Abdel Abdellaoui
@dr-appie.bsky.social
Complex Trait Genetics | Population Genetics | Evolutionary Genetics
https://scholar.google.nl/citations?user=hsyseKEAAAAJ&hl=en
https://scholar.google.nl/citations?user=hsyseKEAAAAJ&hl=en
Pinned
Abdel Abdellaoui
@dr-appie.bsky.social
Β· Mar 26
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.socialπ°π§¬π
Link: rdcu.be/efacK
Thread below ππ½
Link: rdcu.be/efacK
Thread below ππ½
Here is a rare opportunity to become a PhD student in Amsterdam with the talented psychiatrist/statistical geneticist Wouter Peyrot and work on genetic risk prediction in psychiatry: werkenbij.amsterdamumc.org/en/vacatures...
Vacatures - PhD student: Genetic Prediction in Psychiatry - Amsterdam UMC
Do you want to develop cutting-edge genetic prediction methods to improve early detection of serious mental illness? Join our ERC-funded PhD project and work with large-scale genetic data in an international research team.
werkenbij.amsterdamumc.org
January 6, 2026 at 1:31 PM
Here is a rare opportunity to become a PhD student in Amsterdam with the talented psychiatrist/statistical geneticist Wouter Peyrot and work on genetic risk prediction in psychiatry: werkenbij.amsterdamumc.org/en/vacatures...
Reposted by Abdel Abdellaoui
This is ridiculous.
12/10.
12/10.
Someone I love made a shower curtain of it π
December 31, 2025 at 11:58 AM
This is ridiculous.
12/10.
12/10.
Ok one more!
Happy New Year! π
Happy New Year! π
December 31, 2025 at 4:12 PM
Ok one more!
Happy New Year! π
Happy New Year! π
Thank you, it was! π
December 31, 2025 at 3:23 PM
Thank you, it was! π
Nice π Are you Dutch? We got them from my Dutch mother-in-law
December 31, 2025 at 3:05 PM
Nice π Are you Dutch? We got them from my Dutch mother-in-law
Someone I love made a shower curtain of it π
December 31, 2025 at 11:47 AM
Someone I love made a shower curtain of it π
Reposted by Abdel Abdellaoui
Last week, our new paper on indirect assortative mating was published.πΎ Letβs take a closer look at what this means, why it matters, and what we found (π§΅/32):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 11, 2025 at 9:52 PM
Last week, our new paper on indirect assortative mating was published.πΎ Letβs take a closer look at what this means, why it matters, and what we found (π§΅/32):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I'm working on some figures for a book to illustrate the foundation of quantitative genetics (as confirmed by GWAS a century later).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
December 28, 2025 at 4:39 PM
I'm working on some figures for a book to illustrate the foundation of quantitative genetics (as confirmed by GWAS a century later).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
I like to bake things in December
(I'll exercise more in January again)
Merry Christmas! π
(I'll exercise more in January again)
Merry Christmas! π
December 24, 2025 at 8:47 PM
I like to bake things in December
(I'll exercise more in January again)
Merry Christmas! π
(I'll exercise more in January again)
Merry Christmas! π
Thank you to all my amazing colleagues that make this work so much more fun.
I hope to share more of our exciting work with you in 2026.
I wish you all a Merry Christmas and a Happy New Year! π π½π
I hope to share more of our exciting work with you in 2026.
I wish you all a Merry Christmas and a Happy New Year! π π½π
December 20, 2025 at 8:06 AM
Thank you to all my amazing colleagues that make this work so much more fun.
I hope to share more of our exciting work with you in 2026.
I wish you all a Merry Christmas and a Happy New Year! π π½π
I hope to share more of our exciting work with you in 2026.
I wish you all a Merry Christmas and a Happy New Year! π π½π
I've also been working on developing a DNA game, but that has been put on hold since I also had an adorable baby this year!
