Hunter Shain
@shainlab.bsky.social
UCSF, Department of Dermatology. Part of HTAN. Cancer, genomics, melanoma, cutaneous squamous cell carcinoma, dermatology, somatic mutations, tumor evolution, spatial transcriptomics, single-cell
Pinned
Hunter Shain
@shainlab.bsky.social
· Dec 13
Molecular effects of indoor tanning
The skin cells of tanning bed users have distinct mutational features as compared to people who only experience natural sunlight.
www.science.org
Proud to share our new paper in Science Advances.
We show that indoor tanning beds cause widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight.
www.science.org/doi/10.1126/...
#Melanoma #SkinCancer
We show that indoor tanning beds cause widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight.
www.science.org/doi/10.1126/...
#Melanoma #SkinCancer
Thinking about the soft money problem in science. My institution will send 100 emails to faculty list serves guilt tripping someone to volunteer to teach before offering a dime of compensation.
January 14, 2026 at 5:07 PM
Thinking about the soft money problem in science. My institution will send 100 emails to faculty list serves guilt tripping someone to volunteer to teach before offering a dime of compensation.
Reading the Mike Lauer interview. A very informative take from an insider on the state of NIH. www.statecraft.pub/p/whats-wron...
What’s Wrong with NIH Grants?
“Science is fundamentally different than remodeling a kitchen”
www.statecraft.pub
January 14, 2026 at 3:47 PM
Reading the Mike Lauer interview. A very informative take from an insider on the state of NIH. www.statecraft.pub/p/whats-wron...
Reposted by Hunter Shain
Likewise, Congressman Cole from Oklahoma is the chair of the overall House Appropriations committee.
If you can, reach out to his office as well.
It is noteworthy that OMB is willing to veto a bill over a minor-seeming NIH operational issue.
This makes me think this is part of a bigger plan...
If you can, reach out to his office as well.
It is noteworthy that OMB is willing to veto a bill over a minor-seeming NIH operational issue.
This makes me think this is part of a bigger plan...
patrick star from spongebob squarepants with his hands folded
ALT: patrick star from spongebob squarepants with his hands folded
media.tenor.com
January 14, 2026 at 1:33 PM
Likewise, Congressman Cole from Oklahoma is the chair of the overall House Appropriations committee.
If you can, reach out to his office as well.
It is noteworthy that OMB is willing to veto a bill over a minor-seeming NIH operational issue.
This makes me think this is part of a bigger plan...
If you can, reach out to his office as well.
It is noteworthy that OMB is willing to veto a bill over a minor-seeming NIH operational issue.
This makes me think this is part of a bigger plan...
The Luka Doncic for Anthony Davis trade looked bad from the get-go for the Mavericks, and it is aging even worse.
January 13, 2026 at 7:57 PM
The Luka Doncic for Anthony Davis trade looked bad from the get-go for the Mavericks, and it is aging even worse.
I think I have reached the point in my career where I have reviewed more grants than I have had grants reviewed.
January 13, 2026 at 7:14 PM
I think I have reached the point in my career where I have reviewed more grants than I have had grants reviewed.
This is probably overkill, but when reviewing grants, I randomize the order in which I read them. I worry that order matters. E.g. for the first grant, you do not have an overall sense of the quality and possibly err on the side of an average score.
January 12, 2026 at 5:15 PM
This is probably overkill, but when reviewing grants, I randomize the order in which I read them. I worry that order matters. E.g. for the first grant, you do not have an overall sense of the quality and possibly err on the side of an average score.
We (U.S. citizens) literally pay the tariffs. I bought something from Etsy from an international seller. UPS guy came to my door holding the package and gave me two options. 1. Write a check to UPS for the tariff or 2. refuse delivery and send it back.
January 9, 2026 at 10:35 PM
We (U.S. citizens) literally pay the tariffs. I bought something from Etsy from an international seller. UPS guy came to my door holding the package and gave me two options. 1. Write a check to UPS for the tariff or 2. refuse delivery and send it back.
Reposted by Hunter Shain
Great to see research on tanning bed and cancer risk from @bishaltandukar.bsky.social @shainlab.bsky.social on today’s @ucsanfrancisco.bsky.social Town Hall www.ucsf.edu/news/2025/12... #UCSFCancerProud
January 8, 2026 at 8:42 PM
Great to see research on tanning bed and cancer risk from @bishaltandukar.bsky.social @shainlab.bsky.social on today’s @ucsanfrancisco.bsky.social Town Hall www.ucsf.edu/news/2025/12... #UCSFCancerProud
Reposted by Hunter Shain
I know for me sports talk was the only thing I missed about Twitter until I found this list.
