Bohdana Hurieva🇺🇦
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bhurieva.bsky.social
Bohdana Hurieva🇺🇦
@bhurieva.bsky.social
MSc student @soreklab.bsky.social at Weizmann Institute of Science
Evolution of immune systems 🌱🦠
Reposted by Bohdana Hurieva🇺🇦
Preprint: Systematic discovery of TIR-based immune signaling systems in bacteria

Conservation of TIR-derived signals accross the tree of life! We found bacterial TIR immune systems that signal via canonical cADPR (like in humans) and 2'cADPR (a plant immune signal).

Documented 11 Thoeris types
December 4, 2025 at 1:56 PM
New Thoeris systems reveal a deep connection between bacterial TIR-produced immune signals to plant and human immunity🦠🌱🧍‍♀️

It was a great honor to contribute to this project! Congratulations to @erezyirmiya.bsky.social and Azita Leavitt!!🎉🥂
I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life.

www.biorxiv.org/content/10.6...
Systematic discovery of TIR-based immune signaling systems in bacteria
Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...
www.biorxiv.org
December 4, 2025 at 11:43 AM
Reposted by Bohdana Hurieva🇺🇦
🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...
Meta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomes
Abstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st
academic.oup.com
December 3, 2025 at 2:34 AM
Very excited to join the upcoming meeting this May!🦠🧫
Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed)
sisb2026.rockefeller.edu
SISB2026
sisb2026.rockefeller.edu
December 2, 2025 at 7:16 AM
Reposted by Bohdana Hurieva🇺🇦
Looking forward to the meeting on the immune system of bacteria! Rockefeller, 5-7 May 2026. A fantastic lineup of speakers, expecting exiting science
Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed)
sisb2026.rockefeller.edu
SISB2026
sisb2026.rockefeller.edu
December 2, 2025 at 6:52 AM
Reposted by Bohdana Hurieva🇺🇦
🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...
November 27, 2025 at 9:35 AM
Reposted by Bohdana Hurieva🇺🇦
I'd also like to highlight a recent publication by @audeber.bsky.social, @enzopoirier.bsky.social, and colleagues showing FAM118B, which they term "SIRal", is essential for innate immune response in mammalian cellular models; they also have great phylogenetic analysis and insights into biochemistry.
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
November 17, 2025 at 2:16 PM
Great structural study expanding on the role of NAD-cleaving sirtuins in humans
November 17, 2025 at 3:56 PM
Reposted by Bohdana Hurieva🇺🇦
📣 New preprint from us at phagefoundry.org 📣
A solid machine learning framework & to predict strain-level phage-host interactions across diverse bacterial genera from genome sequences alone. Avery Noonan from the Arkin Lab led this massive effort
www.biorxiv.org/content/10.1...
Phage Foundry
phagefoundry.org
November 16, 2025 at 5:58 PM
Reposted by Bohdana Hurieva🇺🇦
NEW pub in @science.org 🥳

Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?

For over 15 years, #phylogenomic studies have been divided.

We provide new evidence suggesting that...

🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
Reposted by Bohdana Hurieva🇺🇦
Congratulations to Sorek lab alumnus Nitzan Tal, who won the prestigious 2025 Science & SciLifeLab prize for the best PhD thesis in Systems Biology! 💫

Read her Prize Assay, published in the journal Science today

www.science.org/doi/10.1126/...

@nitzantal.bsky.social
November 14, 2025 at 6:33 PM
Reposted by Bohdana Hurieva🇺🇦
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...

Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
www.science.org
November 13, 2025 at 10:15 PM
Reposted by Bohdana Hurieva🇺🇦
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41...
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
the sun is shining through the clouds in the sky above the ocean
ALT: the sun is shining through the clouds in the sky above the ocean
media.tenor.com
November 12, 2025 at 4:00 PM
Reposted by Bohdana Hurieva🇺🇦
📖Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶‍♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com

Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n

www.nature.com/articles/s41...
Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations - Nature Ecology & Evolution
A search for analogues of the human SAMD9/9L antiviral genes identifies convergent evolution of this gene family in the bacterial and animal kingdoms, with species-specific and recent genomic signatur...
www.nature.com
November 12, 2025 at 5:55 PM
Reposted by Bohdana Hurieva🇺🇦
How is epigenetic information inherited? We found that CDCA7 proteins are critical players in the inheritance of DNA methylation at CG sites in plants, and this is true both in the lab and in the wild. How does this work? 🧵👇
New paper! Work led by @p-bourguet.bsky.social and Frédéric Berger at the GMI of the @oeaw.bsky.social and @esasaki007.bsky.social identified how protein CDCA7 helps plants stably maintain epigenetic modifications across generations.

Read more: www.oeaw.ac.at/gmi/detail/n...
November 7, 2025 at 5:05 PM
Reposted by Bohdana Hurieva🇺🇦
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Bohdana Hurieva🇺🇦
Amazing discovery by @ostermanilya.bsky.social - two systems that can detect methylated mononucleotides after genome degradation!

Watching Ilya decipher this mechanism was a masterclass of scientific detective work - and I was happy to contribute a bit with a phylogenetic perspective🔎
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides.
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
November 6, 2025 at 11:34 AM
Reposted by Bohdana Hurieva🇺🇦
Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79).

Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Labs in bacterial immunity
docs.google.com
November 4, 2025 at 3:06 PM
Reposted by Bohdana Hurieva🇺🇦
Last year it was discovered that a single bacterial NLR-like protein can recognize multiple, structurally unrelated phage proteins (Béchon et al, Kibby et al)

Now, a new study shows the same for a plant NLR. Another example how principles of immunity remain conserved from bacteria to eukaryotes
November 2, 2025 at 6:34 PM
Reposted by Bohdana Hurieva🇺🇦
New article alert: Bacterial TIR-based immune systems sense phage capsids to initiate defense

Out now in Nature Microbiology by Cameron G. Roberts, Chloe B. Fishman, Zhiying Zhang, Dalton V. Banh, Dinshaw J. Patel & Luciano A. Marraffini

#microsky

www.nature.com/articles/s41...
Bacterial TIR-based immune systems sense phage capsids to initiate defense - Nature Microbiology
After sensing capsids, the Thoeris antiphage defense system triggers a cascade that leads to NAD+ cleavage and cell arrest, which are dynamics that are mirrored in some mammalian immune pathways.
www.nature.com
October 24, 2025 at 5:23 PM
Reposted by Bohdana Hurieva🇺🇦
🚨 Systems Virology Journal Club – 8th Series! 🚨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
October 20, 2025 at 2:55 PM
Reposted by Bohdana Hurieva🇺🇦
Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by @hugovaysset.bsky.social and @audeber.bsky.social @cp-molcell.bsky.social

#MicroSky

www.cell.com/molecular-ce...
October 16, 2025 at 2:58 PM
Reposted by Bohdana Hurieva🇺🇦
We are happy to share our latest work in @nature.com . We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and @xgrau.bsky.social
rdcu.be/eLbaZ
October 15, 2025 at 7:58 PM
Reposted by Bohdana Hurieva🇺🇦
A little late to the Panoptes party, but I’m delighted to share that our paper is published! 👁️ www.nature.com/articles/s41...
The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
www.nature.com
October 3, 2025 at 4:11 PM