Greifflab
@victorgreiff.bsky.social
Professor of Computational and Systems Immunology @UniOslo.
Cofounder & Director of Computational Immunology @imprintlabs.bsky.social
Cofounder & Director of Computational Immunology @imprintlabs.bsky.social
Pinned
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo
Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
Reminder that we are recruiting for a PhD Fellow. All details below. Application deadline: Oct 29th.
The AIRR-ML-2025 challenge is LIVE on @kaggle.com!
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system.
💰 $10,000 prize pool
📄 Co-author a NatureMethods paper
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system.
💰 $10,000 prize pool
📄 Co-author a NatureMethods paper
November 15, 2025 at 3:31 PM
The AIRR-ML-2025 challenge is LIVE on @kaggle.com!
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system.
💰 $10,000 prize pool
📄 Co-author a NatureMethods paper
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system.
💰 $10,000 prize pool
📄 Co-author a NatureMethods paper
📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
October 22, 2025 at 7:09 PM
📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Reminder that we are recruiting for a PhD Fellow. All details below. Application deadline: Oct 29th.
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo
Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
October 21, 2025 at 3:20 PM
Reminder that we are recruiting for a PhD Fellow. All details below. Application deadline: Oct 29th.
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo
Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
September 28, 2025 at 11:55 AM
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
Reposted by Greifflab
Models trained on harder antibody binding tasks learned deeper biological rules + generalized better.
New NatureMachIntel paper by CTO @victorgreiff.bsky.social shows training on hard negatives (weak vs strong binders) boosts antibody ML generalization.
Read the paper: doi.org/10.1038/s422...
New NatureMachIntel paper by CTO @victorgreiff.bsky.social shows training on hard negatives (weak vs strong binders) boosts antibody ML generalization.
Read the paper: doi.org/10.1038/s422...
Training data composition determines machine learning generalization and biological rule discovery - Nature Machine Intelligence
Negative data composition critically shapes machine learning robustness in sequence-based biological tasks. Training data composition and its implications are investigated on biological rule discoveri...
doi.org
September 18, 2025 at 3:02 PM
Models trained on harder antibody binding tasks learned deeper biological rules + generalized better.
New NatureMachIntel paper by CTO @victorgreiff.bsky.social shows training on hard negatives (weak vs strong binders) boosts antibody ML generalization.
Read the paper: doi.org/10.1038/s422...
New NatureMachIntel paper by CTO @victorgreiff.bsky.social shows training on hard negatives (weak vs strong binders) boosts antibody ML generalization.
Read the paper: doi.org/10.1038/s422...
Reposted by Greifflab
Deadline extended - last chance, second edition!
Last chance to register for the 2025 European RosettaCon - we had a blast last year, and @ajasjaljubetic.bsky.social is putting together a great program. With Easter eggs 🥚 in the submission system!
September 18, 2025 at 3:53 PM
Deadline extended - last chance, second edition!
Reposted by Greifflab
Earlier this year, Imprint came out of stealth on the TED Mainstage to share our vision:
What if the immune system holds the key to curing chronic diseases—and we just need the tools to read it?
We’re building those tools.
Our TED talk is now live 👉 go.ted.com/beckbrachman
What if the immune system holds the key to curing chronic diseases—and we just need the tools to read it?
We’re building those tools.
Our TED talk is now live 👉 go.ted.com/beckbrachman
go.ted.com
September 9, 2025 at 3:00 PM
Earlier this year, Imprint came out of stealth on the TED Mainstage to share our vision:
What if the immune system holds the key to curing chronic diseases—and we just need the tools to read it?
We’re building those tools.
Our TED talk is now live 👉 go.ted.com/beckbrachman
What if the immune system holds the key to curing chronic diseases—and we just need the tools to read it?
We’re building those tools.
Our TED talk is now live 👉 go.ted.com/beckbrachman
Reposted by Greifflab
Identifying malignant cells in single-cell transcriptomics data – from first principles to computational solutions, framed around the hallmarks of cancer
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Identification of malignant cells in single-cell transcriptomics data - Communications Biology
This review article discusses the challenges of identifying cancer cells in single-cell data, summarizing current computational solutions as well as underexplored features of malignancy.
www.nature.com
August 22, 2025 at 4:05 PM
Identifying malignant cells in single-cell transcriptomics data – from first principles to computational solutions, framed around the hallmarks of cancer
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Greifflab
EMBL is back on hiring faculty! Check out the multiple open positions:
3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble
1 Head of Unit (Cell Biology & Biophysics, Heidelberg).
Closing deadlines in Sep!
+3 more positions to come out then, stay tuned...
@embl.org
3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble
1 Head of Unit (Cell Biology & Biophysics, Heidelberg).
Closing deadlines in Sep!
+3 more positions to come out then, stay tuned...
