Alessandra Boletta
@bolettalab.bsky.social
Head of Unit @SanRaffaele Milan, Italy | Past Director, Div. Genetics and Cell Biology | Alumna @JHMI, Baltimore, USA | Marie Curie Excellence Team leader | ERCAdvG
Cell Biologist with interest in renal disorders #PKD #Cilia #Cancermetabolism
Cell Biologist with interest in renal disorders #PKD #Cilia #Cancermetabolism
Reposted by Alessandra Boletta
CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....
October 31, 2025 at 5:14 PM
CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....
Reposted by Alessandra Boletta
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Advances in ciliary proteomics – towards cracking the hidden proteome code of cilia
Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.
journals.biologists.com
November 1, 2025 at 4:34 PM
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Reposted by Alessandra Boletta
Save the date!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!
July 29, 2025 at 8:50 AM
Save the date!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!
We have an open #ERC funded PhD position to work on #cilia #mitochondria #PKD and #matabolism
Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan
👇
Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan
👇
June 11, 2025 at 12:57 PM
We have an open #ERC funded PhD position to work on #cilia #mitochondria #PKD and #matabolism
Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan
👇
Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan
👇
Reposted by Alessandra Boletta
Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail
https://go.nature.com/45L9NlX
https://go.nature.com/45L9NlX
How a mysterious epidemic of kidney disease is killing thousands of young men
Nature - Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail.
go.nature.com
June 8, 2025 at 10:34 AM
Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail
https://go.nature.com/45L9NlX
https://go.nature.com/45L9NlX
Reposted by Alessandra Boletta
🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
www.science.org
February 10, 2025 at 6:45 AM
🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...
Reposted by Alessandra Boletta
Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...
Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various
pathophysiological states in pigs shows impaired metabolic activity across organs
by a Western diet or hypercholest...
www.cell.com
May 29, 2025 at 2:20 PM
Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...
Reposted by Alessandra Boletta
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
May 15, 2025 at 6:05 PM
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
Reposted by Alessandra Boletta
Very happy to find our last article in Kidney International Reports online today!
#cilia #ciliopathies #kidney
#cilia #ciliopathies #kidney
Our last paper is now available on the Kidney International website! Thanks to all collaborators and special congrats to Alice and Guillaume... #cilia #ciliopathies #kidney
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis
Primary cilia are sensory antennas that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development …
www.sciencedirect.com
May 7, 2025 at 1:16 PM
Very happy to find our last article in Kidney International Reports online today!
#cilia #ciliopathies #kidney
#cilia #ciliopathies #kidney
Reposted by Alessandra Boletta
How curvature affects epithelial tissues?
Answer in 5 papers! To understand this, one must first gain control over curvature.
The most logical way of doing this is through scaffolding in vitro — make a shape and attach cells.
Answer in 5 papers! To understand this, one must first gain control over curvature.
The most logical way of doing this is through scaffolding in vitro — make a shape and attach cells.
March 16, 2025 at 4:04 AM
How curvature affects epithelial tissues?
Answer in 5 papers! To understand this, one must first gain control over curvature.
The most logical way of doing this is through scaffolding in vitro — make a shape and attach cells.
Answer in 5 papers! To understand this, one must first gain control over curvature.
The most logical way of doing this is through scaffolding in vitro — make a shape and attach cells.
Reposted by Alessandra Boletta
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌
Another big win for #cilia biology!!
Another big win for #cilia biology!!
May 4, 2025 at 1:16 PM
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
Reposted by Alessandra Boletta
Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌
Another big win for #cilia biology!!
Another big win for #cilia biology!!
May 2, 2025 at 3:07 PM
Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌
Another big win for #cilia biology!!
Another big win for #cilia biology!!
Reposted by Alessandra Boletta
Congratulations Susan! Super deserved!
Congratulations to Susan Dutcher, a luminary in the cilia field! @dutcherlab.bsky.social
www.nasonline.org/news/2025-na...
www.nasonline.org/news/2025-na...
National Academy of Sciences Elects Members and International Members - NAS
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...
www.nasonline.org
April 30, 2025 at 5:38 PM
Congratulations Susan! Super deserved!
