Abdel Mazouzi
@amazouzi.bsky.social
Scientist at the Netherlands Cancer Institute, EMBO fellow, Opinions are my own
Pinned
Abdel Mazouzi
@amazouzi.bsky.social
· Aug 13
I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.
Reposted by Abdel Mazouzi
FINALLY the BBC starts covering what we’ve all already seen.
“A 55-year-old Palestinian woman has been taken to hospital after being clubbed over the head by a masked Jewish settler as she was picking olives.”
“A 55-year-old Palestinian woman has been taken to hospital after being clubbed over the head by a masked Jewish settler as she was picking olives.”
Palestinian woman in hospital after being clubbed by masked Israeli settler
The attacker is seen striking the 55-year-old woman with a large wooden stick during the assault in the West Bank village of Turmus Ayaa.
www.bbc.co.uk
October 21, 2025 at 12:01 PM
FINALLY the BBC starts covering what we’ve all already seen.
“A 55-year-old Palestinian woman has been taken to hospital after being clubbed over the head by a masked Jewish settler as she was picking olives.”
“A 55-year-old Palestinian woman has been taken to hospital after being clubbed over the head by a masked Jewish settler as she was picking olives.”
Reposted by Abdel Mazouzi
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
embl.wd103.myworkdayjobs.com
October 10, 2025 at 7:30 AM
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Abdel Mazouzi
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
Directors
The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.
www.mpg.de
September 17, 2025 at 3:25 PM
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
Reposted by Abdel Mazouzi
Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊
Histone Recycling Promotes PARP Inhibitor Resistance
Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...
aacrjournals.org
September 15, 2025 at 8:15 AM
Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊
Reposted by Abdel Mazouzi
Sarah Moser ( @sarahmoser.bsky.social) from the lab of Jos Jonkers, Netherlands Cancer Institute (@nkinl.bsky.social) & Oncode Institute (@oncodeinstitute.bsky.social). 👏🏾 5/
September 10, 2025 at 10:24 AM
Sarah Moser ( @sarahmoser.bsky.social) from the lab of Jos Jonkers, Netherlands Cancer Institute (@nkinl.bsky.social) & Oncode Institute (@oncodeinstitute.bsky.social). 👏🏾 5/
Reposted by Abdel Mazouzi
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
September 10, 2025 at 10:19 AM
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
Reposted by Abdel Mazouzi
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
August 28, 2025 at 5:35 PM
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Reposted by Abdel Mazouzi
Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/...
#fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer
#fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer
August 22, 2025 at 11:27 AM
Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/...
#fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer
#fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer
Reposted by Abdel Mazouzi
Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance
go.nature.com/45vRWhd
go.nature.com/45vRWhd
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
go.nature.com
August 18, 2025 at 1:31 PM
Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance
go.nature.com/45vRWhd
go.nature.com/45vRWhd
Reposted by Abdel Mazouzi
Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out!
Congratulations!! and happy we could contribute a tiny bit.
Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.
Congratulations!! and happy we could contribute a tiny bit.
Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com
August 16, 2025 at 12:32 PM
Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out!
Congratulations!! and happy we could contribute a tiny bit.
Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.
Congratulations!! and happy we could contribute a tiny bit.
Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.
Reposted by Abdel Mazouzi
This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.
August 13, 2025 at 3:44 PM
This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.
Reposted by Abdel Mazouzi
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com
August 13, 2025 at 3:44 PM
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
Reposted by Abdel Mazouzi
Extremely cool!
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com
August 13, 2025 at 7:20 PM
Extremely cool!
Reposted by Abdel Mazouzi
new out in Nature yesterday www.nature.com/articles/s41...
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com
August 14, 2025 at 8:12 AM
new out in Nature yesterday www.nature.com/articles/s41...
I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.
August 13, 2025 at 3:57 PM
I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.
Reposted by Abdel Mazouzi
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
July 8, 2025 at 1:11 AM
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
Reposted by Abdel Mazouzi
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
July 4, 2025 at 11:00 AM
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Reposted by Abdel Mazouzi
Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research.
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
June 27, 2025 at 5:51 AM
Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research.
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
Reposted by Abdel Mazouzi
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
June 13, 2025 at 9:33 AM
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
Reposted by Abdel Mazouzi
Hey my fellow Germans! I wasn't aware, but there is an AvH-JSPP postdoc fellowship, dedicated to German citizens aiming to do their postdoc in Japan. It covers salary + travel to Japan + startup for your life in Japan. Let me know if you are interested!
www.humboldt-foundation.de/en/apply/spo...
www.humboldt-foundation.de/en/apply/spo...
JSPS Research Fellowship
The Japan Society for the Promotion of Science (JSPS) Research Fellowship supports you as a highly qualified postdoc from Germany in conducting your research in Japan – regardless of discipline.
www.humboldt-foundation.de
June 6, 2025 at 10:46 AM
Hey my fellow Germans! I wasn't aware, but there is an AvH-JSPP postdoc fellowship, dedicated to German citizens aiming to do their postdoc in Japan. It covers salary + travel to Japan + startup for your life in Japan. Let me know if you are interested!
www.humboldt-foundation.de/en/apply/spo...
www.humboldt-foundation.de/en/apply/spo...
Great news from The ERC : erc.europa.eu/news-events/...:
June 2, 2025 at 3:35 PM
Great news from The ERC : erc.europa.eu/news-events/...:
Really cool story highlighting one of the most beautiful genetic suppression interactions between SRBD1 and condensin II! #CoolScience
www.linkedin.com/feed/update/...
www.linkedin.com/feed/update/...
SRBD1, a highly conserved gene required for chromosome individualization | Jonne Raaijmakers
Excited to share our latest publication in Cell Reports!
Our study reveals the critical role of SRBD1, a highly conserved and previously enigmatic essential…
www.linkedin.com
March 21, 2025 at 11:07 AM
Really cool story highlighting one of the most beautiful genetic suppression interactions between SRBD1 and condensin II! #CoolScience
www.linkedin.com/feed/update/...
www.linkedin.com/feed/update/...
Reposted by Abdel Mazouzi
Some DNA damage, RAD51, MND1, cohesin and RAD54L with a lot of imaging! www.biorxiv.org/content/10.1...
Visualizing homology search in living cells
Homologous recombination (HR) is a DNA repair process that requires a homologous sequence for the repair of DNA double-stranded breaks. The search for homology is the rate limiting step for HR, but th...
www.biorxiv.org
March 6, 2025 at 2:14 AM
Some DNA damage, RAD51, MND1, cohesin and RAD54L with a lot of imaging! www.biorxiv.org/content/10.1...
Extensive review of 30 years of BRCA1 biology by @sarahmoser.bsky.social and @josjonkers.bsky.social! Such a fascinating protein, and this is probably just the tip of the iceberg of what BRCA1 can do. I am sure more surprises are coming in the next three decades!
BRCA1 turned 30 🎉
To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers.
Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers.
Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers
Abstract. Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiate...
aacrjournals.org
March 3, 2025 at 9:53 AM
Extensive review of 30 years of BRCA1 biology by @sarahmoser.bsky.social and @josjonkers.bsky.social! Such a fascinating protein, and this is probably just the tip of the iceberg of what BRCA1 can do. I am sure more surprises are coming in the next three decades!
Reposted by Abdel Mazouzi
*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany
It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
Professorship in genetics and molecular cell biology (W3) (f/m/d) - Academic Positions
The University of Cologne is one of the oldest and largest universities in Germany. With its six Faculties covering a broad spectrum of disciplines and its i...
academicpositions.com
February 24, 2025 at 3:14 PM
*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany
It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer