Lucie Etienne
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lucievirevolte.bsky.social
Lucie Etienne
@lucievirevolte.bsky.social
1.1K followers 960 following 18 posts
Researcher PI @CIRI_Lyon @CNRS @ENSdeLyon
Functional evolution of virus-host interactions. Impact on cross-species transmissions. 🦇 🦍 🦠 🧬 🌳
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lucievirevolte.bsky.social
Lucie Etienne @lucievirevolte.bsky.social · Feb 17
👀Our latest work, led by Amandine Le Corf fantastic PhD student alumni @biorxivpreprint.bsky.social . Great collab @denard.bsky.social @psudmant.bsky.social

Genomic and functional #adaptations in #GBP5 highlight specificities of #bat antiviral innate #immunity 🦇🦠

www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted by Lucie Etienne
cnrsbiologie.bsky.social
#ResultatScientifique 🔎 Certains gènes antiviraux humains partagent des défenses communes avec les bactéries, révélant une convergence évolutive surprenante 🧬
✍️ Alexandre Legrand et @lucievirevolte.bsky.social
📕 Nature Ecology and Evolution
buff.ly/Su0EdiU
Défenses immunitaires : une invention répétée au cours de l’évolution
Dans une étude publiée dans Nature Ecology and Evolution, des scientifiques montrent que les gènes SAMD9 et SAMD9L, a
www.insb.cnrs.fr
November 12, 2025 at 9:00 AM
lucievirevolte.bsky.social
📖Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶‍♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com

Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n

www.nature.com/articles/s41...
Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations - Nature Ecology & Evolution
A search for analogues of the human SAMD9/9L antiviral genes identifies convergent evolution of this gene family in the bacterial and animal kingdoms, with species-specific and recent genomic signatur...
www.nature.com
November 12, 2025 at 5:55 PM
Reposted by Lucie Etienne
denard.bsky.social
Come join us in beautiful Britanny, France in May 2026 for a workshop that I am organizing with @lucievirevolte.bsky.social and @psudmant.bsky.social on Rapid host adaptations to infections:

sites.google.com/berkeley.edu...
October 23, 2025 at 1:20 PM
Reposted by Lucie Etienne
francoisrousset.bsky.social
Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏
erc.europa.eu European Research Council (ERC) @erc.europa.eu · Sep 4
📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 11:40 AM
Reposted by Lucie Etienne
audeber.bsky.social
🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...
www.science.org
July 24, 2025 at 6:23 PM
Reposted by Lucie Etienne
banerjeelab.ca
🚨Our new study out today in Nature Communications. Bats can asymptomatically host multiple viruses while remaining apparently healthy. Here we identify how interferon-mediated responses protect bats and identify molecular adaptations in GBP1. #LZCI
Link: www.nature.com/articles/s41...
Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity - Nature Communications
Bats harbor diverse viruses but it’s less clear how they tolerate infection. Here, by characterizing innate immune responses in bat cells the authors show that IFN-beta signaling resists antagonistic ...
www.nature.com
July 1, 2025 at 1:39 PM
lucievirevolte.bsky.social
#standupforscience in Lyon!
For science in France and in the world.
In solidarity to our American colleagues.
March 7, 2025 at 8:22 PM
Reposted by Lucie Etienne
standupforscifr.bsky.social
Stand up for science Lyon / Grand Est :

*Lyon*
16h00 – Rassemblement place des Terreaux.

*Nancy*
10h00 – Débats. Amphithéâtre de la présidence Léopold, 34 cours Léopold, Nancy.
12-30-13h30 – ronde des obstiné·e·s.
Place Stanislas, Nancy.
March 6, 2025 at 7:58 AM
Reposted by Lucie Etienne
irim-life.bsky.social
We're hiring a Group Leader in Infection Biology! 🧬
Apply now to join us at the IRIM in Montpellier, and lead cutting-edge research in pathogen virulence, host-pathogen interactions or drug resistance, and shape the future of infection biology! 🦠🧫
Please RT (and follow us!)
🗓️ Deadline: Feb. 28, 2025
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November 12, 2024 at 1:35 PM
Reposted by Lucie Etienne
cnrs-rhoneauvergne.bsky.social
#TalentsCNRS 🥉 | Découvrez la vidéo de Lucie Etienne, chercheuse au Centre international de recherche en infectiologie et lauréate de la médaille de bronze du @cnrs.fr en 2024 !

@cnrsbiologie.bsky.social @lucievirevolte.bsky.social @ensdelyon.bsky.social @inserm.fr

www.youtube.com/watch?v=jE8b...
Lucie Etienne : décryptage des épidémies virales et des défenses immunitaires l TalentsCNRS
YouTube video by CNRS
www.youtube.com
February 18, 2025 at 3:03 PM
Reposted by Lucie Etienne
banerjeelab.ca
Thorough and nice study from @lucievirevolte.bsky.social and colleagues. Bat GBP5.
denard.bsky.social David Enard @denard.bsky.social · Feb 18
New paper with @lucievirevolte.bsky.social and @psudmant.bsky.social, led by Lucie Etienne and Amandine Le Corf.
The sub-cellular localization of important innate antiviral factor GBP5 has evolved multiple times during bat evolution, with consequences for activity.
www.biorxiv.org/content/10.1...
www.biorxiv.org
February 20, 2025 at 6:39 AM
Reposted by Lucie Etienne
denard.bsky.social
New paper with @lucievirevolte.bsky.social and @psudmant.bsky.social, led by Lucie Etienne and Amandine Le Corf.
The sub-cellular localization of important innate antiviral factor GBP5 has evolved multiple times during bat evolution, with consequences for activity.
www.biorxiv.org/content/10.1...
www.biorxiv.org
February 18, 2025 at 5:49 PM
lucievirevolte.bsky.social
👀Our latest work, led by Amandine Le Corf fantastic PhD student alumni @biorxivpreprint.bsky.social . Great collab @denard.bsky.social @psudmant.bsky.social

Genomic and functional #adaptations in #GBP5 highlight specificities of #bat antiviral innate #immunity 🦇🦠

www.biorxiv.org/content/10.1...
www.biorxiv.org
February 17, 2025 at 5:25 PM
Reposted by Lucie Etienne
freddelsuc.bsky.social
New @erc.europa.eu funded #ConvergeAnt paper on phylogenetics and transcriptomics of chitinase gene repertoires in convergent ant-eating mammals finally published in @genomebiolevol.bsky.social

doi.org/10.1093/gbe/...
February 7, 2025 at 6:45 AM
lucievirevolte.bsky.social
Congratulations @memerman.bsky.social !! So well deserved!

Your mentorship is incredible - Thank you
harmitmalik.bsky.social Harmit Singh Malik @harmitmalik.bsky.social · Jan 31
Congrats to @memerman.bsky.social for winning the @fredhutch.bsky.social faculty conclave award for education, training, and mentorship. I cannot think of someone more deserving for three decades of transforming lives of trainees (and naive junior colleagues)!
February 7, 2025 at 6:02 PM
lucievirevolte.bsky.social
We are looking for a #postdoc to discover cell-autonomous innate immune antiviral factors in mammals, based on newly-identified defense of prokaryotes!
#EvoCure #comparativeImmunology #virology
Please share
@inserm.fr @ciri-lyon.bsky.social @cnrsbiologie.bsky.social
ciri.ens-lyon.fr/teams/lp2l/j...
Postdoc position in comparative immunology and virology — Centre International de Recherche en Infectiologie
A 1-year renewable postdoctoral researcher position is available in our lab (PI: Lucie ETIENNE, CIRI, ENS-Lyon) to discover new antiviral cell-autonomous innate immune factors in mammals, based on new...
ciri.ens-lyon.fr
February 7, 2025 at 2:42 PM
Reposted by Lucie Etienne
soreklab.bsky.social
Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...
Structure-guided discovery of viral proteins that inhibit host immunity
Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...
www.cell.com
January 23, 2025 at 4:12 PM
Reposted by Lucie Etienne
francoisrousset.bsky.social
Exciting to see our paper now published 🙌
www.science.org/doi/10.1126/...