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
I'm developing a strategic 1-on-1 game called Base Pairβ’ β based on biologically accurate rules π§¬π²
Want to play and give feedback? Reply to this tweet (or RT), and I might send you a free handmade beta copy!
(I have a limited nr right now, but more are on the way)
Want to play and give feedback? Reply to this tweet (or RT), and I might send you a free handmade beta copy!
(I have a limited nr right now, but more are on the way)
December 20, 2025 at 7:53 AM
I've also been working on developing a DNA game, but that has been put on hold since I also had an adorable baby this year!
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
I published my thoughts on the biggest study to date on the shared risk of 14 major psychiatric disorders in @nature.com
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
December 20, 2025 at 7:53 AM
I published my thoughts on the biggest study to date on the shared risk of 14 major psychiatric disorders in @nature.com
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
We published the first study on the relationship between DNA and the educational fields people choose, in @natgenet.nature.com
bsky.app/profile/rosa...
bsky.app/profile/rosa...
1/ π¨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
December 20, 2025 at 7:53 AM
We published the first study on the relationship between DNA and the educational fields people choose, in @natgenet.nature.com
bsky.app/profile/rosa...
bsky.app/profile/rosa...
We then published the largest study on late life virginity, (N >400k individuals) in @pnas.org
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
The largest study on late life virginity, based on >400k individuals, out now in @pnas.org
Open access link: pnas.org/doi/10.1073/...
Shoutout to shared first author @laurawesseldijk.bsky.social β€οΈ
Thread below ππ½
Open access link: pnas.org/doi/10.1073/...
Shoutout to shared first author @laurawesseldijk.bsky.social β€οΈ
Thread below ππ½
December 20, 2025 at 7:53 AM
We then published the largest study on late life virginity, (N >400k individuals) in @pnas.org
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
In the summer, I wrote this piece that summarizes my current thoughts on the promising field of social science genetics:
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
December 20, 2025 at 7:53 AM
In the summer, I wrote this piece that summarizes my current thoughts on the promising field of social science genetics:
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
We published a pre-print of the biggest study on the relationship between DNA and intelligence (N ~450k), where we estimated missing intelligence test scores to reduce bias and boost power.
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Studying the genetics of intelligence measures can help us understand the neurobiology of cognition and neurodevelopmental conditions π§¬π§
We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.
Preprint: www.medrxiv.org/content/10.1...
Thread π
We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.
Preprint: www.medrxiv.org/content/10.1...
Thread π
December 20, 2025 at 7:53 AM
We published a pre-print of the biggest study on the relationship between DNA and intelligence (N ~450k), where we estimated missing intelligence test scores to reduce bias and boost power.
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
We published a pre-print of the biggest study on the relationship between DNA and the big five personality dimensions (N=611K-1.14M):
bsky.app/profile/tedm...
bsky.app/profile/tedm...
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
December 20, 2025 at 7:53 AM
We published a pre-print of the biggest study on the relationship between DNA and the big five personality dimensions (N=611K-1.14M):
bsky.app/profile/tedm...
bsky.app/profile/tedm...
We published the biggest study on the relationship between DNA and OCD in @natgenet.nature.com (N > 2 million):
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com π§¬π§
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
December 20, 2025 at 7:53 AM
We published the biggest study on the relationship between DNA and OCD in @natgenet.nature.com (N > 2 million):
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
To make the big lines of the larger SES/DNA story more accessible (and fun), we also published an accompanying comic with visual artist @lizahaart.bsky.social
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Did you get a chance to read the thread on our new @naturehumbehav.bsky.social paper on SES yet?
If not, don't worry, I have something better for you!
Check out this comic by the amazing @lizahaart.bsky.social
Complete comic: communities.springernature.com/posts/are-we...
Or in this thread ππΎ
If not, don't worry, I have something better for you!
Check out this comic by the amazing @lizahaart.bsky.social
Complete comic: communities.springernature.com/posts/are-we...