If you're missing having NFL memes and analysis in your feed in-between the politics and whatever reason you made a Bluesky account in the first place, Mina has an A+ list of peeps to follow.
If you're missing having NFL memes and analysis in your feed in-between the politics and whatever reason you made a Bluesky account in the first place, Mina has an A+ list of peeps to follow.
Alright here is the NFL STARTER PACK
Subscribe and your timeline will immediately be full of football talk and takes
Share widely, on other platforms, etc etc
go.bsky.app/8RH6KbH
Subscribe and your timeline will immediately be full of football talk and takes
Share widely, on other platforms, etc etc
go.bsky.app/8RH6KbH
January 2, 2026 at 9:31 PM
I know for me sports talk was the only thing I missed about Twitter until I found this list.
If you're missing having NFL memes and analysis in your feed in-between the politics and whatever reason you made a Bluesky account in the first place, Mina has an A+ list of peeps to follow.
If you're missing having NFL memes and analysis in your feed in-between the politics and whatever reason you made a Bluesky account in the first place, Mina has an A+ list of peeps to follow.
Proud to share our new paper in Science Advances.
We show that indoor tanning beds cause widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight.
www.science.org/doi/10.1126/...
#Melanoma #SkinCancer
We show that indoor tanning beds cause widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight.
www.science.org/doi/10.1126/...
#Melanoma #SkinCancer
Molecular effects of indoor tanning
The skin cells of tanning bed users have distinct mutational features as compared to people who only experience natural sunlight.
www.science.org
December 13, 2025 at 6:45 PM
Proud to share our new paper in Science Advances.
We show that indoor tanning beds cause widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight.
www.science.org/doi/10.1126/...
#Melanoma #SkinCancer
We show that indoor tanning beds cause widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight.
www.science.org/doi/10.1126/...
#Melanoma #SkinCancer
Hitting 1800 elo in style with a smothered mate!
December 5, 2025 at 9:42 PM
Hitting 1800 elo in style with a smothered mate!
What drives the earliest steps of skin cancer development?
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
December 2, 2025 at 12:32 AM
What drives the earliest steps of skin cancer development?
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
I remain stunned by this finding -- melanocytes have 5x more mutations than keratinocytes, despite the fact that the cells are next to each other in the basal layer of the epidermis, [theoretically] experiencing the same doses of UV radiation.
November 29, 2025 at 5:22 PM
I remain stunned by this finding -- melanocytes have 5x more mutations than keratinocytes, despite the fact that the cells are next to each other in the basal layer of the epidermis, [theoretically] experiencing the same doses of UV radiation.
I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Nature Communications - The evolution of cutaneous squamous cell carcinoma (cSCC) remains poorly understood. Here, the authors employ multi-omics and multi-scale analyses to explore the genetic...
www.nature.com
November 27, 2025 at 4:11 PM
I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...
Too small!
November 15, 2025 at 3:57 AM
Too small!
Reposted by Hunter Shain
Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social
November 14, 2025 at 8:49 PM
Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social
Nancy Pelosi is retiring after decades of service. I still remember when I received my first R01, and she sent me a congratulatory letter!
November 6, 2025 at 3:49 PM
Nancy Pelosi is retiring after decades of service. I still remember when I received my first R01, and she sent me a congratulatory letter!
1/ Should you get feedback on your grant proposals?
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
October 24, 2025 at 8:07 PM
1/ Should you get feedback on your grant proposals?
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
What is your favorite gene expression deconvolution software?
October 21, 2025 at 7:36 PM
What is your favorite gene expression deconvolution software?
Hey @bontahill.bsky.social , who are you rooting for? Stanford or FSU?
October 19, 2025 at 2:47 AM
Hey @bontahill.bsky.social , who are you rooting for? Stanford or FSU?
Reposted by Hunter Shain
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
a dog is sitting on a rug in front of a brick wall and a plant .
ALT: a dog is sitting on a rug in front of a brick wall and a plant .
media.tenor.com
October 16, 2025 at 12:25 AM
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Reposted by Hunter Shain
A bundle of interesting papers just dropped on Nature. Collectively, they describe the somatic mutational landscapes normal tissues.
October 9, 2025 at 2:01 PM
A bundle of interesting papers just dropped on Nature. Collectively, they describe the somatic mutational landscapes normal tissues.
Reposted by Hunter Shain
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)