Wafik S. El-Deiry, MD, PhD, FACP
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Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social
730 followers 190 following 2.8K posts
Physician-Scientist Oncologist, Director Legorreta Cancer Center, Associate Dean, past Faculty Exec Cmte member, Brown Univ, ACS Professor, Chair, WIN Consortium in Precision Oncology, Entrepreneur, Boat Captain, joined Nov 16 ‘24 Pubs: tinyurl.com/s98xg3u
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Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · Nov 17
On 10-26-2024 I was at Brown University Family Weekend on College Green to share exciting progress at #LegorretaCancerCenter.

As a colon cancer doctor my message was to make sure you get your screening colonoscopy to prevent colon cancer as this could save your life.

www.tiktok.com/t/ZTYLaQo9J/
I’m here at @BrownUniversity Family Weekend on the College Green to speak with you about exciting developments at the #LegorretaCancerCenter over the last few years. As a colon cancer doctor my messa...
TikTok video by weldeiry
www.tiktok.com
Reposted by Wafik S. El-Deiry, MD, PhD, FACP
oncodaily.bsky.social
Killing of Human NSCLC Cells by TRAIL - Wafik El-Deiry

@weldeiry.bsky.social

oncodaily.com/voices/wafik...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Wafik El-Deiry: Killing of Human NSCLC Cells by TRAIL - OncoDaily
Wafik El-Deiry: Killing of Human NSCLC Cells by TRAIL / Lung cancer, non small cell lung cancer, NSCLC, TRAIL, Wafik El-Deiry, Wafik S. El-Deiry
oncodaily.com
November 11, 2025 at 12:23 AM
weldeiry.bsky.social
The morning sun comes through the Danoff Life Sciences Laboratories building bridge to the molecular medicine building at @BrownMedicine @BrownUniversity
November 11, 2025 at 12:49 PM
weldeiry.bsky.social
Oncoceutics, originally founded by me in 2004 was reincorporated in 2009. Oncoceutics licensed TRAIL-Inducing Compound #10/ONC201 for development pmc.ncbi.nlm.nih.gov/articles/PMC...
Cancer Biology & Therapy Editor-in-Chief, Wafik S El-Deiry, MD, PhD, FACP, inducted into the Society of Scholars of the Johns Hopkins University on April 7, 2014
An official website of the United States government
pmc.ncbi.nlm.nih.gov
November 10, 2025 at 7:57 AM
weldeiry.bsky.social
For nearly three decades since my lab reported the discovery of Death Receptor 5, the #eldeirylab has studied the TRAIL pathway that engages a powerful cancer self-destruct apoptosis mechanism through the innate immune system and natural killer cells. youtu.be/5wCkU13SkR4
Killing of human non-small cell lung cancer cells by TRAIL
YouTube video by weldeiry
youtu.be
November 10, 2025 at 7:18 AM
weldeiry.bsky.social
The US cannot afford to fall behind in global leadership and further damage the academic research ecosystem.

Battle between Trump and universities hurting scientific research in need of federal funding

www.cbsnews.com/news/researc...
Battle between Trump and universities hurting scientific research in need of federal funding
Federal research funding to universities has fueled breakthroughs for years. The White House is pressuring universities to align with the president's political agenda, or risk losing their funding.
www.cbsnews.com
November 10, 2025 at 2:34 AM
weldeiry.bsky.social
Some p53 mutations could help fight cancer, Baylor study finds

cancerletter.com/clinical-rou...
Some p53 mutations could help fight cancer, Baylor study finds - The Cancer Letter
The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading ...
cancerletter.com
November 9, 2025 at 7:27 PM
weldeiry.bsky.social
Interesting read👇

James Watson and the Price of Truth

open.substack.com/pub/chadcrow...
James Watson and the Price of Truth
With the recent death of James Dewey Watson, one of the last titans of twentieth-century science has fallen.
open.substack.com
November 9, 2025 at 1:12 AM
weldeiry.bsky.social
(RARE) Interview with James Watson and Francis Crick

www.youtube.com/watch?v=NGBD...
(RARE) Interview with James Watson and Francis Crick
YouTube video by Josefa`s Thoughts
www.youtube.com
November 9, 2025 at 12:29 AM
weldeiry.bsky.social
Rhode Island’s health care crisis needs a Ruggerio-style fix

State leaders aren’t showing enough urgency to save Our Lady of Fatima Hospital and Roger Williams Medical Center

www.bostonglobe.com/2025/11/06/m...
Rhode Island’s health care crisis needs a Ruggerio-style fix - The Boston Globe
State leaders aren’t showing enough urgency to save Our Lady of Fatima Hospital and Roger Williams Medical Center.
www.bostonglobe.com
November 8, 2025 at 6:30 PM
weldeiry.bsky.social
Prospect, R.I. reach temporary deal to keep Roger Williams, Fatima hospitals open

www.bostonglobe.com/2025/11/07/m...
Prospect, R.I. reach temporary deal to keep Roger Williams, Fatima hospitals open - The Boston Globe
New court filings show Fatima and Roger Williams hospitals are expected to lose about $6 million in November alone
www.bostonglobe.com
November 8, 2025 at 6:21 PM
weldeiry.bsky.social
FDA broadens search for new top drug regulator after early setbacks

www.statnews.com/2025/11/07/f...
FDA broadens search for new top drug regulator after early setbacks
George Tidmarsh left the agency amid accusations of misusing his authority and after clashing with another top official.
www.statnews.com
November 8, 2025 at 6:15 PM
Reposted by Wafik S. El-Deiry, MD, PhD, FACP
oncodaily.bsky.social
Cancer Doesn’t Pick and Choose Between Black, White, Latino, Democrat, Republican, or Independent - Wafik El-Deiry

