Chris Thorpe
@drchristhorpe.bsky.social
Immunology/bioinformatics. Working towards higher fidelity models of MHC:peptide complexes/tools for immunologists/equity in data
EMBL / Marie Skłodowska-Curie Actions ARISE fellow.
https://orcid.org/0000-0002-4341-0320
https://www.histo.fyi/
EMBL / Marie Skłodowska-Curie Actions ARISE fellow.
https://orcid.org/0000-0002-4341-0320
https://www.histo.fyi/
Reposted by Chris Thorpe
🚨 Today is a big day for #BSI25... two deadlines!
📝 Late breaking abstract submissions close tonight
💳 Early bird registration also ends today
This is your last chance to present your work and secure your place at the best rate ➡️ https://bit.ly/3K6eFJz
📝 Late breaking abstract submissions close tonight
💳 Early bird registration also ends today
This is your last chance to present your work and secure your place at the best rate ➡️ https://bit.ly/3K6eFJz
October 22, 2025 at 9:00 AM
🚨 Today is a big day for #BSI25... two deadlines!
📝 Late breaking abstract submissions close tonight
💳 Early bird registration also ends today
This is your last chance to present your work and secure your place at the best rate ➡️ https://bit.ly/3K6eFJz
📝 Late breaking abstract submissions close tonight
💳 Early bird registration also ends today
This is your last chance to present your work and secure your place at the best rate ➡️ https://bit.ly/3K6eFJz
Reposted by Chris Thorpe
Journalist Edward R. Murrow used his platform on CBS to criticize the witch hunts led by Senator Joseph McCarthy in the 1950s.
This is what real journalism should do — hold power to account, not capitulate to it.
This is what real journalism should do — hold power to account, not capitulate to it.
October 6, 2025 at 8:57 PM
Journalist Edward R. Murrow used his platform on CBS to criticize the witch hunts led by Senator Joseph McCarthy in the 1950s.
This is what real journalism should do — hold power to account, not capitulate to it.
This is what real journalism should do — hold power to account, not capitulate to it.
Reposted by Chris Thorpe
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Reposted by Chris Thorpe
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
September 28, 2025 at 9:16 PM
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
I’ll just leave this here as it’s awesome in every way and very needed.
Thank you Pulp and LCD Soundsystem. And of course Heaven 17
youtu.be/ydWHNkLtpcA
Thank you Pulp and LCD Soundsystem. And of course Heaven 17
youtu.be/ydWHNkLtpcA
LCD Soundsystem & Pulp - (We Don’t Need This) Fascist Groove Thang, Hollywood Bowl, LA, CA 9-26-25
YouTube video by Prestoff2001
youtu.be
September 28, 2025 at 8:27 PM
I’ll just leave this here as it’s awesome in every way and very needed.
Thank you Pulp and LCD Soundsystem. And of course Heaven 17
youtu.be/ydWHNkLtpcA
Thank you Pulp and LCD Soundsystem. And of course Heaven 17
youtu.be/ydWHNkLtpcA
Reposted by Chris Thorpe
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo
Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
September 28, 2025 at 11:55 AM
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
If you see this, post a bridge.
September 27, 2025 at 8:26 AM
If you see this, post a bridge.
Reposted by Chris Thorpe
Labor productivity has more than doubled since the late 1960s. But workers’ compensation has barely budged.
Yes. The economy is rigged in favor of the wealthy.
Yes. The economy is rigged in favor of the wealthy.
September 26, 2025 at 8:32 PM
Labor productivity has more than doubled since the late 1960s. But workers’ compensation has barely budged.
Yes. The economy is rigged in favor of the wealthy.
Yes. The economy is rigged in favor of the wealthy.
Reposted by Chris Thorpe
We are hiring a PhD student 🎓
Work with me and Matthias Rüdt in our department on an exciting industry collaboration with Lonza combining high-throughput experiments and molecular modelling using AlphaFold and MolecularDynamics
📍 Sion, Valais, Switzerland
More info: www.jobup.ch/fr/emplois/d...
Work with me and Matthias Rüdt in our department on an exciting industry collaboration with Lonza combining high-throughput experiments and molecular modelling using AlphaFold and MolecularDynamics
📍 Sion, Valais, Switzerland
More info: www.jobup.ch/fr/emplois/d...
September 25, 2025 at 11:19 AM
We are hiring a PhD student 🎓
Work with me and Matthias Rüdt in our department on an exciting industry collaboration with Lonza combining high-throughput experiments and molecular modelling using AlphaFold and MolecularDynamics
📍 Sion, Valais, Switzerland
More info: www.jobup.ch/fr/emplois/d...
