Carolina Cigankova
@cigankova.bsky.social
Research Intern @ErturkLab | Biotechnology student @TUM
Reposted by Carolina Cigankova
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Reposted by Carolina Cigankova
📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
March 1, 2025 at 6:36 PM
📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
Reposted by Carolina Cigankova
Want to know what we do at our startup Deep Piction? Check out our paper with Denali Therapeutics. Using our proprietary clearing & imaging technologies, we mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in whole mouse bodies and monkey brains. go.nature.com/3Xifva2
February 26, 2025 at 5:04 PM
Want to know what we do at our startup Deep Piction? Check out our paper with Denali Therapeutics. Using our proprietary clearing & imaging technologies, we mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in whole mouse bodies and monkey brains. go.nature.com/3Xifva2
Reposted by Carolina Cigankova
2/ The relative scarcity of interactions between dormant disseminated tumor cells (DTC) and antigen specific T-cells explains immune evasion for metastasis! The authors reveal immune-strategies to overcome this for DTC eradication.
Cyrus Ghajar @fredhutch.bsky.social
www.cell.com/cancer-cell/...
Cyrus Ghajar @fredhutch.bsky.social
www.cell.com/cancer-cell/...
Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies
Dormant disseminated tumor cells (DTCs) persist despite anti-tumor immunity. How these cells evade immunosurveillance is unknown. Goddard et al. reveal a previously unappreciated form of immunoevasion called “relative scarcity” that underlies DTC persistence. T cell-based immunotherapies increase interaction frequency between DTCs and antigen-specific T cells, leading to DTC depletion.
www.cell.com
December 31, 2024 at 4:32 PM
2/ The relative scarcity of interactions between dormant disseminated tumor cells (DTC) and antigen specific T-cells explains immune evasion for metastasis! The authors reveal immune-strategies to overcome this for DTC eradication.
Cyrus Ghajar @fredhutch.bsky.social
www.cell.com/cancer-cell/...
Cyrus Ghajar @fredhutch.bsky.social
www.cell.com/cancer-cell/...
Reposted by Carolina Cigankova
We got a message from the university to remove any use of the "DEI", "diversity", "equity", or "inclusion" from all public-facing documents. They said that even "biodiversity" is being flagged by the federal government. We live in the dumbest timeline.
February 11, 2025 at 8:47 AM
We got a message from the university to remove any use of the "DEI", "diversity", "equity", or "inclusion" from all public-facing documents. They said that even "biodiversity" is being flagged by the federal government. We live in the dumbest timeline.
Reposted by Carolina Cigankova
Deep visual multi-omics profiling reveals mechanisms that underly cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma https://www.biorxiv.org/content/10.1101/2025.01.31.635927v1
February 4, 2025 at 4:49 PM
Deep visual multi-omics profiling reveals mechanisms that underly cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma https://www.biorxiv.org/content/10.1101/2025.01.31.635927v1
Reposted by Carolina Cigankova
A new generation of cancer-preventing vaccines could wipe out tumors before they form.
Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo
Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo
February 4, 2025 at 7:56 PM
A new generation of cancer-preventing vaccines could wipe out tumors before they form.
Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo
Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo
Reposted by Carolina Cigankova
New Paper Online:
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.
www.nature.com/articles/s41...
#Apolipoprotein #Nanotechnology #RNA
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.
www.nature.com/articles/s41...
#Apolipoprotein #Nanotechnology #RNA
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors - Nature Nanotechnology
In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their prog...
www.nature.com
February 3, 2025 at 11:17 AM
New Paper Online:
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.
www.nature.com/articles/s41...
#Apolipoprotein #Nanotechnology #RNA
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.
www.nature.com/articles/s41...
#Apolipoprotein #Nanotechnology #RNA
Reposted by Carolina Cigankova
A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg
A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology
Mapping the metabolic effects of drugs helps define their mode of action.
go.nature.com
January 28, 2025 at 3:42 PM
A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg
Reposted by Carolina Cigankova
See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...
January 30, 2025 at 4:43 PM
See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...
Reposted by Carolina Cigankova
Spatial-Mux-seq is a multimodal spatial platform for simultaneously profiling the transcriptome, chromatin accessibility, histone modifications, and select proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 27, 2025 at 6:30 PM
Spatial-Mux-seq is a multimodal spatial platform for simultaneously profiling the transcriptome, chromatin accessibility, histone modifications, and select proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Carolina Cigankova
DeepSeek, a Chinese #AI firm and family of large language models, says it has found a way to match the performance of its U.S. rivals using second-tier graphics processing units—and at a fraction of the cost. scim.ag/4jqcFcF
Chinese firm’s faster, cheaper AI language model makes a splash
DeepSeek’s open-source answer to ChatGPT is “a highly impressive display of research,” expert says
scim.ag
January 27, 2025 at 2:26 PM
DeepSeek, a Chinese #AI firm and family of large language models, says it has found a way to match the performance of its U.S. rivals using second-tier graphics processing units—and at a fraction of the cost. scim.ag/4jqcFcF
Elon Musk makes surprise appearance at AfD event in eastern Germany
Elon Musk makes surprise appearance at AfD event in eastern Germany
Tycoon tells 4,500 people at campaign event in Halle to be proud of German culture in speech via video link
Elon Musk made a surprise appearance during Germany’s Alternative für Deutschland (AfD) election campaign event in Halle in eastern Germany on…
www.theguardian.com
January 26, 2025 at 12:43 PM
Some good news
Billionaire Michael Bloomberg announced Thursday that Bloomberg Philanthropies will step in to help fund the United Nations climate change work after President Donald Trump withdrew from the Paris Climate Agreement—for the second time.
