David Shaywitz
@dshaywitz.bsky.social
Biology-grounded MD/PhD exec | Healthy aging & flourishing at scale | Evidence-based medicine x lifestyle × tech | Agency as engine of change | Strategic Advisor | Writer | kindwellhealth.com
Reposted by David Shaywitz
Happiness is:
Seeing your kids happy.
Seeing your kids happy.
November 10, 2025 at 12:41 AM
Happiness is:
Seeing your kids happy.
Seeing your kids happy.
Surprised myself by unsubscribing to the a16z podcasts that were inundating me. Not because of politics-but bc of what feels like a “flood the zone” mindset combined with relentless propaganda advancing their increasingly large bets (crypto, AI esp). Genug es genug. @dereklowe.bsky.social
November 9, 2025 at 7:45 PM
Surprised myself by unsubscribing to the a16z podcasts that were inundating me. Not because of politics-but bc of what feels like a “flood the zone” mindset combined with relentless propaganda advancing their increasingly large bets (crypto, AI esp). Genug es genug. @dereklowe.bsky.social
Late in the season but still the occasional breathtaking beauty…
November 5, 2025 at 2:16 PM
Late in the season but still the occasional breathtaking beauty…
Reposted by David Shaywitz
Physical activity and risk of Alzheimer's disease.
In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition
@naturemedicine.bsky.social
nature.com/articles/s41...
In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition
@naturemedicine.bsky.social
nature.com/articles/s41...
November 3, 2025 at 4:09 PM
Physical activity and risk of Alzheimer's disease.
In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition
@naturemedicine.bsky.social
nature.com/articles/s41...
In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition
@naturemedicine.bsky.social
nature.com/articles/s41...
Tx for highlighting @nachristakis.bsky.social - this contributes to the present optimism and opportunity around healthy aging as I recently discussed in @wsj.com -> www.wsj.com/opinion/nobo...
November 3, 2025 at 2:26 PM
Tx for highlighting @nachristakis.bsky.social - this contributes to the present optimism and opportunity around healthy aging as I recently discussed in @wsj.com -> www.wsj.com/opinion/nobo...
"Everyone has won and all must have prizes."
- The Dodo
- The Dodo
October 31, 2025 at 3:47 PM
"Everyone has won and all must have prizes."
- The Dodo
- The Dodo
Reposted by David Shaywitz
In my latest TR column, I:
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
The Outsized Significance of A New Study of AI in Diabetes Prevention - TimmermanReport.com
A lifestyle intervention delivered by AI was found to be as effective as validated traditional interventions delivered by trained experts in a carefully conducted implementation study conducted by Joh...
timmermanreport.com
October 30, 2025 at 8:32 PM
In my latest TR column, I:
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
In my latest TR column, I:
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
The Outsized Significance of A New Study of AI in Diabetes Prevention - TimmermanReport.com
A lifestyle intervention delivered by AI was found to be as effective as validated traditional interventions delivered by trained experts in a carefully conducted implementation study conducted by Joh...
timmermanreport.com
October 30, 2025 at 8:32 PM
In my latest TR column, I:
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
- Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie);
- Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches);
- Suggest top practitioners, FTF, still v best
timmermanreport.com/2025/10/the-...
In my latest TR column, I go over a just-published study comparing human and AI health coaches for DPP-based diabetes prevention, and discussion the implications for implementing health-promoting behavior change at scale. timmermanreport.com/2025/10/the-... @luketimmerman.bsky.social
The Outsized Significance of A New Study of AI in Diabetes Prevention - TimmermanReport.com
A lifestyle intervention delivered by AI was found to be as effective as validated traditional interventions delivered by trained experts in a carefully conducted implementation study conducted by Joh...
timmermanreport.com
October 30, 2025 at 5:27 PM
In my latest TR column, I go over a just-published study comparing human and AI health coaches for DPP-based diabetes prevention, and discussion the implications for implementing health-promoting behavior change at scale. timmermanreport.com/2025/10/the-... @luketimmerman.bsky.social
Reposted by David Shaywitz
"The marathon is glorious in no small part because the day represents an ideal of civic life: people striving to accomplish their goals while seeking connection…let us take solace from this model of civic participation that reveals all that we can accomplish together when we cheer one another on."
Opinion | Thank Goodness for the New York City Marathon
www.nytimes.com
October 28, 2025 at 3:22 PM
"The marathon is glorious in no small part because the day represents an ideal of civic life: people striving to accomplish their goals while seeking connection…let us take solace from this model of civic participation that reveals all that we can accomplish together when we cheer one another on."
Thx for flagging, @erictopol.bsky.social!
tl;dr: Why I see such hope in the longevity movement, despite the often-dubious science & frequently exaggerated claims.
In short: we're embracing agency, recognizing that we have a measure of control over our long-term health.
More: kindwellhealth.com.
tl;dr: Why I see such hope in the longevity movement, despite the often-dubious science & frequently exaggerated claims.
In short: we're embracing agency, recognizing that we have a measure of control over our long-term health.
More: kindwellhealth.com.
October 28, 2025 at 9:09 AM
Thx for flagging, @erictopol.bsky.social!
tl;dr: Why I see such hope in the longevity movement, despite the often-dubious science & frequently exaggerated claims.
In short: we're embracing agency, recognizing that we have a measure of control over our long-term health.
More: kindwellhealth.com.
tl;dr: Why I see such hope in the longevity movement, despite the often-dubious science & frequently exaggerated claims.
In short: we're embracing agency, recognizing that we have a measure of control over our long-term health.
More: kindwellhealth.com.
If gift link not working for you, here's an accessible PDF: drive.google.com/file/d/1DaoF...
October 27, 2025 at 9:30 PM
If gift link not working for you, here's an accessible PDF: drive.google.com/file/d/1DaoF...
Just out: @wsj.com op-ed I wrote on why I see such hope in the longevity movement, despite often dubious science & frequently exaggerated claims; in short: we're embracing agency, recognizing that we have a measure of control over our long-term health. wsj.com/opinion/nobo... (gift link).
Opinion | Nobody Ever Got Younger, but It May Be Worth a Try
The science behind the longevity movement is dubious. But the trend is promoting healthy habits.
wsj.com
October 27, 2025 at 8:27 PM
Just out: @wsj.com op-ed I wrote on why I see such hope in the longevity movement, despite often dubious science & frequently exaggerated claims; in short: we're embracing agency, recognizing that we have a measure of control over our long-term health. wsj.com/opinion/nobo... (gift link).
Looking for w/e reading on social connection, aging clocks, and longevity? TR has you covered -> timmermanreport.com/2025/10/the-... Incl: new book rec; two interesting new papers; reflections on this wk's biomarker & aging conf @harvardmed.bsky.social.
@nachristakis.bsky.social @jvl.bsky.social
@nachristakis.bsky.social @jvl.bsky.social
The Biology of Belonging: Social Connection Meets Geroscience - TimmermanReport.com
Digital health, fitness, and longevity platforms have focused on the constant measurement and relentless optimization of biometric parameters, an often-valuable effort but one that has systematically ...
timmermanreport.com
October 25, 2025 at 12:45 PM
Looking for w/e reading on social connection, aging clocks, and longevity? TR has you covered -> timmermanreport.com/2025/10/the-... Incl: new book rec; two interesting new papers; reflections on this wk's biomarker & aging conf @harvardmed.bsky.social.
@nachristakis.bsky.social @jvl.bsky.social
@nachristakis.bsky.social @jvl.bsky.social
Latest TR on intersection of 2 topics: underappreciated importance of social connection as key driver of longevity & increased availability of easy-to-apply tools to assess "biological" aging: timmermanreport.com/2025/10/the-.... Bottom line ⬇️. @alicecallahan.bsky.social @sarahlongwell25.bsky.social
October 24, 2025 at 9:00 PM
Latest TR on intersection of 2 topics: underappreciated importance of social connection as key driver of longevity & increased availability of easy-to-apply tools to assess "biological" aging: timmermanreport.com/2025/10/the-.... Bottom line ⬇️. @alicecallahan.bsky.social @sarahlongwell25.bsky.social
@nachristakis.bsky.social @ashishkjha.bsky.social @meganranney.bsky.social @thgoetz.bsky.social @jvl.bsky.social cc
Digital health tracks biometrics relentlessly.
