Hunter Shain
@shainlab.bsky.social
UCSF, Department of Dermatology. Part of HTAN. Cancer, genomics, melanoma, cutaneous squamous cell carcinoma, dermatology, somatic mutations, tumor evolution, spatial transcriptomics, single-cell
Pinned
Hunter Shain
@shainlab.bsky.social
· Dec 12
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
We performed multi-omic profiling of epidermal keratinocytes, precancerous actinic keratoses, and squamous cell carcinomas to understand the molecular transitions during skin carcinogenesis. Single-ce...
www.biorxiv.org
We have an update to our preprint, "Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma", which is part of the Human Tumor Atlas Network (HTAN). Also, the first manuscript post from the Shain lab to Blue Sky! www.biorxiv.org/content/10.1...
Too small!
November 15, 2025 at 3:57 AM
Too small!
Reposted by Hunter Shain
Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social
November 14, 2025 at 8:49 PM
Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social
Nancy Pelosi is retiring after decades of service. I still remember when I received my first R01, and she sent me a congratulatory letter!
November 6, 2025 at 3:49 PM
Nancy Pelosi is retiring after decades of service. I still remember when I received my first R01, and she sent me a congratulatory letter!
1/ Should you get feedback on your grant proposals?
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
October 24, 2025 at 8:07 PM
1/ Should you get feedback on your grant proposals?
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
What is your favorite gene expression deconvolution software?
October 21, 2025 at 7:36 PM
What is your favorite gene expression deconvolution software?
Hey @bontahill.bsky.social , who are you rooting for? Stanford or FSU?
October 19, 2025 at 2:47 AM
Hey @bontahill.bsky.social , who are you rooting for? Stanford or FSU?
Reposted by Hunter Shain
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
a dog is sitting on a rug in front of a brick wall and a plant .
ALT: a dog is sitting on a rug in front of a brick wall and a plant .
media.tenor.com
October 16, 2025 at 12:25 AM
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Reposted by Hunter Shain
A bundle of interesting papers just dropped on Nature. Collectively, they describe the somatic mutational landscapes normal tissues.
October 9, 2025 at 2:01 PM
A bundle of interesting papers just dropped on Nature. Collectively, they describe the somatic mutational landscapes normal tissues.
Reposted by Hunter Shain
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Dear collaborator, I am writing to confirm support for your grant. Before I write one sentence describing my tiny role on your project, please read 3 paragraphs about how awesome your grant is, which I definitely wrote myself.
October 7, 2025 at 3:37 PM
Dear collaborator, I am writing to confirm support for your grant. Before I write one sentence describing my tiny role on your project, please read 3 paragraphs about how awesome your grant is, which I definitely wrote myself.
What a satisfying mate!
September 30, 2025 at 2:40 PM
What a satisfying mate!
Reposted by Hunter Shain
I felt it #moderate
#California #quake M4.8 | 3 km ESE of Berkeley, California | 1m ago | Sep 22, 2025 01:56 am (Pacific Standard Time)
Did you feel it? Submit a report!
#moderate #M2+ #M3+ #M4+ #United_States #California
Did you feel it? Submit a report!
#moderate #M2+ #M3+ #M4+ #United_States #California
Moderate magnitude 4.8 earthquake at 9 km depth
See detailed quake info, read user reports, submit your own if you felt it!
www.volcanodiscovery.com
September 22, 2025 at 1:48 PM
I felt it #moderate
Earthquake! Bay Area
September 22, 2025 at 9:58 AM
Earthquake! Bay Area
RFK said he would determine the cause of autism by "September" and Trump has pre-announced a major announcement on autism to come on Monday. 🍿
September 21, 2025 at 3:22 PM
RFK said he would determine the cause of autism by "September" and Trump has pre-announced a major announcement on autism to come on Monday. 🍿
STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution
September 21, 2025 at 3:21 PM
STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution
Does anyone else have dogs that ruin their sleep score? I was all good till 7am, but then an intermittent Mastiff with a HrV of 300 took over
September 20, 2025 at 4:53 AM
Does anyone else have dogs that ruin their sleep score? I was all good till 7am, but then an intermittent Mastiff with a HrV of 300 took over
After clearly saving changes to an NIH RPPR form, the system inevitably gives this warning.
September 18, 2025 at 3:36 PM
After clearly saving changes to an NIH RPPR form, the system inevitably gives this warning.
Serious question for the crowd: has a K-awardee ever actually done the coursework/mentor meetings they promised in the training plan? Or is it just a rite of passage?
September 16, 2025 at 3:29 PM
Serious question for the crowd: has a K-awardee ever actually done the coursework/mentor meetings they promised in the training plan? Or is it just a rite of passage?
Reposted by Hunter Shain
1,333 Notices issued by the NIH in the past week. Including 116 new R01 projects.
reporter.nih.gov/search/6lVq4...
reporter.nih.gov/search/6lVq4...
RePORT ⟩ RePORTER
reporter.nih.gov
September 8, 2025 at 2:12 PM
1,333 Notices issued by the NIH in the past week. Including 116 new R01 projects.
reporter.nih.gov/search/6lVq4...
reporter.nih.gov/search/6lVq4...
Politicized research comes and goes, but it always leave behind a legacy of permanent paperwork.
September 4, 2025 at 8:07 PM
Politicized research comes and goes, but it always leave behind a legacy of permanent paperwork.
Reposted by Hunter Shain
Very happy to share our work on signature SBS5. See Molly's thread for a short summary
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 3, 2025 at 3:56 PM
Very happy to share our work on signature SBS5. See Molly's thread for a short summary
Reposted by Hunter Shain
I HAVE BEEN SILENCED and CENSORED BY OUR GOVERNMENT!!!!
My latest…
sciencebasedmedicine.org/vinayprasadl...
My latest…
sciencebasedmedicine.org/vinayprasadl...
I am a Private Citizen Seeking to Hold My Government Accountable. Dr. Vinay Prasad, a Government Doctor, Killed My YouTube Channel.
Americans do not need our government's permission to remember the words of our public officials, and I refuse to let them be silenced or censored.
sciencebasedmedicine.org
August 31, 2025 at 4:05 PM
I HAVE BEEN SILENCED and CENSORED BY OUR GOVERNMENT!!!!
My latest…
sciencebasedmedicine.org/vinayprasadl...
My latest…
sciencebasedmedicine.org/vinayprasadl...