Eszter Posfai
@eposfai.bsky.social
Preimplantation development and germline biology. Live imaging and genome engineering. Assistant Prof at Princeton.
Reposted by Eszter Posfai
🔊New preprint from our lab!
Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans
www.researchsquare.com/article/rs-7...
Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans
www.researchsquare.com/article/rs-7...
Zygotene cilia regulate meiosis, germ cell development and fertility in zebrafish, mice, and humans
Germ cells accurately organize their chromosomes through the program of meiosis to successfully generate haploid gametes for fertilization1. Chromosomal pairing, which is essential for homologous reco...
www.researchsquare.com
October 26, 2025 at 4:01 PM
🔊New preprint from our lab!
Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans
www.researchsquare.com/article/rs-7...
Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans
www.researchsquare.com/article/rs-7...
Reposted by Eszter Posfai
LIMmunity is growing! 🤰🤱👶
We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!
Come be part of our collaborative team!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!
Come be part of our collaborative team!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Postdoctoral Scientist- Lim Lab
Primary Work Address: Dept of Molecular Biology, Princeton, NJ, 08544 Current HHMI Employees, click here to apply via your Workday account. The Lim Lab at Princeton University is seeking an energetic,...
hhmi.wd1.myworkdayjobs.com
September 10, 2025 at 8:40 PM
LIMmunity is growing! 🤰🤱👶
We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!
Come be part of our collaborative team!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!
Come be part of our collaborative team!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Reposted by Eszter Posfai
Mathematical modelling of the first fate decision
This Research Highlight showcases the work from Maria Avdeeva, Madeleine Chalifoux, Bradley Joyce, Stanislav Y. Shvartsman, Eszter Posfai @eposfai.bsky.social :
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Maria Avdeeva, Madeleine Chalifoux, Bradley Joyce, Stanislav Y. Shvartsman, Eszter Posfai @eposfai.bsky.social :
journals.biologists.com/dev/article/...
September 10, 2025 at 3:42 PM
Mathematical modelling of the first fate decision
This Research Highlight showcases the work from Maria Avdeeva, Madeleine Chalifoux, Bradley Joyce, Stanislav Y. Shvartsman, Eszter Posfai @eposfai.bsky.social :
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Maria Avdeeva, Madeleine Chalifoux, Bradley Joyce, Stanislav Y. Shvartsman, Eszter Posfai @eposfai.bsky.social :
journals.biologists.com/dev/article/...
Reposted by Eszter Posfai
our unexpected results on the importance of a neural cell adhesion molecule in sea anemone epithelialization and gastrulation are just posted in the following preprint.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Depletion of a neural cell adhesion molecule disrupts both epithelial and germ layer identity in sea anemone embryos
Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epith...
www.biorxiv.org
August 6, 2025 at 5:27 AM
our unexpected results on the importance of a neural cell adhesion molecule in sea anemone epithelialization and gastrulation are just posted in the following preprint.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Eszter Posfai
The #devbio project that encompassed the majority of my postdoc is finally out! Huge thanks to my coauthors and our collaborators without whom this work would not have been possible, and my adviser Eszter Posfai who let me play with a light sheet microscope and some colorful mice :)
Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!
August 3, 2025 at 4:45 PM
The #devbio project that encompassed the majority of my postdoc is finally out! Huge thanks to my coauthors and our collaborators without whom this work would not have been possible, and my adviser Eszter Posfai who let me play with a light sheet microscope and some colorful mice :)
Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!
August 2, 2025 at 7:31 PM
Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!
Reposted by Eszter Posfai
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
July 22, 2025 at 8:52 PM
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
Reposted by Eszter Posfai
We’re hiring! Our lab at WashU has an opening for a Senior/Staff Scientist position. If you're passionate about ovarian physiology, oocyte quality, and excited to contribute to a dynamic and growing team, we’d love to hear from you! Reach out to me directly for more information.
July 21, 2025 at 10:39 PM
We’re hiring! Our lab at WashU has an opening for a Senior/Staff Scientist position. If you're passionate about ovarian physiology, oocyte quality, and excited to contribute to a dynamic and growing team, we’d love to hear from you! Reach out to me directly for more information.
Reposted by Eszter Posfai
Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...
July 1, 2025 at 1:58 PM
Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...
Reposted by Eszter Posfai
For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁
Done with some awesome colleagues @florpratto.bsky.social
www.nature.com/articles/s41...
Done with some awesome colleagues @florpratto.bsky.social
www.nature.com/articles/s41...
Intercellular bridges are essential for transposon repression and meiosis in the male germline - Nature Communications
A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meio...
www.nature.com
April 8, 2025 at 10:47 PM
For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁
Done with some awesome colleagues @florpratto.bsky.social
www.nature.com/articles/s41...
Done with some awesome colleagues @florpratto.bsky.social
www.nature.com/articles/s41...
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
www.science.org
March 22, 2025 at 1:47 AM
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...
Reposted by Eszter Posfai
Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
www.science.org
March 21, 2025 at 4:45 PM
Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...
A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron).
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
March 5, 2025 at 2:54 AM
A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron).
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
Reposted by Eszter Posfai
Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 7, 2025 at 5:46 PM
Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Eszter Posfai
An intriguing mechanism of germline cyst formation through innovative live imaging in fetal mice gonads, and computational modeling.
Check out my dispatch in @currentbiology.bsky.social on this beautiful work.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
Check out my dispatch in @currentbiology.bsky.social on this beautiful work.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
December 16, 2024 at 5:39 PM
An intriguing mechanism of germline cyst formation through innovative live imaging in fetal mice gonads, and computational modeling.
Check out my dispatch in @currentbiology.bsky.social on this beautiful work.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
Check out my dispatch in @currentbiology.bsky.social on this beautiful work.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
Reposted by Eszter Posfai
Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition.
Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...
www.biorxiv.org
November 29, 2024 at 1:49 PM
Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Reposted by Eszter Posfai
Sharing my latest preprint as a re-introduction to bsky!
biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
November 11, 2024 at 6:34 PM
Sharing my latest preprint as a re-introduction to bsky!
biorxiv.org/content/10.1...
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
biorxiv.org/content/10.1...
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
Check out our new paper in @currentbiology.bsky.social by amazing grad students @ezlevy.bsky.social and @isabellaleite.bsky.social “A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice”
authors.elsevier.com/a/1k7fg3QW8S...
authors.elsevier.com/a/1k7fg3QW8S...
November 20, 2024 at 7:44 PM
Check out our new paper in @currentbiology.bsky.social by amazing grad students @ezlevy.bsky.social and @isabellaleite.bsky.social “A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice”
authors.elsevier.com/a/1k7fg3QW8S...
authors.elsevier.com/a/1k7fg3QW8S...