Work with me and Matthias Rüdt in our department on an exciting industry collaboration with Lonza combining high-throughput experiments and molecular modelling using AlphaFold and MolecularDynamics
📍 Sion, Valais, Switzerland
More info: www.jobup.ch/fr/emplois/d...
Reposted by Chris Thorpe
MolViewSpec: describe, share, and reproduce Mol* molecular scenes with a simple extension
MolViewSpec: a Mol* extension for describing and sharing molecular visualizations
Abstract. Data visualization is a pivotal component of a structural biologist’s arsenal. The Mol* Viewer makes molecular visualizations available to broade
academic.oup.com
September 24, 2025 at 4:12 PM
MolViewSpec: describe, share, and reproduce Mol* molecular scenes with a simple extension
Reposted by Chris Thorpe
Investing in people behind medical research fuels UK growth. A new report by Frontier Economics (funded by @amrc-uk.bsky.social & @wellcometrust.bsky.social) shows non-commercial clinical research adds £72.7bn to the economy. Driving innovation in prevention, diagnosis & treatment.
bit.ly/3KrW7nf
bit.ly/3KrW7nf
September 24, 2025 at 12:44 PM
Investing in people behind medical research fuels UK growth. A new report by Frontier Economics (funded by @amrc-uk.bsky.social & @wellcometrust.bsky.social) shows non-commercial clinical research adds £72.7bn to the economy. Driving innovation in prevention, diagnosis & treatment.
bit.ly/3KrW7nf
bit.ly/3KrW7nf
Reposted by Chris Thorpe
Reposted by Chris Thorpe
Why did all of us never realise the greatest medical breakthroughs were this easy! Evidence from controlled studies with a sample size of millions falls away in thrall to a ‘feeling’ that it was the mothers’ ‘fault’ all along
The @washingtonpost.com story on Tylenol & autism leaves out a MAJOR 2.5M sibling-controlled study of children in Denmark, which "found no evidence that acetaminophen use during pregnancy was associated with children’s risk of autism, ADHD or intellectual disability." jamanetwork.com/journals/jam...
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
jamanetwork.com
September 23, 2025 at 5:42 AM
Why did all of us never realise the greatest medical breakthroughs were this easy! Evidence from controlled studies with a sample size of millions falls away in thrall to a ‘feeling’ that it was the mothers’ ‘fault’ all along
Reposted by Chris Thorpe
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 2:39 PM
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Today I had to install Adobe InDesign, remind myself how to use it after almost 20 years and deliver files for printing in the space of 2 hours or the conference would not have had nice name badges. Underworld playlist helped.
I'm also on holiday, so I then went for a walk in this heavenly place.
I'm also on holiday, so I then went for a walk in this heavenly place.
September 22, 2025 at 7:10 PM
Today I had to install Adobe InDesign, remind myself how to use it after almost 20 years and deliver files for printing in the space of 2 hours or the conference would not have had nice name badges. Underworld playlist helped.
I'm also on holiday, so I then went for a walk in this heavenly place.
I'm also on holiday, so I then went for a walk in this heavenly place.
Reposted by Chris Thorpe
GPU-accelerated MMseqs2 offers tremendous speedup for homology retrieval, protein structure prediction with ColabFold, and protein structure search with Foldseek. @martinsteinegger.bsky.social @milot.bsky.social @machine.learning.bio
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
www.nature.com
September 18, 2025 at 8:09 PM
GPU-accelerated MMseqs2 offers tremendous speedup for homology retrieval, protein structure prediction with ColabFold, and protein structure search with Foldseek. @martinsteinegger.bsky.social @milot.bsky.social @machine.learning.bio
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chris Thorpe
Immunology affects everyone.
Join our new PPI Network to bring your voice into research & policy.
No science background needed – just passion & lived experience.
Applications close in 1 week.
🔗 https://bit.ly/3Jz7cT6
Join our new PPI Network to bring your voice into research & policy.
No science background needed – just passion & lived experience.
Applications close in 1 week.
🔗 https://bit.ly/3Jz7cT6
September 15, 2025 at 9:12 AM
Immunology affects everyone.
Join our new PPI Network to bring your voice into research & policy.
No science background needed – just passion & lived experience.
Applications close in 1 week.
🔗 https://bit.ly/3Jz7cT6
Join our new PPI Network to bring your voice into research & policy.
No science background needed – just passion & lived experience.
Applications close in 1 week.
🔗 https://bit.ly/3Jz7cT6
Reposted by Chris Thorpe
MLSB is coming to Copenhagen, DK 🎉
Submission is under the same portal, just simply indicate your location preference(s).
