Hunter Shain
@shainlab.bsky.social
UCSF, Department of Dermatology. Part of HTAN. Cancer, genomics, melanoma, cutaneous squamous cell carcinoma, dermatology, somatic mutations, tumor evolution, spatial transcriptomics, single-cell
6/ Bottom line:
If you only ask for feedback right before the deadline, you’ll get compliments.
If you ask early and involve people deeply, you’ll get insight.
If you only ask for feedback right before the deadline, you’ll get compliments.
If you ask early and involve people deeply, you’ll get insight.
October 24, 2025 at 8:07 PM
6/ Bottom line:
If you only ask for feedback right before the deadline, you’ll get compliments.
If you ask early and involve people deeply, you’ll get insight.
If you only ask for feedback right before the deadline, you’ll get compliments.
If you ask early and involve people deeply, you’ll get insight.
5/ You can still get critical feedback on a solo grant, but:
Send it early.
Make it clear you want honesty, not reassurance.
Send it early.
Make it clear you want honesty, not reassurance.
October 24, 2025 at 8:07 PM
5/ You can still get critical feedback on a solo grant, but:
Send it early.
Make it clear you want honesty, not reassurance.
Send it early.
Make it clear you want honesty, not reassurance.
4/ If you want real feedback, write a team science proposal together.
Involve your colleague early. Give them some skin in the game — salary support, co-PI status, etc.
That’s when the harsh truths come out — and the proposal actually improves.
Involve your colleague early. Give them some skin in the game — salary support, co-PI status, etc.
That’s when the harsh truths come out — and the proposal actually improves.
October 24, 2025 at 8:07 PM
4/ If you want real feedback, write a team science proposal together.
Involve your colleague early. Give them some skin in the game — salary support, co-PI status, etc.
That’s when the harsh truths come out — and the proposal actually improves.
Involve your colleague early. Give them some skin in the game — salary support, co-PI status, etc.
That’s when the harsh truths come out — and the proposal actually improves.
3/ In hindsight, what else could my colleagues do?
It was too close to the deadline for major changes, and negative feedback that late just feels discouraging.
It was too close to the deadline for major changes, and negative feedback that late just feels discouraging.
October 24, 2025 at 8:07 PM
3/ In hindsight, what else could my colleagues do?
It was too close to the deadline for major changes, and negative feedback that late just feels discouraging.
It was too close to the deadline for major changes, and negative feedback that late just feels discouraging.
2/ Early in my career, I’d send my grant to 5 colleagues the week it was due.
They’d fix a few typos and say it looked “great!”
Then the reviewers would find issues no one else had mentioned.
They’d fix a few typos and say it looked “great!”
Then the reviewers would find issues no one else had mentioned.
October 24, 2025 at 8:07 PM
2/ Early in my career, I’d send my grant to 5 colleagues the week it was due.
They’d fix a few typos and say it looked “great!”
Then the reviewers would find issues no one else had mentioned.
They’d fix a few typos and say it looked “great!”
Then the reviewers would find issues no one else had mentioned.
But there are more! Will be busy for the next few days!
October 9, 2025 at 2:01 PM
But there are more! Will be busy for the next few days!
Second is: www.nature.com/articles/s41...
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 9, 2025 at 2:01 PM
Second is: www.nature.com/articles/s41...
First on the to-read list is: www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 9, 2025 at 2:01 PM
First on the to-read list is: www.nature.com/articles/s41...