Bérénice A. Benayoun

Bérénice A. Benayoun, PhD

@bbparis1984.bsky.social

3.3K followers 2.8K following 200 posts

Associate prof @USC Gero. She/her.
French 🇫🇷 scientist. Aging👴🏻👵🏻, omics🧬, immunity (macrophages/neutrophils)🦠, sex-dimorphism ⚧️, hormones.
Mouse 🐁 and turquoise killifish 🐟.
Views my own.
http://gero.usc.edu/labs/benayounlab/
ORCID: 0000-0002-7401-4777 .. more

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Biology 68%

Medicine 19%

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Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Dec 12

🥳 Excited to share that our multi-omic study on the cellular impacts of Alu overexpression in healthy fibroblasts, co-led by former trainee Dr. Juan Bravo @the-te-guy.bsky.social and grad student Ms. Eyael Tewelde is out today in #Geroscience! 🧬🧪🖥️ #GeroSky
A 🧵 1/4
link.springer.com/article/10.1...

Reposted by Bérénice A. Benayoun

Waggoner Lab @labwaggoner.bsky.social · 2d

@biorxivpreprint.bsky.social macrophage aging in mice is shaped by both tissue niche and sex
www.biorxiv.org/content/10.6... @bbparis1984.bsky.social

Reposted by Bérénice A. Benayoun

Aging Science News @agingbiology.bsky.social · 11d

Rethinking the heritability of aging
www.science.org/doi/10.1126/...

Rethinking the heritability of aging

The genetic contribution to human longevity is greater than previously thought

www.science.org

Reposted by Ben Bond‐Lamberty, Steve Peers, Leslie Mabon , and 3 more Ben Bond‐Lamberty, Steve Peers, Leslie Mabon, Woodrow Hartzog, Bérénice A. Benayoun, Markus P. Eichhorn

Carl T. Bergstrom @carlbergstrom.com · 13d

“The idea is to put ChatGPT front and center inside software that scientists use to write up their work in much the same way that chatbots are now embedded into popular programming editors.

It’s vibe coding, but for science.”

OpenAI’s latest product lets you vibe code science

Prism is a ChatGPT-powered text editor that automates much of the work involved in writing scientific papers.

www.technologyreview.com

Reposted by Bérénice A. Benayoun

bioRxivpreprint @biorxivpreprint.bsky.social · 14d

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle https://www.biorxiv.org/content/10.64898/2026.01.23.700915v1

Reposted by Bérénice A. Benayoun

Melike Dönertaş @mdonertas.bsky.social · 18d

Nature Aging @nataging.nature.com turns 5 and asked ~50 researchers to reflect on the field. I am honored to contribute alongside colleagues whose work has shaped how I think about #aging science.

Past, present and future perspectives on the science of aging
www.nature.com/articles/s43...

Reposted by Andreas J. Bäumler, Santiago Gassó, Bérénice A. Benayoun

Dr Kathleen Millen @neurodevkathy.bsky.social · Jan 2

I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1

Reposted by Bérénice A. Benayoun

Genes & Development @genesdev.bsky.social · Dec 23

⏪ G&D RECAP ⏪

🗓️ August 2025
REVIEW: Studying ovarian aging and its health impacts: modern tools and approaches
By Bérénice Benayoun, Alison Kochersberger, and Jennifer Garrison
➡️ https://genesdev.cshlp.org/content/39/15-16/975.full

Bérénice A. Benayoun, PhD Jennifer Garrison
#aging #womenshealth

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Dec 12

Grateful for the fantastic time I had in the “from gametes to birth” team at Institut Cochin in Paris for my sabbatical. Learned a lot about pregnancy, reproductive biology and preeclampsia! Hope we will continue to collaborate moving forward! ❤️

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Dec 12

We are grateful to our collaborators at the @buckinstitute.org led by Dr. Schilling and late Dr. Campisi for their help through the USC/Buck @nathanshockcenters.org, and for support from #NIGMS.
We hope this work will help the #TE/#geroscience field! 4/4
@uscleonarddavis.bsky.social

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Dec 12

We also performed functional assays to validate our omic findings, and found that indeed, AluJb-overexpressing fibroblasts show remodeled mitochondria metabolism, S-phase accumulation/replication stalling and decreased aggresome load. 3/4

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Dec 12

Here, we show that overexpression of AluJb, a transposition-incompetent SINE, in human fibroblasts, leads to profound remodeling of transcriptome, proteome and secretome. Intriguingly, many AluJb-regulated pathways correspond to aging hallmarks (i.e. mitochondria, proteostasis, self-renewal). 2/4

Reposted by Bérénice A. Benayoun

Dr. Katja Thieme (she/they) @katjathieme.bsky.social · Dec 3

„The resistance is spreading beyond California. Dutch university faculty have issued an open letter calling for a moratorium on AI in academic settings, warning that its use ‘deskills critical thought‘ and reduces students to operators of machines.“

Reposted by Bérénice A. Benayoun

Jayce the Creature Creator @creatorjayce.bsky.social · Dec 2

Chibi Banded Killifish

#fishart #chibiart #killifish

A digitally colored illustration of a chibi banded killifish with a green background.

Reposted by Bérénice A. Benayoun

Cell Press @cellpress.bsky.social · Nov 15

"Strategies for studying sex differences in brain aging"
http://dlvr.it/TPHP3x

@bbparis1984.bsky.social @suhlab-aging.bsky.social @ctmurphy1.bsky.social @denadubal.bsky.social & colleagues

@cp-trendsgenetics.bsky.social
#SfN2025

Strategies for studying sex differences in brain aging, Trends in Genetics

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Oct 16

We are grateful for funding from the @cziscience.bsky.social data insights program for supporting this study, which we hope will be useful for the field!
#ovarian #singlecell #genomics #aging
Find the preprint at www.biorxiv.org/content/10.1...

Single-cell exploration of ovarian aging across vertebrate models

Mammalian female reproductive span is thought to be limited by a fixed "ovarian reserve" determined at birth. With age, a dwindling ovarian reserve leads to infertility, culminating in menopause in hu...

www.biorxiv.org

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Oct 16

Minhoo also leveraged #ASGARD to identify potential drugs that could revert transcriptional aging signatures across cell types and across species, yielding candidate conserved anti-ovarian aging compounds which will deserve further investigation. 5/5

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Oct 16

Granulosa and Theca cells, major somatic cell types of ovarian follicles, showed clear changes with aging, with some species-specific gene regulation, but also conserved changes. Importantly, expression of FSHR and OSGIN2 was consistently decreased across datasets and models. 4/5

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Oct 16

Datasets were processed with a unified standardized pipeline for easy #integration and #comparison. This included analysis of cell proportion changes, differential gene expression, and potential drug repurposing targets. 3/5

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Oct 16

Minhoo identified a number of high-quality #ovarian aging datasets across mammalian species, spanning humans🚶‍♀️, monkeys🐒, mice 🐁, and goat🐐, with samples across the reproductive lifespan. We reasoned this would allow us to identify conserved signatures of #ovarian aging. 2/5

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Oct 16

Happy to share a new @biorxivpreprint.bsky.social from the lab, led by talented postdoctoral fellow #MinhooKim: "Single-cell exploration of ovarian aging across vertebrate models", a meta-analysis study of public ovarian aging sc/snRNA-seq data! www.biorxiv.org/content/10.1... A 🧵, 1/5 🧬🖥️🧪 #GeroSky

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 11

I think mandating preprinting (like many private funders like CZI do) would be the perfect compromise instead of mandating gold OA and then restricting the amount of APC that can be spent. We always preprint before 1st submission in my lab, and I consider it the “director’s cut” anyway.

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 5

Undergrad flash talks are starting - the future of #Geroscience research is here!

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 5

😅

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 5

USC LDS Vice Dean Sean Curran opening the day!!!

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 5

#GLAM2025

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 5

#GLA2025 is on! attendees from all over and >100 trainee presentations (talks, flash talks, posters)!
Thanks to our sponsors for supporting the event!
#Hevolution @simonsfoundation.org @activemotifusa.bsky.social #CedarsSinai #Vwr #Echo #IDT and @cellpress.bsky.social editor Swapnila Ranu

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 5

So excited for #GLAM2025 tomorrow at the Cal Science Center! Looking forward to a day of great science from our LA and SoCal #Geroscience trainees, as well as a keynote from Pr Eileen Crimmins!

Reposted by Bérénice A. Benayoun

Andy Carr @andycarr.bsky.social · Sep 3

can journal editors see how often a deranged manuscript-submitter has checked the status of their submission within ~96 hours of sending it?

asking for...no reason. no reason at all, actually.

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Sep 3

The outrage is great, but the reality is gold OA is >>$2K, and capping the spending will have 2 effects: (1) only rich labs will be able to afford publishing in the most prestigious journals, (2) ECR who need these papers in their CVs will be screwed. At this point- not a victory for us scientists.

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