@embl.org
August 12, 2025 at 5:25 AM
EMBL is back on hiring faculty! Check out the multiple open positions:
3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble
1 Head of Unit (Cell Biology & Biophysics, Heidelberg).
Closing deadlines in Sep!
+3 more positions to come out then, stay tuned...
@embl.org
3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble
1 Head of Unit (Cell Biology & Biophysics, Heidelberg).
Closing deadlines in Sep!
+3 more positions to come out then, stay tuned...
@embl.org
Reposted by Greifflab
📣Major thanks to @faylinphd.bsky.social at GEN News for this lovely piece on IMPRINT! It was a pleasure for our founders — @beckbrachman.bsky.social, @victorgreiff.bsky.social, and Raymond Alvarez — to speak about our mission and research, and being NYC's first FRO.
@convergentresearch.bsky.social
@convergentresearch.bsky.social
Imprint Labs Launches to Pioneer "Forensic Immunology" For Chronic Disease
Imprint has raised $15 million to decode the body's immune memory for understanding chronic diseases, such as long-COVID and psychiatric disorders.
www.genengnews.com
May 20, 2025 at 1:08 PM
📣Major thanks to @faylinphd.bsky.social at GEN News for this lovely piece on IMPRINT! It was a pleasure for our founders — @beckbrachman.bsky.social, @victorgreiff.bsky.social, and Raymond Alvarez — to speak about our mission and research, and being NYC's first FRO.
@convergentresearch.bsky.social
@convergentresearch.bsky.social
Excited to co-found and help lead @imprintlabs.bsky.social —a focused effort to decode the immune system’s memory through cutting-edge computation and experimentation. Grateful to be on this journey with an exceptional team.
🧵 Today, IMPRINT, a pioneering new nonprofit initiative, is announcing $15 million in philanthropic funding to advance our work to decode the body's immune memory and uncover the causes of chronic diseases.
#Immunology #Biotech #BiotechResearch
#Immunology #Biotech #BiotechResearch
Press Release May 2025 — Imprint FRO
Imprint FRO launches with $15M in funding
www.imprint.org
May 15, 2025 at 7:30 PM
Excited to co-found and help lead @imprintlabs.bsky.social —a focused effort to decode the immune system’s memory through cutting-edge computation and experimentation. Grateful to be on this journey with an exceptional team.
Reposted by Greifflab
We have available a 3-year postdoc position in Bioinformatics in our lab at the University of Oslo focusing on the adaptive immune response in rheumatoid arthritis. Please see details here
lds.easycruit.com/vacancy/3490...
lds.easycruit.com/vacancy/3490...
Lovisenberg Diakonale Sykehus
Postdoctoral research fellowship in Bioinformatics and Immunology (3-year, full-time)
lds.easycruit.com
May 8, 2025 at 8:33 PM
We have available a 3-year postdoc position in Bioinformatics in our lab at the University of Oslo focusing on the adaptive immune response in rheumatoid arthritis. Please see details here
lds.easycruit.com/vacancy/3490...
lds.easycruit.com/vacancy/3490...
Reposted by Greifflab
Online now: Somatic hypermutation unlocks antibody specificities beyond the primary repertoire
Somatic hypermutation unlocks antibody specificities beyond the primary repertoire
Initial specificity is thought to be required for somatic hypermutation (SHM)-driven antibody evolution. Zuo, Gautam, et al. demonstrate that non-cognate B cells can enter germinal centers, undergo SHM, and acquire new antigen specificities, highlighting the capacity of antibodies to generate new recognition through SHM.
dlvr.it
May 7, 2025 at 7:55 PM
Online now: Somatic hypermutation unlocks antibody specificities beyond the primary repertoire
Reposted by Greifflab
Looking for a job in immunology or biotech research?
✨IMPRINT is #hiring! ✨
Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research.
#BiotechJobs #Immunology #sciencejobs
✨IMPRINT is #hiring! ✨
Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research.
#BiotechJobs #Immunology #sciencejobs
Jobs — Imprint FRO
Join our team—current openings at Imprint
www.imprint.org
May 1, 2025 at 1:03 PM
Looking for a job in immunology or biotech research?
✨IMPRINT is #hiring! ✨
Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research.
#BiotechJobs #Immunology #sciencejobs
✨IMPRINT is #hiring! ✨
Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research.
#BiotechJobs #Immunology #sciencejobs
Reposted by Greifflab
The BioEmu-1 model and inference code are now public under MIT license!!!
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
February 19, 2025 at 8:17 PM
The BioEmu-1 model and inference code are now public under MIT license!!!
