Étienne Becht | Lightnews

Etienne Becht

@ebecht.bsky.social

500 followers 660 following 7 posts

Computational immunologist. Interested in immunooncology, cytometry, single cell data, spatial data, T and B cell specificities...

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Biology 56%

Medicine 40%

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Etienne Becht @ebecht.bsky.social · 11d

Thanks, will try it ! We use cells for unstained/autofluorescence and viability, for the other markers we use beads

Etienne Becht @ebecht.bsky.social · 11d

Thanks a lot for the informative thread! Looks very exciting

Are single stained cellular controls necessary or only better ? We are using rare human samples so it's difficult to cells for single color controls, can we still hope to see improvements with AutoSpectral unmixing ?

Reposted by Étienne Becht

Adrian Liston @labliston.bsky.social · 14d

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Reposted by Étienne Becht

Iannacone Lab @iannaconelab.bsky.social · Sep 26

🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers

Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....

onlinelibrary.wiley.com

Reposted by Étienne Becht

Nature @nature.com · Sep 5

Nature research paper: One mother for two species via obligate cross-species cloning in ants

go.nature.com/45PYV6d

One mother for two species via obligate cross-species cloning in ants - Nature

In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same mother having distinct genomes and morphologies.

go.nature.com

Reposted by Étienne Becht

Rita Strack @ritastrack.bsky.social · Apr 10

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

Etienne Becht @ebecht.bsky.social · Mar 11

🧪💻 We're hiring ! Post-doctoral position open for a data scientist

👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...

Reposted by Kevin F. McCarthy, Robbie Gilligan, Ankur Pandya , and 3 more Kevin F. McCarthy, Robbie Gilligan, Ankur Pandya, Étienne Becht, Sabrina Wulff Pabilonia, Xavier De Lamo

Derek Thompson @dkthomp.bsky.social · Feb 27

Unbelievable news.

Pancreatic is one of the deadliest cancers.

New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.

www.nature.com/articles/s41...

Etienne Becht @ebecht.bsky.social · Feb 23

6. found just enough strength to relay dread while being funny

That is no tiny victory.

I hope you find support until you are strong enough to support those who need it !

Reposted by Étienne Becht

Nicole La Gruta @niclag.bsky.social · Feb 21

Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity

LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

www.science.org

Etienne Becht @ebecht.bsky.social · Feb 20

Flow cytometry batch effect correction without requiring normalization controls 🤩
onlinelibrary.wiley.com/doi/full/10....

CytoNorm 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls

Cytometry is a single cell, high-dimensional, high-throughput technique that is being applied across a range of disciplines. However, many elements alongside the data acquisition process might give r...

onlinelibrary.wiley.com

Reposted by Étienne Becht

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 18

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters

The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...

www.biorxiv.org

Reposted by Thomas R. Cox, Étienne Becht

Reposted by Étienne Becht

HIPC @hipcproject.bsky.social · Feb 17

Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...

tagtango: an application to compare single-cell annotations

AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c

academic.oup.com

Reposted by Étienne Becht

Alexander Dent @follicular.bsky.social · Feb 13

So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature

Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...

www.nature.com

Reposted by Étienne Becht

Institut du Cancer AP-HP. Nord @cancerparisnord.bsky.social · Jan 23

La FHU* MOSAIC² relabellisée pour 5 ans !

Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !

Plus d'informations sur le projet prochainement.

@hopitalbeaujon.bsky.social @ap-hp.bsky.social

Reposted by Étienne Becht

ACIR @acir-org.bsky.social · Jan 16

Luo et al. developed ATLAS-seq (Aptamer-based T-Lymphocyte Activity Screening and Sequencing), a microfluidic-based high-throughput platform for isolating and profiling antigen-reactive T cells. bit.ly/4fThnwo

Reposted by Étienne Becht

Waggoner Lab @labwaggoner.bsky.social · Jan 15

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org‪
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....

Etienne Becht @ebecht.bsky.social · Jan 7

Permanent position (research and teaching) for a bioinformatician immunologist available in a great lab and institute, in a beautiful campus in the center of Paris

www.linkedin.com/posts/isabel...

Isabelle Cremer on LinkedIn: Poste MCU immunologie-bioinformatique

Un poste de maître de conférences en immunologie-bioinformatique est ouvert au concours à Sorbonne Université, au sein de la Faculté des Sciences et…

www.linkedin.com

Reposted by Étienne Becht

Javier Santoyo @jsantoyo.bsky.social · Dec 19

Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references. #GenomeAssembly #HaplotypeResolved #Pangenomes #Genomics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....

Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references - Genome Biology

Background Long-read technologies from Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) have transformed genomics research by providing diverse data types like HiFi, Duplex, and ult...

genomebiology.biomedcentral.com

Reposted by Andreas J. Bäumler, Étienne Becht

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Reposted by Rémy Nicolle

Etienne Becht @ebecht.bsky.social · Dec 10

🌟 Calling all computational biology enthusiasts! 🌟 The awesome @remynicolle.bsky.social & friends created this Discord community to connect, collaborate, and share insights in this rapidly evolving field.

👉 Click here to join : discord.gg/2PzSE4dC

#Bioinformatics #ComputationalBiology

Reposted by Étienne Becht

Tomàs Montserrat Ayuso @tmontsay.bsky.social · Dec 3

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

bmcgenomics.biomedcentral.com

Reposted by Étienne Becht

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