Etienne Becht
@ebecht.bsky.social
Computational immunologist. Interested in immunooncology, cytometry, single cell data, spatial data, T and B cell specificities...
Reposted by Etienne Becht
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Etienne Becht
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....
onlinelibrary.wiley.com
September 26, 2025 at 7:19 AM
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
Reposted by Etienne Becht
Nature research paper: One mother for two species via obligate cross-species cloning in ants
go.nature.com/45PYV6d
go.nature.com/45PYV6d
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same mother having distinct genomes and morphologies.
go.nature.com
September 5, 2025 at 10:42 AM
Nature research paper: One mother for two species via obligate cross-species cloning in ants
go.nature.com/45PYV6d
go.nature.com/45PYV6d
Reposted by Etienne Becht
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
April 10, 2025 at 1:38 PM
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
🧪💻 We're hiring ! Post-doctoral position open for a data scientist
👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...
👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...
March 11, 2025 at 11:36 AM
🧪💻 We're hiring ! Post-doctoral position open for a data scientist
👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...
👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...
Reposted by Etienne Becht
Unbelievable news.
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
February 27, 2025 at 5:03 PM
Unbelievable news.
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Reposted by Etienne Becht
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 21, 2025 at 10:32 PM
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
Flow cytometry batch effect correction without requiring normalization controls 🤩
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
CytoNorm 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls
Cytometry is a single cell, high-dimensional, high-throughput technique that is being applied across a range of disciplines. However, many elements alongside the data acquisition process might give r...
onlinelibrary.wiley.com
February 20, 2025 at 7:23 AM
Flow cytometry batch effect correction without requiring normalization controls 🤩
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Etienne Becht
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...
www.biorxiv.org
February 18, 2025 at 7:27 PM
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Etienne Becht
Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
February 18, 2025 at 4:46 AM
Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
Reposted by Etienne Becht
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...
#bioinformatics
academic.oup.com/bioinformati...
tagtango: an application to compare single-cell annotations
AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c
academic.oup.com
February 17, 2025 at 9:34 PM
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...
#bioinformatics
academic.oup.com/bioinformati...
Reposted by Etienne Becht
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature
Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...
www.nature.com
February 13, 2025 at 6:54 PM
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
Reposted by Etienne Becht
La FHU* MOSAIC² relabellisée pour 5 ans !
Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !
Plus d'informations sur le projet prochainement.
@hopitalbeaujon.bsky.social @ap-hp.bsky.social
Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !
Plus d'informations sur le projet prochainement.
@hopitalbeaujon.bsky.social @ap-hp.bsky.social
January 23, 2025 at 9:13 AM
La FHU* MOSAIC² relabellisée pour 5 ans !
Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !
Plus d'informations sur le projet prochainement.
@hopitalbeaujon.bsky.social @ap-hp.bsky.social
Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !
Plus d'informations sur le projet prochainement.
@hopitalbeaujon.bsky.social @ap-hp.bsky.social
Reposted by Etienne Becht
Luo et al. developed ATLAS-seq (Aptamer-based T-Lymphocyte Activity Screening and Sequencing), a microfluidic-based high-throughput platform for isolating and profiling antigen-reactive T cells. bit.ly/4fThnwo
January 16, 2025 at 5:00 PM
Luo et al. developed ATLAS-seq (Aptamer-based T-Lymphocyte Activity Screening and Sequencing), a microfluidic-based high-throughput platform for isolating and profiling antigen-reactive T cells. bit.ly/4fThnwo
Reposted by Etienne Becht
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
January 15, 2025 at 10:17 PM
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
@jem.org
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
Permanent position (research and teaching) for a bioinformatician immunologist available in a great lab and institute, in a beautiful campus in the center of Paris
www.linkedin.com/posts/isabel...
www.linkedin.com/posts/isabel...
Isabelle Cremer on LinkedIn: Poste MCU immunologie-bioinformatique
Un poste de maître de conférences en immunologie-bioinformatique est ouvert au concours à Sorbonne Université, au sein de la Faculté des Sciences et…
www.linkedin.com
January 7, 2025 at 12:09 PM
Permanent position (research and teaching) for a bioinformatician immunologist available in a great lab and institute, in a beautiful campus in the center of Paris
www.linkedin.com/posts/isabel...
www.linkedin.com/posts/isabel...
Reposted by Etienne Becht
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references. #GenomeAssembly #HaplotypeResolved #Pangenomes #Genomics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references - Genome Biology
Background Long-read technologies from Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) have transformed genomics research by providing diverse data types like HiFi, Duplex, and ult...
genomebiology.biomedcentral.com
December 19, 2024 at 8:56 PM
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references. #GenomeAssembly #HaplotypeResolved #Pangenomes #Genomics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Reposted by Etienne Becht
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
🌟 Calling all computational biology enthusiasts! 🌟 The awesome @remynicolle.bsky.social & friends created this Discord community to connect, collaborate, and share insights in this rapidly evolving field.
👉 Click here to join : discord.gg/2PzSE4dC
#Bioinformatics #ComputationalBiology
👉 Click here to join : discord.gg/2PzSE4dC
#Bioinformatics #ComputationalBiology
December 10, 2024 at 10:44 AM
🌟 Calling all computational biology enthusiasts! 🌟 The awesome @remynicolle.bsky.social & friends created this Discord community to connect, collaborate, and share insights in this rapidly evolving field.
👉 Click here to join : discord.gg/2PzSE4dC
#Bioinformatics #ComputationalBiology
👉 Click here to join : discord.gg/2PzSE4dC
#Bioinformatics #ComputationalBiology
Reposted by Etienne Becht
I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities.
Please feel free to share/join!
go.bsky.app/4P64DmM
Please feel free to share/join!
go.bsky.app/4P64DmM
December 3, 2024 at 11:09 PM
I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities.
Please feel free to share/join!
go.bsky.app/4P64DmM
Please feel free to share/join!
go.bsky.app/4P64DmM
Reposted by Etienne Becht
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
Reposted by Etienne Becht
I made a starter pack for single cell and spatial people on BlueSky! 🧬🧪🥳
I’m certain it’s very incomplete, so please just let me know if you’d like to be included 😊
go.bsky.app/U57Mar8
I’m certain it’s very incomplete, so please just let me know if you’d like to be included 😊
go.bsky.app/U57Mar8
November 7, 2024 at 12:04 PM
I made a starter pack for single cell and spatial people on BlueSky! 🧬🧪🥳
I’m certain it’s very incomplete, so please just let me know if you’d like to be included 😊
go.bsky.app/U57Mar8
I’m certain it’s very incomplete, so please just let me know if you’d like to be included 😊
go.bsky.app/U57Mar8
Reposted by Etienne Becht
November 25, 2024 at 9:34 AM
Reposted by Etienne Becht
Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics
go.bsky.app/73rcuJn
go.bsky.app/73rcuJn
November 24, 2024 at 7:50 AM
Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics
go.bsky.app/73rcuJn
go.bsky.app/73rcuJn