Reposted by Alessandra Boletta
📣 Don’t miss the review by @bolettalab.bsky.social & S. Clerici on metabolic and mitochondrial alterations in #PolycysticKidneyDisease and other renal #ciliopathies ➡️ doi.org/10.1038/s443...
at IRCCS San Raffaele Scientific Institute
at IRCCS San Raffaele Scientific Institute
April 22, 2025 at 2:49 PM
📣 Don’t miss the review by @bolettalab.bsky.social & S. Clerici on metabolic and mitochondrial alterations in #PolycysticKidneyDisease and other renal #ciliopathies ➡️ doi.org/10.1038/s443...
at IRCCS San Raffaele Scientific Institute
at IRCCS San Raffaele Scientific Institute
Reposted by Alessandra Boletta
A week until our 51st @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social UK Cilia and Centrosome Network e-symposium: 15/04/2025 15:00-17:15 BST. Still not registered for the series- join us here: www.eventbrite.co.uk/e/bscb-genso... Free and open to all! /1
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
www.eventbrite.co.uk
April 15, 2025 at 7:56 AM
A week until our 51st @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social UK Cilia and Centrosome Network e-symposium: 15/04/2025 15:00-17:15 BST. Still not registered for the series- join us here: www.eventbrite.co.uk/e/bscb-genso... Free and open to all! /1
Reposted by Alessandra Boletta
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
April 14, 2025 at 8:42 AM
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
Reposted by Alessandra Boletta
Reposted by Alessandra Boletta
I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.
April 4, 2025 at 1:29 PM
I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.
Reposted by Alessandra Boletta
Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans - Nature Communications
Decoding the content of extracellular vesicles (EVs) is key to understanding cell communication. Nikonorova et al. used targeted proximity labeling to uncover polycystin EV cargo and cargo-loading mec...
www.nature.com
April 3, 2025 at 2:28 PM
Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alessandra Boletta
Reposted by Alessandra Boletta
Looking for a home for your #cilia submission? Still time to be part of this special issue of the Journal of Cell Science- the journal for the cell biology community, by the cell biology community! ⏰ Reach out to @lottepedersen.bsky.social or I to discuss....
Today is the last day to submit to @jcellsci.bsky.social's upcoming special issue on cilia and flagella. This issue will be coordinated by two Guest Editors: Pleasantine Mill
@cilialab.bsky.social
and Lotte Pedersen
@lottepedersen.bsky.social
journals.biologists.com/jcs/pages/ci...
@cilialab.bsky.social
and Lotte Pedersen
@lottepedersen.bsky.social
journals.biologists.com/jcs/pages/ci...
March 31, 2025 at 4:03 PM
Looking for a home for your #cilia submission? Still time to be part of this special issue of the Journal of Cell Science- the journal for the cell biology community, by the cell biology community! ⏰ Reach out to @lottepedersen.bsky.social or I to discuss....
Reposted by Alessandra Boletta
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
January 6, 2025 at 11:19 AM
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
Reposted by Alessandra Boletta
Our Guest Editor @lottepedersen.bsky.social is attending our Biologists @ 100 conference. Reach out to Lotte if you have questions about submitting your research to our special issue on cilia and flagella biology: journals.biologists.com/jcs/pages/ci...
Submission deadline: 31 March
#biologists100
Submission deadline: 31 March
#biologists100
March 25, 2025 at 3:01 PM
Our Guest Editor @lottepedersen.bsky.social is attending our Biologists @ 100 conference. Reach out to Lotte if you have questions about submitting your research to our special issue on cilia and flagella biology: journals.biologists.com/jcs/pages/ci...
Submission deadline: 31 March
#biologists100
Submission deadline: 31 March
#biologists100
In L.A. heading to Ventura Beach for the #GRC on #mitochondria. Excited to share our long-standing work on mitochondria in #PKD and our more recent discovery of the cross-talk between #cilia and #mitochondria
@erc.europa.eu
@erc.europa.eu
March 23, 2025 at 3:47 PM
In L.A. heading to Ventura Beach for the #GRC on #mitochondria. Excited to share our long-standing work on mitochondria in #PKD and our more recent discovery of the cross-talk between #cilia and #mitochondria
@erc.europa.eu
@erc.europa.eu
Reposted by Alessandra Boletta
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
www.science.org
March 22, 2025 at 1:47 AM
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...