Michael Bloomberg Will Help Fund UN Climate Body After Trump Withdraws From Paris Climate Agreement
President Donald Trump announced Monday the U.S. would begin the process of withdrawing from the Paris Agreement again.
www.forbes.com
January 26, 2025 at 10:45 AM
Some good news
Reposted by Carolina Cigankova
As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳
Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....
🧵
Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....
🧵
Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex
We find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the...
doi.org
January 20, 2025 at 3:40 PM
As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳
Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....
🧵
Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....
🧵
Reposted by Carolina Cigankova
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8
Targeting FOXM1 condensates reduces breast tumour growth and metastasis - Nature
The transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and metastasis.
go.nature.com
January 16, 2025 at 8:58 PM
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8
Reposted by Carolina Cigankova
Excited to share our new technique for visualizing nanoparticles or viruses at single-cell resolution across the entire mouse body! This approach uses deep learning for precise quantification, and we’ve made the code available-give it a try with your dataset! Thanks so much to the whole team!
Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
January 14, 2025 at 3:30 PM
Excited to share our new technique for visualizing nanoparticles or viruses at single-cell resolution across the entire mouse body! This approach uses deep learning for precise quantification, and we’ve made the code available-give it a try with your dataset! Thanks so much to the whole team!
Reposted by Carolina Cigankova
Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
January 14, 2025 at 3:13 PM
Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
Reposted by Carolina Cigankova
Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System https://www.biorxiv.org/content/10.1101/2024.12.02.626440v1
Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System https://www.biorxiv.org/content/10.1101/2024.12.02.626440v1
During the progression of cancer, metastatic cells frequently enter a dormant phase. The immune syst
www.biorxiv.org
December 5, 2024 at 6:50 PM
Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System https://www.biorxiv.org/content/10.1101/2024.12.02.626440v1
Reposted by Carolina Cigankova
SCP-Nano: #PrecisionMedicine with Nanocarrier Visualization
Combining advanced imaging & AI, researchers at #HelmholtzMunich, LMU& TUM developed SCP-Nano, mapping nanocarriers in the body at single-cell resolution – offering more precise therapies.
👉https://t1p.de/muluc
Combining advanced imaging & AI, researchers at #HelmholtzMunich, LMU& TUM developed SCP-Nano, mapping nanocarriers in the body at single-cell resolution – offering more precise therapies.
👉https://t1p.de/muluc
January 14, 2025 at 10:04 AM
SCP-Nano: #PrecisionMedicine with Nanocarrier Visualization
Combining advanced imaging & AI, researchers at #HelmholtzMunich, LMU& TUM developed SCP-Nano, mapping nanocarriers in the body at single-cell resolution – offering more precise therapies.
👉https://t1p.de/muluc
Combining advanced imaging & AI, researchers at #HelmholtzMunich, LMU& TUM developed SCP-Nano, mapping nanocarriers in the body at single-cell resolution – offering more precise therapies.
👉https://t1p.de/muluc
Reposted by Carolina Cigankova
"propaganda by Trump’s allies to shift blame to scientists for his administration's disastrous handling of the COVID pandemic that killed 1.2M Americans..worked on some Republican voters" www.scientificamerican.com/article/the-...
The Real Reason People Don’t Trust in Science Has Nothing to Do with Scientists
Propaganda works, is the real upshot of a survey showing lingering post-pandemic distrust of science
www.scientificamerican.com
January 6, 2025 at 6:50 PM
"propaganda by Trump’s allies to shift blame to scientists for his administration's disastrous handling of the COVID pandemic that killed 1.2M Americans..worked on some Republican voters" www.scientificamerican.com/article/the-...
Reposted by Carolina Cigankova
Do you have a favorite proteomic paper of 2024? I narrowed my list down to 20-ish. (It's pretty clear what Nature had a favorite) proteomicsnews.blogspot.com/2024/12/my-f...
My favorite proteomics papers of 2024!
It's been...a...year....for sure. And for proteomics, this is EASILY the biggest year ever. Mine kicked off with the honor of being invit...
proteomicsnews.blogspot.com
December 29, 2024 at 1:40 PM
Do you have a favorite proteomic paper of 2024? I narrowed my list down to 20-ish. (It's pretty clear what Nature had a favorite) proteomicsnews.blogspot.com/2024/12/my-f...
Reposted by Carolina Cigankova
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal
imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy.
This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated
downregulation ...
www.embopress.org
January 3, 2025 at 9:30 AM
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....
Reposted by Carolina Cigankova
new out in Nature www.nature.com/articles/s41...
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
www.nature.com
January 2, 2025 at 6:03 PM
new out in Nature www.nature.com/articles/s41...
Reposted by Carolina Cigankova
In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis
Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis
Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor cell state evolution. However, the molecular mechanisms underlying metastasis remain elusive...
www.biorxiv.org
December 31, 2024 at 1:12 PM
In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis