Yue Kris Wu
kriswu.bsky.social
Yue Kris Wu
@kriswu.bsky.social

Postdoc at the Center for Theoretical Neuroscience at Columbia University

Wu Yue may refer to the following:Wuyue, a 10th-century kingdom during the Five Dynasties and Ten Kingdoms period Sacred Mountains of China, also known as "Wu Yue" in Chinese

Source: Wikipedia
Environmental science 42%
Computer science 38%

Reposted by Yue Wu

Episode #34 in #TheoreticalNeurosciencePodcast: On balanced neural networks – with Nicolas Brunel

theoreticalneuroscience.no/thn34

Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.

Reposted by Yue Wu

How does our brain excel at complex object recognition, yet get fooled by simple illusory contours? What unifying principle governs all Gestalt laws of perceptual organization?

We may have an answer: integration of learned priors through feedback. New paper with @kenmiller.bsky.social! 🧵

Reposted by Yue Wu

Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!

Reposted by Yue Wu

📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?

Two calls are open:

Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review

🔗 wti.yale.edu/opportunities

#KnowTogether
How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com

Reposted by Yue Wu

Do you see a white square?

A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.

🔗 alleninstitute.org/news/scienti...

#OpenScienceWeek

Reposted by Yue Wu

Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org

Reposted by Yue Wu

The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.

Come join me at ND! Feel free to reach out with any questions.

And please share!

apply.interfolio.com/173031
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com

Reposted by Yue Wu

📢We're #hiring Group Leaders!

Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.

🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines

Apply by Nov. 4👉 https://janelia.link/groupleader
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Reposted by Yue Wu

Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.

www.biorxiv.org/content/10.1...

Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org

Reposted by Yue Wu

I’m excited to share my final co-first author paper from my postdoc in Dan Dombeck's lab!

We explored how behavior, senses, and neurons influence how much information in the brain changes over time.

www.nature.com/articles/s41...

#science #research #neuroscience #hippocampus #placecells
Hippocampal representations drift in stable multisensory environments - Nature
Tracking of individual place cells in mouse CA1 shows that representational drift is not influenced by changes in environment or behaviour, and is lower for more excitable place cells.
www.nature.com
👨‍💻 Open PI position in our institute 👨‍💻 !! If you are an expert in Computational Neuroscience and want to start your lab in Bordeaux, contact us !
www.fens.org/careers/job-...
@neuromagendie.bsky.social
@neurobordeaux.bsky.social

Reposted by Yue Wu

We are seeking two independent Max Planck Research Groups working in scientific disciplines relevant to our institute. Applications should be sent in PDF format no later than 15th August 2025. Visit our call for applications on our institute website for detailed information!

Reposted by Yue Wu

⌛ One week left to submit your poster abstracts and travel grant applications for the #BernsteinConference 2025!

🗓️ Deadline: July 15

All info and submission 👉 bernstein-network.de/bernstein-co...

I would be happy to help, Joao. Just send me the document via email.

Reposted by Yue Wu

New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...

⚠️ Application deadline: end of September 2025

@neurobordeaux.bsky.social @neuromagendie.bsky.social
Group leader tenured-track position in Computational Neuroscience - Bordeaux Neurocampus
Neurocentre Magendie
www.bordeaux-neurocampus.fr
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Discovering cognitive strategies with tiny recurrent neural networks - Nature
Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...
doi.org

Congrats, Claire!

Reposted by Yue Wu

Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...

Reposted by Yue Wu

Very happy that this work is finally out in ‪@pnas.org‬! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS
Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...
www.pnas.org

Happy to share our new preprint! We show how cell-type-specific synaptic scaling mechanisms shape memory representations during associative learning and highlight a critical role of top-down inputs in modulating this process. www.biorxiv.org/content/10.1...
Cell-type-specific synaptic scaling mechanisms differentially contribute to associative learning
Excitatory synaptic scaling regulates network dynamics by proportionally adjusting excitatory synaptic strengths after sensory perturbations. During associative learning, blocking excitatory scaling i...
www.biorxiv.org

Reposted by Yue Wu

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n
Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
rdcu.be

Reposted by Yue Wu

Theory of interaction between untuned modulatory inputs and tuned sensory inputs https://www.biorxiv.org/content/10.1101/2025.04.28.651100v1
Our new paper is out in Science.

What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.

Congrats Jake!

www.science.org/doi/10.1126/...
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...
www.science.org

Reposted by Yue Wu

Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈

In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience
This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...
www.nature.com

Reposted by Yue Wu

Recruiting postdocs! Please get in touch if you wanna discuss projects on biologically plausible learning in RNNs through TUM's global postdoctoral fellowship. I'll be at Cosyne this year if you wanna talk more. www.tum.de/ueber-die-tu...
TUM Global Postdoc Fellowship - TUM
www.tum.de

Reposted by Yue Wu

Applications are due in two weeks (March 18) for the MBL's Methods in Computational Neuroscience course! 🧠 🖥️ Explore the computational and mathematical techniques that are used to address how the brain solves problems.

Read more: bit.ly/3EZZ6Rs
#ScienceStartsHere

Reposted by Yue Wu

📣 The 11th Statistical Analysis of Neuronal Data (SAND11) workshop will be held June 11-13, 2025 in New York at the @flatironinstitute.org with generous support from @simonsfoundation.org

Submissions for talks+posters are due March 21. See our website for details 👇

sandworkshop.github.io
SAND - 2025
SAND - 2025
sandworkshop.github.io