In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇
January 31, 2025 at 11:41 AM
Reposted by Lucie Etienne
frafiorini.bsky.social
Delighted to share our latest work on SARS-CoV-2 Nucleocapsid and Nonsense-Mediated mRNA Decay. 👇
doi.org/10.1093/nar/...
The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2
Abstract. The nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs the expression of mRNAs with specific char
doi.org
January 28, 2025 at 3:26 PM
Reposted by Lucie Etienne
jeffmugridge.bsky.social
Final thoughts:
💡TRMT1 cleavage & inactivation may be another mechanism by which SARS-CoV-2 manipulates host tRNA modifications and translation!
🦠We think this could impact viral pathogenesis or phenotypes!
💊Our structure might help understand Mpro substrate recognition or different pockets to drug!
A comical summary of the paper! A short cartoon with 4 panels showing: (1) TRMT1 wanting to transfer methyl groups to tRNA; the tRNA loves this because those methyl groups (on G26) will help its stability and overall translation properties. (2) But, uh oh, here comes the SARS-CoV-2 main protease! (3) The protease takes a big bite out of TRMT1, severing its leg (ie Zinc finger domain); *CHOMP*. (4) TRMT1 and tRNA cry out to one another in grief, as the wounded TRMT1 is no longer able transfer methyl groups to tRNA - disrupting its structure and translation properties!
January 9, 2025 at 2:36 PM
Reposted by Lucie Etienne
jeffmugridge.bsky.social
Next, with @lucievirevolte.bsky.social we found that the TRMT1 cleavage sequence is highly conserved in mammals, except for some #rodents 🐭, where a Q -> K mutation at the absolutely critical Q residue makes TRMT1 variants with this change entirely resistant to cleavage!... 6/9
(Top) Sequence logo showing that the TRMT1 cleavage consensus sequence is highly conserved in mammals, except in some rodents (denoted by a cute little mouse), where a key Q residue is replaced with K. (Bottom) Western blots showing that while WT TRMT1 is efficiently cleaved by Mpro, TRMT1 with the Q->K mutation (like in some rodents) is not cleaved! (Does this help out rodents during coronavirus infection? We don't know!)
January 9, 2025 at 2:36 PM
Reposted by Lucie Etienne
jeffmugridge.bsky.social
📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification!

elifesciences.org/articles/91168

A short bluetorial... 🧵 1/9
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltr...
elifesciences.org
January 9, 2025 at 2:36 PM
Reposted by Lucie Etienne
grovearmada.bsky.social
🎁 Early Xmas present from your friends at the MRC-University of Glasgow Centre for Virus Research @cvrinfo.bsky.social

We're thrilled to unwrap Viro3D - a comprehensive database of virus protein structures: >85,000 predicted structures from 4,400 human & animal viruses! 🦠

viro3d.cvr.gla.ac.uk
Viro3D
viro3d.cvr.gla.ac.uk
December 20, 2024 at 5:51 PM
Reposted by Lucie Etienne
tarnopol.bsky.social
Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr
Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
Metazoan parasites have played a major role in shaping innate immunity in animals. Insect hosts and parasitoid wasps are excellent models for illumina…
www.sciencedirect.com
December 20, 2024 at 5:58 PM
Reposted by Lucie Etienne
amersocvirology.bsky.social
Get ready for ASV 2025! The 2025 American Society for Virology meeting will be hosted by McGill University and held at the Palais des Congrès de Montréal, Montréal, Québec, Canada from July 14 - 17, 2025. Abstract submission, travel award apps, and registration are now open! asv.org/asv2025/regi...
Register 2025 | American Society for Virology
The 44th Annual Meeting of the American Society for Virology! Dates: July 14 – 17, 2025 (Monday – Thursday) Palais des congrès de Montréal Host: McGill University *TEACHER TRAVEL GRANTS: Applications…
asv.org
December 4, 2024 at 6:25 PM