Jeff Mugridge
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jeffmugridge.bsky.social
Jeff Mugridge
@jeffmugridge.bsky.social
I'm a scientist! Asst Prof at Univ of Delaware | RNA biochemistry, RNA modifications, (metallo)enzymology, structural biology, and chemistry | Postdoc at UCSF | PhD at UCBerkeley | he/him

mugridgelab.org
Pinned
💥Latest preprint from our lab is now live! We propose a crazy(!?) new mechanism for how the radical SAM enzyme Elp3 (a subunit of the Elongator complex) modifies tRNA! #RNAsky #enzymes 🧵...
Reposted by Jeff Mugridge
DUCK AROUND, FIND OUT! With our duck delivery in tow, we waddled up to the Hill to let our representatives know that it's time to send the Quack-In-Chief packing. #ImpeachRFK
September 16, 2025 at 9:37 PM
Reposted by Jeff Mugridge
THIS IS IT! THIS IS HUGE!!

PLAINTIFF'S WIN!!

Judge Young rules that the NIH grant terminations at issue in these cases are illegal and therefore vacated. BOOM!
"This Court rules that the challenged directives . . . are arbitrary and capricious."

"They are of no force and effect."

"They are illegal and so are each of the terminations before this Court"
June 16, 2025 at 6:21 PM
Reposted by Jeff Mugridge
We are just getting started. “American Spring? How nonviolent protest in the US is accelerating…” wagingnonviolence.org/2025/06/amer...
American Spring? How nonviolent protest in the US is accelerating
Contrary to conventional wisdom, anti-Trump protests this year have dwarfed 2017 in size, and they have been extraordinarily peaceful.
wagingnonviolence.org
June 14, 2025 at 6:40 PM
LOTS of people and LOTS of energy for #NoKings in Newark DE! ❌👑❌

@indivisiblenewark.bsky.social
June 14, 2025 at 7:35 PM
Reposted by Jeff Mugridge
Please sign on and add your voice in calling for an NIH that prioritizes the safety of research participants and public health over political momentum.
actionnetwork.org/forms/add-na...
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
June 10, 2025 at 4:10 AM
My favorite is the 'world tour' tee shirt 🤣🤣
Looking forward to this GRC!
June 4, 2025 at 1:24 AM
Reposted by Jeff Mugridge
Without basic science, there is nothing to translate.
I know you all know this, but apparently it needs to be said that basic science is a NECESSARY PRECURSOR to translational science
NSF to ONLY fund research in five areas: artificial intelligence, quantum information science, biotechnology, nuclear energy, and translational science. Can this be happening?

www.science.org/content/arti...
May 10, 2025 at 12:05 AM
💥Latest preprint from our lab is now live! We propose a crazy(!?) new mechanism for how the radical SAM enzyme Elp3 (a subunit of the Elongator complex) modifies tRNA! #RNAsky #enzymes 🧵...
May 8, 2025 at 2:46 PM
😬😬
May 2, 2025 at 1:07 AM
Tucson!🌵 #desert #photography
April 23, 2025 at 5:57 PM
Reposted by Jeff Mugridge
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...
www.training.nih.gov
April 10, 2025 at 1:22 AM
Well done.
Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
www.harvard.edu
April 14, 2025 at 11:52 PM
Yes, thanks to @aaup.bsky.social and others!
10 national unions repping 3 million members demand the release of abducted immigrant workers and call for employers and university admins to refuse to cooperate and elected officials to “find their spines.”

This is the way.

labornotes.org/blogs/2025/0...
April 9, 2025 at 1:02 PM
Reposted by Jeff Mugridge
📣 GET IN, DORKS!
We are going protesting...AGAIN! 📣

This time we are standing up for our core value of academic freedom and asking university leadership to STAND UP WITH US against Trump's attack on higher ed ✊

#StandUpWithUS

Register/find an event: actionnetwork.org/event_campai...
April 8, 2025 at 10:09 PM
Reposted by Jeff Mugridge
🚨 BIG week for lawsuits against the NIH.

Now 16 states have sued NIH and HHS for "engag[ing] in a concerted, and multi-pronged effort to disrupt NIH’s grants."

"The result of these disruptions has been, in a word, devastating," they write.

ag.ny.gov/press-releas...
Attorney General James Sues Trump Administration for Illegally Cutting Funding for Medical Research
NEW YORK – New York Attorney General Letitia James and a coalition of 15 other attorneys general today filed a lawsuit against the Trump administration for its
ag.ny.gov
April 4, 2025 at 2:44 PM
Reposted by Jeff Mugridge
Our 28-yr U-RISE/MARC NIH grant that has served over 500 students and made us one of the top institutions producing African American students who go on to receive MD/PhDs in the United States was just cancelled yesterday. What a unnecessary and tragic end to such an impactful program...
March 28, 2025 at 8:56 PM
Reposted by Jeff Mugridge
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.

Find out how your community may be impacted.

Explore more at SCIMaP: scienceimpacts.org

a 🧵
March 28, 2025 at 2:15 AM
Reposted by Jeff Mugridge
powerful detailed account of ICE captivity

"To put things into perspective: I had a Canadian passport, lawyers, resources, media attention, friends, family and even politicians advocating for me...Imagine what this system is like for every other person in there"

www.theguardian.com/us-news/2025...
I’m the Canadian who was detained by Ice for two weeks. It felt like I had been kidnapped
I was stuck in a freezing cell without explanation despite eventually having lawyers and media attention. Yet, compared with others, I was lucky
www.theguardian.com
March 19, 2025 at 11:46 AM
Me, leaving the US for a conference in Europe.
March 15, 2025 at 12:25 AM
Great crowd and a great time at #StandUpForScience DC today at the Lincoln Memorial! @standupforscience.bsky.social
Photos… 🧵
March 7, 2025 at 8:59 PM
Reposted by Jeff Mugridge
Write for @sciencehomecoming.bsky.social A major property of communication is that only repeated messages stick. Even if there’s already an op-ed on science funding in your town, adding more makes an impact. After we @standupforscience.bsky.social today, let’s write to bring it home. 🧪🏠
March 7, 2025 at 2:29 PM
Ready to #StandUpForScience tomorrow in DC! Let’s go! @standupforscience.bsky.social
March 6, 2025 at 12:52 PM
Anyone have tips for making active homemade Phusion polymerase? We have a plasmid (no his tag), and are doing purification by heat denaturation and then sizing, from which we get *a lot* of purified protein. But we can't see any polymerase activity from these purified preps!
March 4, 2025 at 5:24 PM
Let's go! Looking like a great Friday in DC! I'll be there!
WHERE WILL YOU BE IN 4 DAYS?

Stand Up for Science with us on March 7th, in DC & Nationwide!

☀️🌎🧪
March 3, 2025 at 10:30 PM
Reposted by Jeff Mugridge
Happy Homecoming to Biochemistry Professor and High School Science Olympian Jeff Mugridge from Central New York who wrote for The Post Standard about the rewards of science funding for NY health and economy 🍎 🧪🧬🔬🏠@jeffmugridge.bsky.social

www.syracuse.com/opinion/2025...
Protect science funding driving innovation, investment in Syracuse (Guest Opinion by Jeffrey Mugridge)
Severe cuts to budgets and staff threaten to undermine the next generation of American scientists, writes professor who discovered his love of science as a Liverpool High student.
www.syracuse.com
February 27, 2025 at 5:16 PM