David Usharauli
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davidusharauli.bsky.social
David Usharauli
@davidusharauli.bsky.social
140 followers 15 following 760 posts
Immunologist & biotech startup co-founder (tregeutix.com) on a mission to harness the power of Tregs & microbiota | Calling on visionary investors to join our journey 🚀
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davidusharauli.bsky.social
The Weekend Tunes

MOCHIII - CÁNH HOA HÉO TÀN (🇻🇳 Vietnam)

"Withered flower petals"

Classical Vietnamese poetry meets modern beats.

Shared for educational and/or commentary purposes only.

#WorldMusic 🌍🎧
#MusicUnites ❤️🎵

youtu.be/K1VomrxrD-c?...
February 7, 2026 at 12:46 AM
davidusharauli.bsky.social
Most of what we know about ancient #Persia was written by Greeks, who often focused on their negative sides. Who were the #Achaemenids, a dynasty who created the first global empire?

#history

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www.goodreads.com
February 5, 2026 at 12:21 AM
davidusharauli.bsky.social
It is unclear whether loss of β2-adrenergic signaling in alveolar macrophages eliminates the tumor or simply delays its growth.

#science
#immunology
#CNS
Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis - Nature
Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereby…
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February 4, 2026 at 8:46 PM
davidusharauli.bsky.social
"an artificial intelligence (AI) program designed specifically to analyze the scientific literature. ...#OpenScholar..."

"OpenScholar’s creators at the Allen Institute"

#science

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Open-source AI program can answer science questions better than humans
Developed by and for academics, OpenScholar aims to improve searches of the ballooning scientific literature
www.science.org
February 4, 2026 at 8:28 PM
davidusharauli.bsky.social
The Weekend Tunes

RIMO PESO - Cizi (Cheese) (🇷🇼 Rwanda)

Who is this singer? Google had nothing. ChatGPT says Rwanda (Gikondo & Kinyarwanda).

Shared for educational and/or commentary purposes only.

#WorldMusic 🌍🎧
#MusicUnites ❤️🎵

youtu.be/Lt_a73ctqI0?...
February 1, 2026 at 12:46 AM
davidusharauli.bsky.social
After the Nobel Prize snub for the TLR discovery, the Medzhitov lab has been keen to explain allergy, this time through antigen cross-reactivity, yet remains reluctant to acknowledge the contributions of others.

#science
#immunology
#SPIRAL_model

www.nature.com/articles/s41...
Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship…
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January 28, 2026 at 9:15 PM
davidusharauli.bsky.social
Evaluation of open-source AI frameworks demonstrates that these systems are limited to conceptual planning and text generation, without the capacity to carry out full research cycles.

#science
#AI_Scientist
#AI

buff.ly/hlj5kAT
January 28, 2026 at 6:34 PM
davidusharauli.bsky.social
Crypto bros must be upset, central banks are buying gold, not digital gold.

#gold
#bitcoin
#crypto
January 25, 2026 at 7:49 PM
davidusharauli.bsky.social
The Weekend Tunes

Lali, Miranda! - MEJOR QUE VOS (🇦🇷 Argentina)

Saxophone never fails 🎷

Shared for educational and/or commentary purposes only.

#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵

youtu.be/Y0tagYoz1Ws?...
January 24, 2026 at 11:52 PM
Reposted by David Usharauli
onestpress.onestnetwork.com
UN Geneva: Words can be weapons.
The Holocaust didn’t start with gas chambers. It started with hate speech.
January 23, 2026 at 3:16 PM
Reposted by David Usharauli
onestpress.onestnetwork.com
Europe may begin selling U.S. assets in response to a new conflict with the US—a move that could trigger a dollar collapse, Bloomberg reports. Deutsche Bank analysts warn Washington’s key vulnerability is living off global financing—and Europe may decide it no longer wants to bankroll the U.S.
January 19, 2026 at 10:00 PM
davidusharauli.bsky.social
A readable account of an ancient empire that arose in modern-day Iraq, ruled the Middle East for a century, and then vanished suddenly and permanently, much like the Hittites. How can an entire nation disappear?

#books
#history
#assyria

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January 18, 2026 at 7:46 PM
davidusharauli.bsky.social
The Weekend Tunes

CHUU (츄) - XO, My Cyberlove (🇰🇷 South Korea)

K-pop international ✅

Shared for educational and/or commentary purposes only.

#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵

www.youtube.com/watch?v=fF7r...
January 18, 2026 at 12:16 AM
davidusharauli.bsky.social
I’m baffled that people believe an AI, trained on existing data, can produce genuinely new ideas. Humans can do it faster, but in biology, discovery is always serendipitous and unknown in advance.