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
Reposted by Greifflab
This paper has been a long time coming: We looked at the genomes of historical bacterial samples over a century to look for trends of antibiotic resistance genes, finding multiple instances of them in infections before the age of antibiotics, but an increase in both frequency and mobility after
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics https://www.biorxiv.org/content/10.1101/2025.01.16.633422v1
January 17, 2025 at 8:53 PM
This paper has been a long time coming: We looked at the genomes of historical bacterial samples over a century to look for trends of antibiotic resistance genes, finding multiple instances of them in infections before the age of antibiotics, but an increase in both frequency and mobility after
Reposted by Greifflab
@timodonnell.bsky.social @giulioisac.bsky.social @jlimenitakis.bsky.social Beck Brachman Raymond Alvarez @victorgreiff.bsky.social Convergent Research
January 9, 2025 at 2:56 PM
@timodonnell.bsky.social @giulioisac.bsky.social @jlimenitakis.bsky.social Beck Brachman Raymond Alvarez @victorgreiff.bsky.social Convergent Research
Reposted by Greifflab
1/10 Small pre-Christmas #bluetorial on the workshop held by the T-cell Receptor (TR) and Immunoglobulin (IG) Nomenclature Sub-Committee of @iuis-online.bsky.social on policies and procedures for TR/IG gene annotation and nomenclature #immunerepertoire #immunogenetics
December 24, 2024 at 5:50 PM
1/10 Small pre-Christmas #bluetorial on the workshop held by the T-cell Receptor (TR) and Immunoglobulin (IG) Nomenclature Sub-Committee of @iuis-online.bsky.social on policies and procedures for TR/IG gene annotation and nomenclature #immunerepertoire #immunogenetics
Reposted by Greifflab
A good start into 2025: www.cell.com/cell-reports.... High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo.
High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo
Kunze-Schumacher et al. have developed an experimental and computational framework to generate a quantitative high-resolution map of cell cycle phase durations during murine T cell development. This map provides insight into how cell cycle phases are adjusted between slow- and fast-dividing populations at steady state and in a preclinical model of thymus regeneration.
www.cell.com
January 5, 2025 at 8:06 PM
A good start into 2025: www.cell.com/cell-reports.... High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo.
Reposted by Greifflab
In a recent article, my group and I laid out some of the recommendations I have learned over the year about research. In 2025, our lab will double down on following our own advice. pubs.rsc.org/en/content/a...
Spiers Memorial Lecture: How to do impactful research in artificial intelligence for chemistry and materials science
Machine learning has been pervasively touching many fields of science. Chemistry and materials science are no exception. While machine learning has been making a great impact, it is still not reaching...
pubs.rsc.org
December 31, 2024 at 4:56 PM
In a recent article, my group and I laid out some of the recommendations I have learned over the year about research. In 2025, our lab will double down on following our own advice. pubs.rsc.org/en/content/a...
Reposted by Greifflab
What an amazing read (h/t Jeff Flier) - esp @michaelmina.bsky.social which felt especially raw. #biosky #medsky www.harvardmagazine.com/2025/01/harv...
Harvard Professors Leaving for Private Sector Research | Harvard Magazine
Three distinguished scientists on leaving academia to advance biomedical research
www.harvardmagazine.com
December 20, 2024 at 6:55 PM
What an amazing read (h/t Jeff Flier) - esp @michaelmina.bsky.social which felt especially raw. #biosky #medsky www.harvardmagazine.com/2025/01/harv...
Reposted by Greifflab
A periodic reminder that biologically meaningful conformational changes do not have to be large
While textbooks may indicate that relevant motions are large, even the original paper on alternating access makes it clear that atoms just need to move a bit to have an effect. doi.org/10.1038/2119... 🧬🧶
While textbooks may indicate that relevant motions are large, even the original paper on alternating access makes it clear that atoms just need to move a bit to have an effect. doi.org/10.1038/2119... 🧬🧶
December 17, 2024 at 9:22 AM
A periodic reminder that biologically meaningful conformational changes do not have to be large
While textbooks may indicate that relevant motions are large, even the original paper on alternating access makes it clear that atoms just need to move a bit to have an effect. doi.org/10.1038/2119... 🧬🧶
While textbooks may indicate that relevant motions are large, even the original paper on alternating access makes it clear that atoms just need to move a bit to have an effect. doi.org/10.1038/2119... 🧬🧶
Extremely pleased to share our new work in collaboration with the @bruskolab.bsky.social lab, where we leveraged one of the largest TCRbeta sequencing datasets to identify T1D-associated TCR-based signatures. Paper link and 🧵 are below. Incredible work led by @puneet021192.bsky.social.
Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in pancreatic lymph nodes (pLN) & spleen. 🧬🧵 #T1D #Immunology #TCR 1/9
December 15, 2024 at 7:52 AM
Extremely pleased to share our new work in collaboration with the @bruskolab.bsky.social lab, where we leveraged one of the largest TCRbeta sequencing datasets to identify T1D-associated TCR-based signatures. Paper link and 🧵 are below. Incredible work led by @puneet021192.bsky.social.