Conner Langeberg
@clangeberg.bsky.social
RNA, viruses, and everything in between | Postdoc in Doudna and Cate Labs @UCBerkeley
Reposted by Conner Langeberg
"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7):
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
January 20, 2026 at 3:53 PM
"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7):
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted by Conner Langeberg
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 6:04 PM
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
Reposted by Conner Langeberg
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
Viral enzymes degrade to evade
Across all domains of life, immune systems rely on nucleotide-based signaling molecules
to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg,
and colleagues identify ...
www.cell.com
December 10, 2025 at 5:24 PM
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
Reposted by Conner Langeberg
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
A conserved viral RNA fold enables nuclease resistance across kingdoms of life
Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence
academic.oup.com
September 2, 2025 at 6:58 PM
Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...
Reposted by Conner Langeberg
Archaeal virus entry and egress
Archaea also have viruses and they are cool!
#microbiology #virology #virus #viruses
@femsmicro.org @femsjournals.bsky.social
academic.oup.com/microlife/ar...
Archaea also have viruses and they are cool!
#microbiology #virology #virus #viruses
@femsmicro.org @femsjournals.bsky.social
academic.oup.com/microlife/ar...
Archaeal virus entry and egress
Abstract. Archaeal viruses display a high degree of structural and genomic diversity. Few details are known about the mechanisms by which these viruses ent
academic.oup.com
July 9, 2025 at 2:41 PM
Archaeal virus entry and egress
Archaea also have viruses and they are cool!
#microbiology #virology #virus #viruses
@femsmicro.org @femsjournals.bsky.social
academic.oup.com/microlife/ar...
Archaea also have viruses and they are cool!
#microbiology #virology #virus #viruses
@femsmicro.org @femsjournals.bsky.social
academic.oup.com/microlife/ar...
Reposted by Conner Langeberg
Our work, co-led by @alfredo0712.bsky.social and @nlue8.bsky.social is out in @natsmb.nature.com Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and S. Kassube for their contributions and thanks to the reviewers for the suggestions that led to the final work.
www.nature.com/articles/s41...
Structural insights into transcriptional regulation by the helicase RECQL5 - Nature Structural & Molecular Biology
Florez Ariza and Lue et al. use cryo-electron microscopy to investigate how the RECQL5 helicase regulates transcription. Their structural findings suggest that RECQL5 can modulate RNA polymerase II’s ...
www.nature.com
July 7, 2025 at 10:35 AM
Our work, co-led by @alfredo0712.bsky.social and @nlue8.bsky.social is out in @natsmb.nature.com Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and S. Kassube for their contributions and thanks to the reviewers for the suggestions that led to the final work.
www.nature.com/articles/s41...
Reposted by Conner Langeberg
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
May 26, 2025 at 9:29 AM
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
Final grad paper is officially out! Grateful for the incredible team and all the support along the way!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure - Nature Communications
Many flaviviruses generate specialized non-coding RNAs that resist degradation by host exonucleases, promoting viral infection. Here, the authors characterize an RNA element in Powassan virus, highlig...
www.nature.com
May 15, 2025 at 10:00 PM
Final grad paper is officially out! Grateful for the incredible team and all the support along the way!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Conner Langeberg
Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.
Check it out:
Check it out:
A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway
Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signaling that share mechanistic features with human anti-viral systems. In these pathways, including CBASS a...
www.biorxiv.org
March 31, 2025 at 4:27 PM
Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.
Check it out:
Check it out:
Reposted by Conner Langeberg
Giving a seminar for the Genome Engineering Seminar Series at Harvard this Monday, April 7 at 1pm EST / 10am PST! 🎙️ I’ll be talking about our Cas9 work—if you’ve ever wondered what the recipe is for high-efficiency CRISPR genome editing, come hang out!🧬💥
📍 Zoom link: harvard.zoom.us/j/94394339529
📍 Zoom link: harvard.zoom.us/j/94394339529
April 3, 2025 at 6:57 AM
Giving a seminar for the Genome Engineering Seminar Series at Harvard this Monday, April 7 at 1pm EST / 10am PST! 🎙️ I’ll be talking about our Cas9 work—if you’ve ever wondered what the recipe is for high-efficiency CRISPR genome editing, come hang out!🧬💥
📍 Zoom link: harvard.zoom.us/j/94394339529
📍 Zoom link: harvard.zoom.us/j/94394339529
Reposted by Conner Langeberg
Really nice issue of RNA this month featuring many Perspective pieces on RNA in disease. rnajournal.cshlp.org/content/31/3...
Table of Contents — March 2025, 31 (3)
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
rnajournal.cshlp.org
February 20, 2025 at 2:56 PM
Really nice issue of RNA this month featuring many Perspective pieces on RNA in disease. rnajournal.cshlp.org/content/31/3...
Reposted by Conner Langeberg
We present Rfam-based RNA structural alignments and other structure-based inputs for RNA 3D structure prediction by deep learning.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 17, 2025 at 5:10 PM
We present Rfam-based RNA structural alignments and other structure-based inputs for RNA 3D structure prediction by deep learning.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Conner Langeberg
Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM
Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology
Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.
go.nature.com
February 18, 2025 at 3:29 PM
Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM
Reposted by Conner Langeberg
Latent Labs comes out of stealth today with $50M funding. Our goal? To push the frontiers of generative biology, giving partners instant access to tools capable of accelerating drug design
February 13, 2025 at 7:00 AM
Latent Labs comes out of stealth today with $50M funding. Our goal? To push the frontiers of generative biology, giving partners instant access to tools capable of accelerating drug design
Reposted by Conner Langeberg
I had the pleasure of co-hosting this new career exploration podcast from ASBMB- tune in to hear from my fellow committee member Tom Kiselak about being a patent attorney!
🎙️ASBMB's new series features interviews with biological and life sciences professionals about their careers!
ow.ly/268250UYcmx
🎧Check out episode 1: A conversation w/Tom Kiselak (Thermo Fisher Scientific), who holds a #PhD in analytical chemistry & works as a patent attorney: youtu.be/enBtSSTQT9A.
ow.ly/268250UYcmx
🎧Check out episode 1: A conversation w/Tom Kiselak (Thermo Fisher Scientific), who holds a #PhD in analytical chemistry & works as a patent attorney: youtu.be/enBtSSTQT9A.
In conversation with... Tom Kiselak
YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)
youtu.be
February 12, 2025 at 5:08 PM
I had the pleasure of co-hosting this new career exploration podcast from ASBMB- tune in to hear from my fellow committee member Tom Kiselak about being a patent attorney!
Excited to see this work finally out, it was a pleasure to be involved!
New article from @jhdcate.bsky.social and collaborators in @narjournal.bsky.social: RNA elements required for the high efficiency of West Nile virus-induced ribosomal frameshifting doi.org/10.1093/nar/... 🧪🧬🦠
RNA elements required for the high efficiency of West Nile virus-induced ribosomal frameshifting
Abstract. West Nile virus (WNV) requires programmed −1 ribosomal frameshifting for translation of the viral genome. The efficiency of WNV frameshifting is
doi.org
February 10, 2025 at 10:49 PM
Excited to see this work finally out, it was a pleasure to be involved!
Reposted by Conner Langeberg
Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025...
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social+@pasteur.fr+@inserm.fr! Many thanks for this great journey!🙌
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social+@pasteur.fr+@inserm.fr! Many thanks for this great journey!🙌
Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome.
The use of antibiotics disrupts the gut microbiota, potentially leading to long-term health issues and the spread of resistance. To investigate the impact of antibiotics on phage populations, we follo...
doi.org
February 10, 2025 at 9:55 AM
Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025...
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social+@pasteur.fr+@inserm.fr! Many thanks for this great journey!🙌
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social+@pasteur.fr+@inserm.fr! Many thanks for this great journey!🙌
Reposted by Conner Langeberg
Today, the IGI turns 10! We’ve grown from a fledgling initiative focused around developing #CRISPR tools to a full-blown research institute bringing together leaders in basic & translational research! ⚕️💊🌱☀️
Take a look at our timeline & key achievements from our first decade: ow.ly/GzVt50UTsbP
Take a look at our timeline & key achievements from our first decade: ow.ly/GzVt50UTsbP
February 4, 2025 at 5:57 PM
Today, the IGI turns 10! We’ve grown from a fledgling initiative focused around developing #CRISPR tools to a full-blown research institute bringing together leaders in basic & translational research! ⚕️💊🌱☀️
Take a look at our timeline & key achievements from our first decade: ow.ly/GzVt50UTsbP
Take a look at our timeline & key achievements from our first decade: ow.ly/GzVt50UTsbP
Reposted by Conner Langeberg
A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions pubmed.ncbi.nlm.nih.gov/39893634/ #cryoem
February 3, 2025 at 7:40 PM
A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions pubmed.ncbi.nlm.nih.gov/39893634/ #cryoem
Thrilled to have been involved in this work and looking forward to what the Sherlock Lab has in store!
A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions pubmed.ncbi.nlm.nih.gov/39893634/ #cryoem
February 4, 2025 at 12:02 AM
Thrilled to have been involved in this work and looking forward to what the Sherlock Lab has in store!
Reposted by Conner Langeberg
✨ New from C-GEM in ACS Central Science:
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
pubs.acs.org/doi/10.1021/...
Congrats to Alexandra & Jacob, along with Isaac, Jess, @alexsolivan.bsky.social, @nxhamlish.bsky.social, Katie, Alanna, Jamie, and Scott!
#NSFfunded @pubs.acs.org
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
pubs.acs.org/doi/10.1021/...
Congrats to Alexandra & Jacob, along with Isaac, Jess, @alexsolivan.bsky.social, @nxhamlish.bsky.social, Katie, Alanna, Jamie, and Scott!
#NSFfunded @pubs.acs.org
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
Thioesters are critical chemical intermediates in numerous extant biochemical reactions and are invoked as key reagents during prebiotic peptide synthesis on an evolving Earth. Here we asked if a thio...
pubs.acs.org
February 3, 2025 at 6:31 PM
✨ New from C-GEM in ACS Central Science:
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
pubs.acs.org/doi/10.1021/...
Congrats to Alexandra & Jacob, along with Isaac, Jess, @alexsolivan.bsky.social, @nxhamlish.bsky.social, Katie, Alanna, Jamie, and Scott!
#NSFfunded @pubs.acs.org
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
pubs.acs.org/doi/10.1021/...
Congrats to Alexandra & Jacob, along with Isaac, Jess, @alexsolivan.bsky.social, @nxhamlish.bsky.social, Katie, Alanna, Jamie, and Scott!
#NSFfunded @pubs.acs.org
Reposted by Conner Langeberg
Reposted by Conner Langeberg
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
January 30, 2025 at 9:57 PM
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
Reposted by Conner Langeberg
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
January 30, 2025 at 3:40 AM
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
Reposted by Conner Langeberg
scary but fascinating - cells have a degradation pathway that hunts down C-terminal scars (amides!) on damaged proteins. just wow. chemical biology plus CRISPR at its best. big congrats to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
January 29, 2025 at 5:57 PM
scary but fascinating - cells have a degradation pathway that hunts down C-terminal scars (amides!) on damaged proteins. just wow. chemical biology plus CRISPR at its best. big congrats to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...