#science
#AI

techcrunch.com/2026/01/16/f...
From OpenAI’s offices to a deal with Eli Lilly — how Chai Discovery became one of the flashiest names in AI drug development | TechCrunch
The startup has partnered with Eli Lilly and enjoys the backing of some of Silicon Valley's most influential VCs.
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January 16, 2026 at 8:38 PM
davidusharauli.bsky.social
This is an inadequate mouse tumor model, as anti-PD-1 works therapeutically in humans but not in this model.

#science
#immunology
#immunotherapy

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Microbiota-induced T cell plasticity enables immune-mediated tumour control - Nature
Molecular mimicry between a gut commensal and a tumour antigen forms part of an important mechanistic framework that can boost the efficacy of immune checkpoint blockade therapy and restrain tumour…
www.nature.com
January 15, 2026 at 12:13 AM
davidusharauli.bsky.social
AI is like a savant.

#AI

buff.ly/vcVgvTf
AI can spark creativity — if we ask it how, not what, to think
Studies aiming to maximize human creativity demonstrate that people work best when buoyed up by others who show them new ways to innovate.
www.nature.com
January 13, 2026 at 11:20 PM
davidusharauli.bsky.social
Recent Treg biotech trajectories show that current Treg-based tech do not work. Why? Unlike conventional T cells, Tregs operate within a tripartite system involving the microbiota and naturally IL-2–producing T cells.

#science
#immunology
#Treg

www.biospace.com/biospace-lay...
Layoff Tracker: SonomaBio Downsizes To Extend Runway
Follow along as BioSpace tracks job cuts and restructuring initiatives.
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January 13, 2026 at 9:21 PM
davidusharauli.bsky.social
The Weekend Tunes

Thalia - Ojitos Mexicanos (🇲🇽 Mexico)

It’s like the Mexican version of ‘Ochi Chyornye.’

Shared for educational and/or commentary purposes only.
#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵

youtu.be/18TN-SP5FVA?...
January 11, 2026 at 12:57 AM
davidusharauli.bsky.social
'Rampart sought to overcome these problems, but it never really publicly explained how.'

Despite that, it still raised $120M in total. And then we complain about the state of the biotech sector.

#biotech

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Rampart Closes Down Less Than 2 Years After Launch
Rampart Bioscience was working on a platform to deliver gene therapies without the need for viral vectors.
www.biospace.com
January 9, 2026 at 5:14 PM
davidusharauli.bsky.social
"People return to their original weight in less than two years after stopping weight-loss treatments as they regain about 0.4 kilos (0.9 pounds) on average each month"

#science
#ozempic
#GLP1

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Patients Gain Weight Faster Coming Off Obesity Drugs Than After a Diet
Patients who stop taking obesity drugs regain weight almost four times faster than people coming off a diet, according to new research that underscores how quickly the benefits of the treatments fade.
www.bloomberg.com
January 8, 2026 at 12:38 AM
davidusharauli.bsky.social
Although IL-10–producing Tr1 cells (T regulatory type 1) develop in response to food antigens, their functional significance can only be determined by selectively targeting this subset.

#science
#immunology

www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly…
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January 8, 2026 at 12:13 AM
davidusharauli.bsky.social
"A photo of Venezuelan President Nicolás Maduro in US custody may have turned him into an accidental fashion influencer."

😂

#Nike

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Nicolás Maduro in custody somehow became free marketing for Nike Tech
The internet can't stop talking about the gray Nike Tech fleece sweatsuit Nicolás Maduro wore while in US custody.
www.businessinsider.com
January 5, 2026 at 9:24 PM
davidusharauli.bsky.social
ferroptosis, apoptosis, cuproptosis, necroptosis...

Too many ways to die for a cell.

#science
#immunology

buff.ly/wMUVe87
Cell Press: Cell Press
www.cell.com
January 5, 2026 at 8:03 PM
davidusharauli.bsky.social
The Weekend Tunes

MONSTA X 몬스타엑스 'baby blue' (🇰🇷 South Korea)

K-pop seems to have two forms: international pop style and distinctly K-pop.

Shared for educational and/or commentary purposes only.
#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵

youtu.be/PxZej9IEVxc?...
January 3, 2026 at 11:45 PM
davidusharauli.bsky.social
Cancer vaccines largely fail because vaccines are not effective against established chronic conditions, whether chronic infections like HSV, CMV, and HBV or cancer. Vaccination is effective when administered prophylactically, not after disease is established.

buff.ly/IphTiCM
Blood-cleansing method faces its first test as cancer vaccine
New clinical trial aims to use whole, light-inactivated tumor cells for immunotherapy
www.science.org
January 1, 2026 at 8:55 PM