Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social
Physician-Scientist Oncologist, Director Legorreta Cancer Center, Associate Dean, past Faculty Exec Cmte member, Brown Univ, ACS Professor, Chair, WIN Consortium in Precision Oncology, Entrepreneur, Boat Captain, joined Nov 16 ‘24 Pubs: tinyurl.com/s98xg3u
ONC201/TIC10 was renamed as Dordaviprone and then approved by the FDA on August 6, 2025 under the trade name Modeyso for treatment of H3K27M-mutated gliomas👇
FDA grants accelerated approval to dordaviprone for diffuse midline glioma
www.fda.gov/drugs/resour...
FDA grants accelerated approval to dordaviprone for diffuse midline glioma
www.fda.gov/drugs/resour...
FDA grants accelerated approval to dordaviprone
On August 6, 2025, the Food and Drug Administration granted accelerated approval to dordaviprone.
www.fda.gov
November 10, 2025 at 8:23 AM
ONC201/TIC10 was renamed as Dordaviprone and then approved by the FDA on August 6, 2025 under the trade name Modeyso for treatment of H3K27M-mutated gliomas👇
FDA grants accelerated approval to dordaviprone for diffuse midline glioma
www.fda.gov/drugs/resour...
FDA grants accelerated approval to dordaviprone for diffuse midline glioma
www.fda.gov/drugs/resour...
First report linking ONC201/TIC10 to the integrated stress response and activation of Death Receptor 5👇
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
www.science.org/doi/10.1126/...
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
www.science.org/doi/10.1126/...
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
ONC201 triggers an apoptotic cellular stress response in both solid and blood tumors.
www.science.org
November 10, 2025 at 8:08 AM
First report linking ONC201/TIC10 to the integrated stress response and activation of Death Receptor 5👇
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
www.science.org/doi/10.1126/...
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
www.science.org/doi/10.1126/...
First report of TRAIL-Inducing Compound #10 (TIC10) discovered in chemical library screen performed in #eldeirylab in 2007 at UPenn👇
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
www.science.org/doi/10.1126/...
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
www.science.org/doi/10.1126/...
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
TIC10 is a small molecule that activates Foxo3a through dual inactivation of Akt and ERK, up-regulates the expression of the TRAIL gene, an endogenous tumor suppressor, and effectively improves the th...
www.science.org
November 10, 2025 at 8:03 AM
First report of TRAIL-Inducing Compound #10 (TIC10) discovered in chemical library screen performed in #eldeirylab in 2007 at UPenn👇
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
www.science.org/doi/10.1126/...
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
www.science.org/doi/10.1126/...
Oncoceutics, originally founded by me in 2004 was reincorporated in 2009. Oncoceutics licensed TRAIL-Inducing Compound #10/ONC201 for development pmc.ncbi.nlm.nih.gov/articles/PMC...
Cancer Biology & Therapy Editor-in-Chief, Wafik S El-Deiry, MD, PhD, FACP, inducted into the Society of Scholars of the Johns Hopkins University on April 7, 2014
An official website of the United States government
pmc.ncbi.nlm.nih.gov
November 10, 2025 at 7:57 AM
Oncoceutics, originally founded by me in 2004 was reincorporated in 2009. Oncoceutics licensed TRAIL-Inducing Compound #10/ONC201 for development pmc.ncbi.nlm.nih.gov/articles/PMC...
Link to original discovery of TRAIL Death Receptor 5👇
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
www.nature.com/articles/ng1...
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
www.nature.com/articles/ng1...
www.nature.com
November 10, 2025 at 7:23 AM
Link to original discovery of TRAIL Death Receptor 5👇
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
www.nature.com/articles/ng1...
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
www.nature.com/articles/ng1...