
Starting at 7pm Central I will be streaming from the bottom of the ocean off the coast of Uruguay!
Feel free to join and ask questions.
www.youtube.com/@SchmidtOcean
Feel free to join and ask questions.
www.youtube.com/@SchmidtOcean
Schmidt Ocean
Our Purpose: to excite interest and inform the wise stewardship of our planet.
Our Mission: Catalyze the discoveries needed to understand our ocean, sustain life, and ensure the health of our planet ...
www.youtube.com
November 15, 2025 at 3:29 AM
Really enjoying watching science happen in real time, with @archaeal.bsky.social, @valdeanda.bsky.social, and colleagues live streaming their robot sub data collection from the R/V Falkor off of the coast of Uruguay
Reposted by Edward Marcotte
Starting at 7pm Central I will be streaming from the bottom of the ocean off the coast of Uruguay!
Feel free to join and ask questions.
www.youtube.com/@SchmidtOcean
Feel free to join and ask questions.
www.youtube.com/@SchmidtOcean
Schmidt Ocean
Our Purpose: to excite interest and inform the wise stewardship of our planet.
Our Mission: Catalyze the discoveries needed to understand our ocean, sustain life, and ensure the health of our planet ...
www.youtube.com
November 14, 2025 at 7:39 PM
Starting at 7pm Central I will be streaming from the bottom of the ocean off the coast of Uruguay!
Feel free to join and ask questions.
www.youtube.com/@SchmidtOcean
Feel free to join and ask questions.
www.youtube.com/@SchmidtOcean
Reposted by Edward Marcotte
Asgard collaborative expedition begins… Falkor (too) has left Montevideo
November 13, 2025 at 12:53 PM
Asgard collaborative expedition begins… Falkor (too) has left Montevideo
Reposted by Edward Marcotte
My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have.
apply.interfolio.com/177547
apply.interfolio.com/177547
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 13, 2025 at 3:23 PM
My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have.
apply.interfolio.com/177547
apply.interfolio.com/177547
Reposted by Edward Marcotte
A wonderful collaboration between my lab and Andy Ellington and Edward Marcotte here at UT.
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
Plastic degradation by enzymes from uncultured deep sea microorganisms
Abstract. Polyethylene terephthalate (PET)-hydrolyzing enzymes (PETases) are a recently discovered enzyme class capable of plastic degradation. PETases are
academic.oup.com
November 10, 2025 at 6:04 PM
A wonderful collaboration between my lab and Andy Ellington and Edward Marcotte here at UT.
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
Reposted by Edward Marcotte
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Edward Marcotte
Baker Lab 2025
The container is our field gear for the research expedition for Uruguay.
sites.utexas.edu/baker-lab/sp...
The container is our field gear for the research expedition for Uruguay.
sites.utexas.edu/baker-lab/sp...
September 18, 2025 at 9:35 PM
Baker Lab 2025
The container is our field gear for the research expedition for Uruguay.
sites.utexas.edu/baker-lab/sp...
The container is our field gear for the research expedition for Uruguay.
sites.utexas.edu/baker-lab/sp...
Reposted by Edward Marcotte
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Edward Marcotte
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Edward Marcotte
New: Researchers are broadly rejecting the Trump administration's compact. In faculty votes and student protests, they have mobilized to pressure their universities—to some effect: 6 of the original 9 universities have rejected the compact
With @alexwitze.bsky.social and @jennaahart.bsky.social:
With @alexwitze.bsky.social and @jennaahart.bsky.social:
How scientists are pushing back against Trump’s funding ‘deal’ for universities
Six institutions have so far rejected the administration’s list of demands over academic freedom concerns.
www.nature.com
October 20, 2025 at 4:36 PM
New: Researchers are broadly rejecting the Trump administration's compact. In faculty votes and student protests, they have mobilized to pressure their universities—to some effect: 6 of the original 9 universities have rejected the compact
With @alexwitze.bsky.social and @jennaahart.bsky.social:
With @alexwitze.bsky.social and @jennaahart.bsky.social:
Reposted by Edward Marcotte
Congratulations to this year's cohort of Packard Fellows! @packardfdn.bsky.social
Such a great program, especially needed in these times.
www.packard.org/insights/new...
Such a great program, especially needed in these times.
www.packard.org/insights/new...
The David and Lucile Packard Foundation Announces the 2025 Class of Packard Fellows for Science and Engineering • The David and Lucile Packard Foundation
The David and Lucile Packard Foundation announced today the recipients of the 2025 Packard Fellowships for Science and Engineering. This year’s class features 20 innovative early-career scientists and...
www.packard.org
October 15, 2025 at 2:11 PM
Congratulations to this year's cohort of Packard Fellows! @packardfdn.bsky.social
Such a great program, especially needed in these times.
www.packard.org/insights/new...