Submission is under the same portal, just simply indicate your location preference(s).
You asked and we listened... @workshopmlsb.bsky.social is excited to be expanding to Copenhagen, DK at @euripsconf.bsky.social 🎉
Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫
Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫
September 12, 2025 at 12:45 PM
MLSB is coming to Copenhagen, DK 🎉
Submission is under the same portal, just simply indicate your location preference(s).
Submission is under the same portal, just simply indicate your location preference(s).
Reposted by Chris Thorpe
Really useful update from Bob Hawkins on Long Covid in England from the annual GP survey
bhawkins3.substack.com/p/long-covid...
bhawkins3.substack.com/p/long-covid...
September 11, 2025 at 9:54 AM
Really useful update from Bob Hawkins on Long Covid in England from the annual GP survey
bhawkins3.substack.com/p/long-covid...
bhawkins3.substack.com/p/long-covid...
Reposted by Chris Thorpe
Thoughtful piece by Abdel on social science genetics - I am definitely taken by “one person’s confounder is another person’s signal”. Also humble about dark histories here and his own perspective
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 9, 2025 at 7:33 AM
Thoughtful piece by Abdel on social science genetics - I am definitely taken by “one person’s confounder is another person’s signal”. Also humble about dark histories here and his own perspective
Reposted by Chris Thorpe
This is a cool story that I've watched with great interest - making big steps in the field of de novo TCR generation! Great work @dkarthikey1.bsky.social / @benjamingvincent.bsky.social / @alexr.bsky.social et al
Conditional generation of real antigen-specific T cell receptor sequences @natmachintell.nature.com
www.nature.com/articles/s42...
www.nature.com/articles/s42...
September 8, 2025 at 8:17 PM
This is a cool story that I've watched with great interest - making big steps in the field of de novo TCR generation! Great work @dkarthikey1.bsky.social / @benjamingvincent.bsky.social / @alexr.bsky.social et al
Very good piece from @dianecoyle1859.bsky.social on AI and future implications for the workplace at large, with context setting around the already existing digital divide. Thought provoking and insightful, I hope policymakers read it, re-read it and then have a really deep think/reset of policies
"Without suitable measures of organisations’ adoption of AI, policymakers will be unable to shape this powerful technology in ways that benefit society as a whole." - @dianecoyle1859.bsky.social's in her new article for #EconToImproveLives
pbe.co.uk/insights/eco...
pbe.co.uk/insights/eco...
Economic progress in the age of AI | PBE
By Diane Coyle If you spend less than four hours and 20 minutes a day online, you are below average for the UK. Using apps and online services, many of them free, is part of the fabric of daily life…
pbe.co.uk
September 8, 2025 at 1:58 PM
Very good piece from @dianecoyle1859.bsky.social on AI and future implications for the workplace at large, with context setting around the already existing digital divide. Thought provoking and insightful, I hope policymakers read it, re-read it and then have a really deep think/reset of policies
Reposted by Chris Thorpe
On to the management of your grant!
You need to keep track of your spending. Remember, you are expected to not just do what you promised, but also do what reviewers want, and create preliminary data for the next grant. This means you need to under-spend on the original deliverables.
You need to keep track of your spending. Remember, you are expected to not just do what you promised, but also do what reviewers want, and create preliminary data for the next grant. This means you need to under-spend on the original deliverables.
September 3, 2025 at 4:03 PM
On to the management of your grant!
You need to keep track of your spending. Remember, you are expected to not just do what you promised, but also do what reviewers want, and create preliminary data for the next grant. This means you need to under-spend on the original deliverables.
You need to keep track of your spending. Remember, you are expected to not just do what you promised, but also do what reviewers want, and create preliminary data for the next grant. This means you need to under-spend on the original deliverables.
Reposted by Chris Thorpe
Particulate air pollution drives Lewy Body Dementia via α-Synuclein @science.org @xiaobomao.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lewy body dementia promotion by air pollutants
Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine p...
www.science.org
September 4, 2025 at 8:07 PM
Particulate air pollution drives Lewy Body Dementia via α-Synuclein @science.org @xiaobomao.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Chris Thorpe
This is very interesting
feels significant that mass-market LLMs like ChatGPT are now capable of generating extensive natural-language dossiers about a given user's interests, location, preferences, identifying information, and more
simonwillison.net/2025/May/21/...
simonwillison.net/2025/May/21/...
I really don’t like ChatGPT’s new memory dossier
Last month ChatGPT got a major upgrade. As far as I can tell the closest to an official announcement was this tweet from @OpenAI: Starting today [April 10th 2025], memory …
simonwillison.net
September 4, 2025 at 8:08 PM
This is very interesting