But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...
But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...
The Biology of Belonging: Social Connection Meets Geroscience - TimmermanReport.com
Digital health, fitness, and longevity platforms have focused on the constant measurement and relentless optimization of biometric parameters, an often-valuable effort but one that has systematically ...
timmermanreport.com
October 24, 2025 at 5:06 PM
Digital health tracks biometrics relentlessly.
But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...
But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...
The Biology of Belonging: Social Connection Meets Geroscience - TimmermanReport.com
Digital health, fitness, and longevity platforms have focused on the constant measurement and relentless optimization of biometric parameters, an often-valuable effort but one that has systematically ...
timmermanreport.com
October 24, 2025 at 4:57 PM
Digital health tracks biometrics relentlessly.
But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...
But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...
This LI post, summarizing recent panel discussion about AI in biopharma, triggered me b/c it seemed absolutely unmoored from reality. In particular, idea that "biotech now calculates success like NASA, not 'shots on goal'"= total fantasy. www.linkedin.com/posts/aaronb... @matthewherper.bsky.social
October 23, 2025 at 11:38 AM
This LI post, summarizing recent panel discussion about AI in biopharma, triggered me b/c it seemed absolutely unmoored from reality. In particular, idea that "biotech now calculates success like NASA, not 'shots on goal'"= total fantasy. www.linkedin.com/posts/aaronb... @matthewherper.bsky.social
Another fantastic @nejm.org Not Otherwise Specified pcast ep from incomparable @lisarosenbaum.bsky.social; this season's topic is primary care, and today's focus=impact of AI - fascinating discussion w Stanford's Steven Lin. podcasts.apple.com/us/podcast/can… cc @meganranney.bsky.social
https://podcasts.apple.com/us/podcast/can…
October 23, 2025 at 12:08 AM
Another fantastic @nejm.org Not Otherwise Specified pcast ep from incomparable @lisarosenbaum.bsky.social; this season's topic is primary care, and today's focus=impact of AI - fascinating discussion w Stanford's Steven Lin. podcasts.apple.com/us/podcast/can… cc @meganranney.bsky.social
Wow. Even if anti-inflam mech would have thought degree of initial chronic inflammation, and consequently degree of cv benefit, might still have been correlated w baseline adipose and mag of wt loss.
The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect
thelancet.com/journals/lan...
thelancet.com/journals/lan...
Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial
The cardioprotective effects of semaglutide were independent of baseline adiposity
and weight loss and had only a small association with waist circumference, suggesting
some mechanisms for benefit bey...
thelancet.com
October 22, 2025 at 11:24 PM
Wow. Even if anti-inflam mech would have thought degree of initial chronic inflammation, and consequently degree of cv benefit, might still have been correlated w baseline adipose and mag of wt loss.
Reposted by David Shaywitz
Astonishing: The cost of health insurance for a family jumps to $27,000 from @tarabannow.bsky.social www.statnews.com/2025/10/22/h...
October 22, 2025 at 1:44 PM
Astonishing: The cost of health insurance for a family jumps to $27,000 from @tarabannow.bsky.social www.statnews.com/2025/10/22/h...
The beauty of autumn in New England
October 22, 2025 at 1:13 PM
The beauty of autumn in New England
Reposted by David Shaywitz
There is nothing like a great farmer's market
October 19, 2025 at 8:43 PM
There is nothing like a great farmer's market
Hard agree! Key theme of my latest @wsj.com rev: wsj.com/arts-culture/b…, & impt overlooked oppy for digital platforms who have pivoted to longevity but are myopically fixated on optimization of performance metrics. Connection w others=vital for health, flourishing. https://www.kindwellhealth.com/
October 19, 2025 at 6:10 PM
Hard agree! Key theme of my latest @wsj.com rev: wsj.com/arts-culture/b…, & impt overlooked oppy for digital platforms who have pivoted to longevity but are myopically fixated on optimization of performance metrics. Connection w others=vital for health, flourishing. https://www.kindwellhealth.com/