Or in this thread ππΎ
December 20, 2025 at 7:53 AM
To make the big lines of the larger SES/DNA story more accessible (and fun), we also published an accompanying comic with visual artist @lizahaart.bsky.social
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Then came one of my favorites in @nathumbehav.nature.com, putting the relationship between our DNA and socio-economic outcomes (like education and income) into a greater perspective - both historically and scientifically.
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.socialπ°π§¬π
Link: rdcu.be/efacK
Thread below ππ½
Link: rdcu.be/efacK
Thread below ππ½
December 20, 2025 at 7:53 AM
Then came one of my favorites in @nathumbehav.nature.com, putting the relationship between our DNA and socio-economic outcomes (like education and income) into a greater perspective - both historically and scientifically.
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
We started 2025 off with a big multi-national study mapping genes associated with income in @nathumbehav.nature.com
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Our first multi-national GWAS on income is out in @naturehumbehav.bsky.social π§¬π°
- 162 loci (88 novel)
- significant heterogeneity between countries
- significant heterogeneity between men and women
- unique non-education income effects
Open Access Link: www.nature.com/articles/s41...
- 162 loci (88 novel)
- significant heterogeneity between countries
- significant heterogeneity between men and women
- unique non-education income effects
Open Access Link: www.nature.com/articles/s41...
December 20, 2025 at 7:53 AM
We started 2025 off with a big multi-national study mapping genes associated with income in @nathumbehav.nature.com
bsky.app/profile/dr-a...
bsky.app/profile/dr-a...
Welcome to my 2025 scientific publications wrapped!
It's been a good year for behavioral genetics, with exciting studies on the relationship between our DNA and socio-economic outcomes, sexual behavior, personality, intelligence, and psychiatric disorders π§¬
See thread below ππ½
It's been a good year for behavioral genetics, with exciting studies on the relationship between our DNA and socio-economic outcomes, sexual behavior, personality, intelligence, and psychiatric disorders π§¬
See thread below ππ½
December 20, 2025 at 7:53 AM
Welcome to my 2025 scientific publications wrapped!
It's been a good year for behavioral genetics, with exciting studies on the relationship between our DNA and socio-economic outcomes, sexual behavior, personality, intelligence, and psychiatric disorders π§¬
See thread below ππ½
It's been a good year for behavioral genetics, with exciting studies on the relationship between our DNA and socio-economic outcomes, sexual behavior, personality, intelligence, and psychiatric disorders π§¬
See thread below ππ½
Reposted by Abdel Abdellaoui
Thanks everyone who attended the 4th annual #GENEAmsterdam meeting - we had a great time! Keep an eye out for the website and socials - more details on the day will be posted soon π !
For now, a large thanks to AdriΓ TΓΊnez AquiluΓ©, Tessa Zonneveld and Aysu Okbay for this years organization.
For now, a large thanks to AdriΓ TΓΊnez AquiluΓ©, Tessa Zonneveld and Aysu Okbay for this years organization.
December 18, 2025 at 9:36 AM
Thanks everyone who attended the 4th annual #GENEAmsterdam meeting - we had a great time! Keep an eye out for the website and socials - more details on the day will be posted soon π !
For now, a large thanks to AdriΓ TΓΊnez AquiluΓ©, Tessa Zonneveld and Aysu Okbay for this years organization.
For now, a large thanks to AdriΓ TΓΊnez AquiluΓ©, Tessa Zonneveld and Aysu Okbay for this years organization.
Reposted by Abdel Abdellaoui
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
go.nature.com/48AooC4
go.nature.com/48AooC4
Shared genetic risk in psychiatric disorders
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
go.nature.com
December 12, 2025 at 9:14 AM
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
go.nature.com/48AooC4
go.nature.com/48AooC4
Are you sending this out for peer-review?
December 11, 2025 at 9:15 AM
Are you sending this out for peer-review?