Such a great program, especially needed in these times.
www.packard.org/insights/new...
Reposted by Edward Marcotte
So sad to hear the news - John truly was an inspiration to so many, and one of a kind.
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 4:02 PM
So sad to hear the news - John truly was an inspiration to so many, and one of a kind.
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Reposted by Edward Marcotte
So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!
October 4, 2025 at 8:56 AM
So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!
Reposted by Edward Marcotte
Delightful to finally meet you @edwardmarcotte.bsky.social and hear about your crazy cool science exploring the proteomes of all the diverse beasties on the planet to reconstruct LECA 🧪🌎. Now I see where Caitie gets it from 👨🔬👩🔬
October 4, 2025 at 10:28 AM
Delightful to finally meet you @edwardmarcotte.bsky.social and hear about your crazy cool science exploring the proteomes of all the diverse beasties on the planet to reconstruct LECA 🧪🌎. Now I see where Caitie gets it from 👨🔬👩🔬
Reposted by Edward Marcotte
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
September 30, 2025 at 9:52 AM
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
Reposted by Edward Marcotte
Love #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms
September 24, 2025 at 3:14 PM
Love #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms
Reposted by Edward Marcotte
Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 24, 2025 at 12:03 PM
Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬
Reposted by Edward Marcotte
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Reposted by Edward Marcotte
The #PRETZEL is out !!!
Okay the CAGE renamed now fine.
Congrats @computingcaitie.bsky.social and team!!
Okay the CAGE renamed now fine.
Congrats @computingcaitie.bsky.social and team!!
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:26 PM
The #PRETZEL is out !!!
Okay the CAGE renamed now fine.
Congrats @computingcaitie.bsky.social and team!!
Okay the CAGE renamed now fine.
Congrats @computingcaitie.bsky.social and team!!
Reposted by Edward Marcotte
YAYYYY, Immune systems of choano !!!!
Beautiful to see how knowledge about bacterial immune systems illuminate immunology in diverse organisms with the always incredible biochemistry and structural approaches of @kranzuschlab.bsky.social.
Wonderful work @yao-li.bsky.social 👏
Beautiful to see how knowledge about bacterial immune systems illuminate immunology in diverse organisms with the always incredible biochemistry and structural approaches of @kranzuschlab.bsky.social.
Wonderful work @yao-li.bsky.social 👏
How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 5, 2025 at 3:56 PM
YAYYYY, Immune systems of choano !!!!
Beautiful to see how knowledge about bacterial immune systems illuminate immunology in diverse organisms with the always incredible biochemistry and structural approaches of @kranzuschlab.bsky.social.
Wonderful work @yao-li.bsky.social 👏
Beautiful to see how knowledge about bacterial immune systems illuminate immunology in diverse organisms with the always incredible biochemistry and structural approaches of @kranzuschlab.bsky.social.
Wonderful work @yao-li.bsky.social 👏
Reposted by Edward Marcotte
Super excited for the full data, especially to see which of the over 400 screened binders actually got us the third place 🥳
Shout-out to the organizers for this very cool competition!
Shout-out to the organizers for this very cool competition!
🚨The Bits to Binders Competition has concluded!🧬
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
September 2, 2025 at 6:10 PM
Super excited for the full data, especially to see which of the over 400 screened binders actually got us the third place 🥳
Shout-out to the organizers for this very cool competition!
Shout-out to the organizers for this very cool competition!
Reposted by Edward Marcotte
🚨The Bits to Binders Competition has concluded!🧬
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
September 2, 2025 at 2:45 PM
🚨The Bits to Binders Competition has concluded!🧬
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
Reposted by Edward Marcotte
Wishing a happy 83rd birthday to mathematician Karen Uhlenbeck, winner of the 2019 Abel Prize for her work applying gauge theory to four dimensional manifolds. Here is her story!
tinyurl.com/ybmvcbpx
#WomenInSTEM #MathSky #HistSci 🧮
tinyurl.com/ybmvcbpx
#WomenInSTEM #MathSky #HistSci 🧮
Non-Linear: How Mathematical Lone Wolf Karen Uhlenbeck Found Her Pack
When you first walk into secondary school your first year and plop yourself nervously into a desk in the back of your geometry class (because you’re far too cool to sit in the front seats), one of the...
tinyurl.com
August 24, 2025 at 3:06 PM
Wishing a happy 83rd birthday to mathematician Karen Uhlenbeck, winner of the 2019 Abel Prize for her work applying gauge theory to four dimensional manifolds. Here is her story!
tinyurl.com/ybmvcbpx
#WomenInSTEM #MathSky #HistSci 🧮
tinyurl.com/ybmvcbpx
#WomenInSTEM #MathSky #HistSci 🧮
Reposted by Edward Marcotte
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy
Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...
www.biorxiv.org
August 5, 2025 at 4:21 PM
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...