@weldeiry.bsky.social

oncodaily.com/voices/wafik...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Wafik El-Deiry: Cancer Doesn’t Pick and Choose Between Black, White, Latino, Democrat, Republican, or Independent - OncoDaily
Wafik El-Deiry: Cancer Doesn’t Pick and Choose Between Black, White, Latino, Democrat, Republican, or Independent / Beth Sawyer, cancer, Hamlet Garcia, Kathy
oncodaily.com
November 7, 2025 at 9:47 PM
weldeiry.bsky.social
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+macrophages

www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
www.nature.com
November 8, 2025 at 10:00 AM
weldeiry.bsky.social
Mitochondria–endoplasmic reticulum cross talk in colorectal cancer (CRC)

www.eurekalert.org/news-release...
Mitochondria–endoplasmic reticulum cross talk in colorectal cancer (CRC)
According to “Global Cancer Statistics- 2022”, colorectal cancer (CRC) ranks third in incidence and second in cancer-related mortality. Given that approximately 50% of cases progress to me...
www.eurekalert.org
November 8, 2025 at 9:58 AM
weldeiry.bsky.social
Squamous cell carcinoma antigen-1/SerpinB3 is an endogenous skin injury response element

www.pnas.org/doi/10.1073/...
Squamous cell carcinoma antigen-1/SerpinB3 is an endogenous skin injury response element | PNAS
The squamous cell carcinoma antigen SerpinB3 is a serum-circulating biomarker of epithelial cancers associated with high metastasis, treatment resi...
www.pnas.org
November 8, 2025 at 9:54 AM
weldeiry.bsky.social
Non-orthosteric inhibition of enolase 1 impedes growth of triple-negative breast cancer

www.cell.com/cell-reports...
Non-orthosteric inhibition of enolase 1 impedes growth of triple-negative breast cancer
Tailor et al. identify enolase 1 (ENO1) as the target of SU212, a promising therapeutic candidate for triple-negative breast cancer (TNBC). By inducing ENO1 degradation, SU212 reduces tumor growth wit...
www.cell.com
November 8, 2025 at 9:51 AM
weldeiry.bsky.social
Radiation May Be Unnecessary for Many Breast Cancer Patients

www.nytimes.com/2025/11/05/h...
Radiation May Be Unnecessary for Many Breast Cancer Patients
www.nytimes.com
November 8, 2025 at 9:48 AM
weldeiry.bsky.social
RIP James Watson

James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97

www.nytimes.com/2025/11/07/s...
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 9:38 PM
weldeiry.bsky.social
Looking forward to attending the 229th meeting of the Interurban Clinical Club at University of Pennsylvania in Philadelphia.
November 7, 2025 at 4:36 AM
weldeiry.bsky.social
Glad to see👇

NCCN Updates Colon Cancer Guidelines Acknowledging FDA's Chemo Label Warning About DPYD Testing

www.precisionmedicineonline.com/precision-on...
NCCN Updates Colon Cancer Guidelines Acknowledging FDA's Chemo Label Warning About DPYD Testing
The influential oncology guidelines body revised guidelines with a nod to the FDA's explicit recommendation for testing in Xeloda's label.
www.precisionmedicineonline.com
November 6, 2025 at 7:54 PM
weldeiry.bsky.social
The dangerous illusion of 'peer-to-peer' review for prior authorization

www.statnews.com/2025/11/05/p...
The dangerous illusion of ‘peer-to-peer’ review for prior authorization
The aggravating prior authorization process includes one step that merits scrutiny and potentially regulatory action: the peer-to-peer review.
www.statnews.com
November 6, 2025 at 2:46 AM
weldeiry.bsky.social
Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs

www.nature.com/articles/s41...
Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs - Nature Chemical Biology
Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...
www.nature.com
November 5, 2025 at 4:27 PM
weldeiry.bsky.social
Glad to see our review👇

“Heterogeneity in Cancer”
by William J. MacDonald, Connor Purcell, Maximilian Pinho-Schwermann et al.
Cancers 2025, 17(3), 441;

on this list:

Cancers | Highly Viewed Papers and Hot Topic Special Issues on Molecular Cancer Biology

www.mdpi.com/about/announ...
www.mdpi.com
November 5, 2025 at 1:53 AM
weldeiry.bsky.social
Cell populations in human breast cancers are molecularly and biologically distinct with age

www.nature.com/articles/s43...
Cell populations in human breast cancers are molecularly and biologically distinct with age - Nature Aging
Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...
www.nature.com
November 5, 2025 at 1:34 AM
weldeiry.bsky.social
Three Investigators Named Winners of Memorial Sloan Kettering Cancer Center’s 2025 Paul Marks Prize for Cancer Research

www.mskcc.org/news-release...
Three Investigators Named Winners of Memorial Sloan Kettering Cancer Center’s 2025 Paul Marks Prize for Cancer Research
Memorial Sloan Kettering Cancer Center (MSK) will award three influential cancer researchers with this year’s Paul Marks Prize for Cancer Research. The prize, named in honor of former MSK president Pa...
www.mskcc.org
November 5, 2025 at 1:31 AM